{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:29:34Z","timestamp":1760203774732,"version":"3.37.3"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["dmd.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Drug Metabolism and Disposition"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1124\/dmd.31.2.147","type":"journal-article","created":{"date-parts":[[2003,1,16]],"date-time":"2003-01-16T00:02:02Z","timestamp":1042675322000},"page":"147-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pharmacokinetics and Metabolism of the Reactive Oxygen Scavenger \u03b1-Phenyl-N-tert-butylnitrone in the Male Sprague-Dawley Rat"],"prefix":"10.1016","volume":"31","author":[{"given":"Mary E.","family":"Trudeau-Lame","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit S.","family":"Kalgutkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"LaFontaine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/dmd.31.2.147_bib1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/jps.2600680845","article-title":"Noncompartment determination of the steady state volume of distribution.","volume":"68","author":"Benet","year":"1979","journal-title":"J Pharm Sci"},{"key":"10.1124\/dmd.31.2.147_bib2","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1021\/ja961469q","article-title":"Solvent effects on hemolytic bond dissociation energies of hydroxylic acids.","volume":"118","author":"Bordwell","year":"1996","journal-title":"J Am Chem Soc"},{"key":"10.1124\/dmd.31.2.147_bib3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2174\/0929867013373048","article-title":"Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer\u2019s disease and Huntingtion\u2019s Disease.","volume":"8","author":"Butterfield","year":"2001","journal-title":"Curr Med Chem"},{"key":"10.1124\/dmd.31.2.147_bib4","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1073\/pnas.88.9.3633","article-title":"Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.","volume":"88","author":"Carney","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/dmd.31.2.147_bib5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/10715769009145690","article-title":"Excretion, metabolism and tissue distribution of a spin trapping agent, alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats.","volume":"9","author":"Chen","year":"1990","journal-title":"Free Radic Res Commun"},{"key":"10.1124\/dmd.31.2.147_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/10715769109088936","article-title":"The role of mixed function oxidase (MFO) in the metabolism of the spin trapping agent alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats.","volume":"14","author":"Chen","year":"1991","journal-title":"Free Rad Res Commun"},{"key":"10.1124\/dmd.31.2.147_bib7","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1021\/jm960243v","article-title":"Design, synthesis and in vitro evaluation of cyclic nitrones as free radical traps for the treatment of stroke.","volume":"39","author":"Fevig","year":"1996","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.31.2.147_bib8","series-title":"Advances in Pharmacology","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1054-3589(08)60991-6","article-title":"Protective action of nitrone based free radical traps against oxidative damage of the central nervous system","author":"Floyd","year":"1996"},{"key":"10.1124\/dmd.31.2.147_bib9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1749-6632.2002.tb02103.x","article-title":"Nitrones as neuroprotectants and antiaging drugs.","volume":"959","author":"Floyd","year":"2002","journal-title":"Ann NY Acad Sci"},{"key":"10.1124\/dmd.31.2.147_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1006\/abbi.2001.2630","article-title":"Reactive oxygen species and protein oxidation in aging: a look back, a look ahead.","volume":"397","author":"Hensley","year":"2002","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/dmd.31.2.147_bib11","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1021\/jo00035a020","article-title":"Synthesis and characterization of phenyl-substituted C-phenyl-N-tert-butylnitrones and some of their radical adducts.","volume":"57","author":"Hinton","year":"1992","journal-title":"J Org Chem"},{"key":"10.1124\/dmd.31.2.147_bib12","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/0006-2952(94)90520-7","article-title":"Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance.","volume":"47","author":"Houston","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.31.2.147_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1124\/dmd.30.1.7","article-title":"Computational models for cytochrome P450: a predictive electronic model for aromatic oxidation and hydrogen atom abstraction.","volume":"30","author":"Jones","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.31.2.147_bib14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/ars.1999.1.4-481","article-title":"Pharmacological properties of phenyl N-tert-butylnitrone.","volume":"1","author":"Kotake","year":"1999","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/dmd.31.2.147_bib15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0167-4889(98)00126-8","article-title":"Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN).","volume":"1448","author":"Kotake","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/dmd.31.2.147_bib16","first-page":"1403","volume":"29","author":"Kuperman","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/dmd.31.2.147_bib17","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1046\/j.1471-4159.2000.0751709.x","article-title":"Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington\u2019s disease.","volume":"75","author":"La Fontaine","year":"2000","journal-title":"J Neurochem"},{"key":"10.1124\/dmd.31.2.147_bib18","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0006-2952(00)00249-5","article-title":"Transcriptional suppression of cytochrome P450 2C11 gene expression by 3-methylcholanthrene.","volume":"59","author":"Lee","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/dmd.31.2.147_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1021\/tx0155350","article-title":"Sex differences in the metabolism of (+)- and (\u2212)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome P450 enzymes in rat liver microsomes.","volume":"15","author":"Miyazawa","year":"2002","journal-title":"Chem Res Toxicol"},{"key":"10.1124\/dmd.31.2.147_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0022-3565(24)36999-X","article-title":"The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.","volume":"283","author":"Obach","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/dmd.31.2.147_bib21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/BF01059688","article-title":"Hepatic clearance of drugs, 1. Theoretical considerations of a \u201cwell-stirred\u201d model and a \u201cparallel tube\u201d model. Influence of hepatic blood flow, plasma and blood cell binding and the hepatocellular enzymatic activity on hepatic drug clearance.","volume":"5","author":"Pang","year":"1977","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1124\/dmd.31.2.147_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1022457605436","article-title":"Regional membrane phospholipid alterations in Alzheimer\u2019s disease.","volume":"23","author":"Prasad","year":"1998","journal-title":"Neurochem Res"},{"key":"10.1124\/dmd.31.2.147_bib23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0891-5849(99)00248-8","article-title":"Aromatic hydroxylation in PBN spin trapping by hydroxyl radicals and cytochrome P-450.","volume":"28","author":"Reinke","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/dmd.31.2.147_bib24","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1021\/jm960244n","article-title":"Cyclic nitrone free radical traps: isolation, identification and synthesis of 3,3-dimethyl-3,4-dihydroisoquinolin-4-ol N-oxide, a metabolite with reduced side effects.","volume":"39","author":"Thomas","year":"1996","journal-title":"J Med Chem"},{"key":"10.1124\/dmd.31.2.147_bib25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0278-6915(89)90105-1","article-title":"Disposition of single oral doses of butylated hydroxytoluene in man and rat.","volume":"27","author":"Verhagen","year":"1989","journal-title":"Food Chem Toxicol"}],"container-title":["Drug Metabolism and Disposition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624026060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0090955624026060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/dmd.31.2.147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T15:09:48Z","timestamp":1739891388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0090955624026060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S0090955624026060"],"URL":"https:\/\/doi.org\/10.1124\/dmd.31.2.147","relation":{},"ISSN":["0090-9556"],"issn-type":[{"type":"print","value":"0090-9556"}],"subject":[],"published":{"date-parts":[[2003,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics and Metabolism of the Reactive Oxygen Scavenger \u03b1-Phenyl-N-tert-butylnitrone in the Male Sprague-Dawley Rat","name":"articletitle","label":"Article Title"},{"value":"Drug Metabolism and Disposition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/dmd.31.2.147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}