{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:06:51Z","timestamp":1792591611799,"version":"4.5.0"},"reference-count":282,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1124\/dmd.124.001809","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T19:45:14Z","timestamp":1725911114000},"page":"1271-1287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitatively Predicting Effects of Exercise on Pharmacokinetics of Drugs Using a Physiologically Based Pharmacokinetic Model"],"prefix":"10.1016","volume":"52","author":[{"given":"Zeyu","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.124.001809_bib1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s13318-016-0352-3","article-title":"Effects of Grapefruit and Pomegranate Juices on the Pharmacokinetic Properties of Dapoxetine and Midazolam in Healthy Subjects","volume":"42","author":"Abdlekawy","year":"2017","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib2","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0002-9149(84)90659-3","article-title":"Lidocaine disposition in obesity","volume":"53","author":"Abernethy","year":"1984","journal-title":"Am J Cardiol"},{"key":"10.1124\/dmd.124.001809_bib3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1365-2125.1995.tb00001.x","article-title":"Effect of itraconazole and terbinafine on the pharmacokinetics and pharmacodynamics of midazolam in healthy volunteers","volume":"40","author":"Ahonen","year":"1995","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1113\/jphysiol.1985.sp015794","article-title":"Maximal perfusion of skeletal muscle in man","volume":"366","author":"Andersen","year":"1985","journal-title":"J Physiol"},{"key":"10.1124\/dmd.124.001809_bib5","first-page":"26","article-title":"The metabolism of midazolam and comparison with other CYP enzyme substrates during intestinal absorption: in vitro studies with rat everted gut sacs","volume":"10","author":"Arellano","year":"2007","journal-title":"J Pharm Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-2125.1980.tb01774.x","article-title":"Drug absorption during physical exercise","volume":"10","author":"Aslaksen","year":"1980","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1152\/jappl.1964.19.2.268","article-title":"Cardiac output during submaximal and maximal work","volume":"19","author":"Astrand","year":"1964","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib8","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s40262-019-00756-2","article-title":"Effect of oral semaglutide on the pharmacokinetics of lisinopril, warfarin, digoxin, and metformin in healthy subjects","volume":"58","author":"B\u00e6kdal","year":"2019","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib9","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1440-1681.2005.04289.x","article-title":"Effect of human splenic contraction on variation in circulating blood cell counts","volume":"32","author":"Bakovi\u0107","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1124\/dmd.124.001809_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/clpt.1982.56","article-title":"Influence of long-term infusions on lidocaine kinetics","volume":"31","author":"Bauer","year":"1982","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0009-9236(01)17221-8","article-title":"Effect of grapefruit juice on digoxin pharmacokinetics in humans","volume":"70","author":"Becquemont","year":"2001","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF01059261","article-title":"Pharmacokinetics of lidocaine and its deethylated metabolite: dose and time dependency studies in man","volume":"10","author":"Bennett","year":"1982","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1124\/dmd.124.001809_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.627320","article-title":"Heart rate dynamics during acute recovery from maximal aerobic exercise in young adults","volume":"12","author":"Berry","year":"2021","journal-title":"Front Physiol"},{"key":"10.1124\/dmd.124.001809_bib14","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1152\/japplphysiol.00395.2014","article-title":"Heart rate recovery after maximal exercise is blunted in hypertensive seniors","volume":"117","author":"Best","year":"2014","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1748-1716.1963.tb02572.x","article-title":"Circulatory studies in well trained athletes at rest and during heavy exercise. With special reference to stroke volume and the influence of body position","volume":"57","author":"Bevegard","year":"1963","journal-title":"Acta Physiol Scand"},{"key":"10.1124\/dmd.124.001809_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1152\/jappl.1989.66.1.57","article-title":"Lidocaine pharmacokinetics during water immersion in normal humans","volume":"66","author":"Blyden","year":"1989","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/hrt.65.6.337","article-title":"Influence of physical exercise on serum digoxin concentration and heart rate in patients with atrial fibrillation","volume":"65","author":"B\u00f8tker","year":"1991","journal-title":"Br Heart J"},{"key":"10.1124\/dmd.124.001809_bib18","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.2337\/dc10-2207","article-title":"Metformin and exercise in type 2 diabetes: examining treatment modality interactions","volume":"34","author":"Boul\u00e9","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1124\/dmd.124.001809_bib19","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/cpf.12464","article-title":"Heart rate recovery improves after exercise in water when compared with on land","volume":"38","author":"Boussuges","year":"2018","journal-title":"Clin Physiol Funct Imaging"},{"key":"10.1124\/dmd.124.001809_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/15563650.2018.1503288","article-title":"Physiologically based pharmacokinetic modelling of acute digoxin toxicity and the effect of digoxin-specific antibody fragments","volume":"57","author":"Bracken","year":"2019","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1124\/dmd.124.001809_bib21","first-page":"790","article-title":"Altered control of skin blood flow during exercise at high internal temperatures","volume":"43","author":"Brengelmann","year":"1977","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"10.1124\/dmd.124.001809_bib22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3109\/00365518109092065","article-title":"Human adipose tissue blood flow during prolonged exercise, III. Effect of beta-adrenergic blockade, nicotinic acid and glucose infusion","volume":"41","author":"B\u00fclow","year":"1981","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1124\/dmd.124.001809_bib23","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/00912700122009872","article-title":"Sevelamer hydrochloride (Renagel), a nonabsorbed phosphate-binding polymer, does not interfere with digoxin or warfarin pharmacokinetics","volume":"41","author":"Burke","year":"2001","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib24","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1152\/japplphysiol.01281.2006","article-title":"Cardiac output and leg and arm blood flow during incremental exercise to exhaustion on the cycle ergometer","volume":"103","author":"Calbet","year":"2007","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib25","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/gut.23.11.957","article-title":"Effect of prolonged exercise on the passage of a solid meal through the stomach and small intestine","volume":"23","author":"Cammack","year":"1982","journal-title":"Gut"},{"key":"10.1124\/dmd.124.001809_bib26","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1136\/gut.30.2.152","article-title":"Gastric emptying in marathon runners","volume":"30","author":"Carri\u00f3","year":"1989","journal-title":"Gut"},{"key":"10.1124\/dmd.124.001809_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1749-6632.1977.tb38194.x","article-title":"Renal function during prolonged exercise","volume":"301","author":"Castenfors","year":"1977","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/dmd.124.001809_bib28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s40261-014-0180-7","article-title":"Effect of lacosamide on the steady-state pharmacokinetics of digoxin: results from a phase I, multiple-dose, double-blind, randomised, placebo-controlled, crossover trial","volume":"34","author":"Cawello","year":"2014","journal-title":"Clin Drug Investig"},{"key":"10.1124\/dmd.124.001809_bib29","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI104136","article-title":"Behavior of stroke volume at rest and during exercise in human beings","volume":"39","author":"Chapman","year":"1960","journal-title":"J Clin Invest"},{"key":"10.1124\/dmd.124.001809_bib30","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fphar.2014.00258","article-title":"Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability","volume":"5","author":"Chetty","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2036.1991.tb00521.x","article-title":"Quinidine single dose pharmacokinetics and pharmacodynamics are unaltered by omeprazole","volume":"5","author":"Ching","year":"1991","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib32","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1152\/ajplegacy.1973.225.3.675","article-title":"Central and peripheral circulatory changes after training of the arms or legs","volume":"225","author":"Clausen","year":"1973","journal-title":"Am J Physiol"},{"key":"10.1124\/dmd.124.001809_bib33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1476-511X-6-30","article-title":"Exercise and postprandial lipaemia: effects on peripheral vascular function, oxidative stress and gastrointestinal transit","volume":"6","author":"Clegg","year":"2007","journal-title":"Lipids Health Dis"},{"key":"10.1124\/dmd.124.001809_bib34","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1249\/00005768-199105000-00018","article-title":"Relationship of heart rate to oxygen uptake during weight lifting exercise","volume":"23","author":"Collins","year":"1991","journal-title":"Med Sci Sports Exerc"},{"key":"10.1124\/dmd.124.001809_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF00315209","article-title":"Effects of moderate exercise on the pharmacokinetics of caffeine","volume":"40","author":"Collomp","year":"1991","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib36","first-page":"633","article-title":"Heart