{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:07:20Z","timestamp":1762520840369,"version":"3.37.3"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1124\/jpet.102.040105","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T18:49:58Z","timestamp":1042224598000},"page":"1283-1290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Inhibition of Allergic Dermal Inflammation by the Novel Imidazopyridazine Derivative TAK-427 in a Guinea Pig Experimental Model of Eczema"],"prefix":"10.1016","volume":"303","author":[{"given":"Shigeru","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuo","family":"Midoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kamei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyo","family":"Gyoten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Ashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Nagaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.102.040105_bib1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0091-6749(97)80015-2","article-title":"Cellular inflammatory responses and mediator release during early developing late-phase allergic cutaneous inflammatory responses: effects of cetirizine.","volume":"99","author":"Atkins","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/jpet.102.040105_bib2","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/S0140-6736(94)92473-2","article-title":"Pathogenesis of atopic eczema.","volume":"343","author":"Bos","year":"1994","journal-title":"Lancet"},{"key":"10.1124\/jpet.102.040105_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2222.1993.tb00304.x","article-title":"The involvement of eosinophils in the patch test reaction to aeroallergens in atopic dermatitis: its relevance for the pathogenesis of atopic dermatitis.","volume":"23","author":"Bruijnzeel","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"10.1124\/jpet.102.040105_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2133.1988.tb01779.x","article-title":"Active participation of eosinophils in patch test reactions to inhalant allergens in patients with atopic dermatitis.","volume":"118","author":"Bruijnzeel-Koomen","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1124\/jpet.102.040105_bib5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/1523-1747.ep12289702","article-title":"Transgenic mice expressing IFN-\u03b3 in the epidermis have eczema, hair hypopigmentation and hair loss.","volume":"108","author":"Carroll","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1124\/jpet.102.040105_bib6","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1172\/JCI114047","article-title":"Cutaneous late-phase response to allergen: mediator release and inflammatory cell infiltration.","volume":"83","author":"Charlesworth","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.102.040105_bib7","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0091-6749(89)90104-8","article-title":"Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction.","volume":"83","author":"Charlesworth","year":"1989","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/jpet.102.040105_bib8","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0190-9622(89)70269-3","article-title":"Aeroallergen contact can exacerbate atopic dermatitis: patch tests as a diagnostic tool.","volume":"21","author":"Clark","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1124\/jpet.102.040105_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0091-6749(73)90119-X","article-title":"Late cutaneous allergic responses in isolated IgE-dependent reaction.","volume":"52","author":"Dolovich","year":"1973","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/jpet.102.040105_bib10","first-page":"L117","article-title":"Interleukin-8 is a potent mediator of eosinophil chemotaxis through endothelium and epithelium.","volume":"268","author":"Erger","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1124\/jpet.102.040105_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2222.1987.tb02027.x","article-title":"Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo.","volume":"17","author":"Fadel","year":"1987","journal-title":"Clin Allergy"},{"key":"10.1124\/jpet.102.040105_bib12","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1172\/JCI117408","article-title":"Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.","volume":"94","author":"Hamid","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.102.040105_bib13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0091-6749(84)90401-9","article-title":"Hypothesis on the contribution of late-phase allergic responses to the understanding and treatment of allergic diseases.","volume":"73","author":"Kaliner","year":"1984","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/jpet.102.040105_bib14","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1067\/mai.2000.109831","article-title":"Modulation of the atopy patch test reaction by topical corticosteroids and tar.","volume":"106","author":"Langeveld-Wildschut","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/jpet.102.040105_bib15","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0091-6749(96)80186-2","article-title":"Evaluation of the atopy patch test and the cutaneous late-phase reaction as relevant models for the study of allergic inflammation in patients with atopic eczema.","volume":"98","author":"Langeveld-Wildschut","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1124\/jpet.102.040105_bib16","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1056\/NEJM198508013130502","article-title":"Dermal deposition of eosinophil granule major basic protein in atopic