{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:03:48Z","timestamp":1784851428416,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1124\/jpet.103.052019","type":"journal-article","created":{"date-parts":[[2003,9,19]],"date-time":"2003-09-19T00:50:21Z","timestamp":1063932621000},"page":"331-338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Crucial Role of Histamine for Regulation of Gastric Acid Secretion Ascertained by Histidine Decarboxylase-Knockout Mice"],"prefix":"10.1016","volume":"307","author":[{"given":"Kazuharu","family":"Furutani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Aihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ohtsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.103.052019_bib1","doi-asserted-by":"crossref","unstructured":"Aihara T, Nakamura E, Amagase K, Tomita K, Fujishita T, Furutani K, and Okabe S (2003) Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present and future. Pharmacol Ther 98: 109\u2013127.","DOI":"10.1016\/S0163-7258(03)00015-9"},{"key":"10.1124\/jpet.103.052019_bib2","doi-asserted-by":"crossref","unstructured":"Andersson K, Cabero JL, Mattsson H, and Hakanson R (1996) Gastric acid secretion after depletion of enterochromaffin-like cell histamine. A study with alpha-fluoromethylhistidine in rats. Scand J Gastroenterol 31: 24\u201330.","DOI":"10.3109\/00365529609031622"},{"key":"10.1124\/jpet.103.052019_bib3","doi-asserted-by":"crossref","unstructured":"Cheng JB, Watson JW, Pazoles CJ, Eskra JD, Griffiths RJ, Cohan VL, Turner CR, Showell HJ, and Pettipher ER (1997) The phosphodiesterase type 4 (PDE4) inhibitor CP-80, 633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy. J Pharmacol Exp Ther 280: 621\u2013626.","DOI":"10.1016\/S0022-3565(24)36487-0"},{"key":"10.1124\/jpet.103.052019_bib4","doi-asserted-by":"crossref","unstructured":"Delvalle J, Tsunoda Y, Williams JA, and Yamada T (1992a) Regulation of [Ca2+]i by secretagogue stimulation of canine gastric parietal cells. Am J Physiol 262: G420\u2013G426.","DOI":"10.1152\/ajpgi.1992.262.3.G420"},{"key":"10.1124\/jpet.103.052019_bib5","doi-asserted-by":"crossref","unstructured":"Delvalle J, Wang L, Gantz I, and Yamada T (1992b) Characterization of H2 histamine receptor: linkage to both adenylate cyclase and [Ca2+]i signaling systems. Am J Physiol 263: G967\u2013G972.","DOI":"10.1152\/ajpgi.1992.263.6.G967"},{"key":"10.1124\/jpet.103.052019_bib6","doi-asserted-by":"crossref","unstructured":"Friis-Hansen L, Sundler F, Li Y, Gillespie PJ, Saunders TL, Greenson JK, Owyang C, Rehfeld JF, and Samuelson LC (1998) Impaired gastric acid secretion in gastrin-deficient mice. Am J Physiol 274: G561\u2013G568.","DOI":"10.1152\/ajpgi.1998.274.3.G561"},{"key":"10.1124\/jpet.103.052019_bib7","doi-asserted-by":"crossref","unstructured":"Gerber JG and Payne NA (1992) The role of gastric secretagogues in regulating gastric histamine release in vivo. Gastroenterology 102: 403\u2013408.","DOI":"10.1016\/0016-5085(92)90083-B"},{"key":"10.1124\/jpet.103.052019_bib8","doi-asserted-by":"crossref","unstructured":"Grossman MI and Konturek SJ (1974) Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2 receptors. Gastroenterology 66: 517\u2013521.","DOI":"10.1016\/S0016-5085(74)80038-7"},{"key":"10.1124\/jpet.103.052019_bib9","doi-asserted-by":"crossref","unstructured":"Hakanson R, Bottcher G, Ekblad E, Panula P, Simonsson M, Dohlsten M, Hallberg T, and Sundler F (1986) Histamine in endocrine