rate-index estimates oxygen uptake, energy expenditure and aerobic fitness in rugby players","volume":"17","author":"Colosio","year":"2018","journal-title":"J Sports Sci Med"},{"key":"10.1124\/dmd.124.001809_bib37","first-page":"665","article-title":"Exercise training-induced hypervolemia: role of plasma albumin, renin, and vasopressin","volume":"48","author":"Convertino","year":"1980","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"10.1124\/dmd.124.001809_bib38","first-page":"657","article-title":"Role of thermal and exercise factors in the mechanism of hypervolemia","volume":"48","author":"Convertino","year":"1980","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"10.1124\/dmd.124.001809_bib39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0002-8703(75)90322-1","article-title":"The effect of congestive heart failure on quinidine pharmacokinetics","volume":"90","author":"Crouthamel","year":"1975","journal-title":"Am Heart J"},{"key":"10.1124\/dmd.124.001809_bib40","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s002280050655","article-title":"Effect of fluvoxamine on the pharmacokinetics of quinidine","volume":"55","author":"Damkier","year":"1999","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF00870985","article-title":"Effect of exercise and heat exposure on percutaneous absorption of methyl salicylate","volume":"31","author":"Danon","year":"1986","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00421-009-1101-y","article-title":"Respiratory compensation and blood pH regulation during variable intensity exercise in trained versus untrained subjects","volume":"107","author":"Del Coso","year":"2009","journal-title":"Eur J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s12325-009-0003-z","article-title":"Pharmacokinetics of digoxin in healthy subjects receiving taranabant, a novel cannabinoid-1 receptor inverse agonist","volume":"26","author":"Denker","year":"2009","journal-title":"Adv Ther"},{"key":"10.1124\/dmd.124.001809_bib44","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1177\/00912709922008579","article-title":"Effect of multiple doses of montelukast, a CysLT1 receptor antagonist, on digoxin pharmacokinetics in healthy volunteers","volume":"39","author":"Depr\u00e9","year":"1999","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib45","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1177\/009127000004001225","article-title":"Rosiglitazone does not affect the steady-state pharmacokinetics of digoxin","volume":"40","author":"Di Cicco","year":"2000","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib46","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1152\/jappl.1974.37.2.247","article-title":"Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration","volume":"37","author":"Dill","year":"1974","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib47","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1152\/physrev.00045.2006","article-title":"Regulation of coronary blood flow during exercise","volume":"88","author":"Duncker","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1124\/dmd.124.001809_bib48","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.yjmcc.2011.10.007","article-title":"Regulation of coronary resistance vessel tone in response to exercise","volume":"52","author":"Duncker","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/dmd.124.001809_bib49","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fphar.2016.00150","article-title":"Pharmacokinetics of oral and inhaled terbutaline after exercise in trained men","volume":"7","author":"Dyreborg","year":"2016","journal-title":"Front Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib50","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1249\/00005768-198406000-00009","article-title":"Intravascular volume and protein responses to running exercise","volume":"16","author":"Edwards","year":"1984","journal-title":"Med Sci Sports Exerc"},{"key":"10.1124\/dmd.124.001809_bib51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/clpt.1987.11","article-title":"The effect of coadministration of verapamil on the pharmacokinetics and metabolism of quinidine","volume":"41","author":"Edwards","year":"1987","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib52","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.3389\/fphys.2018.01780","article-title":"Prediction of core body temperature based on skin temperature, heat flux, and heart rate under different exercise and clothing conditions in the heat in young adult males","volume":"9","author":"Eggenberger","year":"2018","journal-title":"Front Physiol"},{"key":"10.1124\/dmd.124.001809_bib53","first-page":"245","article-title":"The effect of adrenergic -receptor blockade on coronary circulation in man during work","volume":"191","author":"Ekstr\u00f6m-Jodal","year":"1972","journal-title":"Acta Med Scand"},{"key":"10.1124\/dmd.124.001809_bib54","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1046\/j.1365-2125.2003.01865.x","article-title":"Effects of sex on the pharmacokinetic and pharmacodynamic properties of quinidine","volume":"56","author":"El-Eraky","year":"2003","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib55","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3181\/00379727-214-44082","article-title":"Effects of blood pH and blood lactate on growth hormone, prolactin, and gonadotropin release after acute exercise in male volunteers","volume":"214","author":"Elias","year":"1997","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1124\/dmd.124.001809_bib56","doi-asserted-by":"crossref","DOI":"10.1136\/bjsm.2010.078972.61","article-title":"Gastric emptying rate and perceived hunger after rest and exercise in man","volume":"44","author":"Evans","year":"2010","journal-title":"Br J Sports Med"},{"key":"10.1124\/dmd.124.001809_bib57","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1038\/s41598-021-83071-w","article-title":"Study of heart rate recovery and cardiovascular autonomic modulation in healthy participants after submaximal exercise","volume":"11","author":"Facioli","year":"2021","journal-title":"Sci Rep"},{"key":"10.1124\/dmd.124.001809_bib58","first-page":"851","article-title":"Effect of exercise on postprandial gastric secretion and emptying in humans","volume":"53","author":"Feldman","year":"1982","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"10.1124\/dmd.124.001809_bib59","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jps.21802","article-title":"Physiologically based predictions of the impact of inhibition of intestinal and hepatic metabolism on human pharmacokinetics of CYP3A substrates","volume":"99","author":"Fenneteau","year":"2010","journal-title":"J Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib60","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1177\/0091270003256113","article-title":"Lack of effect of aprepitant on digoxin pharmacokinetics in healthy subjects","volume":"43","author":"Feuring","year":"2003","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib61","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1113\/jphysiol.2012.244905","article-title":"Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals","volume":"591","author":"Fisher","year":"2013","journal-title":"J Physiol"},{"key":"10.1124\/dmd.124.001809_bib62","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/bjsm.19.2.85","article-title":"Predictability of VO2 max from submaximal cycle ergometer and bench stepping tests","volume":"19","author":"Fitchett","year":"1985","journal-title":"Br J Sports Med"},{"key":"10.1124\/dmd.124.001809_bib63","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1161\/01.CIR.81.5.1550","article-title":"Redistribution of regional and organ blood volume and effect on cardiac function in relation to upright exercise intensity in healthy human subjects","volume":"81","author":"Flamm","year":"1990","journal-title":"Circulation"},{"key":"10.1124\/dmd.124.001809_bib64","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1152\/jappl.1967.23.3.331","article-title":"Gastric emptying and intestinal absorption during prolonged severe exercise","volume":"23","author":"Fordtran","year":"1967","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib65","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1139\/H08-087","article-title":"Splenic constriction during isometric handgrip exercise in humans","volume":"33","author":"Frances","year":"2008","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1124\/dmd.124.001809_bib66","first-page":"27","article-title":"Postprandial walking but not consumption of alcoholic digestifs or espresso accelerates gastric emptying in healthy volunteers","volume":"17","author":"Franke","year":"2008","journal-title":"J Gastrointestin Liver Dis"},{"key":"10.1124\/dmd.124.001809_bib67","first-page":"1714","article-title":"Redistribution of visceral blood volume in upright exercise in healthy volunteers","volume":"29","author":"Froelich","year":"1988","journal-title":"J Nucl Med"},{"key":"10.1124\/dmd.124.001809_bib68","first-page":"19","article-title":"The effect of apixaban on the pharmacokinetics of digoxin and atenolol in healthy subjects","volume":"9","author":"Frost","year":"2017","journal-title":"Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib69","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1536\/ihj.51.170","article-title":"Effects of acute hypoxia at moderate altitude on stroke volume and cardiac output during exercise","volume":"51","author":"Fukuda","year":"2010","journal-title":"Int Heart J"},{"key":"10.1124\/dmd.124.001809_bib70","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1124\/jpet.106.106013","article-title":"Intestinal and hepatic metabolic activity of five cytochrome P450 enzymes: impact on prediction of first-pass metabolism","volume":"318","author":"Galetin","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.124.001809_bib71","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1177\/0091270011419850","article-title":"Effect of telaprevir on the pharmacokinetics of midazolam and digoxin","volume":"52","author":"Garg","year":"2012","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib72","first-page":"110","article-title":"A comparison between ventilation and heart rate as indicator of oxygen uptake during different intensities of