{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:12:18Z","timestamp":1777443138987,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1124\/jpet.102.044909","type":"journal-article","created":{"date-parts":[[2003,3,21]],"date-time":"2003-03-21T02:35:49Z","timestamp":1048214149000},"page":"173-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Activation of \u03ba-Opioid Receptors Inhibits Pruritus Evoked by Subcutaneous or Intrathecal Administration of Morphine in Monkeys"],"prefix":"10.1016","volume":"305","author":[{"given":"M.C. Holden","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heeseung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Sobczyk-Kojiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry I.","family":"Mosberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiroh","family":"Kishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norah N.","family":"Naughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.102.044909_bib1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0304-3959(00)00464-4","article-title":"A cellular mechanism for the antinociceptive effect of a \u03ba-opioid receptor agonist.","volume":"91","author":"Ackley","year":"2001","journal-title":"Pain"},{"key":"10.1124\/jpet.102.044909_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/82924","article-title":"Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch.","volume":"4","author":"Andrew","year":"2001","journal-title":"Nat Neurosci"},{"key":"10.1124\/jpet.102.044909_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00000542-199307000-00010","article-title":"Dose-response pharmacology of intrathecal morphine in human volunteers.","volume":"79","author":"Bailey","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.102.044909_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0304-3959(88)90085-1","article-title":"Itching after epidural and spinal opiates.","volume":"33","author":"Ballantyne","year":"1988","journal-title":"Pain"},{"key":"10.1124\/jpet.102.044909_bib5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/00000542-198102000-00007","article-title":"Intrathecal injection of morphine for obstetric analgesia.","volume":"54","author":"Baraka","year":"1981","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.102.044909_bib6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0022-3565(24)37419-1","article-title":"\u03ba-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception.","volume":"285","author":"Butelman","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.044909_bib7","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0022-3565(25)39577-7","article-title":"\u03ba Opioid antagonist effects of systemically administered nor-binaltorphimine in a thermal antinociception assay in rhesus monkeys.","volume":"267","author":"Butelman","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.044909_bib8","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0022-3565(25)24501-3","article-title":"Butorphanol: characterization of agonist and antagonist effects in rhesus monkeys.","volume":"272","author":"Butelman","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.044909_bib9","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/BF03011037","article-title":"Side effects of intrathecal and epidural opioids.","volume":"42","author":"Chaney","year":"1995","journal-title":"Can J Anaesth"},{"key":"10.1124\/jpet.102.044909_bib10","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1213\/00000539-199211000-00016","article-title":"Nalbuphine is better than naloxone for treatment of side effects after epidural morphine.","volume":"75","author":"Cohen","year":"1992","journal-title":"Anesth Analg"},{"key":"10.1124\/jpet.102.044909_bib11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00000542-198409000-00008","article-title":"Intrathecal and epidural administration of opioids.","volume":"61","author":"Cousins","year":"1984","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.102.044909_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0165-6147(86)90257-9","article-title":"In-vivo studies on \u03ba opioid receptors.","volume":"7","author":"Cowan","year":"1986","journal-title":"Trends Pharmacol Sci"},{"issue":"Suppl","key":"10.1124\/jpet.102.044909_bib13","first-page":"169","article-title":"Antagonism by opioids of compound 48\/80-induced scratching in mice.","volume":"122","author":"Cowan","year":"1997","journal-title":"Br J Pharmacol"},{"issue":"Suppl","key":"10.1124\/jpet.102.044909_bib14","first-page":"A51","article-title":"GNTI, a \u03ba receptor antagonist, causes compulsive scratching in mice.","volume":"44","author":"Cowan","year":"2002","journal-title":"Pharmacologist"},{"key":"10.1124\/jpet.102.044909_bib15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0885-3924(96)00154-6","article-title":"Transnasal butorphanol for the treatment of opioid-induced pruritus unresponsive to antihistamines.","volume":"12","author":"Dunteman","year":"1996","journal-title":"J Pain Symptom Manage"},{"key":"10.1124\/jpet.102.044909_bib16","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1213\/00000539-198708000-00005","article-title":"Histamine release by four narcotics: a double-blind study in humans.","volume":"66","author":"Flacke","year":"1987","journal-title":"Anesth Analg"},{"key":"10.1124\/jpet.102.044909_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3565(25)38497-1","article-title":"Comparison of \u03ba opioids in rhesus monkeys: behavioral effects and receptor binding affinities.","volume":"268","author":"France","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.044909_bib18","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0022-3565(25)39099-3","article-title":"\u03ba Opioids in rhesus monkeys. III. Dependence associated with chronic administration.","volume":"242","author":"Gmerek","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.044909_bib19","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1097\/00001756-199806010-00019","article-title":"\u03bc and \u03ba opioid receptors in periaqueductal gray and rostral ventromedial medulla.","volume":"9","author":"Gutstein","year":"1998","journal-title":"Neuroreport"},{"key":"10.1124\/jpet.102.044909_bib20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00000542-198502000-00005","article-title":"Comparison of histamine release in human skin mast cells induced by morphine, fentanyl and oxymorphone.","volume":"62","author":"Hermens","year":"1985","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.102.044909_bib21","series-title":"Advances