{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:11:41Z","timestamp":1782123101893,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1124\/dmd.122.001080","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T21:00:27Z","timestamp":1686171627000},"page":"1308-1315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of Traditional and Proteomic Methods in the Assessment of a Preclinical Model of Preeclampsia"],"prefix":"10.1016","volume":"51","author":[{"given":"Wanying","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Pollinzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheline","family":"Piquette-Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.122.001080_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: a systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1124\/dmd.122.001080_bib2","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1124\/dmd.120.000067","article-title":"Gestational age-dependent abundance of human placental transporters as determined by quantitative targeted proteomics","volume":"48","author":"Anoshchenko","year":"2020","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.001080_bib3","first-page":"117","article-title":"Investigating the association of IL-17A and IL-17F with susceptibility to pre-eclampsia in Iranian women","volume":"12","author":"Anvari","year":"2015","journal-title":"Iran J Immunol"},{"key":"10.1124\/dmd.122.001080_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms19051496","article-title":"Oxidative stress in preeclampsia and placental diseases","volume":"19","author":"Aouache","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1124\/dmd.122.001080_bib5","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.jprot.2009.12.014","article-title":"Serum profile in preeclampsia and intra-uterine growth restriction revealed by iTRAQ technology","volume":"73","author":"Auer","year":"2010","journal-title":"J Proteomics"},{"key":"10.1124\/dmd.122.001080_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1559-0275-11-40","article-title":"Proteomic analysis of human placental syncytiotrophoblast microvesicles in preeclampsia","volume":"11","author":"Baig","year":"2014","journal-title":"Clin Proteomics"},{"key":"10.1124\/dmd.122.001080_bib7","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1002\/pmic.200800625","article-title":"A proteomic approach identifies early pregnancy biomarkers for preeclampsia: novel linkages between a predisposition to preeclampsia and cardiovascular disease","volume":"9","author":"Blumenstein","year":"2009","journal-title":"Proteomics"},{"key":"10.1124\/dmd.122.001080_bib8","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ"},{"key":"10.1124\/dmd.122.001080_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.preghy.2010.12.002","article-title":"Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia","volume":"1","author":"Burton","year":"2011","journal-title":"Pregnancy Hypertens"},{"key":"10.1124\/dmd.122.001080_bib10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tice.2014.08.004","article-title":"Oxidative stress and apoptosis in preeclampsia","volume":"46","author":"Can","year":"2014","journal-title":"Tissue Cell"},{"key":"10.1124\/dmd.122.001080_bib11","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41371-021-00637-x","article-title":"Progress in preeclampsia: the contribution of animal models","volume":"36","author":"Chau","year":"2022","journal-title":"J Hum Hypertens"},{"key":"10.1124\/dmd.122.001080_bib12","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.placenta.2014.05.002","article-title":"Inflammation-induced fetal growth restriction in rats is associated with altered placental morphometrics","volume":"35","author":"Cotechini","year":"2014","journal-title":"Placenta"},{"key":"10.1124\/dmd.122.001080_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1084\/jem.20130295","article-title":"Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia","volume":"211","author":"Cotechini","year":"2014","journal-title":"J Exp Med"},{"key":"10.1124\/dmd.122.001080_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1586\/ecp.11.66","article-title":"Inflammation-mediated changes in drug transporter expression\/activity: implications for therapeutic drug response","volume":"5","author":"Cressman","year":"2012","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1124\/dmd.122.001080_bib15","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/proteomes1030180","article-title":"Comparative and quantitative global proteomics approaches: an overview","volume":"1","author":"Deracinois","year":"2013","journal-title":"Proteomes"},{"key":"10.1124\/dmd.122.001080_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.preghy.2017.03.005","article-title":"Proteinuria in preeclampsia: Not essential to diagnosis but related to disease severity and fetal outcomes","volume":"8","author":"Dong","year":"2017","journal-title":"Pregnancy Hypertens"},{"key":"10.1124\/dmd.122.001080_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/CS20150702","article-title":"The role of inflammation in the pathology of preeclampsia","volume":"130","author":"Harmon","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"10.1124\/dmd.122.001080_bib18","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/cts.12742","article-title":"Role of elevated SFLT-1 on the regulation of placental transporters in women with pre-eclampsia","volume":"13","author":"Kojovic","year":"2020","journal-title":"Clin Transl Sci"},{"key":"10.1124\/dmd.122.001080_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/305964","article-title":"Quantitative proteomic (iTRAQ) analysis of 1st trimester maternal plasma samples in pregnancies at risk for preeclampsia","volume":"2012","author":"Kolla","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"10.1124\/dmd.122.001080_bib20","first-page":"412","article-title":"Tumor necrosis factor-alpha, interleukin-6, and interleukin-10 levels are altered in preeclampsia: a systematic review and meta-analysis","volume":"70","author":"Lau","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"10.1124\/dmd.122.001080_bib21","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1161\/HYPERTENSIONAHA.119.13348","article-title":"Soluble endoglin as a marker for preeclampsia, its severity, and the occurrence of adverse outcomes","volume":"74","author":"Lea\u00f1os-Miranda","year":"2019","journal-title":"Hypertension"},{"key":"10.1124\/dmd.122.001080_bib22","first-page":"178","article-title":"The role of apoptosis in preeclampsia","volume":"7","author":"Levy","year":"2005","journal-title":"Isr Med Assoc J"},{"key":"10.1124\/dmd.122.001080_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001144","article-title":"Quantitative proteome comparison of human hearts with those of model organisms","volume":"19","author":"Linscheid","year":"2021","journal-title":"PLoS Biol"},{"key":"10.1124\/dmd.122.001080_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.726513","article-title":"Preeclampsia: from cellular wellness to inappropriate cell death, and the roles of nutrition","volume":"9","author":"Lokeswara","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1124\/dmd.122.001080_bib25","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1161\/HYPERTENSIONAHA.120.16454","article-title":"Mechanisms