exercise","volume":"9","author":"Gastinger","year":"2010","journal-title":"J Sports Sci Med"},{"key":"10.1124\/dmd.124.001809_bib73","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/taap.1993.1067","article-title":"In vivo metabolism of chloroform in B6C3F1 mice determined by the method of gas uptake: the effects of body temperature on tissue partition coefficients and metabolism","volume":"119","author":"Gearhart","year":"1993","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib74","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1124\/dmd.110.032649","article-title":"Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data","volume":"38","author":"Gertz","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.124.001809_bib75","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1124\/dmd.111.039248","article-title":"Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction","volume":"39","author":"Gertz","year":"2011","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.124.001809_bib76","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2165\/00003088-200342110-00003","article-title":"Factors affecting the clinical development of cytochrome p450 3A substrates","volume":"42","author":"Gibbs","year":"2003","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib77","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1113\/jphysiol.2007.142158","article-title":"The cardiovascular challenge of exercising in the heat","volume":"586","author":"Gonz\u00e1lez-Alonso","year":"2008","journal-title":"J Physiol"},{"key":"10.1124\/dmd.124.001809_bib78","article-title":"Supine exercise restores arterial blood pressure and skin blood flow despite dehydration and hyperthermia","volume":"277","author":"Gonz\u00e1lez-Alonso","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1124\/dmd.124.001809_bib79","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1152\/jappl.1999.86.3.1032","article-title":"Influence of body temperature on the development of fatigue during prolonged exercise in the heat","volume":"86","author":"Gonz\u00e1lez-Alonso","year":"1999","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib80","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0022-3565(25)30967-5","article-title":"Pharmacokinetics of quinidine in humans after intravenous, intramuscular and oral administration","volume":"202","author":"Greenblatt","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.124.001809_bib81","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0300-9572(01)00355-0","article-title":"Prediction of lidocaine tissue concentrations following different dose regimes during cardiac arrest using a physiologically based pharmacokinetic model","volume":"50","author":"Grillo","year":"2001","journal-title":"Resuscitation"},{"key":"10.1124\/dmd.124.001809_bib82","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1152\/jappl.1965.20.6.1294","article-title":"Renal clearances during prolonged supine exercise at different loads","volume":"20","author":"Grimby","year":"1965","journal-title":"J App Physiol"},{"key":"10.1124\/dmd.124.001809_bib83","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0026-895X(25)10372-6","article-title":"Oxidation of quinidine by human liver cytochrome P-450","volume":"30","author":"Guengerich","year":"1986","journal-title":"Mol Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib84","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1007\/s11095-017-2193-4","article-title":"A two-way randomized cross-over pharmacokinetic and pharmacodynamic study of an innovative oral solution of midazolam (ADV6209)","volume":"34","author":"Guittet","year":"2017","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.124.001809_bib85","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1002\/jps.23613","article-title":"A mechanistic physiologically based pharmacokinetic-enzyme turnover model involving both intestine and liver to predict CYP3A induction-mediated drug-drug interactions","volume":"102","author":"Guo","year":"2013","journal-title":"J Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib86","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1124\/dmd.106.012708","article-title":"Effect of goldenseal (Hydrastis canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans","volume":"35","author":"Gurley","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.124.001809_bib87","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/j.1552-4604.1989.tb03283.x","article-title":"The effect of everyday exercise on steady state digoxin concentrations","volume":"29","author":"Hall","year":"1989","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib88","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00421-019-04075-z","article-title":"Heart rate recovery after maximal exercise is impaired in healthy young adults born preterm","volume":"119","author":"Haraldsdottir","year":"2019","journal-title":"Eur J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib89","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/BF01536420","article-title":"Identical orocecal transit time and serum motilin in hyperthermia and normothermia","volume":"35","author":"Harris","year":"1990","journal-title":"Dig Dis Sci"},{"key":"10.1124\/dmd.124.001809_bib90","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1152\/jappl.1975.39.6.925","article-title":"Effect of exercise and thermal stress on plasma volume","volume":"39","author":"Harrison","year":"1975","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib91","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s40262-017-0532-6","article-title":"Effect of semaglutide on the pharmacokinetics of metformin, warfarin, atorvastatin and digoxin in healthy subjects","volume":"56","author":"Hausner","year":"2017","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib92","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1152\/japplphysiol.00541.2005","article-title":"Relationship between ventilatory response and body temperature during prolonged submaximal exercise","volume":"100","author":"Hayashi","year":"2006","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib93","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ejps.2012.06.013","article-title":"Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - an evaluation and case study using GastroPlus","volume":"47","author":"Heikkinen","year":"2012","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib94","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1111\/sms.13064","article-title":"Regulation of bone blood flow in humans: The role of nitric oxide, prostaglandins, and adenosine","volume":"28","author":"Heinonen","year":"2018","journal-title":"Scand J Med Sci Sports"},{"key":"10.1124\/dmd.124.001809_bib95","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/jbmr.1833","article-title":"Bone blood flow and metabolism in humans: effect of muscular exercise and other physiological perturbations","volume":"28","author":"Heinonen","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1124\/dmd.124.001809_bib96","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1152\/jappl.1970.29.1.82","article-title":"Cardiac output during submaximal and maximal treadmill and bicycle exercise","volume":"29","author":"Hermansen","year":"1970","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib97","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00007691-199109000-00001","article-title":"Pharmacokinetics of digoxin and main metabolites\/derivatives in healthy humans","volume":"13","author":"Hinderling","year":"1991","journal-title":"Ther Drug Monit"},{"key":"10.1124\/dmd.124.001809_bib98","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1152\/jappl.1997.82.4.1126","article-title":"Age, fitness, and regional blood flow during exercise in the heat","volume":"82","author":"Ho","year":"1997","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib99","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00228-012-1403-6","article-title":"Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects","volume":"69","author":"Hoch","year":"2013","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib100","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.0954-6820.1971.tb07462.x","article-title":"Coronary circulation during heavy exercise in control subjects and patients with coronary heart disease","volume":"190","author":"Holmberg","year":"1971","journal-title":"Acta Med Scand"},{"key":"10.1124\/dmd.124.001809_bib101","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1124\/jpet.119.262154","article-title":"Sampling site has a critical impact on physiologically based pharmacokinetic modeling","volume":"372","author":"Huang","year":"2020","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.124.001809_bib102","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1185\/030079907X199646","article-title":"Effect of NXY-059, a novel neuroprotectant, on the pharmacokinetics of a single dose of digoxin in healthy subjects","volume":"23","author":"Huledal","year":"2007","journal-title":"Curr Med Res Opin"},{"key":"10.1124\/dmd.124.001809_bib103","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1017\/S0265021505001316","article-title":"Effect of ciprofloxin on the pharmacokinetics of intravenous lidocaine","volume":"22","author":"Isohanni","year":"2005","journal-title":"Eur J Anaesthesiol"},{"key":"10.1124\/dmd.124.001809_bib104","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s002280050513","article-title":"Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine","volume":"54","author":"Isohanni","year":"1998","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib105","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1590\/S0100-879X2002000800018","article-title":"Heart rate recovery after exercise: relations to heart rate variability and complexity","volume":"35","author":"Javorka","year":"2002","journal-title":"Braz J Med Biol Res"},{"key":"10.1124\/dmd.124.001809_bib106","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/bdd.2510070108","article-title":"Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration","volume":"7","author":"Jochemsen","year":"1986","journal-title":"Biopharm Drug Dispos"},{"key":"10.1124\/dmd.124.001809_bib107","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1475-097X.1981.tb00877.x","article-title":"Effect of physical exercise on the digoxin concentrations in skeletal