{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:16:30Z","timestamp":1791191790202,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1124\/jpet.102.038141","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:48:30Z","timestamp":1042224510000},"page":"695-703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Self-Administration of Intravenous Buprenorphine and the Buprenorphine\/Naloxone Combination by Recently Detoxified Heroin Abusers"],"prefix":"10.1016","volume":"303","author":[{"given":"Sandra D.","family":"Comer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1124\/jpet.102.038141_bib1","first-page":"S6","article-title":"Abuse liability of i.v. buprenorphine-naloxone, buprenorphine and hydromorphone in buprenorphine-naloxone maintained volunteers.","volume":"60","author":"Amass","year":"2000","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.102.038141_bib2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1177\/106002809703100706","article-title":"Abuse of prescription medicines in southwestern France.","volume":"31","author":"Baumevieille","year":"1997","journal-title":"Ann Pharmacother"},{"key":"10.1124\/jpet.102.038141_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1037\/1064-1297.3.4.477","article-title":"Buprenorphine treatment of opioid dependence: a review.","volume":"3","author":"Bickel","year":"1995","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1124\/jpet.102.038141_bib4","series-title":"Problems of Drug Dependence 1986 Proceeding of the 48th Annual Scientific Meeting (National Institute on Drug Abuse Research Monograph, No. 76","first-page":"145","article-title":"Abuse liability assessment of buprenorphine-naloxone combinations","author":"Bigelow","year":"1987"},{"key":"10.1124\/jpet.102.038141_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/00008877-199712000-00002","article-title":"Choice between money and intranasal heroin in morphine-maintained humans.","volume":"8","author":"Comer","year":"1997","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.102.038141_bib6","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1124\/jpet.301.1.266","article-title":"Intravenous buprenorphine self-administration by detoxified heroin abusers.","volume":"301","author":"Comer","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.038141_bib7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s002130050956","article-title":"Comparison of intravenous and intranasal heroin self-administration by morphine-maintained humans.","volume":"143","author":"Comer","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.102.038141_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0014-2999(97)01572-0","article-title":"Effects of an alternative reinforcer on i. v. heroin self-administration by humans.","volume":"345","author":"Comer","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.102.038141_bib9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0022-3565(25)12294-5","article-title":"Buprenorphine\u2019s physical dependence potential: antagonist-precipitated withdrawal in humans.","volume":"276","author":"Eissenberg","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.038141_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0376-8716(98)00008-8","article-title":"Effects of buprenorphine and naloxone in morphine-stabilized opioid addicts.","volume":"50","author":"Fudala","year":"1998","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.102.038141_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0376-8716(00)00126-5","article-title":"Buprenorphine and naloxone co-administration in opiate-dependent patients stabilized on sublingual buprenorphine.","volume":"61","author":"Harris","year":"2000","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.102.038141_bib12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s002130050051","article-title":"Reinforcing and subjective effects of morphine in human opioid abusers: effect of dose and alternative reinforcer.","volume":"148","author":"Heishman","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.102.038141_bib13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0024-3205(94)00878-7","article-title":"Influence of an alternative reinforcer on human cocaine self-administration.","volume":"55","author":"Higgins","year":"1994","journal-title":"Life Sci"},{"key":"10.1124\/jpet.102.038141_bib14","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1056\/NEJM200011023431802","article-title":"A comparison of levomethadyl acetate, buprenorphine and methadone for opioid dependence.","volume":"343","author":"Johnson","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.102.038141_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0014-2999(00)00039-X","article-title":"Buprenorphine and methoclocinnamox: agonist and antagonist effects on respiratory function in rhesus monkeys.","volume":"391","author":"Kishioka","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.102.038141_bib16","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0022-3565(25)20504-3","article-title":"The reinforcing and subjective effects of morphine in post-addicts: a dose-response study.","volume":"259","author":"Lamb","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.038141_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0376-8716(88)90053-1","article-title":"Progressive ratio performance maintained by buprenorphine, heroin and methadone in macaque monkeys.","volume":"21","author":"Mello","year":"1988","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.102.038141_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0009-9236(96)90173-3","article-title":"Buprenorphine and naloxone interactions in opiate-dependent volunteers.","volume":"60","author":"Mendelson","year":"1996","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.102.038141_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s002130050804","article-title":"Buprenorphine and naloxone combinations: the effects of three dose ratios in morphine-stabilized, opiate-dependent volunteers.","volume":"141","author":"Mendelson","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.102.038141_bib20","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0006-3223(96)00266-1","article-title":"Buprenorphine