{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:00:29Z","timestamp":1791547229353,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"am","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42 ES013648"],"award-info":[{"award-number":["P42 ES013648"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 GM123253"],"award-info":[{"award-number":["R01 GM123253"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1124\/dmd.124.001939","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T14:15:14Z","timestamp":1729520114000},"page":"100012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Environmentally persistent free radicals stimulate CYP2E1-mediated generation of reactive oxygen species at the expense of substrate metabolism"],"prefix":"10.1016","volume":"53","author":[{"given":"George F.","family":"Cawley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Patrick","family":"Connick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn K.","family":"Eyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne L.","family":"Backes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.124.001939_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tiv.2008.09.020","article-title":"Air pollution particulate matter (PM2.5)-induced gene expression of volatile organic compound and\/or polycyclic aromatic hydrocarbon-metabolizing enzymes in an in\u00a0vitro coculture lung model","volume":"23","author":"Abbas","year":"2009","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1124\/dmd.124.001939_bib2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jinorgbio.2018.05.014","article-title":"The relationships between cytochromes P450 and H2O2: production, reaction, and inhibition","volume":"186","author":"Albertolle","year":"2018","journal-title":"J\u00a0Inorg Biochem"},{"key":"10.1124\/dmd.124.001939_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122183","article-title":"Environmentally persistent free radicals: methods for combustion generation, whole-body inhalation and assessing cardiopulmonary consequences","volume":"334","author":"Aryal","year":"2023","journal-title":"Environ Pollut"},{"key":"10.1124\/dmd.124.001939_bib4","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1016\/S0021-9258(18)83341-5","article-title":"Cytochrome P-450 LM2 reduction. Substrate effects on the rate of reductase-LM2 association","volume":"264","author":"Backes","year":"1989","journal-title":"J\u00a0Biol Chem"},{"key":"10.1124\/dmd.124.001939_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0021-9258(19)57385-9","article-title":"The effect of NADPH concentration on the reduction of cytochrome P-450 LM2","volume":"263","author":"Backes","year":"1988","journal-title":"J\u00a0Biol Chem"},{"key":"10.1124\/dmd.124.001939_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1743-8977-6-11","article-title":"Environmentally persistent free radicals amplify ultrafine particle mediated cellular oxidative stress and cytotoxicity","volume":"6","author":"Balakrishna","year":"2009","journal-title":"Part Fibre Toxicol"},{"key":"10.1124\/dmd.124.001939_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1743-8977-8-11","article-title":"Environmentally persistent free radicals induce airway hyperresponsiveness in neonatal rat lungs","volume":"8","author":"Balakrishna","year":"2011","journal-title":"Part Fibre Toxicol"},{"key":"10.1124\/dmd.124.001939_bib8","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.4049\/jimmunol.130.4.1910","article-title":"Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation","volume":"130","author":"Bass","year":"1983","journal-title":"J\u00a0Immunol"},{"key":"10.1124\/dmd.124.001939_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0006-2952(94)90235-6","article-title":"Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species","volume":"48","author":"Bondy","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.124.001939_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0304-3940(94)90409-X","article-title":"The formation of reactive oxygen species in a fraction of rat brain by metabolism of nitric oxide","volume":"168","author":"Bondy","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.1124\/dmd.124.001939_bib11","first-page":"1529","article-title":"Evidence supporting the interaction of CYP2B4 and CYP1A2 in microsomal preparations","volume":"29","author":"Cawley","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.124.001939_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pep.2003.08.009","article-title":"High-level expression of recombinant rabbit cytochrome P450 2E1 in Escherichia coli C41 and its purification","volume":"33","author":"Cheng","year":"2004","journal-title":"Protein Expr Purif"},{"key":"10.1124\/dmd.124.001939_bib13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/BCJ20200768","article-title":"Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1","volume":"478","author":"Connick","year":"2021","journal-title":"Biochem J"},{"key":"10.1124\/dmd.124.001939_bib14","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1289\/ehp.8629","article-title":"Origin