muscle and serum in man","volume":"1","author":"Jogestrand","year":"1981","journal-title":"Clinical Physiology"},{"key":"10.1124\/dmd.124.001809_bib108","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00005344-198907000-00013","article-title":"Effect of physical exercise on the pharmacokinetics of digoxin during maintenance treatment","volume":"14","author":"Jogestrand","year":"1989","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib109","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/clpt.2014.155","article-title":"Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil","volume":"96","author":"Johannesen","year":"2014","journal-title":"Clin Pharmacol Ther"},{"issue":"Suppl 3","key":"10.1124\/dmd.124.001809_bib110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-0838.2010.01206.x","article-title":"Exercise in a hot environment: the skin circulation","volume":"20","author":"Johnson","year":"2010","journal-title":"Scand J Med Sci Sports"},{"key":"10.1124\/dmd.124.001809_bib111","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/11318160-000000000-00000","article-title":"A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance","volume":"49","author":"Johnson","year":"2010","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib112","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1152\/jappl.1976.41.6.826","article-title":"Interactions between local and reflex influences on human forearm skin blood flow","volume":"41","author":"Johnson","year":"1976","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib113","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1152\/jappl.1975.39.6.920","article-title":"Forearm skin and muscle vascular responses to prolonged leg exercise in man","volume":"39","author":"Johnson","year":"1975","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib114","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1475-097X.1986.tb00241.x","article-title":"Binding of digoxin to slow- and fast-twitch skeletal muscle fibres","volume":"6","author":"Joreteg","year":"1986","journal-title":"Clin Physiol"},{"key":"10.1124\/dmd.124.001809_bib115","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/BF00542343","article-title":"Physical exercise and digoxin binding to skeletal muscle: relation to exercise intensity","volume":"25","author":"Joreteg","year":"1983","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib116","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/BF00556893","article-title":"Physical exercise and binding of digoxin to skeletal muscle\u2013effect of muscle activation frequency","volume":"27","author":"Joreteg","year":"1984","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib117","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1475-097X.1986.tb00067.x","article-title":"Beta-blockade and binding of digoxin to skeletal muscle","volume":"6","author":"Joreteg","year":"1986","journal-title":"Clin Physiol"},{"key":"10.1124\/dmd.124.001809_bib118","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/01.CIR.48.6.1173","article-title":"Effect of propranolol on myocardial oxygen consumption and its hemodynamic correlates during upright exercise","volume":"48","author":"Jorgensen","year":"1973","journal-title":"Circulation"},{"key":"10.1124\/dmd.124.001809_bib119","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1152\/jappl.1992.73.5.1825","article-title":"Regional cerebral artery mean flow velocity and blood flow during dynamic exercise in humans","volume":"73","author":"J\u00f8rgensen","year":"1992","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib120","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00228-017-2282-7","article-title":"A pharmacokinetic drug-drug interaction study between selexipag and midazolam, a CYP3A4 substrate, in healthy male subjects","volume":"73","author":"Juif","year":"2017","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib121","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF00315417","article-title":"The effect of exercise on atropine pharmacokinetics","volume":"39","author":"Kamimori","year":"1990","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib122","first-page":"1186","article-title":"Acute hypervolemia, cardiac performance, and aerobic power during exercise","volume":"52","author":"Kanstrup","year":"1982","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"10.1124\/dmd.124.001809_bib123","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00421-003-0975-3","article-title":"Effect of low oxygen inhalation on changes in blood pH, lactate, and ammonia due to exercise","volume":"91","author":"Kato","year":"2004","journal-title":"Eur J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib124","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s00421-005-0046-z","article-title":"Effect of hypercapnia on changes in blood pH, plasma lactate and ammonia due to exercise","volume":"95","author":"Kato","year":"2005","journal-title":"Eur J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib125","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1152\/jappl.1990.68.4.1350","article-title":"Orocecal transit during mild exercise in women","volume":"68","author":"Keeling","year":"1990","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib126","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1152\/jappl.1987.63.3.978","article-title":"Gastrointestinal transit during mild exercise","volume":"63","author":"Keeling","year":"1987","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib127","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1152\/jappl.1995.79.4.1112","article-title":"Age alters regional distribution of blood flow during moderate-intensity exercise","volume":"79","author":"Kenney","year":"1995","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib128","first-page":"292","article-title":"The effects of exercise on the pharmacokinetics of drugs","volume":"3","author":"Khazaeinia","year":"2000","journal-title":"J Pharm Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib129","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1152\/jappl.1972.32.4.516","article-title":"Hemodynamic correlates of myocardial oxygen consumption during upright exercise","volume":"32","author":"Kitamura","year":"1972","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib130","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0002-9149(00)01332-1","article-title":"Effect of dofetilide on the pharmacokinetics of digoxin","volume":"87","author":"Kleinermans","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1124\/dmd.124.001809_bib131","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41401-019-0353-2","article-title":"Physiologically based pharmacokinetic-pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous\/oral administration to rats, dogs and humans","volume":"41","author":"Kong","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1124\/dmd.124.001809_bib132","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1177\/0091270005278806","article-title":"Effect of exenatide on the steady-state pharmacokinetics of digoxin","volume":"45","author":"Kothare","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib133","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s002280050075","article-title":"Effect of diprafenone on the pharmacokinetics of digoxin","volume":"50","author":"Koytchev","year":"1996","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib134","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.clinthera.2009.02.022","article-title":"Effects of oral posaconazole on the pharmacokinetic properties of oral and intravenous midazolam: a phase I, randomized, open-label, crossover study in healthy volunteers","volume":"31","author":"Krishna","year":"2009","journal-title":"Clin Ther"},{"key":"10.1124\/dmd.124.001809_bib135","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/cpdd.1027","article-title":"Pharmacokinetics and safety of letermovir and midazolam coadministration in healthy subjects","volume":"11","author":"Kropeit","year":"2022","journal-title":"Clin Pharmacol Drug Dev"},{"key":"10.1124\/dmd.124.001809_bib136","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1007\/s12325-017-0634-4","article-title":"Pharmacokinetic evaluation of the interactions of Amenamevir (ASP2151) with ketoconazole, rifampicin, midazolam, and warfarin in healthy adults","volume":"34","author":"Kusawake","year":"2017","journal-title":"Adv Ther"},{"key":"10.1124\/dmd.124.001809_bib137","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0009-9236(96)90052-1","article-title":"Pharmacokinetic and pharmacodynamic interactions between diltiazem and quinidine","volume":"60","author":"Lagani\u00e8re","year":"1996","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib138","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1022262818573","article-title":"N-in-one permeability studies of heterogeneous sets of compounds across Caco-2 cell monolayers","volume":"20","author":"Laitinen","year":"2003","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.124.001809_bib139","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1177\/0091270003259216","article-title":"Pharmacokinetic and pharmacodynamic interactions of oral midazolam with ketoconazole, fluoxetine, fluvoxamine, and nefazodone","volume":"43","author":"Lam","year":"2003","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib140","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/00912700122010041","article-title":"Lack of citalopram effect on oral digoxin pharmacokinetics","volume":"41","author":"Larsen","year":"2001","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib141","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1152\/jappl.1993.74.3.1024","article-title":"Spleen emptying and venous hematocrit in humans during exercise","volume":"74","author":"Laub","year":"1993","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib142","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/59.3.778S","article-title":"The effects of physical effort on gastric emptying","volume":"59","author":"Laurens","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1124\/dmd.124.001809_bib143","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2125.1990.tb03778.x","article-title":"Influence of exercise on nitroglycerin plasma concentrations after transdermal