dermatitis: comparison with onchocerciasis.","volume":"313","author":"Leiferman","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.102.040105_bib17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/intimm\/9.3.461","article-title":"Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC\/Nga mice.","volume":"9","author":"Matsuda","year":"1997","journal-title":"Int Immunol"},{"key":"10.1124\/jpet.102.040105_bib18","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1084\/jem.179.4.1145","article-title":"Role of vascular cell adhesion molecule 1\/very late activation antigen 4 and intercellular adhesion molecule 1\/lymphocyte function-associated antigen 1 interaction in antigen-induced eosinophil and T cell recruitment into the tissue.","volume":"179","author":"Nakajima","year":"1994","journal-title":"J Exp Med"},{"key":"10.1124\/jpet.102.040105_bib19","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.4049\/jimmunol.154.4.1956","article-title":"Overexpression of IL-10 in atopic dermatitis: contrasting cytokine patterns with delayed-type hypersensitivity reactions.","volume":"154","author":"Ohmen","year":"1995","journal-title":"J Immunol"},{"key":"10.1124\/jpet.102.040105_bib20","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1172\/JCI119496","article-title":"Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis: implications for sustained dendritic cell activation in the skin.","volume":"99","author":"Pastore","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.102.040105_bib21","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1056\/NEJM199805283382206","article-title":"Eosinophilia.","volume":"338","author":"Rothenberg","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.102.040105_bib22","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1172\/JCI1647","article-title":"Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice.","volume":"101","author":"Spergel","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.102.040105_bib23","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1172\/JCI5669","article-title":"Role of TH1 and TH2 cytokines in a murine model of allergic dermatitis.","volume":"103","author":"Spergel","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.102.040105_bib24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1346-8138.1992.tb03209.x","article-title":"Eosinophil involvement in atopic dermatitis as reflected by elevated serum levels of eosinophil cationic protein.","volume":"19","author":"Tsuda","year":"1992","journal-title":"J Dermatol"},{"key":"10.1124\/jpet.102.040105_bib25","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1046\/j.1365-2249.1997.4671365.x","article-title":"IL-13 over-expression in skin is not confined to IgE-mediated skin inflammation.","volume":"109","author":"Van der Ploeg","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"10.1124\/jpet.102.040105_bib26","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/0190-9622(92)70288-Q","article-title":"Cyclosporine in atopic dermatitis: modulation in the expression of immunologic markers in lesional skin.","volume":"27","author":"Van Joost","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"10.1124\/jpet.102.040105_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2222.1992.tb00113.x","article-title":"The effect of a single oral dose of prednisolone or cetirizine on inflammatory cells infiltrating allergen induced cutaneous late phase reaction in atopic subjects.","volume":"22","author":"Varney","year":"1992","journal-title":"Clin Exp Allergy"},{"key":"10.1124\/jpet.102.040105_bib28","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.4049\/jimmunol.156.11.4079","article-title":"Epicutaneous exposure of protein antigen induces a predominant TH2-like response with high IgE production in mice.","volume":"156","author":"Wang","year":"1996","journal-title":"J Immunol"},{"key":"10.1124\/jpet.102.040105_bib29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1523-1747.1999.00619.x","article-title":"Enhanced expression of eotaxin and CCR3 in atopic dermatitis.","volume":"113","author":"Yawalkar","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1124\/jpet.102.040105_bib30","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.4049\/jimmunol.158.10.5050","article-title":"Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages and T cells in allergen-induced late-phase cutaneous reaction in atopic subjects.","volume":"158","author":"Ying","year":"1997","journal-title":"J Immunol"},{"key":"10.1124\/jpet.102.040105_bib31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0091-6749(97)70247-1","article-title":"Cellular inflammatory responses during immediate, developing and established late-phase allergic cutaneous reactions: effects of cetirizine.","volume":"100","author":"Zweiman","year":"1997","journal-title":"J Allergy Clin Immunol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524360665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524360665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.102.040105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:32:51Z","timestamp":1740007971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524360665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0022356524360665"],"URL":"https:\/\/doi.org\/10.1124\/jpet.102.040105","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of Allergic Dermal Inflammation by the Novel Imidazopyridazine Derivative TAK-427 in a Guinea Pig Experimental Model of Eczema","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.102.040105","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}