{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:02:49Z","timestamp":1782248569891,"version":"3.54.5"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1124\/dmd.120.000166","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T20:35:13Z","timestamp":1603398913000},"page":"62-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Gender and Various Diets on Bile Acid Profile and Related Genes in Mice"],"prefix":"10.1016","volume":"49","author":[{"given":"Chong","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-6563","authenticated-orcid":false,"given":"Ying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis D.","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.120.000166_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jchromb.2008.08.018","article-title":"Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS\/MS","volume":"873","author":"Alnouti","year":"2008","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1124\/dmd.120.000166_bib2","first-page":"19","article-title":"Regulation of cholesterol metabolism in liver: link to NAFLD and impact of n-3 PUFAs","volume":"3","author":"Bae","year":"2013","journal-title":"J Lifestyle Med"},{"key":"10.1124\/dmd.120.000166_bib3","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0022-2275(20)36958-3","article-title":"Effect of dietary n-3 versus n-6 polyunsaturated fatty acids on hepatic excretion of cholesterol in the hamster","volume":"34","author":"Berr","year":"1993","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.120.000166_bib4","doi-asserted-by":"crossref","first-page":"E121","DOI":"10.1152\/ajpendo.00409.2016","article-title":"Cyp8b1 ablation prevents Western diet-induced weight gain and hepatic steatosis because of impaired fat absorption","volume":"313","author":"Bertaggia","year":"2017","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1124\/dmd.120.000166_bib5","doi-asserted-by":"crossref","first-page":"152302","DOI":"10.1016\/j.tox.2019.152302","article-title":"Serum metabolic profile characteristics of offspring rats before and after birth caused by prenatal caffeine exposure","volume":"427","author":"Chen","year":"2019","journal-title":"Toxicology"},{"key":"10.1124\/dmd.120.000166_bib6","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1124\/dmd.109.027177","article-title":"Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys","volume":"37","author":"Cheng","year":"2009","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.120.000166_bib7","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1124\/dmd.105.003640","article-title":"Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps)","volume":"33","author":"Cheng","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.120.000166_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1124\/jpet.114.216796","article-title":"Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum","volume":"351","author":"Cheng","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.120.000166_bib9","doi-asserted-by":"crossref","first-page":"d176","DOI":"10.2741\/A273","article-title":"Regulation of bile acid synthesis","volume":"3","author":"Chiang","year":"1998","journal-title":"Front Biosci"},{"key":"10.1124\/dmd.120.000166_bib10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1124\/dmd.108.023721","article-title":"Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice","volume":"37","author":"Cui","year":"2009","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.120.000166_bib11","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s11357-012-9430-x","article-title":"Chronic caloric restriction partially protects against age-related alteration in serum metabolome","volume":"35","author":"De Guzman","year":"2013","journal-title":"Age (Dordr)"},{"key":"10.1124\/dmd.120.000166_bib12","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1158\/0008-5472.CAN-16-2860","article-title":"Western diet deregulates bile acid homeostasis, cell proliferation, and tumorigenesis in colon","volume":"77","author":"Dermadi","year":"2017","journal-title":"Cancer Res"},{"key":"10.1124\/dmd.120.000166_bib13","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/hep.28707","article-title":"G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice","volume":"65","author":"Donepudi","year":"2017","journal-title":"Hepatology"},{"key":"10.1124\/dmd.120.000166_bib14","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jhep.2017.07.004","article-title":"Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants","volume":"67","author":"Dr\u00f6ge","year":"2017","journal-title":"J Hepatol"},{"key":"10.1124\/dmd.120.000166_bib15","doi-asserted-by":"crossref","first-page":"e32551","DOI":"10.1371\/journal.pone.0032551","article-title":"Gender-divergent profile of bile acid homeostasis during aging of mice","volume":"7","author":"Fu","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/dmd.120.000166_bib16","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.taap.2013.10.020","article-title":"Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice","volume":"273","author":"Fu","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.120.000166_bib17","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/toxsci\/kfr114","article-title":"Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles","volume":"122","author":"Gong","year":"2011","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.120.000166_bib18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol Cell"},{"key":"10.1124\/dmd.120.000166_bib19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s12906-016-1367-7","article-title":"Dose-response effect of berberine on bile acid profile and gut microbiota in mice","volume":"16","author":"Guo","year":"2016","journal-title":"BMC Complement Altern