{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:23:03Z","timestamp":1756189383354,"version":"3.37.3"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1124\/jpet.103.060053","type":"journal-article","created":{"date-parts":[[2004,5,25]],"date-time":"2004-05-25T22:48:09Z","timestamp":1085525289000},"page":"1198-1205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacokinetics and Tissue Distribution of the Stereoisomers of 4-Methylaminorex in the Rat"],"prefix":"10.1016","volume":"309","author":[{"given":"Esa","family":"Meririnne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satu","family":"Ellermaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aino","family":"Kankaanp\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Bardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.103.060053_bib1","unstructured":"Akaike H (1976) An information criterion (AIC). Math Sci 14: 5-9."},{"key":"10.1124\/jpet.103.060053_bib2","doi-asserted-by":"crossref","unstructured":"Ashby CR Jr, Pan H, Minabe Y, Toor A, Fishkin L, and Wang RY (1995) Comparison of the actions of the stereoisomers of the psychostimulant 4-methylaminorex (4-MAX) on midbrain dopamine cells in the rat: an extracellular single unit study. Synapse 20: 351-361.","DOI":"10.1002\/syn.890200408"},{"key":"10.1124\/jpet.103.060053_bib3","doi-asserted-by":"crossref","unstructured":"Batsche K, Ashby CR, Lee C, Schwartz J, and Wang RY (1994) The behavioral effects of the stereoisomers of 4-methylaminorex, a psychostimulant, in the rat. J Pharmacol Exp Ther 269: 1029-1039.","DOI":"10.1016\/S0022-3565(25)38829-4"},{"key":"10.1124\/jpet.103.060053_bib4","doi-asserted-by":"crossref","unstructured":"Cho AK, Hiramatsu M, Distefano EW, Chang AS, and Jenden DJ (1990) Stereo-chemical differences in the metabolism of 3,4-methylenedioxymethamphetamine in vivo and in vitro: a pharmacokinetic analysis. Drug Metab Dispos 18: 686-691.","DOI":"10.1016\/S0090-9556(25)08631-3"},{"key":"10.1124\/jpet.103.060053_bib5","doi-asserted-by":"crossref","unstructured":"Coutts RT, Prelusky DB, and Baker GB (1984) Determination of amphetamine, norephedrine and their phenolic metabolites in rat brain by gas chromatography. J Pharm Sci 73: 808-812.","DOI":"10.1002\/jps.2600730625"},{"key":"10.1124\/jpet.103.060053_bib6","doi-asserted-by":"crossref","unstructured":"Davis FT and Brewster ME (1988) A fatality involving U4Euh, a cyclic derivative of phenylpropanolamine. J Forensic Sci 33: 549-553.","DOI":"10.1520\/JFS11971J"},{"key":"10.1124\/jpet.103.060053_bib7","unstructured":"Federal Register, Schedules of Controlled Substances (1989) Placement of (\u00b1) cis-4-methylaminorex into schedule I. 54: 14799-14800."},{"key":"10.1124\/jpet.103.060053_bib8","unstructured":"Frosch F (1977) Biopharmazeutische untersuchungen an d-norpseudoephedrin. Arzneimittelforschung 27: 665-668."},{"key":"10.1124\/jpet.103.060053_bib9","doi-asserted-by":"crossref","unstructured":"Gaine SP, Rubin LJ, Kmetzo JJ, Palevsky HI, and Traill TA (2000) Recreational use of aminorex and pulmonary hypertension. Chest 118: 1496-1497.","DOI":"10.1378\/chest.118.5.1496"},{"key":"10.1124\/jpet.103.060053_bib10","doi-asserted-by":"crossref","unstructured":"Glennon RA and Misenheimer B (1989) Stimulus properties of a new designer drug: 4-methylaminorex (`U4Euh\u2019). Pharmacol Biochem Behav 35: 517-521.","DOI":"10.1016\/0091-3057(90)90282-M"},{"key":"10.1124\/jpet.103.060053_bib11","doi-asserted-by":"crossref","unstructured":"Henderson GL, Harkey MR, and Chueh YT (1995) Metabolism of 4-methylaminorex (`Eu4EA\u2019) in the rat. J Anal Toxicol 19: 563-570.","DOI":"10.1093\/jat\/19.7.563"},{"key":"10.1124\/jpet.103.060053_bib12","unstructured":"Henderson MG and Fuller RW (1992) Comparative brain levels of phenylpropanolamine and amphetamine in rats. Res Commun Chem Pathol Pharmacol 75: 247-250."