{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:45:48Z","timestamp":1785750348037,"version":"3.56.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1124\/dmd.122.000930","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T20:40:13Z","timestamp":1655239213000},"page":"1434-1441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes"],"prefix":"10.1016","volume":"50","author":[{"given":"Yasuhiro","family":"Uno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norie","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe","family":"Ijiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yamato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuya","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Teraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazuki","family":"Mizukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouta M.M.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Ikenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-4261","authenticated-orcid":false,"given":"Hiroshi","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.122.000930_bib1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cvsm.2013.05.001","article-title":"Canine cytochrome P-450 pharmacogenetics","volume":"43","author":"Court","year":"2013","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"10.1124\/dmd.122.000930_bib2","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1124\/dmd.106.012823","article-title":"Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues","volume":"35","author":"Delozier","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.000930_bib3","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1080\/00498254.2020.1763513","article-title":"Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver","volume":"50","author":"Elmorsi","year":"2020","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.122.000930_bib4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0021-9258(18)48462-1","article-title":"Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences","volume":"267","author":"Gotoh","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.122.000930_bib5","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1124\/dmd.112.049429","article-title":"Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily","volume":"41","author":"Graves","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.000930_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1124\/jpet.300.1.298","article-title":"Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes","volume":"300","author":"Hashizume","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.122.000930_bib7","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0006-2952(97)00643-6","article-title":"High catalytic activity of human cytochrome P450 co-expressed with human NADPH-cytochrome P450 reductase in Escherichia coli","volume":"55","author":"Iwata","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.122.000930_bib8","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0026-895X(24)12335-8","article-title":"Cloning of CYP2J2 gene and identification of functional polymorphisms","volume":"61","author":"King","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.122.000930_bib9","doi-asserted-by":"crossref","first-page":"10237","DOI":"10.1021\/bi700876a","article-title":"Unusual regioselectivity and active site topology of human cytochrome P450 2J2","volume":"46","author":"Lafite","year":"2007","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.122.000930_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1124\/dmd.109.030270","article-title":"Identification of novel substrates for human cytochrome P450 2J2","volume":"38","author":"Lee","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.000930_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jvp.12717","article-title":"High interindividual variability in plasma clopidogrel active metabolite concentrations in healthy cats is associated with sex and cytochrome P450 2C genetic polymorphism","volume":"42","author":"Lee","year":"2019","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1124\/dmd.122.000930_bib12","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/prot.21778","article-title":"Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking","volume":"71","author":"Li","year":"2008","journal-title":"Proteins"},{"key":"10.1124\/dmd.122.000930_bib13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3109\/03602532.2013.765445","article-title":"Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics","volume":"45","author":"Martinez","year":"2013","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.122.000930_bib14","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1124\/dmd.30.11.1240","article-title":"Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole","volume":"30","author":"Matsumoto","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.000930_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/03602532.2016.1188938","article-title":"CYP2J2 - regulation, function and polymorphism","volume":"48","author":"Murray","year":"2016","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.122.000930_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1479-7364-4-1-59","article-title":"The cytochrome p450 homepage","volume":"4","author":"Nelson","year":"2009","journal-title":"Hum Genomics"},{"key":"10.1124\/dmd.122.000930_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-200401000-00001","article-title":"Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants","volume":"14","author":"Nelson","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1124\/dmd.122.000930_bib18","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature","volume":"239","author":"Omura","year":"1964","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.122.000930_bib19","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1080\/00498254.2018.1483543","article-title":"Limited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats","volume":"49","author":"Ono","year":"2019","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.122.000930_bib20","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1124\/dmd.105.008672","article-title":"The human intestinal cytochrome P450 \u201cpie\u201d","volume":"34","author":"Paine","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.000930_bib21","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/S0021-9258(19)73803-4","article-title":"Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies","volume":"237","author":"Phillips","year":"1962","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.122.000930_bib22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2174\/138920011795713698","article-title":"Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model","volume":"12","author":"Puccinelli","year":"2011","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.122.000930_bib23","doi-asserted-by":"crossref","first-page":"25467","DOI":"10.1074\/jbc.M100545200","article-title":"Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain","volume":"276","author":"Qu","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.122.000930_bib24","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1124\/dmd.117.078964","article-title":"Cytochrome P450 2J2: potential role in drug metabolism and cardiotoxicity","volume":"46","author":"Solanki","year":"2018","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.000930_bib25","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3109\/00498254.2014.895882","article-title":"Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys","volume":"44","author":"Uehara","year":"2014","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.122.000930_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3109\/00498254.2014.952800","article-title":"Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine","volume":"45","author":"Uehara","year":"2015","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.122.000930_bib27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3109\/00498254.2016.1146366","article-title":"Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine","volume":"46","author":"Uehara","year":"2016","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.122.000930_bib28","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/00498254.2017.1321811","article-title":"Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines","volume":"48","author":"Uehara","year":"2018","journal-title":"Xenobiotica"},{"key":"10.1124\/dmd.122.000930_bib29","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/mol.106.022673","article-title":"CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone","volume":"70","author":"Uno","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.122.000930_bib30","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1074\/jbc.271.7.3460","article-title":"Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart","volume":"271","author":"Wu","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1124\/dmd.122.000930_bib31","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2174\/1389200215666140908095647","article-title":"Research\/review: Insights into the mutation-induced dysfunction of arachidonic acid metabolism from modeling of human CYP2J2","volume":"15","author":"Xia","year":"2014","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.122.000930_bib32","doi-asserted-by":"crossref","first-page":"22267","DOI":"10.1038\/s41598-020-79284-0","article-title":"Molecular determinant of substrate binding and specificity of cytochrome P450 2J2","volume":"10","author":"Xu","year":"2020","journal-title":"Sci Rep"},{"key":"10.1124\/dmd.122.000930_bib33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/03602532.2013.806537","article-title":"Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance","volume":"45","author":"Xu","year":"2013","journal-title":"Drug Metab Rev"},{"key":"10.1124\/dmd.122.000930_bib34","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1124\/mol.51.6.931","article-title":"CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization, and potential functional significance","volume":"51","author":"Zeldin","year":"1997","journal-title":"Mol Pharmacol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624008894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624008894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.122.000930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T08:57:41Z","timestamp":1739955461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624008894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0090955624008894"],"URL":"https:\/\/doi.org\/10.1124\/dmd.122.000930","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.122.000930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}