in Drug Research","first-page":"79","article-title":"Activities and sites of antinociceptive action of morphine-like analgesics and kinetics of distribution following intravenous, intracerebral and intraventricular application","author":"Herz","year":"1971"},{"key":"10.1124\/jpet.102.044909_bib22","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1365-2044.1996.tb15050.x","article-title":"Pruritus - itching for a cause and relief?","volume":"51","author":"Kam","year":"1996","journal-title":"Anaesthesia"},{"key":"10.1124\/jpet.102.044909_bib23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(01)00941-4","article-title":"Norbinaltorphimine, a selective \u03ba-opioid receptor antagonist, induces an itch-associated response in mice.","volume":"418","author":"Kamei","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.102.044909_bib24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0022-3565(24)37416-6","article-title":"Differentiation of \u03ba opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys.","volume":"285","author":"Ko","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.044909_bib25","first-page":"622.611","article-title":"An experimental itch model in rats: characterization of intracisternal morphine-induced scratching and antinociception.","volume":"13","author":"Ko","year":"1999","journal-title":"FASEB Journal"},{"key":"10.1124\/jpet.102.044909_bib26","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0022-3565(24)35216-4","article-title":"Intracisternal nor-binaltorphimine distinguishes central and peripheral \u03ba-opioid antinociception in rhesus monkeys.","volume":"291","author":"Ko","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.102.044909_bib27","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/00000542-200003000-00023","article-title":"An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.","volume":"92","author":"Ko","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.102.044909_bib28","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF02255473","article-title":"Itch-scratch responses induced by opioids through central \u03bc opioid receptors in mice.","volume":"7","author":"Kuraishi","year":"2000","journal-title":"J Biomed Sci"},{"key":"10.1124\/jpet.102.044909_bib29","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0143-4179(84)90083-0","article-title":"Effects of full and partial \u03ba agonists and \u03bc agonists on urine output of normally hydrated rats.","volume":"5","author":"Leander","year":"1984","journal-title":"Neuropeptides"},{"key":"10.1124\/jpet.102.044909_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1124\/mol.61.1.73","article-title":"Molecular basis of differences in (\u2212)-(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzeneac etamide-induced desensitization and phosphorylation between human and rat \u03ba-opioid receptors expressed in Chinese hamster ovary cells.","volume":"61","author":"Li","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.102.044909_bib31","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00000542-199902000-00018","article-title":"Dose-response relationship of intrathecal morphine for postcesarean analgesia.","volume":"90","author":"Palmer","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.102.044909_bib32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0165-6147(98)01169-9","article-title":"\u03bc-Opposing actions of the \u03ba-opioid receptor.","volume":"19","author":"Pan","year":"1998","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.102.044909_bib33","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1213\/00000539-199406000-00013","article-title":"Epidural-morphine-induced pruritus: propofol versus naloxone.","volume":"78","author":"Saiah","year":"1994","journal-title":"Anesth Analg"},{"key":"10.1124\/jpet.102.044909_bib34","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/00000542-199211000-00016","article-title":"Human basophil\/mast cell releasability.","volume":"77","author":"Stellato","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.102.044909_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0006-8993(92)91227-6","article-title":"Effects of central administration of opioids on facial scratching in monkeys.","volume":"585","author":"Thomas","year":"1992","journal-title":"Brain Res"},{"key":"10.1124\/jpet.102.044909_bib36","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00000542-199309000-00019","article-title":"The medullary dorsal horn. A site of action of morphine in producing facial scratching in monkeys.","volume":"79","author":"Thomas","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.102.044909_bib37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0014-2999(01)01588-6","article-title":"Antipruritic activity of the \u03ba-opioid receptor agonist, TRK-820.","volume":"435","author":"Togashi","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.102.044909_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0021-5198(19)31429-5","article-title":"Intracisternal injection of opioids induces itch-associated response through \u03bc-opioid receptors in mice.","volume":"74","author":"Tohda","year":"1997","journal-title":"Jpn J Pharmacol"},{"key":"10.1124\/jpet.102.044909_bib39","first-page":"479","article-title":"Comparison of intravenous nalbuphine infusion versus naloxone in the prevention of epidural morphine-related side effects.","volume":"23","author":"Wang","year":"1998","journal-title":"Reg Anesth Pain Med"},{"key":"10.1124\/jpet.102.044909_bib40","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0022-3565(25)24481-0","article-title":"Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.","volume":"244","author":"Yaksh","year":"1988","journal-title":"J Pharmacol Exp Ther"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524362640?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524362640?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.102.044909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:41:23Z","timestamp":1740008483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524362640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S0022356524362640"],"URL":"https:\/\/doi.org\/10.1124\/jpet.102.044909","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of \u03ba-Opioid Receptors Inhibits Pruritus Evoked by Subcutaneous or Intrathecal Administration of Morphine in Monkeys","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.102.044909","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}