application","volume":"30","author":"Lefebvre","year":"1990","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib144","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1097\/00005768-200108000-00005","article-title":"Effect of intermittent high-intensity exercise on gastric emptying in man","volume":"33","author":"Leiper","year":"2001","journal-title":"Med Sci Sports Exerc"},{"key":"10.1124\/dmd.124.001809_bib145","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1517\/17425255.2011.553190","article-title":"The effects of high physical activity on pharmacokinetic drug interactions","volume":"7","author":"Lenz","year":"2011","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1124\/dmd.124.001809_bib146","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2165\/11586080-000000000-00000","article-title":"Transdermal patch drug delivery interactions with exercise","volume":"41","author":"Lenz","year":"2011","journal-title":"Sports Med"},{"key":"10.1124\/dmd.124.001809_bib147","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2165\/00007256-200434050-00002","article-title":"Potential interactions between exercise and drug therapy","volume":"34","author":"Lenz","year":"2004","journal-title":"Sports Med"},{"key":"10.1124\/dmd.124.001809_bib148","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1249\/01.MSS.0000135977.12456.8F","article-title":"Effect of exercise intensity on relationship between VO2max and cardiac output","volume":"36","author":"Lepretre","year":"2004","journal-title":"Med Sci Sports Exerc"},{"key":"10.1124\/dmd.124.001809_bib149","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0920-1211(01)00253-4","article-title":"Repeated administration of the novel antiepileptic agent levetiracetam does not alter digoxin pharmacokinetics and pharmacodynamics in healthy volunteers","volume":"46","author":"Levy","year":"2001","journal-title":"Epilepsy Res"},{"key":"10.1124\/dmd.124.001809_bib150","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/aps.2012.103","article-title":"Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling","volume":"33","author":"Li","year":"2012","journal-title":"Acta Pharmacol Sin"},{"key":"10.1124\/dmd.124.001809_bib151","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1152\/japplphysiol.00551.2009","article-title":"Muscle blood flow responses to dynamic exercise in young obese humans","volume":"108","author":"Limberg","year":"2010","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib152","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00421-024-05428-z","article-title":"Effect of exercise intensity and apnea on splenic contraction and hemoglobin increase in well-trained cross-country skiers","volume":"124","author":"Lindblom","year":"2024","journal-title":"Eur J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib153","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1177\/0091270009356571","article-title":"Effects of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, on the steady-state pharmacokinetics of digoxin in healthy adult subjects","volume":"50","author":"Liu","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib154","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0002-9149(78)90997-9","article-title":"Pharmacokinetics and bioavailability of digoxin capsules, solution and tablets after single and multiple doses","volume":"42","author":"Lloyd","year":"1978","journal-title":"Am J Cardiol"},{"key":"10.1124\/dmd.124.001809_bib155","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/j.1552-4604.1998.tb04408.x","article-title":"Effect of troglitazone on steady-state pharmacokinetics of digoxin","volume":"38","author":"Loi","year":"1998","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib156","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.0954-6820.1974.tb01017.x","article-title":"Changes in hepatic circulation at rest, during and after exercise in young males with infectious hepatitis compared with controls","volume":"196","author":"Lundbergh","year":"1974","journal-title":"Acta Med Scand"},{"key":"10.1124\/dmd.124.001809_bib157","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/jappl.1993.74.1.245","article-title":"Middle cerebral artery blood velocity and cerebral blood flow and O2 uptake during dynamic exercise","volume":"74","author":"Madsen","year":"1993","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib158","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1249\/01.MSS.0000099180.80952.83","article-title":"Heart rate recovery from submaximal exercise in boys and girls","volume":"35","author":"Mahon","year":"2003","journal-title":"Med Sci Sports Exerc"},{"key":"10.1124\/dmd.124.001809_bib159","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/01.CIR.55.3.537","article-title":"The effect of jejunoileal bypass on the pharmacokinetics of digoxin in man","volume":"55","author":"Marcus","year":"1977","journal-title":"Circulation"},{"key":"10.1124\/dmd.124.001809_bib160","first-page":"13","article-title":"[Maximal gastric secretion during physical exertion and restitution in patients with chronic duodenal ulcer]","volume":"79","author":"Markiewicz","year":"1988","journal-title":"Pol Arch Med Wewn"},{"key":"10.1124\/dmd.124.001809_bib161","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1177\/0091270002042012008","article-title":"No effect of rosuvastatin on the pharmacokinetics of digoxin in healthy volunteers","volume":"42","author":"Martin","year":"2002","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib162","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1046\/j.1365-2125.1997.00608.x","article-title":"Lack of effect of eprosartan on the single dose pharmacokinetics of orally administered digoxin in healthy male volunteers","volume":"43","author":"Martin","year":"1997","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib163","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/jps.2600650916","article-title":"Comparative plasma concentrations of quinidine following administration of one intramuscular and three oral formulations to 13 human subjects","volume":"65","author":"Mason","year":"1976","journal-title":"J Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib164","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1152\/jappl.1988.64.5.1947","article-title":"Breath holding during intense exercise: arterial blood gases, pH, and lactate","volume":"64","author":"Matheson","year":"1988","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib165","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00045391-200307000-00003","article-title":"Impact of ginkgo biloba on the pharmacokinetics of digoxin","volume":"10","author":"Mauro","year":"2003","journal-title":"Am J Ther"},{"key":"10.1124\/dmd.124.001809_bib166","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1249\/JES.0000000000000111","article-title":"Exercise is medicine, but does it interfere with medicine?","volume":"45","author":"McLaughlin","year":"2017","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1124\/dmd.124.001809_bib167","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2710.1987.tb00555.x","article-title":"Prescribing digoxin in geriatric units\u2013exercise and redistribution of drug","volume":"12","author":"Meghee","year":"1987","journal-title":"J Clin Pharm Ther"},{"key":"10.1124\/dmd.124.001809_bib168","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/j.1552-4604.1995.tb04128.x","article-title":"The influence of reduced dietary fat absorption induced by orlistat on the pharmacokinetics of digoxin in healthy volunteers","volume":"35","author":"Melia","year":"1995","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib169","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0016-5085(89)80100-3","article-title":"Effect of aerobic exercise on mouth-to-cecum transit time","volume":"96","author":"Meshkinpour","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1124\/dmd.124.001809_bib170","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/j.1552-4604.1996.tb05034.x","article-title":"Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers","volume":"36","author":"Min","year":"1996","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib171","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1440-1681.2009.05285.x","article-title":"Pharmacokinetics and pharmacodynamics of low doses of midazolam administered intravenously and orally to healthy volunteers","volume":"37","author":"Misaka","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1124\/dmd.124.001809_bib172","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1007\/s00421-013-2723-7","article-title":"Skin blood flow influences cerebral oxygenation measured by near-infrared spectroscopy during dynamic exercise","volume":"113","author":"Miyazawa","year":"2013","journal-title":"Eur J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib173","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1208\/s12248-016-0009-9","article-title":"Clarithromycin, midazolam, and digoxin: application of PBPK modeling to gain new insights into drug-drug interactions and co-medication regimens","volume":"19","author":"Moj","year":"2017","journal-title":"AAPS J"},{"key":"10.1124\/dmd.124.001809_bib174","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/BF01536914","article-title":"Exercise increases solid meal gastric emptying rates in men","volume":"35","author":"Moore","year":"1990","journal-title":"Dig Dis Sci"},{"key":"10.1124\/dmd.124.001809_bib175","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1113\/jphysiol.2007.149401","article-title":"Restrictions in systemic and locomotor skeletal muscle perfusion, oxygen supply and VO2 during high-intensity whole-body exercise in humans","volume":"586","author":"Mortensen","year":"2008","journal-title":"J Physiol"},{"key":"10.1124\/dmd.124.001809_bib176","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2165\/00007256-199009030-00004","article-title":"The effect of exercise on the gastrointestinal tract","volume":"9","author":"Moses","year":"1990","journal-title":"Sports Med"},{"key":"10.1124\/dmd.124.001809_bib177","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1023\/A:1026183200740","article-title":"P-glycoprotein increases from proximal to distal regions of human small intestine","volume":"20","author":"Mouly","year":"2003","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.124.001809_bib178","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1152\/jappl.1999.86.3.867","article-title":"Mechanism