cells in the stomach. A survey of several species using a panel of histamine antibodies. Histochemistry 86: 5\u201317.","DOI":"10.1007\/BF00492340"},{"key":"10.1124\/jpet.103.052019_bib10","doi-asserted-by":"crossref","unstructured":"Hersey SJ and Sachs G (1995) Gastric acid secretion. Physiol Rev 75: 155\u2013189.","DOI":"10.1152\/physrev.1995.75.1.155"},{"key":"10.1124\/jpet.103.052019_bib11","doi-asserted-by":"crossref","unstructured":"Hirschowitz BI, Keeling D, Lewin M, Okabe S, Parsons M, Sewing K, Wallmark B, and Sachs G (1995) Pharmacological aspects of acid secretion. Dig Dis Sci 40: 3S\u201323S.","DOI":"10.1007\/BF02214869"},{"key":"10.1124\/jpet.103.052019_bib12","doi-asserted-by":"crossref","unstructured":"Kobayashi T, Tonai S, Ishihara Y, Koga R, Okabe S, and Watanabe T (2000) Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. J Clin Investig 105: 1741\u20131749.","DOI":"10.1172\/JCI9441"},{"key":"10.1124\/jpet.103.052019_bib13","doi-asserted-by":"crossref","unstructured":"Langhans N, Rindi G, Chiu M, Rehfeld JF, Ardman B, Beinborn M, and Kopin AS (1997) Abnormal gastric histology and decreased acid production in cholecystokinin-B\/gastrin receptor-deficient mice. Gastroenterology 112: 280\u2013286.","DOI":"10.1016\/S0016-5085(97)90000-7"},{"key":"10.1124\/jpet.103.052019_bib14","doi-asserted-by":"crossref","unstructured":"Li ZQ, Cabero JL, and Mardh S (1995) Gastrin and carbachol require cAMP to elicit aminopyrine accumulation in isolated pig and rat parietal cells. Am J Physiol 268: G82\u2013G89.","DOI":"10.1152\/ajpgi.1995.268.1.G82"},{"key":"10.1124\/jpet.103.052019_bib15","doi-asserted-by":"crossref","unstructured":"Lindstrom E, Chen D, Norlen P, Andersson K, and Hakanson R (2001) Control of gastric acid secretion: the gastrin-ECL cell-parietal cell axis. Comp Biochem Physiol A Mol Integr Physiol 128: 505\u2013514.","DOI":"10.1016\/S1095-6433(00)00331-7"},{"key":"10.1124\/jpet.103.052019_bib16","doi-asserted-by":"crossref","unstructured":"Miyazaki T, Ohgoh M, Ohmori E, Yamamoto J, Emoto S, Yatsunami K, and Ichikawa A (1992) Synergistic effects of cyclic AMP and Ca2+ ionophore A23187 on de novo synthesis of histidine decarboxylase in mastocytoma P-815 cells. Biochim Biophys Acta 1133: 179\u2013186.","DOI":"10.1016\/0167-4889(92)90067-L"},{"key":"10.1124\/jpet.103.052019_bib17","doi-asserted-by":"crossref","unstructured":"Nagata A, Ito M, Iwata N, Kuno J, Takano H, Minowa O, Chihara K, Matsui T, and Noda T (1996) G protein-coupled cholecystokinin-B\/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo. Proc Natl Acad Sci USA 93: 11825\u201311830.","DOI":"10.1073\/pnas.93.21.11825"},{"key":"10.1124\/jpet.103.052019_bib18","doi-asserted-by":"crossref","unstructured":"Norlen P, Bernsand M, Konagaya T, and Hakanson R (2001) ECL-cell histamine mobilization in conscious rats: effects of locally applied regulatory peptides, candidate neurotransmitters and inflammatory mediators. Br J Pharmacol 134: 1767\u20131777.","DOI":"10.1038\/sj.bjp.0704419"},{"key":"10.1124\/jpet.103.052019_bib19","doi-asserted-by":"crossref","unstructured":"Ogawa T, Maeda K, Tonai S, Kobayashi T, Watanabe T, and Okabe S (2003) Utilization of knockout mice to examine the potential role of gastric histamine H2-receptors in Menetrier\u2019s disease. J Pharmacol Sci 91: 61\u201370.","DOI":"10.1254\/jphs.91.61"},{"key":"10.1124\/jpet.103.052019_bib20","doi-asserted-by":"crossref","unstructured":"Ohtsu H, Kuramasu