{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:31:40Z","timestamp":1769016700749,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1124\/jpet.102.038331","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:48:30Z","timestamp":1042224510000},"page":"592-600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Pharmacological Profile of the Novel Inotropic Agent (E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride (PST2744)"],"prefix":"10.1016","volume":"303","author":[{"given":"R.","family":"Micheletti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.G.","family":"Mattera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rocchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schiavone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Loi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.P.","family":"Gagnol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"De Munari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Melloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Carminati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.102.038331_bib1","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1056\/NEJM199812173392503","article-title":"A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators.","volume":"339","author":"Cohn","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.102.038331_bib2","first-page":"1A","article-title":"On behalf of the membership of the advisory council to improve outcomes nationwide in heart failure.","volume":"83","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1124\/jpet.102.038331_bib3","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1021\/jm980108d","article-title":"A new approach to the design of novel inhibitors of Na+,K+-ATPase: 17\u03b2-substituted seco-d-5\u03b2-androstane as cassaine analogs.","volume":"41","author":"De Munari","year":"1998","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.102.038331_bib4","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/01.CIR.94.5.992","article-title":"Evidence for functional relevance of an enhanced expression of the Na+-Ca2+ exchanger in failing human myocardium.","volume":"94","author":"Flesch","year":"1996","journal-title":"Circulation"},{"key":"10.1124\/jpet.102.038331_bib5","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1021\/jm0109208","article-title":"17\u03b1-O-(Aminoalkyl)oxime derivatives of 3\u03b2,14\u03b2-dihydroxy-5\u03b2-androstane and 3\u03b2-hydroxy-14-oxoseco-d-5\u03b2-androstane as inhibitors of Na+,K+-ATPase at the digitalis receptor.","volume":"44","author":"Gobbini","year":"2001","journal-title":"J Med Chem"},{"key":"10.1124\/jpet.102.038331_bib6","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1097-2765(00)80349-4","article-title":"Identification of a specific role for the Na,K-ATPase \u03b12 isoform as regulator of calcium in the heart.","volume":"3","author":"James","year":"1999","journal-title":"Mol Cell"},{"key":"10.1124\/jpet.102.038331_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0735-1097(83)80375-1","article-title":"Susceptibility of infarcted canine hearts to digitalis-toxic ventricular tachycardia.","volume":"2","author":"Iesaka","year":"1983","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.102.038331_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurements with the Folin phenol reagent.","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.102.038331_bib9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1023\/A:1009884820941","article-title":"Incidence and epidemiology of heart failure.","volume":"5","author":"Kannel","year":"2000","journal-title":"Heart Failure Rev"},{"key":"10.1124\/jpet.102.038331_bib10","doi-asserted-by":"crossref","first-page":"C675","DOI":"10.1152\/ajpcell.1995.269.3.C675","article-title":"Reciprocal regulation of cardiac Na-K-ATPase and Na\/Ca exchanger: hypertension, thyroid hormone, development.","volume":"269","author":"Magyar","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1124\/jpet.102.038331_bib11","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1056\/NEJM199111213252103","article-title":"Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group.","volume":"325","author":"Packer","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.102.038331_bib12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0008-6363(95)00176-X","article-title":"Cardiac Na+\/Ca2+ exchange activity in patients with end-stage heart failure.","volume":"31","author":"Reinecke","year":"1996","journal-title":"Cardiovasc Res"},{"key":"10.1124\/jpet.102.038331_bib13","first-page":"H1118","article-title":"Activation of cardiac ryanodine receptors by cardiac glycosides.","volume":"282","author":"Sagawa","year":"2002","journal-title":"Am J Physiol"},{"key":"10.1124\/jpet.102.038331_bib14","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1161\/01.CIR.101.12.1441","article-title":"KB-R7943 block of Ca2+ influx via Na+\/Ca2+ exchange does not alter twitches or glycoside inotropy but prevents Ca2+ overload in rat ventricular myocytes.","volume":"101","author":"Satoh","year":"2000","journal-title":"Circulation"},{"key":"10.1124\/jpet.102.038331_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1161\/01.RES.75.3.443","article-title":"Gene expression of the cardiac Na+-Ca2+ exchanger in end-stage human heart failure.","volume":"75","author":"Studer","year":"1994","journal-title":"Circ Res"},{"key":"10.1124\/jpet.102.038331_bib16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1056\/NEJM199702203360801","article-title":"The effect of digoxin on mortality and morbidity in patients with heart failure.","volume":"336","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.102.038331_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0140-6736(90)91517-E","volume":"336","year":"1990","journal-title":"Lancet"},{"key":"10.1124\/jpet.102.038331_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1073\/pnas.89.1.99","article-title":"The cardiac conduction system in the rat expresses the \u03b12 and \u03b13 isoforms of the Na+,K+-ATPase.","volume":"89","author":"Zahler","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.102.038331_bib19","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/01.RES.78.5.870","article-title":"The \u03b13 isoform protein of the Na+, K+-ATPase is associated with the sites of cardiac and neuromuscular impulse transmission.","volume":"78","author":"Zahler","year":"1996","journal-title":"Circ Res"},{"key":"10.1124\/jpet.102.038331_bib20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1161\/01.RES.82.9.947","article-title":"Dynamic Ca2+-induced inward rectification of K+ current during the ventricular action potential.","volume":"82","author":"Zaza","year":"1998","journal-title":"Circ Res"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524359774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524359774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.102.038331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:29:46Z","timestamp":1740007786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524359774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0022356524359774"],"URL":"https:\/\/doi.org\/10.1124\/jpet.102.038331","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological Profile of the Novel Inotropic Agent (E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride (PST2744)","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.102.038331","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}