for the posture-specific plasma volume increase after a single intense exercise protocol","volume":"86","author":"Nagashima","year":"1999","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib179","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2133\/dmpk.23.95","article-title":"No effect of imidafenacin, a novel antimuscarinic drug, on digoxin pharmacokinetics in healthy subjects","volume":"23","author":"Nakade","year":"2008","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib180","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jacc.2005.08.064","article-title":"Caffeine decreases exercise-induced myocardial flow reserve","volume":"47","author":"Namdar","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/dmd.124.001809_bib181","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2125.2006.02762.x","article-title":"Lack of a pharmacokinetic interaction between steady-state roflumilast and single-dose midazolam in healthy subjects","volume":"63","author":"Nassr","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib182","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2125.1977.tb00759.x","article-title":"Lignocaine kinetics in cardiac patients and aged subjects","volume":"4","author":"Nation","year":"1977","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib183","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1161\/01.CIR.50.6.1179","article-title":"Hemodynamic predictors of myocardial oxygen consumption during static and dynamic exercise","volume":"50","author":"Nelson","year":"1974","journal-title":"Circulation"},{"key":"10.1124\/dmd.124.001809_bib184","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1002\/jps.23594","article-title":"Application of permeability-limited physiologically-based pharmacokinetic models: part I-digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux","volume":"102","author":"Neuhoff","year":"2013","journal-title":"J Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib185","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/BF00943365","article-title":"Cardiovascular responses to heat stress and blood volume displacements during exercise in man","volume":"52","author":"Nielsen","year":"1984","journal-title":"Eur J Appl Physiol Occup Physiol"},{"key":"10.1124\/dmd.124.001809_bib186","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1152\/jappl.1990.69.3.1040","article-title":"Muscle blood flow and muscle metabolism during exercise and heat stress","volume":"69","author":"Nielsen","year":"1990","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib187","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/japplphysiol.00049.2002","article-title":"Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans","volume":"93","author":"Nybo","year":"2002","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib188","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/QAI.0b013e3181627566","article-title":"Pharmacokinetic effect of AMD070, an oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers","volume":"47","author":"Nyunt","year":"2008","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1124\/dmd.124.001809_bib189","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2165\/00003088-198005020-00003","article-title":"Clinical pharmacokinetics of quinidine","volume":"5","author":"Ochs","year":"1980","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib190","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/j.1552-4604.1983.tb02723.x","article-title":"Dose-independent pharmacokinetics of intravenous lidocaine in humans","volume":"23","author":"Ochs","year":"1983","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib191","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jep.2012.10.001","article-title":"P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport","volume":"144","author":"Oga","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"10.1124\/dmd.124.001809_bib192","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s00540-011-1176-6","article-title":"Propofol increases the rate of albumin-unbound free midazolam in serum albumin solution","volume":"25","author":"Ohmori","year":"2011","journal-title":"J Anesth"},{"key":"10.1124\/dmd.124.001809_bib193","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1213\/01.ANE.0000148123.79437.F9","article-title":"The effect of erythromycin and fluvoxamine on the pharmacokinetics of intravenous lidocaine","volume":"100","author":"Olkkola","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1124\/dmd.124.001809_bib194","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00006231-198702000-00009","article-title":"Exercise and small intestinal transit","volume":"8","author":"Ollerenshaw","year":"1987","journal-title":"Nucl Med Commun"},{"key":"10.1124\/dmd.124.001809_bib195","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1365-2125.1991.tb03953.x","article-title":"Minor effect of multiple dose omeprazole on the pharmacokinetics of digoxin after a single oral dose","volume":"32","author":"Oosterhuis","year":"1991","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib196","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1055\/s-2008-1025747","article-title":"Blood flow in the extremities of athletes","volume":"7","author":"Ozolin","year":"1986","journal-title":"Int J Sports Med"},{"key":"10.1124\/dmd.124.001809_bib197","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0022-3565(24)37149-6","article-title":"Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism","volume":"283","author":"Paine","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.124.001809_bib198","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0009-9236(99)70051-2","article-title":"Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam","volume":"66","author":"Palkama","year":"1999","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib199","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/psp4.12717","article-title":"Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P-glycoprotein-cytochrome P450 3A4 dual substrates","volume":"10","author":"Pan","year":"2021","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib200","first-page":"168","article-title":"Effects of smoking on heart rate at rest and during exercise, and on heart rate recovery, in young adults","volume":"54","author":"Papathanasiou","year":"2013","journal-title":"Hellenic J Cardiol"},{"key":"10.1124\/dmd.124.001809_bib201","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s13318-011-0046-9","article-title":"Validation of quinidine as a probe substrate for the in vitro P-gp inhibition assay in Caco-2 cell monolayer","volume":"36","author":"Patil","year":"2011","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib202","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/clpt.1983.172","article-title":"Effects of physical activity and immobilization on plasma digoxin concentration and renal digoxin clearance","volume":"34","author":"Pedersen","year":"1983","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib203","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1177\/0091270010393344","article-title":"A review of psychophysiological stressors on pharmacokinetics","volume":"51","author":"Peng","year":"2011","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib204","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/j.1552-4604.1989.tb03327.x","article-title":"Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects","volume":"29","author":"Pentik\u00e4inen","year":"1989","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib205","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2165\/11318130-000000000-00000","article-title":"Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil","volume":"49","author":"Perdaems","year":"2010","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib206","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-2001-13811","article-title":"Reproducibility of ultrasound blood flow measurement of the superior mesenteric artery before and after exercise","volume":"22","author":"Peters","year":"2001","journal-title":"Int J Sports Med"},{"key":"10.1124\/dmd.124.001809_bib207","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2165\/00007256-198401020-00003","article-title":"Exercise and renal function","volume":"1","author":"Poortmans","year":"1984","journal-title":"Sports Med"},{"key":"10.1124\/dmd.124.001809_bib208","first-page":"167","article-title":"Heart rate recovery in exercise test in diabetic patients with and without microalbuminuria","volume":"9","author":"Pourmoghaddas","year":"2013","journal-title":"ARYA Atheroscler"},{"issue":"Suppl 1","key":"10.1124\/dmd.124.001809_bib209","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-2125.2003.01998.x","article-title":"Voriconazole does not affect the steady-state pharmacokinetics of digoxin","volume":"56","author":"Purkins","year":"2003","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib210","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1136\/gut.28.5.583","article-title":"Effects of exercise on mesenteric blood flow in man","volume":"28","author":"Qamar","year":"1987","journal-title":"Gut"},{"key":"10.1124\/dmd.124.001809_bib211","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejps.2019.04.026","volume":"134","author":"Qian","year":"2019","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000197517","article-title":"Effect of exercise on gastric emptying and gastric secretion","volume":"10","author":"Ramsbottom","year":"1974","journal-title":"Digestion"},{"key":"10.1124\/dmd.124.001809_bib213","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1515\/DMDI.1995.12.1.45","article-title":"Absence of a pharmacokinetic interaction between quinidine and diazepam","volume":"12","author":"Rao","year":"1995","journal-title":"Drug Metabol Drug Interact"},{"key":"10.1124\/dmd.124.001809_bib214","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1172\/JCI104293","article-title":"Myocardial oxygen consumption during exercise in fasting and lipemic subjects","volume":"40","author":"Regan","year":"1961","journal-title":"J Clin Invest"},{"key":"10.1124\/dmd.124.001809_bib215","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00000658-197805000-00002","article-title":"Cardiac function at rest and during exercise in normals