and naloxone interactions in methadone maintenance patients.","volume":"41","author":"Mendelson","year":"1997","journal-title":"Biol Psychiatry"},{"key":"10.1124\/jpet.102.038141_bib21","series-title":"Buprenorphine: Combating Drug Abuse with a Unique Opioid","first-page":"71","article-title":"Reinforcing effects, discriminative stimulus effects and physical dependence liability of buprenorphine","author":"Negus","year":"1995"},{"key":"10.1124\/jpet.102.038141_bib22","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.1360-0443.1988.tb00536.x","article-title":"Buprenorphine abuse among opiate addicts.","volume":"83","author":"O\u2019Connor","year":"1988","journal-title":"Br J Addiction"},{"key":"10.1124\/jpet.102.038141_bib23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1037\/1064-1297.7.1.38","article-title":"Buprenorphine dose self-selection: effects of an alternative reinforcer, behavioral economic analysis of demand and examination of subjective drug effects.","volume":"7","author":"Petry","year":"1999","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1124\/jpet.102.038141_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/clpt.1993.72","article-title":"Subjective and physiologic effects of intravenous buprenorphine in humans.","volume":"53","author":"Pickworth","year":"1993","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.102.038141_bib25","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/BF00212842","article-title":"Buprenorphine and naloxone alone and in combination in opioid-dependent humans.","volume":"94","author":"Preston","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.102.038141_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0376-8716(93)90036-P","article-title":"The misuse of buprenorphine and a buprenorphine-naloxone combination in Wellington, New Zealand.","volume":"33","author":"Robinson","year":"1993","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.102.038141_bib27","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1360-0443.1989.tb00589.x","article-title":"Buprenorphine and temazepam abuse by drug takers in Glasgow\u2014an increase.","volume":"84","author":"Sakol","year":"1989","journal-title":"Br J Addiction"},{"key":"10.1124\/jpet.102.038141_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s002130051045","article-title":"Onset, magnitude and duration of opioid blockade produced by buprenorphine and naltrexone in humans.","volume":"145","author":"Schuh","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.102.038141_bib29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1600-0447.1992.tb03224.x","article-title":"Cases of buprenorphine abuse in India.","volume":"86","author":"Singh","year":"1992","journal-title":"Acta Psychiatry Scand"},{"key":"10.1124\/jpet.102.038141_bib30","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s002130000637","article-title":"Effects of buprenorphine\/naloxone in opioid-dependent humans.","volume":"154","author":"Stoller","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.102.038141_bib31","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s002130050066","article-title":"Effects of buprenorphine versus buprenorphine\/naloxone tablets in non-dependent opioid abusers.","volume":"148","author":"Strain","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.102.038141_bib32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s002130050199","article-title":"The effects of buprenorphine in buprenorphine-maintained volunteers.","volume":"129","author":"Strain","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.102.038141_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/clpt.1983.124","article-title":"Oral methadone self-administration: effects of dose and alternative reinforcers.","volume":"34","author":"Stitzer","year":"1983","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.102.038141_bib34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1037\/0021-843X.92.4.408","article-title":"Behavioral theories of choice as a framework for studying drinking behavior.","volume":"92","author":"Vuchinich","year":"1983","journal-title":"J Abnorm Psychol"},{"key":"10.1124\/jpet.102.038141_bib35","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0022-3565(25)09651-X","article-title":"Buprenorphine antagonism of \u03bc opioids in the rhesus monkey tail-withdrawal procedure.","volume":"273","author":"Walker","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.038141_bib36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/clpt.1994.71","article-title":"Clinical pharmacology of buprenorphine: ceiling effects at high doses.","volume":"55","author":"Walsh","year":"1994","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.102.038141_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0376-8716(92)90061-G","article-title":"Buprenorphine alone and in combination with naloxone in non-dependent humans.","volume":"30","author":"Weinhold","year":"1992","journal-title":"Drug Alcohol Depend"},{"key":"10.1124\/jpet.102.038141_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0376-8716(00)00166-6","article-title":"The effects of chronic morphine on behavior reinforced by several opioids or by cocaine in rhesus monkeys.","volume":"62","author":"Winger","year":"2001","journal-title":"Drug Alcohol Depend"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524359907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524359907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.102.038141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:30:24Z","timestamp":1740007824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524359907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0022356524359907"],"URL":"https:\/\/doi.org\/10.1124\/jpet.102.038141","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-Administration of Intravenous Buprenorphine and the Buprenorphine\/Naloxone Combination by Recently Detoxified Heroin Abusers","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.102.038141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}