{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:53:51Z","timestamp":1790949231997,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1124\/jpet.102.036129","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:45:31Z","timestamp":1042224331000},"page":"1062-1069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Differential Transport of a Secretin Analog across the Blood-Brain and Blood-Cerebrospinal Fluid Barriers of the Mouse"],"prefix":"10.1016","volume":"302","author":[{"given":"William A.","family":"Banks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Goulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Rusche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Niehoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Boismenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.102.036129_bib1","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1212\/WNL.53.9.2145","article-title":"MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults.","volume":"53","author":"Aylward","year":"1999","journal-title":"Neurology"},{"key":"10.1124\/jpet.102.036129_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0361-9230(85)90153-4","article-title":"Peptides and the blood-brain barrier: lipophilicity as a predictor of permeability.","volume":"15","author":"Banks","year":"1985","journal-title":"Brain Res Bull"},{"key":"10.1124\/jpet.102.036129_bib3","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0022-3565(25)39457-7","article-title":"Passage of pituitary adenylate cyclase activating polypeptide1\u201327 and pituitary adenylate cyclase activating polypeptide1\u201338 across the blood-brain barrier.","volume":"267","author":"Banks","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.036129_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1113\/jphysiol.1902.sp000920","article-title":"The mechanisms of pancreatic secretion.","volume":"28","author":"Bayliss","year":"1902","journal-title":"J Physiol (Lond)"},{"key":"10.1124\/jpet.102.036129_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0167-0115(82)90145-8","article-title":"A microsphere study on the effects of somatostatin and secretin on regional blood flow in anesthetized dogs.","volume":"4","author":"Becker","year":"1982","journal-title":"Regul Pept"},{"key":"10.1124\/jpet.102.036129_bib6","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0196-9781(83)90029-3","article-title":"Secretin modulation of behavioral and physiological functions in the rat.","volume":"4","author":"Charlton","year":"1983","journal-title":"Peptides"},{"key":"10.1124\/jpet.102.036129_bib7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/A:1005443119324","article-title":"Secretin and autism: a two-part clinical investigation.","volume":"30","author":"Chez","year":"2000","journal-title":"J Autism Dev Disorders"},{"key":"10.1124\/jpet.102.036129_bib8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0039-6060(96)80171-1","article-title":"Intracerebroventricular secretin enhances pancreatic volume and bicarbonate response in rats.","volume":"119","author":"Cotner","year":"1996","journal-title":"Surgery"},{"key":"10.1124\/jpet.102.036129_bib9","series-title":"Physiology of the CSF and Blood-Brain Barriers","first-page":"607","article-title":"Ontogenetic aspects of the cerebrospinal system","author":"Davson","year":"1996"},{"key":"10.1124\/jpet.102.036129_bib10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1074\/jbc.274.2.903","article-title":"Demonstration of a direct interaction between residue 22 in the carboxyl-terminal half of secretin and the amino-terminal tail of the secretin receptor using photoaffinity labeling.","volume":"274","author":"Dong","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.102.036129_bib11","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1469-8749.2000.tb00692.x","article-title":"Effect of secretin on children with autism: a randomized controlled trial.","volume":"42","author":"Dunn-Geier","year":"2000","journal-title":"Dev Med Child Neurol"},{"key":"10.1124\/jpet.102.036129_bib12","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1523\/JNEUROSCI.03-08-01620.1983","article-title":"Secretin: specific binding to rat brain membranes.","volume":"3","author":"Fremeau","year":"1983","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.102.036129_bib13","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/j.1471-4159.1986.tb08518.x","article-title":"Secretin stimulates cyclic AMP formation in the rat brain.","volume":"46","author":"Fremeau","year":"1986","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.102.036129_bib14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1471-4159.1966.tb09873.x","article-title":"Regional studies of catecholamines in the rat brain. I. The [3H]DOPA in various regions of the brain.","volume":"13","author":"Glowinski","year":"1966","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.102.036129_bib15","first-page":"90.18","article-title":"Activation of the rat central nervous system by intravenous secretin infusion.","volume":"27","author":"Goulet","year":"2001","journal-title":"Soc Neurosci Abstr"},{"key":"10.1124\/jpet.102.036129_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0165-5728(93)90027-V","article-title":"Murine tumor necrosis factor \u03b1 is transported from blood to brain in the mouse.","volume":"47","author":"Gutierrez","year":"1993","journal-title":"J Neuroimmunol"},{"key":"10.1124\/jpet.102.036129_bib17","first-page":"9","article-title":"Improved