A, Tanaka S, Terui T, Hirasawa N, Hara M, Makabe-Kobayashi Y, Yamada N, Yanai K, Sakurai E, et al. (2002) Plasma extravasation induced by dietary supplemented histamine in histamine-free mice. Eur J Immunol 32: 1698\u20131708.","DOI":"10.1002\/1521-4141(200206)32:6<1698::AID-IMMU1698>3.0.CO;2-7"},{"key":"10.1124\/jpet.103.052019_bib21","doi-asserted-by":"crossref","unstructured":"Ohtsu H, Tanaka S, Terui T, Hori Y, Makabe-Kobayashi Y, Pejler G, Tchougounova E, Hellman L, Gertsenstein M, Hirasawa N, et al. (2001) Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett 502: 53\u201356.","DOI":"10.1016\/S0014-5793(01)02663-1"},{"key":"10.1124\/jpet.103.052019_bib22","doi-asserted-by":"crossref","unstructured":"Pfeiffer A, Rochlitz H, Noelke B, Tacke R, Moser U, Mutschler E, and Lambrecht G (1990) Muscarinic receptors mediating acid secretion in isolated rat gastric parietal cells are of M3 type. Gastroenterology 98: 218\u2013222.","DOI":"10.1016\/0016-5085(90)91314-V"},{"key":"10.1124\/jpet.103.052019_bib23","doi-asserted-by":"crossref","unstructured":"Prinz C, Kajimura M, Scott DR, Mercier F, Helander HF, and Sachs G (1993) Histamine secretion from rat enterochromaffinlike cells. Gastroenterology 105: 449\u2013461.","DOI":"10.1016\/0016-5085(93)90719-S"},{"key":"10.1124\/jpet.103.052019_bib24","doi-asserted-by":"crossref","unstructured":"Prinz C, Zanner R, and Gratzl M (2003) Physiology of gastric enterochromaffin-like cells. Annu Rev Physiol 65: 371\u2013382.","DOI":"10.1146\/annurev.physiol.65.092101.142205"},{"key":"10.1124\/jpet.103.052019_bib25","doi-asserted-by":"crossref","unstructured":"Sandvik AK, Cui G, Bakke I, Munkvold B, and Waldum HL (2001) PACAP stimulates gastric acid secretion in the rat by inducing histamine release. Am J Physiol 281: G997\u2013G1003.","DOI":"10.1152\/ajpgi.2001.281.4.G997"},{"key":"10.1124\/jpet.103.052019_bib26","doi-asserted-by":"crossref","unstructured":"Soll AH (1980) Secretagogue stimulation of [14C]aminopyrine accumulation by isolated canine parietal cells. Am J Physiol 238: G366\u2013G375.","DOI":"10.1152\/ajpgi.1980.238.4.G366"},{"key":"10.1124\/jpet.103.052019_bib27","doi-asserted-by":"crossref","unstructured":"Tanaka S, Hamada K, Yamada N, Sugita Y, Tonai S, Hunyady B, Palkovits M, Falus A, Watanabe T, Okabe S, et al. (2002) Gastric acid secretion in l-histidine decarboxylase-deficient mice. Gastroenterology 122: 145\u2013155.","DOI":"10.1053\/gast.2002.30312"},{"key":"10.1124\/jpet.103.052019_bib28","doi-asserted-by":"crossref","unstructured":"Wilkes JM, Kajimura M, Scott DR, Hersey SJ, and Sachs G (1991) Muscarinic responses of gastric parietal cells. J Membr Biol 122: 97\u2013110.","DOI":"10.1007\/BF01872634"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524309632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524309632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.103.052019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T14:33:57Z","timestamp":1739975637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524309632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S0022356524309632"],"URL":"https:\/\/doi.org\/10.1124\/jpet.103.052019","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crucial Role of Histamine for Regulation of Gastric Acid Secretion Ascertained by Histidine Decarboxylase-Knockout Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.103.052019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}