Med"},{"key":"10.1124\/dmd.120.000166_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1161\/01.ATV.0000195793.73118.b4","article-title":"Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4","volume":"26","author":"Gutierrez","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/dmd.120.000166_bib21","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1101\/gad.1083503","article-title":"Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis","volume":"17","author":"Holt","year":"2003","journal-title":"Genes Dev"},{"key":"10.1124\/dmd.120.000166_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jnutbio.2016.10.007","article-title":"A diet-induced Sprague-Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis","volume":"40","author":"Ichimura","year":"2017","journal-title":"J Nutr Biochem"},{"key":"10.1124\/dmd.120.000166_bib23","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.ajpath.2017.04.019","article-title":"Western diet-induced dysbiosis in farnesoid X receptor knockout mice causes persistent hepatic inflammation after antibiotic treatment","volume":"187","author":"Jena","year":"2017","journal-title":"Am J Pathol"},{"key":"10.1124\/dmd.120.000166_bib24","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3389\/fendo.2019.00665","article-title":"Inhibiting ceramide synthesis attenuates hepatic steatosis and fibrosis in rats with non-alcoholic fatty liver disease","volume":"10","author":"Jiang","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1124\/dmd.120.000166_bib25","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1136\/gutjnl-2017-314307","article-title":"Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD","volume":"67","author":"Jiao","year":"2018","journal-title":"Gut"},{"key":"10.1124\/dmd.120.000166_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.109.002014","article-title":"Xenobiotic, bile acid, and cholesterol transporters: function and regulation","volume":"62","author":"Klaassen","year":"2010","journal-title":"Pharmacol Rev"},{"key":"10.1124\/dmd.120.000166_bib27","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jnutbio.2018.01.001","article-title":"Lifelong calorie restriction affects indicators of colonic health in aging C57Bl\/6J mice","volume":"56","author":"Kok","year":"2018","journal-title":"J Nutr Biochem"},{"key":"10.1124\/dmd.120.000166_bib28","doi-asserted-by":"crossref","first-page":"109915","DOI":"10.1016\/j.biopha.2020.109915","article-title":"Salidroside improves high-fat diet-induced non-alcoholic steatohepatitis by regulating the gut microbiota-bile acid-farnesoid X receptor axis","volume":"124","author":"Li","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1124\/dmd.120.000166_bib29","first-page":"7","article-title":"Protective effect of Lycium barbarum polysaccharides against high-fat diet-induced renal injury and lipid deposition in rat kidneys","volume":"33","author":"Liao","year":"2019","journal-title":"J Biol Regul Homeost Agents"},{"key":"10.1124\/dmd.120.000166_bib30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1053\/j.gastro.2018.04.032","article-title":"Mechanisms of MAFG dysregulation in cholestatic liver injury and development of liver cancer","volume":"155","author":"Liu","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.120.000166_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1124\/dmd.107.014845","article-title":"Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5\/6 nephrectomized rats","volume":"36","author":"Lu","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.120.000166_bib32","doi-asserted-by":"crossref","first-page":"G520","DOI":"10.1152\/ajpgi.00091.2009","article-title":"Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice","volume":"297","author":"Lukovac","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/dmd.120.000166_bib33","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.3892\/etm.2016.3619","article-title":"Triptolide inhibits the progression of atherosclerosis in apolipoprotein E-\/- mice","volume":"12","author":"Luo","year":"2016","journal-title":"Exp Ther Med"},{"key":"10.1124\/dmd.120.000166_bib34","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3945\/jn.116.234419","article-title":"Consumption of walnuts in combination with other whole foods produces physiologic, metabolic, and gene expression changes in obese C57bl\/6J high-fat-fed male mice","volume":"146","author":"Luo","year":"2016","journal-title":"J Nutr"},{"key":"10.1124\/dmd.120.000166_bib35","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","article-title":"Identification of a nuclear receptor for bile acids","volume":"284","author":"Makishima","year":"1999","journal-title":"Science"},{"key":"10.1124\/dmd.120.000166_bib36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1582-4934.2009.00997.x","article-title":"FXR an emerging therapeutic target for the treatment of atherosclerosis","volume":"14","author":"Mencarelli","year":"2010","journal-title":"J Cell Mol Med"},{"key":"10.1124\/dmd.120.000166_bib37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbalip.2005.06.001","article-title":"Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice","volume":"1735","author":"Murphy","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.120.000166_bib38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1074\/jbc.M107107200","article-title":"The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism","volume":"277","author":"Phan","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.120.000166_bib39","doi-asserted-by":"crossref","first-page":"e88584","DOI":"10.1371\/journal.pone.0088584","article-title":"Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis","volume":"9","author":"Renaud","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/dmd.120.000166_bib40","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1124\/dmd.115.065276","article-title":"Importance of large intestine in regulating bile acids and glucagon-like peptide-1 in germ-free mice","volume":"43","author":"Selwyn","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.120.000166_bib41","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1038\/s41598-017-01576-9","article-title":"Gender differences in bile acids and microbiota in relationship with gender dissimilarity in steatosis