and health impacts of emissions of toxic by-products and fine particles from combustion and thermal treatment of hazardous wastes and materials","volume":"114","author":"Cormier","year":"2006","journal-title":"Environ Health Perspect"},{"key":"10.1124\/dmd.124.001939_bib15","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1042\/BCJ20170543","article-title":"Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences","volume":"474","author":"Davydov","year":"2017","journal-title":"Biochem J"},{"key":"10.1124\/dmd.124.001939_bib16","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1074\/jbc.M114.615443","article-title":"Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences","volume":"290","author":"Davydov","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1124\/dmd.124.001939_bib17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/BJ20130398","article-title":"Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of \u03b1-naphthoflavone","volume":"453","author":"Davydov","year":"2013","journal-title":"Biochem J"},{"key":"10.1124\/dmd.124.001939_bib18","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1021\/es2012947","article-title":"Detection of environmentally persistent free radicals at a superfund wood treating site","volume":"45","author":"dela Cruz","year":"2011","journal-title":"Environ Sci Technol"},{"key":"10.1124\/dmd.124.001939_bib19","first-page":"79","article-title":"Chemical aspects of combustion of hazardous wastes","volume":"6","author":"Dellinger","year":"1998","journal-title":"Cent Eur J Public Health"},{"key":"10.1124\/dmd.124.001939_bib20","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1016\/S0082-0784(00)80687-6","article-title":"The role of combustion-generated radicals in the toxicity of PM2.5","volume":"28","author":"Dellinger","year":"2000","journal-title":"Proc Combust Inst"},{"key":"10.1124\/dmd.124.001939_bib21","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1021\/tx010050x","article-title":"Role of free radicals in the toxicity of airborne fine particulate matter","volume":"14","author":"Dellinger","year":"2001","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/dmd.124.001939_bib22","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/ijerph13060573","article-title":"Addressing emerging risks: scientific and regulatory challenges associated with environmentally persistent free radicals","volume":"13","author":"Dugas","year":"2016","journal-title":"Int J Environ Res Public Health"},{"key":"10.1124\/dmd.124.001939_bib23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.etap.2009.12.007","article-title":"In\u00a0vitro and in\u00a0vivo assessment of pulmonary risk associated with exposure to combustion generated fine particles","volume":"29","author":"Fahmy","year":"2010","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1124\/dmd.124.001939_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114444","article-title":"The pathophysiological and molecular mechanisms of atmospheric PM2.5 affecting cardiovascular health: a review","volume":"249","author":"Feng","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1124\/dmd.124.001939_bib25","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.3390\/ijms22158221","article-title":"CYP2E1 in alcoholic and non-alcoholic liver injury. Roles of ROS, reactive intermediates and lipid overload","volume":"22","author":"Harjum\u00e4ki","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1124\/dmd.124.001939_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205412","article-title":"Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells","volume":"13","author":"Harmon","year":"2018","journal-title":"PLoS One"},{"key":"10.1124\/dmd.124.001939_bib27","doi-asserted-by":"crossref","first-page":"H667","DOI":"10.1152\/ajpheart.00725.2020","article-title":"Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function","volume":"321","author":"Harmon","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/dmd.124.001939_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tox.2015.10.001","article-title":"Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates","volume":"338","author":"Hartman","year":"2015","journal-title":"Toxicology"},{"key":"10.1124\/dmd.124.001939_bib29","doi-asserted-by":"crossref","first-page":"5710","DOI":"10.1021\/acs.est.0c00351","article-title":"Comparative studies of environmentally persistent free radicals on total particulate matter collected from electronic and tobacco cigarettes","volume":"54","author":"Hasan","year":"2020","journal-title":"Environ Sci Technol"},{"key":"10.1124\/dmd.124.001939_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/bs.apha.2015.03.003","article-title":"Involvement of cytochrome P450 in reactive oxygen species formation and cancer","volume":"74","author":"Hrycay","year":"2015","journal-title":"Adv Pharmacol"},{"key":"10.1124\/dmd.124.001939_bib31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12989-018-0255-3","article-title":"Radical containing