{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:42:44Z","timestamp":1777588964144,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1124\/jpet.102.045195","type":"journal-article","created":{"date-parts":[[2003,3,21]],"date-time":"2003-03-21T02:35:49Z","timestamp":1048214149000},"page":"232-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Significant Role of Ceramide Pathway in Experimental Gastric Ulcer Formation in Rats"],"prefix":"10.1016","volume":"305","author":[{"given":"Keita","family":"Uehara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Taki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Nakashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Inamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutada","family":"Akiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.102.045195_bib1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-\u03baB and I\u03baB proteins: new discoveries and insights.","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1124\/jpet.102.045195_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0005-2760(96)00004-5","article-title":"Ceramide signalling and the immune response.","volume":"1301","author":"Ballou","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.102.045195_bib3","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-\u03baB: a pivotal transcription factor in chronic inflammatory diseases.","volume":"336","author":"Barnes","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.102.045195_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0021-9673(97)00686-9","article-title":"Development of a supercritical fluid extraction method for determination of lipid classes and total fat in meats and its comparison with conventional methods.","volume":"785","author":"Berg","year":"1997","journal-title":"J Chromatogr A"},{"key":"10.1124\/jpet.102.045195_bib5","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1016\/S0021-9258(17)37215-0","article-title":"Dissociation of endogenous cellular ceramide from NF-\u03baB activation.","volume":"269","author":"Betts","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.102.045195_bib6","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1084\/jem.180.4.1547","article-title":"Apoptotic signaling through CD95 (Fas\/Apo-1) activates an acidic sphingomyelinase.","volume":"180","author":"Cifone","year":"1994","journal-title":"J Exp Med"},{"key":"10.1124\/jpet.102.045195_bib7","doi-asserted-by":"crossref","first-page":"17762","DOI":"10.1016\/S0021-9258(17)46770-6","article-title":"Tumor necrosis factor-\u03b1 (TNF-\u03b1) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-\u03b1 from activation of nuclear factor-\u03baB.","volume":"268","author":"Dbaibo","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.102.045195_bib8","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1002\/eji.1830270909","article-title":"Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-\u03baB.","volume":"27","author":"Dhawan","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1124\/jpet.102.045195_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/bbrc.1999.1312","article-title":"Ceramide synergizes with phorbol ester or okadaic acid to induce I\u03baB degradation.","volume":"263","author":"Fernandez","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.102.045195_bib10","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1046\/j.1365-2036.1998.00409.x","article-title":"TNF\u03b1 processing enzyme inhibitors prevent aspirin-induced TNF\u03b1 release and protect against gastric mucosal injury in rats.","volume":"12","author":"Fiorucci","year":"1998","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1124\/jpet.102.045195_bib11","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/oxfordjournals.jbchem.a124992","article-title":"Functional role of glycosphingolipids in cell recognition and signaling.","volume":"118","author":"Hakomori","year":"1995","journal-title":"J Biochem (Tokyo)"},{"key":"10.1124\/jpet.102.045195_bib12","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1126\/science.274.5294.1855","article-title":"Functions of ceramide in coordinating cellular responses to stress.","volume":"274","author":"Hannun","year":"1996","journal-title":"Science (Wash DC)"},{"key":"10.1124\/jpet.102.045195_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4049\/jimmunol.157.1.297","article-title":"Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-\u03baB activation.","volume":"157","author":"Higuchi","year":"1996","journal-title":"J Immunol"},{"key":"10.1124\/jpet.102.045195_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1073\/pnas.91.1.73","article-title":"Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.","volume":"91","author":"Jarvis","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.102.045195_bib15","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.bjp.0703383","article-title":"Opposite effects of flurbiprofen and the nitroxybutyl ester of flurbiprofen on apoptosis in cultured guinea-pig gastric mucous cells.","volume":"130","author":"Johal","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.102.045195_bib16","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.4049\/jimmunol.152.12.5877","article-title":"Inhibition of ceramide pathway does not affect ability of TNF-\u03b1 to activate nuclear factor-\u03baB.","volume":"152","author":"Johns","year":"1994","journal-title":"J Immunol"},{"key":"10.1124\/jpet.102.045195_bib17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2302\/kjm.46.10","article-title":"Oxidant-regulation of gene expression in the chronically inflamed intestine.","volume":"46","author":"Jourd\u2019heuil","year":"1997","journal-title":"Keio J Med"},{"key":"10.1124\/jpet.102.045195_bib18","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF00731479","article-title":"Microscale analysis of glycosphingolipids by TCL blotting\/secondary ion mass spectrometry: a novel blood group A-active glycosphingolipid and changes in glycosphingolipid expression in rat mammary tumor cells with different metastatic potentials.","volume":"13","author":"Kasama","year":"1996","journal-title":"Glycoconj J"},{"key":"10.1124\/jpet.102.045195_bib19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0021-9258(18)52461-3","article-title":"Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor \u03b1 and \u03b3-interferon. Specific role in cell differentiation.","volume":"266","author":"Kim","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.102.045195_bib20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0092-8674(94)90147-3","article-title":"The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling.","volume":"77","author":"Kolesnick","year":"1994","journal-title":"Cell"},{"key":"10.1124\/jpet.102.045195_bib21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH812>3.0.CO;2-W","article-title":"Detection