induced by diet and FXR inactivation","volume":"7","author":"Sheng","year":"2017","journal-title":"Sci Rep"},{"key":"10.1124\/dmd.120.000166_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mce.2015.07.012","article-title":"Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance","volume":"414","author":"Shihabudeen","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"10.1124\/dmd.120.000166_bib43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2014.12.005","article-title":"Individual bile acids have differential effects on bile acid signaling in mice","volume":"283","author":"Song","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.120.000166_bib44","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1194\/jlr.M071183","article-title":"Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans","volume":"57","author":"Takahashi","year":"2016","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.120.000166_bib45","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrd2619","article-title":"Targeting bile-acid signalling for metabolic diseases","volume":"7","author":"Thomas","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/dmd.120.000166_bib46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000282091","article-title":"Bile acids as regulators of hepatic lipid and glucose metabolism","volume":"28","author":"Trauner","year":"2010","journal-title":"Dig Dis"},{"key":"10.1124\/dmd.120.000166_bib47","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.metabol.2011.10.023","article-title":"Ursodeoxycholic acid improves insulin sensitivity and hepatic steatosis by inducing the excretion of hepatic lipids in high-fat diet-fed KK-Ay mice","volume":"61","author":"Tsuchida","year":"2012","journal-title":"Metabolism"},{"key":"10.1124\/dmd.120.000166_bib48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0005-2760(93)90065-H","article-title":"Effect of various n-3\/n-6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochondrial beta-oxidation","volume":"1170","author":"Vamecq","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.120.000166_bib49","doi-asserted-by":"crossref","first-page":"10899","DOI":"10.1002\/jcp.27905","article-title":"Bile salt (glycochenodeoxycholate acid) induces cell survival and chemoresistance in hepatocellular carcinoma","volume":"234","author":"Wang","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1124\/dmd.120.000166_bib50","doi-asserted-by":"crossref","first-page":"16502","DOI":"10.1038\/s41598-018-34453-0","article-title":"Maternal high-fat diet programs offspring liver steatosis in a sexually dimorphic manner in association with changes in gut microbial ecology in mice","volume":"8","author":"Wankhade","year":"2018","journal-title":"Sci Rep"},{"key":"10.1124\/dmd.120.000166_bib51","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/hep.510270320","article-title":"The effects of cholesterol uptake from high-density lipoprotein subfractions on biliary sterol secretion in rats with essential fatty-acid deficiency","volume":"27","author":"Wanon","year":"1998","journal-title":"Hepatology"},{"key":"10.1124\/dmd.120.000166_bib52","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1002\/ijc.30219","article-title":"Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis","volume":"139","author":"Xie","year":"2016","journal-title":"Int J Cancer"},{"key":"10.1124\/dmd.120.000166_bib53","doi-asserted-by":"crossref","first-page":"45232","DOI":"10.1038\/srep45232","article-title":"Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes","volume":"7","author":"Xie","year":"2017","journal-title":"Sci Rep"},{"key":"10.1124\/dmd.120.000166_bib54","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bcp.2014.08.018","article-title":"All-trans retinoic acid regulates hepatic bile acid homeostasis","volume":"91","author":"Yang","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.120.000166_bib55","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/toxsci\/kfs123","article-title":"Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury","volume":"127","author":"Zhang","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.120.000166_bib56","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/toxsci\/kfr236","article-title":"Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability","volume":"124","author":"Zhang","year":"2011","journal-title":"Toxicol Sci"},{"key":"10.1124\/dmd.120.000166_bib57","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bcp.2013.05.020","article-title":"Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism","volume":"86","author":"Zhang","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.120.000166_bib58","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1478-3231.2011.02662.x","article-title":"Effect of bile duct ligation on bile acid composition in mouse serum and liver","volume":"32","author":"Zhang","year":"2012","journal-title":"Liver Int"},{"key":"10.1124\/dmd.120.000166_bib59","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1194\/jlr.M007641","article-title":"Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice","volume":"51","author":"Zhang","year":"2010","journal-title":"J Lipid Res"},{"key":"10.1124\/dmd.120.000166_bib60","doi-asserted-by":"crossref","first-page":"e34522","DOI":"10.1371\/journal.pone.0034522","article-title":"Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624079492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624079492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.120.000166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T12:49:49Z","timestamp":1740055789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624079492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0090955624079492"],"URL":"https:\/\/doi.org\/10.1124\/dmd.120.000166","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Gender and Various Diets on Bile Acid Profile and Related Genes in Mice","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.120.000166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}