{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:26:47Z","timestamp":1787016407959,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1124\/dmd.121.000451","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T14:45:12Z","timestamp":1639752312000},"page":"1389-1395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Attenuated Ochratoxin A Transporter Expression in a Mouse Model of Nonalcoholic Steatohepatitis Protects against Proximal Convoluted Tubule Toxicity"],"prefix":"10.1016","volume":"50","author":[{"given":"Joseph L.","family":"Jilek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla L.","family":"Frost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Marie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra M.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goedken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan J.","family":"Cherrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.121.000451_bib1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2885.2006.00718.x","article-title":"Immunotoxic activity of ochratoxin A","volume":"29","author":"Al-Anati","year":"2006","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1124\/dmd.121.000451_bib2","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3390\/toxins2061381","article-title":"Molecular mechanism of ochratoxin a transport in the kidney","volume":"2","author":"Anzai","year":"2010","journal-title":"Toxins (Basel)"},{"key":"10.1124\/dmd.121.000451_bib3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1124\/jpet.105.088583","article-title":"Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules","volume":"315","author":"Anzai","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.121.000451_bib4","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1124\/dmd.119.086579","article-title":"Kidney cortical transporter expression across species using quantitative proteomics","volume":"47","author":"Basit","year":"2019","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.121.000451_bib5","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1080\/10408398.2012.724480","article-title":"Ochratoxin A and human health risk: a review of the evidence","volume":"55","author":"Bui-Klimke","year":"2015","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1124\/dmd.121.000451_bib6","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1517\/17425255.2014.936378","article-title":"Drug disposition alterations in liver disease: extrahepatic effects in cholestasis and nonalcoholic steatohepatitis","volume":"10","author":"Canet","year":"2014","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1124\/dmd.121.000451_bib7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1124\/dmd.114.060574","article-title":"Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis","volume":"43","author":"Canet","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.121.000451_bib8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/mnfr.200500182","article-title":"Balkan endemic nephropathy: role of ochratoxins A through biomarkers","volume":"50","author":"Castegnaro","year":"2006","journal-title":"Mol Nutr Food Res"},{"key":"10.1124\/dmd.121.000451_bib9","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1074\/jbc.275.6.4507","article-title":"Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta","volume":"275","author":"Cha","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.121.000451_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pharmthera.2015.03.005","article-title":"Nonalcoholic steatohepatitis in precision medicine: unraveling the factors that contribute to individual variability","volume":"151","author":"Clarke","year":"2015","journal-title":"Pharmacol Ther"},{"key":"10.1124\/dmd.121.000451_bib11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jhep.2014.02.021","article-title":"Synergistic interaction between genetics and disease on pravastatin disposition","volume":"61","author":"Clarke","year":"2014","journal-title":"J Hepatol"},{"key":"10.1124\/dmd.121.000451_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22035","article-title":"Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis","volume":"32","author":"Dzierlenga","year":"2018","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1124\/dmd.121.000451_bib13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0022-3565(25)12063-6","article-title":"Time- and concentration-dependent biphasic effect of ochratoxin A on growth of proximal tubular cells in primary culture","volume":"275","author":"Gekle","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.121.000451_bib14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0022-3565(25)39445-0","article-title":"Mechanism of ochratoxin A-induced reduction of glomerular filtration rate in rats","volume":"267","author":"Gekle","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.121.000451_bib15","first-page":"40","article-title":"The role of the proximal tubule in ochratoxin A nephrotoxicity in vivo: toxodynamic and toxokinetic aspects","volume":"17","author":"Gekle","year":"1994","journal-title":"Ren Physiol Biochem"},{"key":"10.1124\/dmd.121.000451_bib16","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3390\/toxins2082055","article-title":"Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity","volume":"2","author":"Hagos","year":"2010","journal-title":"Toxins (Basel)"},{"key":"10.1124\/dmd.121.000451_bib17","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1124\/dmd.111.041012","article-title":"Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver disease","volume":"39","author":"Hardwick","year":"2011","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.121.000451_bib18","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.3390\/toxins7104253","article-title":"Comparative ochratoxin toxicity: a review of the available data","volume":"7","author":"Heussner","year":"2015","journal-title":"Toxins (Basel)"},{"key":"10.1124\/dmd.121.000451_bib19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1128\/am.30.1.48-51.1975","article-title":"Nephrotoxicity of dietary ochratoxin A in broiler chickens","volume":"30","author":"Huff","year":"1975","journal-title":"Appl Microbiol"},{"key":"10.1124\/dmd.121.000451_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejps.2017.11.001","article-title":"Renal organic anion transporters in drug-drug interactions and diseases","volume":"112","author":"Huo","year":"2018","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/dmd.121.000451_bib21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s40262-017-0506-8","article-title":"Renal drug transporters and drug interactions","volume":"56","author":"Ivanyuk","year":"2017","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.121.000451_bib22","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1016\/j.apsb.2021.05.030","article-title":"Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity","volume":"11","author":"Jilek","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1124\/dmd.121.000451_bib23","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0024-3205(01)01296-6","article-title":"Characterization of ochratoxin A transport by human organic anion transporters","volume":"69","author":"Jung","year":"2001","journal-title":"Life Sci"},{"key":"10.1124\/dmd.121.000451_bib24","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1254\/jphs.10227SC","article-title":"A novel human organic anion transporter NPT4 mediates the transport of ochratoxin A","volume":"116","author":"Jutabha","year":"2011","journal-title":"J Pharmacol Sci"},{"key":"10.1124\/dmd.121.000451_bib25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bcp.2016.07.001","article-title":"Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir","volume":"115","author":"Laho","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.121.000451_bib26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3390\/toxins6010371","article-title":"A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity","volume":"6","author":"Limonciel","year":"2014","journal-title":"Toxins (Basel)"},{"key":"10.1124\/dmd.121.000451_bib27","doi-asserted-by":"crossref","first-page":"F361","DOI":"10.1152\/ajprenal.00207.2006","article-title":"Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones","volume":"292","author":"Ljubojevi\u0107","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/dmd.121.000451_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3390\/toxins8070191","article-title":"Ochratoxin A: 50 years of research","volume":"8","author":"Malir","year":"2016","journal-title":"Toxins (Basel)"},{"key":"10.1124\/dmd.121.000451_bib29","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1021\/tx049651p","article-title":"Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats","volume":"18","author":"Mally","year":"2005","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/dmd.121.000451_bib30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1081\/DMR-120000654","article-title":"Mechanisms and clinical implications of renal drug excretion","volume":"33","author":"Masereeuw","year":"2001","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.121.000451_bib31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/hep.21214","article-title":"Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver","volume":"44","author":"Meier","year":"2006","journal-title":"Hepatology"},{"key":"10.1124\/dmd.121.000451_bib32","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1124\/dmd.114.056929","article-title":"Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters","volume":"42","author":"Mooij","year":"2014","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.121.000451_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2133\/dmpk.DMPK-11-RV-099","article-title":"Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs","volume":"27","author":"Nakanishi","year":"2012","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.121.000451_bib34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1152\/physrev.00025.2013","article-title":"The organic anion transporter (OAT) family: a systems biology perspective","volume":"95","author":"Nigam","year":"2015","journal-title":"Physiol Rev"},{"key":"10.1124\/dmd.121.000451_bib35","doi-asserted-by":"crossref","first-page":"836","DOI":"10.4315\/0362-028X.JFP-14-471","article-title":"Occurrence of ochratoxin a contamination and detection of ochratoxigenic Aspergillus species in retail samples of dried fruits and nuts","volume":"78","author":"Palumbo","year":"2015","journal-title":"J Food