social and language skills after secretin administration in patients with autistic spectrum disorders.","volume":"9","author":"Horvath","year":"1998","journal-title":"J Assoc Acad Minor Phys"},{"key":"10.1124\/jpet.102.036129_bib18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0031-9384(79)90386-X","article-title":"Cholecystokinin, motilin and secretin effects on the central nervous system.","volume":"23","author":"Ishibashi","year":"1979","journal-title":"Physiol Behav"},{"key":"10.1124\/jpet.102.036129_bib19","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/j.1460-2075.1991.tb07686.x","article-title":"Molecular cloning and expression of a cDNA encoding the secretin receptor.","volume":"10","author":"Ishihara","year":"1991","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"10.1124\/jpet.102.036129_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0143-4179(95)90070-5","article-title":"Regulation of adenylate cyclase by galanin, neuropeptide Y, secretin and vasoactive intestinal polypeptide in rat frontal cortex, hippocampus and hypothalamus.","volume":"28","author":"Karelson","year":"1995","journal-title":"Neuropeptides"},{"key":"10.1124\/jpet.102.036129_bib21","series-title":"Principles and Practice of Endocrinology and Metabolism","first-page":"1611","article-title":"The endocrine brain","author":"Kastin","year":"2001"},{"key":"10.1124\/jpet.102.036129_bib22","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1073\/pnas.87.6.2299","article-title":"Secretin: structure of the precursor and tissue distribution of the mRNA.","volume":"87","author":"Kopin","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.102.036129_bib23","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/0024-3205(79)90472-7","article-title":"Secretin-like bioactivity in extracts of porcine brain.","volume":"25","author":"Mutt","year":"1979","journal-title":"Life Sci"},{"key":"10.1124\/jpet.102.036129_bib24","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1073\/pnas.78.8.5221","article-title":"Identification, characterization and distribution of secretin immunoreactivity in rat and pig brain.","volume":"78","author":"O\u2019Donohue","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.102.036129_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s004010050401","article-title":"Hippocampus in autism: a Golgi analysis.","volume":"91","author":"Raymond","year":"1996","journal-title":"Acta Neuropathol"},{"key":"10.1124\/jpet.102.036129_bib26","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1056\/NEJM199912093412404","article-title":"Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder.","volume":"341","author":"Sandler","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.102.036129_bib27","first-page":"PL115","article-title":"The putative blood-brain barrier transporter for the \u03b2-amyloid binding protein apolipoprotein J is saturated at physiological concentrations.","volume":"60","author":"Shayo","year":"1996","journal-title":"Life Sci"},{"key":"10.1124\/jpet.102.036129_bib28","series-title":"Neuropeptides: Regulators of Physiological Processes","first-page":"383","article-title":"Gut and brain neuropeptides I. Neuropeptide families: gastrin\/CCK; VIP\/secretin\/glucagon; PP\/PYY\/NPY; BN\/GRP","author":"Strand","year":"1999"},{"key":"10.1124\/jpet.102.036129_bib29","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1111\/j.1471-4159.1990.tb04886.x","article-title":"Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins.","volume":"54","author":"Triguero","year":"1990","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.102.036129_bib30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0006-8993(96)00716-0","article-title":"Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide.","volume":"736","author":"Uchida","year":"1996","journal-title":"Brain Res"},{"key":"10.1124\/jpet.102.036129_bib31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11920-000-0063-x","article-title":"The molecular genetics of autism.","volume":"2","author":"Wassink","year":"2000","journal-title":"Curr Psychiatry Rep"},{"key":"10.1124\/jpet.102.036129_bib32","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1523\/JNEUROSCI.21-18-07063.2001","article-title":"Secretin facilitates GABA transmission in the cerebellum.","volume":"21","author":"Yung","year":"2001","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.102.036129_bib33","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1471-4159.1988.tb04864.x","article-title":"Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea pig brain.","volume":"51","author":"Zlokovic","year":"1988","journal-title":"J Neurochem"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524358665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524358665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.102.036129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:26:05Z","timestamp":1740007565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524358665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0022356524358665"],"URL":"https:\/\/doi.org\/10.1124\/jpet.102.036129","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential Transport of a Secretin Analog across the Blood-Brain and Blood-Cerebrospinal Fluid Barriers of the Mouse","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.102.036129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government","name":"copyright","label":"Copyright"}]}}