combustion derived particulate matter enhance pulmonary Th17 inflammation via the aryl hydrocarbon receptor","volume":"15","author":"Jaligama","year":"2018","journal-title":"Part Fibre Toxicol"},{"key":"10.1124\/dmd.124.001939_bib32","doi-asserted-by":"crossref","first-page":"10192","DOI":"10.1021\/bi7003476","article-title":"Global analysis of protein-protein interactions reveals multiple CYP2E1-reductase complexes","volume":"46","author":"Jamakhandi","year":"2007","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.124.001939_bib33","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1021\/tx400227s","article-title":"Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species","volume":"26","author":"Kelley","year":"2013","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/dmd.124.001939_bib34","doi-asserted-by":"crossref","first-page":"15807","DOI":"10.1021\/bi061803n","article-title":"Heteromeric complex formation between CYP2E1 and CYP1A2: evidence for the involvement of electrostatic interactions","volume":"45","author":"Kelley","year":"2006","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.124.001939_bib35","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1021\/bi0477900","article-title":"Effects of ionic strength on the functional interactions between CYP2B4 and CYP1A2","volume":"44","author":"Kelley","year":"2005","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.124.001939_bib36","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1021\/es501158r","article-title":"Environmentally persistent free radicals (EPFRs). 3. Free versus bound hydroxyl radicals in EPFR aqueous solutions","volume":"48","author":"Khachatryan","year":"2014","journal-title":"Environ Sci Technol"},{"key":"10.1124\/dmd.124.001939_bib37","doi-asserted-by":"crossref","first-page":"8559","DOI":"10.1021\/es201309c","article-title":"Environmentally persistent free radicals (EPFRs). 1. Generation of reactive oxygen species in aqueous solutions","volume":"45","author":"Khachatryan","year":"2011","journal-title":"Environ Sci Technol"},{"key":"10.1124\/dmd.124.001939_bib38","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1021\/es404013g","article-title":"Effect of copper oxide concentration on the formation and persistency of environmentally persistent free radicals (EPFRs) in particulates","volume":"48","author":"Kiruri","year":"2014","journal-title":"Environ Sci Technol"},{"key":"10.1124\/dmd.124.001939_bib39","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1021\/bi9715627","article-title":"Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites","volume":"37","author":"Korzekwa","year":"1998","journal-title":"Biochemistry"},{"key":"10.1124\/dmd.124.001939_bib40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0197-0186(90)90025-O","article-title":"Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes","volume":"17","author":"Lebel","year":"1990","journal-title":"Neurochem Int"},{"key":"10.1124\/dmd.124.001939_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0041-008X(90)90278-3","article-title":"Organometal-induced increases in oxygen reactive species: the potential of 2',7'-dichlorofluorescin diacetate as an index of neurotoxic damage","volume":"104","author":"LeBel","year":"1990","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.124.001939_bib42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12989-014-0057-1","article-title":"Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection","volume":"11","author":"Lee","year":"2014","journal-title":"Part Fibre Toxicol"},{"key":"10.1124\/dmd.124.001939_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/10799893.2011.555767","article-title":"Environmentally persistent free radicals decrease cardiac function before and after ischemia\/reperfusion injury in\u00a0vivo","volume":"31","author":"Lord","year":"2011","journal-title":"J\u00a0Recept Signal Transduct Res"},{"key":"10.1124\/dmd.124.001939_bib44","doi-asserted-by":"crossref","first-page":"H1135","DOI":"10.1152\/ajpheart.00545.2012","article-title":"Environmentally persistent free radicals decrease cardiac function and increase pulmonary artery pressure","volume":"303","author":"Mahne","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/dmd.124.001939_bib45","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.freeradbiomed.2023.10.396","article-title":"Redox and inflammatory mechanisms linking air pollution particulate matter with cardiometabolic derangements","volume":"209","author":"Marchini","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/dmd.124.001939_bib46","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/hc0402.104118","article-title":"Passage of inhaled particles into the blood circulation in humans","volume":"105","author":"Nemmar","year":"2002","journal-title":"Circulation"},{"key":"10.1124\/dmd.124.001939_bib47","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2174\/187231211794455253","article-title":"Inhibition of cytochrome P450 1A2-mediated metabolism and production of reactive oxygen species by heme