of apoptotic cells in archival tissue from diffuse astrocytomas using a monoclonal antibody to single stranded DNA.","volume":"193","author":"Korkolopoulou","year":"2001","journal-title":"J Pathol"},{"key":"10.1124\/jpet.102.045195_bib22","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1182\/blood.V87.3.871.bloodjournal873871","article-title":"Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells.","volume":"87","author":"Latinis","year":"1996","journal-title":"Blood"},{"key":"10.1124\/jpet.102.045195_bib23","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1084\/jem.182.2.599","article-title":"Ceramide induces interleukin 6 gene expression in human fibroblasts.","volume":"182","author":"Laulederkind","year":"1995","journal-title":"J Exp Med"},{"key":"10.1124\/jpet.102.045195_bib24","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1074\/jbc.271.16.9368","article-title":"Regulatory role of ceramide in interleukin (IL)-1\u03b2-induced E-selectin expression in human umbilical vein endothelial cells. Ceramide enhances IL-1\u03b2 action, but is not sufficient for E-selectin expression.","volume":"271","author":"Masamune","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.102.045195_bib25","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/S0016-5085(99)70497-X","article-title":"Helicobacter pylori-dependent ceramide production may mediate increased interleukin 8 expression in human gastric cancer cell lines.","volume":"116","author":"Masamune","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1124\/jpet.102.045195_bib26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1126\/science.8424175","article-title":"Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1\u03b2.","volume":"259","author":"Mathias","year":"1993","journal-title":"Science (Wash DC)"},{"key":"10.1124\/jpet.102.045195_bib27","doi-asserted-by":"crossref","first-page":"27299","DOI":"10.1016\/S0021-9258(19)74249-5","article-title":"Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.","volume":"268","author":"Merrill","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.102.045195_bib28","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1126\/science.8456305","article-title":"Programmed cell death induced by ceramide.","volume":"259","author":"Obeid","year":"1993","journal-title":"Science (Wash DC)"},{"key":"10.1124\/jpet.102.045195_bib29","first-page":"691","article-title":"Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.","volume":"55","author":"Ohta","year":"1995","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.102.045195_bib30","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0092-8674(92)90553-O","article-title":"TNF activates NF-\u03baB by phosphatidylcholine-specific phospholipase C-induced \u201cacidic\u201d sphingomyelin breakdown.","volume":"71","author":"Schutze","year":"1992","journal-title":"Cell"},{"key":"10.1124\/jpet.102.045195_bib31","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0024-3205(00)00959-0","article-title":"Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2.","volume":"68","author":"Shimada","year":"2000","journal-title":"Life Sci"},{"key":"10.1124\/jpet.102.045195_bib32","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1096\/fasebj.10.12.8903509","article-title":"Sphingolipid metabolism and cell growth regulation.","volume":"10","author":"Spiegel","year":"1996","journal-title":"FASEB J"},{"key":"10.1124\/jpet.102.045195_bib33","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/(SICI)1097-0215(19960503)66:3<358::AID-IJC16>3.0.CO;2-7","article-title":"Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines.","volume":"66","author":"Sweeney","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1124\/jpet.102.045195_bib34","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1021\/jf00091a064","article-title":"Evidence of the natural occurrence of fumonisin B1 a mycotoxin produced by Fusarium moniliforme in corn.","volume":"38","author":"Sydenham","year":"1990","journal-title":"J Agric Food Chem"},{"key":"10.1124\/jpet.102.045195_bib35","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1023\/A:1019633114854","article-title":"Nuclear factor \u03baB and TNF-\u03b1 mediate gastric ulceration induced by phorbol myristate acetate.","volume":"47","author":"Takeuchi","year":"2002","journal-title":"Dig Dis Sci"},{"key":"10.1124\/jpet.102.045195_bib36","doi-asserted-by":"crossref","first-page":"8443","DOI":"10.1073\/pnas.92.18.8443","article-title":"Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.","volume":"92","author":"Tepper","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.102.045195_bib37","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1101\/gad.9.22.2723","article-title":"Rel\/NF-\u03baB\/I\u03baB family: intimate tales of association and dissociation.","volume":"9","author":"Verma","year":"1995","journal-title":"Genes Dev"},{"key":"10.1124\/jpet.102.045195_bib38","doi-asserted-by":"crossref","first-page":"14486","DOI":"10.1016\/S0021-9258(18)98712-0","article-title":"Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme.","volume":"266","author":"Wang","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.102.045195_bib39","doi-asserted-by":"crossref","first-page":"22689","DOI":"10.1074\/jbc.270.39.22689","article-title":"Ceramide activates the stress-activated protein kinases.","volume":"270","author":"Westwick","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.102.045195_bib40","doi-asserted-by":"crossref","first-page":"20520","DOI":"10.1016\/S0021-9258(20)80756-X","article-title":"Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor \u03baB translocation in intact HL-60 cells.","volume":"268","author":"Yang","year":"1993","journal-title":"J Biol Chem"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652436272X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652436272X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.102.045195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T23:41:48Z","timestamp":1740008508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235652436272X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S002235652436272X"],"URL":"https:\/\/doi.org\/10.1124\/jpet.102.045195","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Significant Role of Ceramide Pathway in Experimental Gastric Ulcer Formation in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.102.045195","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}