},{"key":"10.1124\/jpet.103.060053_bib13","doi-asserted-by":"crossref","unstructured":"Hutchaleelaha A, Sukbuntherng J, Chow HH, and Mayersohn M (1994) Disposition kinetics of d- and l-amphetamine following intravenous administration of racemic amphetamine to rats. Drug Metab Dispos 22: 406-411.","DOI":"10.1016\/S0090-9556(25)08390-4"},{"key":"10.1124\/jpet.103.060053_bib14","doi-asserted-by":"crossref","unstructured":"Kalix P (1983) A comparison of the catecholamine releasing effect of the Khat alkaloids (-)-cathinone and (+)-norpseudoephedrine. Drug Alcohol Depend 11: 395-401.","DOI":"10.1016\/0376-8716(83)90031-5"},{"key":"10.1124\/jpet.103.060053_bib15","doi-asserted-by":"crossref","unstructured":"Kalix P, Geissh\u00fcsler S, and Brenneisen R (1987) The effect of phenylpentenylkhatamines on the release of radioactivity from rat striatal tissue prelabeled with [3H]dopamine. J Pharm Pharmacol 39: 135-137.","DOI":"10.1111\/j.2042-7158.1987.tb06961.x"},{"key":"10.1124\/jpet.103.060053_bib16","doi-asserted-by":"crossref","unstructured":"Kamakura H and Satake M (1998) Pharmacokinetics of (-)-, (+)- and (\u00b1)norephedrine. Plasma concentrations, serum protein binding and urinary excretions. Yakugaku Zasshi 118: 143-149.","DOI":"10.1248\/yakushi1947.118.4_143"},{"key":"10.1124\/jpet.103.060053_bib17","doi-asserted-by":"crossref","unstructured":"Kankaanp\u00e4\u00e4 A, Ellermaa S, Meririnne E, Hirsjarvi P, and Seppala T (2002) Acute neurochemical and behavioral effects of stereoisomers of 4-methylaminorex in relation to brain drug concentrations. J Pharmacol Exp Ther 300: 450-459.","DOI":"10.1124\/jpet.300.2.450"},{"key":"10.1124\/jpet.103.060053_bib18","doi-asserted-by":"crossref","unstructured":"Kankaanp\u00e4\u00e4 A, Meririnne E, Ellermaa S, Ariniemi K, and Seppala T (2001) Detection and assay of cis- and trans-isomers of 4-methylaminorex in urine, plasma and tissue samples. Forensic Sci Int 121: 57-64.","DOI":"10.1016\/S0379-0738(01)00453-4"},{"key":"10.1124\/jpet.103.060053_bib19","doi-asserted-by":"crossref","unstructured":"Klein RFX, Sperling AR, Cooper DA, and Kram TC (1989) The stereoisomers of 4-methylaminorex. J Forensic Sci 34: 962-979.","DOI":"10.1520\/JFS12723J"},{"key":"10.1124\/jpet.103.060053_bib20","unstructured":"Meyer J and Portmann P (1982) Fluorometric determination of the d-norpseudoephedrine in the plasma. Plasma levels during the resorption from the free and extended-release form. Pharm Acta Helv 57: 12-15."},{"key":"10.1124\/jpet.103.060053_bib21","doi-asserted-by":"crossref","unstructured":"Poos GI, Carson JR, Rosenau JD, Roszkowski AP, Kelley NM, and McGowin J (1963) 2-Amino-5-aryl-2-oxazolines. Potent new anorectic agents. J Med Chem 6: 266-272.","DOI":"10.1021\/jm00339a011"},{"key":"10.1124\/jpet.103.060053_bib22","doi-asserted-by":"crossref","unstructured":"Quinn DI, Wodak A, and Day RO (1997) Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users. Clin Pharmacokinet 33: 344-400.","DOI":"10.2165\/00003088-199733050-00003"},{"key":"10.1124\/jpet.103.060053_bib23","doi-asserted-by":"crossref","unstructured":"Riviere GJ, Gentry WB, and Owens SM (2000) Disposition of methamphetamine and its metabolite amphetamine in brain and other tissues in rats after intravenous administration. J Pharmacol Exp Ther 292: 1042-1047.","DOI":"10.1016\/S0022-3565(24)35387-X"},{"key":"10.1124\/jpet.103.060053_bib24","unstructured":"Rowland M and Tozer TN (1995) Clinical Pharmacokinetics. Concepts and Applications, 3rd ed. Lippincott Williams & Wilkins, Media, PA."}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524313904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524313904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.103.060053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:53:58Z","timestamp":1739998438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524313904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0022356524313904"],"URL":"https:\/\/doi.org\/10.1124\/jpet.103.060053","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2004,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics and Tissue Distribution of the Stereoisomers of 4-Methylaminorex in the Rat","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.103.060053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2004 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}