oxygenase-1 in rat liver microsomes","volume":"5","author":"Reed","year":"2011","journal-title":"Drug Metab Lett"},{"key":"10.1124\/dmd.124.001939_bib48","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.taap.2014.03.021","article-title":"Environmentally persistent free radicals inhibit cytochrome P450 activity in rat liver microsomes","volume":"277","author":"Reed","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.124.001939_bib49","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.taap.2015.09.021","article-title":"Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2","volume":"289","author":"Reed","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.124.001939_bib50","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bcp.2015.03.012","article-title":"Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter","volume":"95","author":"Reed","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.124.001939_bib51","doi-asserted-by":"crossref","first-page":"8942","DOI":"10.1074\/jbc.M109.076885","article-title":"Functional interactions between cytochromes P450 1A2 and 2B4 require both enzymes to reside in the same phospholipid vesicle: evidence for physical complex formation","volume":"285","author":"Reed","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1124\/dmd.124.001939_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1294205","article-title":"A\u00a0comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog","volume":"15","author":"Saleem","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1124\/dmd.124.001939_bib53","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/jbt.21465","article-title":"Particulate matter containing environmentally persistent free radicals and adverse infant respiratory health effects: a review","volume":"27","author":"Saravia","year":"2013","journal-title":"J\u00a0Biochem Mol Toxicol"},{"key":"10.1124\/dmd.124.001939_bib54","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/taap.2000.8910","article-title":"Ethylbenzene induces microsomal oxygen free radical generation: antibody-directed characterization of the responsible cytochrome P450 enzymes","volume":"164","author":"Serron","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/dmd.124.001939_bib55","doi-asserted-by":"crossref","first-page":"E1003","DOI":"10.1152\/ajpendo.00521.2015","article-title":"Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in adult mice","volume":"310","author":"Stephenson","year":"2016","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1124\/dmd.124.001939_bib56","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.4049\/jimmunol.133.6.3303","article-title":"Flow cytometric quantitation of oxidative product formation by polymorphonuclear leukocytes during phagocytosis","volume":"133","author":"Szejda","year":"1984","journal-title":"J\u00a0Immunol"},{"key":"10.1124\/dmd.124.001939_bib57","first-page":"130","article-title":"Sediment from hurricane katrina: potential to produce pulmonary dysfunction in mice","volume":"1","author":"Wang","year":"2008","journal-title":"Int J Clin Exp Med"},{"key":"10.1124\/dmd.124.001939_bib58","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1165\/rcmb.2011-0001OC","article-title":"Radical-containing particles activate dendritic cells and enhance Th17 inflammation in a mouse model of asthma","volume":"45","author":"Wang","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1124\/dmd.124.001939_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1144903","article-title":"Nrf2\u2212\/\u2212 regulated lung DNA demethylation and CYP2E1 DNA methylation under PM2.5 exposure","volume":"14","author":"Wu","year":"2023","journal-title":"Front Genet"},{"key":"10.1124\/dmd.124.001939_bib60","doi-asserted-by":"crossref","first-page":"16209","DOI":"10.1021\/acs.est.2c04453","article-title":"Medium-low temperature conditions induce the formation of environmentally persistent free radicals in microplastics with conjugated aromatic-ring structures during sewage sludge pyrolysis","volume":"56","author":"Yuan","year":"2022","journal-title":"Environ Sci Technol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624148520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624148520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.124.001939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T04:36:19Z","timestamp":1761194179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624148520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0090955624148520"],"URL":"https:\/\/doi.org\/10.1124\/dmd.124.001939","relation":{},"ISSN":["0090-9556"],"issn-type":[{"value":"0090-9556","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmentally persistent free radicals stimulate CYP2E1-mediated generation of reactive oxygen species at the expense of substrate metabolism","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.124.001939","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Society for Pharmacology and Experimental Therapeutics. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100012"}}