and in patients with coronary heart disease: evaluation by radionuclide angiocardiography","volume":"187","author":"Rerych","year":"1978","journal-title":"Ann Surg"},{"key":"10.1124\/dmd.124.001809_bib216","first-page":"591","article-title":"Study on the interaction of the dopamine agonist alpha-dihydroergocryptine with the pharmacokinetics of digoxin","volume":"50","author":"Retzow","year":"2000","journal-title":"Arzneimittelforschung"},{"key":"10.1124\/dmd.124.001809_bib217","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00004836-199306000-00006","article-title":"Effects of exercise on total and segmental colon transit","volume":"16","author":"Robertson","year":"1993","journal-title":"J Clin Gastroenterol"},{"key":"10.1124\/dmd.124.001809_bib218","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1177\/0091270005282627","article-title":"Effect of lasofoxifene on the pharmacokinetics of digoxin in healthy postmenopausal women","volume":"45","author":"Roman","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib219","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s11239-015-1248-9","article-title":"Impact of regular physical activity on weekly warfarin dose requirement","volume":"41","author":"Rouleau-Mailloux","year":"2016","journal-title":"J Thromb Thrombolysis"},{"key":"10.1124\/dmd.124.001809_bib220","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1172\/JCI105043","article-title":"Indocyanine green clearance and estimated hepatic blood flow during mild to maximal exercise in upright man","volume":"43","author":"Rowell","year":"1964","journal-title":"J Clin Invest"},{"key":"10.1124\/dmd.124.001809_bib221","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1152\/jappl.1965.20.3.384","article-title":"Hepatic clearance of indocyanine green in man under thermal and exercise stresses","volume":"20","author":"Rowell","year":"1965","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib222","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ejps.2009.12.002","volume":"39","author":"Rowland Yeo","year":"2010","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib223","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejps.2011.04.008","article-title":"Prediction of time-dependent CYP3A4 drug-drug interactions by physiologically based pharmacokinetic modelling: impact of inactivation parameters and enzyme turnover","volume":"43","author":"Rowland Yeo","year":"2011","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib224","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.clpt.2005.12.305","article-title":"Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam","volume":"79","author":"Saari","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib225","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jappl.1964.19.6.1125","article-title":"Circulatory response to submaximal and maximal exercise after thermal dehydration","volume":"19","author":"Saltin","year":"1964","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib226","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/jappl.1988.64.2.649","article-title":"Muscle blood flow is not reduced in humans during moderate exercise and heat stress","volume":"64","author":"Savard","year":"1988","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib227","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0002-9343(54)90371-X","article-title":"Effects of vigorous physical exercise on cerebral circulation and metabolism","volume":"16","author":"Scheinberg","year":"1954","journal-title":"Am J Med"},{"key":"10.1124\/dmd.124.001809_bib228","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cpdd.1043","article-title":"The effect of oral letermovir administration on the pharmacokinetics of a single oral dose of P-glycoprotein substrate digoxin in healthy volunteers","volume":"11","author":"Scheuenpflug","year":"2022","journal-title":"Clin Pharmacol Drug Dev"},{"key":"10.1124\/dmd.124.001809_bib229","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.679232","article-title":"Effect of exercise-induced reductions in blood volume on cardiac output and oxygen transport capacity","volume":"12","author":"Schierbauer","year":"2021","journal-title":"Front Physiol"},{"key":"10.1124\/dmd.124.001809_bib230","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1159\/000194651","article-title":"Effect of exercise and environmental heat on theophylline kinetics","volume":"45","author":"Schlaeffer","year":"1984","journal-title":"Respiration"},{"key":"10.1124\/dmd.124.001809_bib231","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1378\/chest.101.3.742","article-title":"Exercise increases the rate of pulmonary absorption of inhaled terbutaline","volume":"101","author":"Schmekel","year":"1992","journal-title":"Chest"},{"key":"10.1124\/dmd.124.001809_bib232","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2125.1998.00711.x","article-title":"Assessment of hepatic blood flow using continuous infusion of high clearance drugs","volume":"45","author":"Schoemaker","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib233","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1365-2125.2008.03285.x","article-title":"Evaluation of the pharmacokinetics of digoxin in healthy subjects receiving etoricoxib","volume":"66","author":"Schwartz","year":"2008","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib234","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/00912700122009755","article-title":"Effect of rofecoxib on the pharmacokinetics of digoxin in healthy volunteers","volume":"41","author":"Schwartz","year":"2001","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib235","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/phar.1401","article-title":"Influence of regular physical activity on warfarin dose and risk of hemorrhagic complications","volume":"34","author":"Shendre","year":"2014","journal-title":"Pharmacotherapy"},{"key":"10.1124\/dmd.124.001809_bib236","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jchromb.2006.10.018","article-title":"A developed determination of midazolam and 1'-hydroxymidazolam in plasma by liquid chromatography-mass spectrometry: application of human pharmacokinetic study for measurement of CYP3A activity","volume":"847","author":"Shimizu","year":"2007","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1124\/dmd.124.001809_bib237","first-page":"159","article-title":"Measurements of cardiac output in maximum exercise. Application of an acetylene rebreathing method to arm and leg exercise","volume":"29","author":"Simmons","year":"1971","journal-title":"Int Z Angew Physiol"},{"key":"10.1124\/dmd.124.001809_bib238","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0091270009340418","article-title":"Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers","volume":"50","author":"Skerjanec","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib239","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/jappl.1952.4.8.659","article-title":"Renal responses to exercise, heat and dehydration","volume":"4","author":"Smith","year":"1952","journal-title":"J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib240","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00690892","article-title":"Skin blood flow during incremental exercise in a thermoneutral and a hot dry environment","volume":"56","author":"Smolander","year":"1987","journal-title":"Eur J Appl Physiol Occup Physiol"},{"key":"10.1124\/dmd.124.001809_bib241","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2125.2006.02638.x","article-title":"Multiple doses of the antimuscarinic agent solifenacin do not affect the pharmacodynamics or pharmacokinetics of warfarin or the steady-state pharmacokinetics of digoxin in healthy subjects","volume":"62","author":"Smulders","year":"2006","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib242","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/0091270010393342","article-title":"Pharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, with coadministration of digoxin","volume":"52","author":"Stangier","year":"2012","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib243","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0009-9236(95)90039-X","article-title":"Stereoselective increase of plasma concentrations of the enantiomers of propranolol and atenolol during exercise","volume":"57","author":"Stoschitzky","year":"1995","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib244","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0140-6736(92)92233-6","article-title":"Stereoselective release of (S)-atenolol from adrenergic nerve endings at exercise","volume":"340","author":"Stoschitzky","year":"1992","journal-title":"Lancet"},{"key":"10.1124\/dmd.124.001809_bib245","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/clpt.1992.58","article-title":"Exercise alters the pharmacokinetics of midazolam","volume":"51","author":"Str\u00f6mberg","year":"1992","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/dmd.124.001809_bib246","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1249\/00005768-198104000-00009","article-title":"Drugs\u2013some basic concepts","volume":"13","author":"Sweeney","year":"1981","journal-title":"Med Sci Sports Exerc"},{"key":"10.1124\/dmd.124.001809_bib247","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1152\/jappl.1991.71.1.236","article-title":"Sweating and skin blood flow during exercise: effects of age and maximal oxygen uptake","volume":"71","author":"Tankersley","year":"1991","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib248","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/j.1875-9114.1995.tb04388.x","article-title":"The effect of age and everyday exercise on steady-state plasma digoxin concentrations","volume":"15","author":"Teague","year":"1995","journal-title":"Pharmacotherapy"},{"key":"10.1124\/dmd.124.001809_bib249","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/cvr\/19.12.737","article-title":"Cardiac output measured by impedance cardiography during maximal exercise tests","volume":"19","author":"Teo","year":"1985","journal-title":"Cardiovasc Res"},{"key":"10.1124\/dmd.124.001809_bib250","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1152\/jappl.1989.67.2.744","article-title":"Cerebral blood flow during submaximal and maximal dynamic exercise in humans","volume":"67","author":"Thomas","year":"1989","journal-title":"J