Prot"},{"key":"10.1124\/dmd.121.000451_bib36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/mnfr.200600137","article-title":"Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans","volume":"51","author":"Pfohl-Leszkowicz","year":"2007","journal-title":"Mol Nutr Food Res"},{"key":"10.1124\/dmd.121.000451_bib37","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1124\/dmd.113.053819","article-title":"Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex","volume":"42","author":"Prasad","year":"2014","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.121.000451_bib38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2005.10.106","article-title":"Toxicokinetics and toxicodynamics of ochratoxin A, an update","volume":"159","author":"Ringot","year":"2006","journal-title":"Chem Biol Interact"},{"key":"10.1124\/dmd.121.000451_bib39","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/jsfa.3647","article-title":"Screening of mycotoxin multicontamination in medicinal and aromatic herbs sampled in Spain","volume":"89","author":"Santos","year":"2009","journal-title":"J Sci Food Agric"},{"key":"10.1124\/dmd.121.000451_bib40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1023\/A:1007662101880","article-title":"The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells","volume":"15","author":"Schwerdt","year":"1999","journal-title":"Cell Biol Toxicol"},{"key":"10.1124\/dmd.121.000451_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.toxlet.2019.01.001","article-title":"Thioacetamide potentiates high cholesterol and high fat diet induced steato-hepatitic changes in livers of C57BL\/6J mice: a novel eight weeks model of fibrosing NASH","volume":"304","author":"Sharma","year":"2019","journal-title":"Toxicol Lett"},{"key":"10.1124\/dmd.121.000451_bib42","doi-asserted-by":"crossref","first-page":"F767","DOI":"10.1152\/ajprenal.00312.2010","article-title":"Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates","volume":"299","author":"Shima","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/dmd.121.000451_bib43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ejps.2005.12.003","article-title":"Transporters as a determinant of drug clearance and tissue distribution","volume":"27","author":"Shitara","year":"2006","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/dmd.121.000451_bib44","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1093\/oxfordjournals.ndt.a027198","article-title":"Ochratoxin a: a new environmental factor which is toxic for the kidney?","volume":"11","author":"Simon","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"10.1124\/dmd.121.000451_bib45","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3390\/toxins2040649","article-title":"Studies on carcinogenic and toxic effects of ochratoxin A in chicks","volume":"2","author":"Stoev","year":"2010","journal-title":"Toxins (Basel)"},{"key":"10.1124\/dmd.121.000451_bib46","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0014-5793(99)01491-X","article-title":"Gender differences in expression of organic cation transporter OCT2 in rat kidney","volume":"461","author":"Urakami","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1124\/dmd.121.000451_bib47","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/2051112a0","article-title":"Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh","volume":"205","author":"van der Merwe","year":"1965","journal-title":"Nature"},{"key":"10.1124\/dmd.121.000451_bib48","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3892\/mmr.2016.5970","article-title":"Age-associated differences in transporter gene expression in kidneys of male rats","volume":"15","author":"Xu","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1124\/dmd.121.000451_bib49","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.bcp.2005.09.020","article-title":"Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the rat","volume":"70","author":"Yonezawa","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.121.000451_bib50","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3390\/toxins2040780","article-title":"Ochratoxin A and \u03b22-microglobulin in BEN patients and controls","volume":"2","author":"Yordanova","year":"2010","journal-title":"Toxins (Basel)"},{"key":"10.1124\/dmd.121.000451_bib51","doi-asserted-by":"crossref","first-page":"F236","DOI":"10.1152\/ajprenal.00012.2004","article-title":"Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney","volume":"287","author":"Youngblood","year":"2004","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624008778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624008778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.121.000451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T03:55:23Z","timestamp":1739937323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624008778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0090955624008778"],"URL":"https:\/\/doi.org\/10.1124\/dmd.121.000451","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Attenuated Ochratoxin A Transporter Expression in a Mouse Model of Nonalcoholic Steatohepatitis Protects against Proximal Convoluted Tubule Toxicity","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.121.000451","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}