underlying vascular endothelial growth factor receptor inhibition-induced hypertension: the HYPAZ Trial","volume":"77","author":"M\u00e4ki-Pet\u00e4j\u00e4","year":"2021","journal-title":"Hypertension"},{"key":"10.1124\/dmd.122.001080_bib26","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1021\/acs.jproteome.6b00955","article-title":"Placental proteomics provides insights into pathophysiology of pre-eclampsia and predicts possible markers in plasma","volume":"16","author":"Mary","year":"2017","journal-title":"J Proteome Res"},{"key":"10.1124\/dmd.122.001080_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1124\/dmd.107.018747","article-title":"Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer","volume":"36","author":"Morgan","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.001080_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jri.2015.05.007","article-title":"Increased circulating interleukin-17 levels in preeclampsia","volume":"112","author":"Molvarec","year":"2015","journal-title":"J Reprod Immunol"},{"key":"10.1124\/dmd.122.001080_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12014-021-09313-1","article-title":"Quantitative proteomics-based analyses performed on pre-eclampsia samples in the 2004-2020 period: a systematic review","volume":"18","author":"Navajas","year":"2021","journal-title":"Clin Proteomics"},{"key":"10.1124\/dmd.122.001080_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214671","article-title":"Using proteomics to advance the search for potential biomarkers for preeclampsia: a systematic review and meta-analysis","volume":"14","author":"Nguyen","year":"2019","journal-title":"PLoS One"},{"key":"10.1124\/dmd.122.001080_bib31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3858\/emm.2011.43.7.047","article-title":"Discovery of the serum biomarker proteins in severe preeclampsia by proteomic analysis","volume":"43","author":"Park","year":"2011","journal-title":"Exp Mol Med"},{"key":"10.1124\/dmd.122.001080_bib32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.intimp.2015.04.020","article-title":"Maternal bacterial infections impact expression of drug transporters in human placenta","volume":"26","author":"Petrovic","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"10.1124\/dmd.122.001080_bib33","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1124\/dmd.110.034470","article-title":"Impact of polyinosinic\/polycytidylic acid on placental and hepatobiliary drug transporters in pregnant rats","volume":"38","author":"Petrovic","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.001080_bib34","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1124\/dmd.107.019851","article-title":"Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats","volume":"36","author":"Petrovic","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.122.001080_bib35","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/OGX.0b013e3182331028","article-title":"A critical review of early-onset and late-onset preeclampsia","volume":"66","author":"Raymond","year":"2011","journal-title":"Obstet Gynecol Surv"},{"key":"10.1124\/dmd.122.001080_bib36","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat Protoc"},{"key":"10.1124\/dmd.122.001080_bib1209244","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/MNH.0000000000000105","article-title":"Pathogenesis of preeclampsia","volume":"24","author":"Sircar","year":"2015","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1124\/dmd.122.001080_bib37","series-title":"The Differences Between Early- and Late-Onset Pre-eclampsia. Comprehensive Gynecology and Obstetrics: Preeclampsia","author":"Staff","year":"2018"},{"key":"10.1124\/dmd.122.001080_bib38","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s11095-013-1129-x","article-title":"Disease, drug metabolism, and transporter interactions","volume":"30","author":"Staudinger","year":"2013","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.122.001080_bib39","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.3390\/pharmaceutics14071376","article-title":"Transporter regulation in critical protective barriers: focus on brain and placenta","volume":"14","author":"Taggi","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1124\/dmd.122.001080_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217273","article-title":"The prediction of early preeclampsia: results from a longitudinal proteomics study","volume":"14","author":"Tarca","year":"2019","journal-title":"PLoS One"},{"key":"10.1124\/dmd.122.001080_bib41","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac096","article-title":"Animal models of preeclampsia: mechanistic insights and promising therapeutics","volume":"163","author":"Taylor","year":"2022","journal-title":"Endocrinology"},{"key":"10.1124\/dmd.122.001080_bib42","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1038\/nprot.2016.136","article-title":"The MaxQuant computational platform for mass spectrometry-based shotgun proteomics","volume":"11","author":"Tyanova","year":"2016","journal-title":"Nat Protoc"},{"key":"10.1124\/dmd.122.001080_bib43","first-page":"467","article-title":"Pre-eclampsia: pathophysiology, diagnosis, and management","volume":"7","author":"Uzan","year":"2011","journal-title":"Vasc Health Risk Manag"},{"key":"10.1124\/dmd.122.001080_bib44","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat Methods"},{"key":"10.1124\/dmd.122.001080_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2009.05.004","article-title":"Is preeclampsia an autoimmune disease?","volume":"133","author":"Xia","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1124\/dmd.122.001080_bib46","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2353\/ajpath.2008.071193","article-title":"Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction","volume":"173","author":"Yung","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1124\/dmd.122.001080_bib47","doi-asserted-by":"crossref","first-page":"18109","DOI":"10.1073\/pnas.1907548116","article-title":"Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia","volume":"116","author":"Yung","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.122.001080_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnmol.2020.00027","article-title":"Proteomics analysis of brain tissue in a rat model of ischemic stroke in the acute phase","volume":"13","author":"Zheng","year":"2020","journal-title":"Front Mol Neurosci"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624010602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624010602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.122.001080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T09:04:59Z","timestamp":1739955899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624010602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S0090955624010602"],"URL":"https:\/\/doi.org\/10.1124\/dmd.122.001080","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of Traditional and Proteomic Methods in the Assessment of a Preclinical Model of Preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.122.001080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}