Appl Physiol (1985)"},{"key":"10.1124\/dmd.124.001809_bib251","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF01062338","article-title":"The pharmacokinetics and pharmacodynamics of lignocaine and MEGX in healthy subjects","volume":"15","author":"Thomson","year":"1987","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1124\/dmd.124.001809_bib252","doi-asserted-by":"crossref","DOI":"10.1136\/bmjsem-2016-000210","article-title":"Changes in lung function during exercise are independently mediated by increases in deep body temperature","volume":"3","author":"Tipton","year":"2017","journal-title":"BMJ Open Sport Exerc Med"},{"key":"10.1124\/dmd.124.001809_bib253","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/cpdd.285","article-title":"Pharmacokinetic evaluation of CYP3A4-mediated drug-drug interactions of isavuconazole with rifampin, ketoconazole, midazolam, and ethinyl estradiol\/norethindrone in healthy adults","volume":"6","author":"Townsend","year":"2017","journal-title":"Clin Pharmacol Drug Dev"},{"key":"10.1124\/dmd.124.001809_bib254","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/cells11030383","article-title":"Physiological function during exercise and environmental stress in humans-an integrative view of body systems and homeostasis","volume":"11","author":"Travers","year":"2022","journal-title":"Cells"},{"key":"10.1124\/dmd.124.001809_bib255","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1023\/A:1025049014674","article-title":"Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers","volume":"20","author":"Troutman","year":"2003","journal-title":"Pharm Res"},{"key":"10.1124\/dmd.124.001809_bib256","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2165\/00003088-199019010-00003","article-title":"Influence of exercise on the pharmacokinetics of drugs","volume":"19","author":"van Baak","year":"1990","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/dmd.124.001809_bib257","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/BF02285100","article-title":"Exercise and the pharmacokinetics of propranolol, verapamil and atenolol","volume":"43","author":"van Baak","year":"1992","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib258","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00421-003-1007-z","article-title":"Gastrointestinal profile of symptomatic athletes at rest and during physical exercise","volume":"91","author":"van Nieuwenhoven","year":"2004","journal-title":"Eur J Appl Physiol"},{"key":"10.1124\/dmd.124.001809_bib259","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/dta.2578","article-title":"Distribution of clomipramine, citalopram, midazolam, and metabolites in skeletal tissue after chronic dosing in rats","volume":"11","author":"Vandenbosch","year":"2019","journal-title":"Drug Test Anal"},{"key":"10.1124\/dmd.124.001809_bib260","first-page":"588","article-title":"Stroke volume and systolic time interval adjustments during bicycle exercise","volume":"46","author":"Vanfraechem","year":"1979","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"10.1124\/dmd.124.001809_bib261","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1472-8206.2009.00691.x","article-title":"Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects","volume":"23","author":"Vaz da Silva","year":"2009","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib262","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jelectrocard.2015.08.004","article-title":"Sex differences in drug-induced changes in ventricular repolarization","volume":"48","author":"Vicente","year":"2015","journal-title":"J Electrocardiol"},{"key":"10.1124\/dmd.124.001809_bib263","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/cpdd.91","article-title":"The effect of maraviroc on the pharmacokinetics of digoxin in healthy volunteers","volume":"3","author":"Vourvahis","year":"2014","journal-title":"Clin Pharmacol Drug Dev"},{"key":"10.1124\/dmd.124.001809_bib264","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1172\/JCI106772","article-title":"Glucose metabolism during leg exercise in man","volume":"50","author":"Wahren","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1124\/dmd.124.001809_bib265","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1249\/00005768-199411000-00002","article-title":"Indomethacin potentiates exercise-induced reduction in renal hemodynamics in athletes","volume":"26","author":"Walker","year":"1994","journal-title":"Med Sci Sports Exerc"},{"key":"10.1124\/dmd.124.001809_bib266","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ejps.2013.07.012","article-title":"A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human","volume":"50","author":"Wang","year":"2013","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/dmd.124.001809_bib267","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/jcph.1005","article-title":"Effects of rolapitant administered intravenously or orally on the pharmacokinetics of digoxin (P-glycoprotein substrate) and sulfasalazine (breast cancer resistance protein substrate) in healthy volunteers","volume":"58","author":"Wang","year":"2018","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib268","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1046\/j.1365-2125.1999.00946.x","article-title":"The effect of bosentan on the pharmacokinetics of digoxin in healthy male subjects","volume":"47","author":"Weber","year":"1999","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib269","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1128\/AAC.02632-12","article-title":"Evaluation of pharmacokinetic interaction between PA-824 and midazolam in healthy adult subjects","volume":"57","author":"Winter","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/dmd.124.001809_bib270","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2125.1988.tb03400.x","article-title":"The pharmacokinetics and pharmacodynamics of quinidine and 3-hydroxyquinidine","volume":"26","author":"Wooding-Scott","year":"1988","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib271","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/01.CIR.0000087432.63671.2E","article-title":"Influence of altitude exposure on coronary flow reserve","volume":"108","author":"Wyss","year":"2003","journal-title":"Circulation"},{"key":"10.1124\/dmd.124.001809_bib272","first-page":"146","article-title":"Bicycle exercise stress in PET for assessment of coronary flow reserve: repeatability and comparison with adenosine stress","volume":"44","author":"Wyss","year":"2003","journal-title":"J Nucl Med"},{"key":"10.1124\/dmd.124.001809_bib273","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/psp4.12458","article-title":"Physiologically--based pharmacokinetic modeling approach to predict rifampin-mediated intestinal P-glycoprotein induction","volume":"8","author":"Yamazaki","year":"2019","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib274","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF01387526","article-title":"A comparison of sweating responses during exercise and recovery in terms of sweating rate and body temperature","volume":"37","author":"Yamazaki","year":"1993","journal-title":"Int J Biometeorol"},{"key":"10.1124\/dmd.124.001809_bib275","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2174\/138920007782109733","article-title":"Prediction of intestinal first-pass drug metabolism","volume":"8","author":"Yang","year":"2007","journal-title":"Curr Drug Metab"},{"key":"10.1124\/dmd.124.001809_bib276","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.3390\/ijms21197023","article-title":"Prediction of Cyclosporin-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Model Characterizing Interplay of Drug Transporters and Enzymes","volume":"21","author":"Yang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1124\/dmd.124.001809_bib277","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/07853899109148062","article-title":"Effect of exercise on pharmacokinetics","volume":"23","author":"Ylitalo","year":"1991","journal-title":"Ann Med"},{"key":"10.1124\/dmd.124.001809_bib278","doi-asserted-by":"crossref","first-page":"537","DOI":"10.33549\/physiolres.931613","article-title":"Effects of sodium bicarbonate ingestion on hyperventilation and recovery of blood pH after a short-term intense exercise","volume":"58","author":"Yunoki","year":"2009","journal-title":"Physiol Res"},{"key":"10.1124\/dmd.124.001809_bib279","first-page":"601","article-title":"Pharmacokinetics and bioequivalence study of two digoxin formulations after single-dose administration in healthy Chinese male volunteers","volume":"61","author":"Zhang","year":"2011","journal-title":"Arzneimittelforschung"},{"key":"10.1124\/dmd.124.001809_bib280","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1097\/00005768-200111000-00008","article-title":"Stroke volume does not plateau during graded exercise in elite male distance runners","volume":"33","author":"Zhou","year":"2001","journal-title":"Med Sci Sports Exerc"},{"key":"10.1124\/dmd.124.001809_bib281","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/00912700122012625","article-title":"The effects of tegaserod (HTF 919) on the pharmacokinetics and pharmacodynamics of digoxin in healthy subjects","volume":"41","author":"Zhou","year":"2001","journal-title":"J Clin Pharmacol"},{"key":"10.1124\/dmd.124.001809_bib282","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1152\/jappl.1965.20.6.1289","article-title":"Effect of exercise on the cerebral circulation and metabolism","volume":"20","author":"Zobl","year":"1965","journal-title":"J App Physiol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624120016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624120016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.124.001809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T12:56:37Z","timestamp":1740056197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624120016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":282,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0090955624120016"],"URL":"https:\/\/doi.org\/10.1124\/dmd.124.001809","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitatively Predicting Effects of Exercise on Pharmacokinetics of Drugs Using a Physiologically Based Pharmacokinetic Model","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.124.001809","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}