{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:51:31Z","timestamp":1784029891071,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1124\/jpet.103.063388","type":"journal-article","created":{"date-parts":[[2004,5,25]],"date-time":"2004-05-25T22:48:09Z","timestamp":1085525289000},"page":"1160-1166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Potassium Canrenoate, an Aldosterone Receptor Antagonist, Reduces Isoprenaline-Induced Cardiac Fibrosis in the Rat"],"prefix":"10.1016","volume":"309","author":[{"given":"Romain","family":"Bos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Mougenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"M\u00e9diani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Vanhoutte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lechat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.103.063388_bib1","doi-asserted-by":"crossref","unstructured":"Araki T, Shimizu M, Yoshio H, Ino H, Mabuchi H, and Takeda R (1995) Effects of angiotensin-converting enzyme inhibitor and aldosterone antagonist on myocardial collagen in cardiomyopathic hamsters. Jpn Circ J 59: 213-218.","DOI":"10.1253\/jcj.59.213"},{"key":"10.1124\/jpet.103.063388_bib2","doi-asserted-by":"crossref","unstructured":"Benjamin IJ, Jalil JE, Tan LB, Cho K, Weber KT, and Clark WA (1989) Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. Circ Res 65: 657-670.","DOI":"10.1161\/01.RES.65.3.657"},{"key":"10.1124\/jpet.103.063388_bib3","doi-asserted-by":"crossref","unstructured":"Bindoli A, Rigobello MP, and Deeble DJ (1992) Biochemical and toxicological properties of the oxidation products of catecholamines. Free Radic Biol Med 13: 391-405.","DOI":"10.1016\/0891-5849(92)90182-G"},{"key":"10.1124\/jpet.103.063388_bib4","unstructured":"Brilla CG and Weber KT (1992) Mineralocorticoid excess, dietary sodium and myocardial fibrosis. J Lab Clin Med 120: 893-901."},{"key":"10.1124\/jpet.103.063388_bib5","doi-asserted-by":"crossref","unstructured":"Brilla CG, Zhou G, Matsubara L, and Weber KT (1994) Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J Mol Cell Cardiol 26: 809-820.","DOI":"10.1006\/jmcc.1994.1098"},{"key":"10.1124\/jpet.103.063388_bib6","doi-asserted-by":"crossref","unstructured":"CIBIS-II (1999) The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 353: 9-13.","DOI":"10.1016\/S0140-6736(98)11181-9"},{"key":"10.1124\/jpet.103.063388_bib7","doi-asserted-by":"crossref","unstructured":"Cook CS, Hauswald CL, Schoenhard GL, Piper CE, Patel A, Radzialowski FM, Hribar JD, Aksamit W, Finnegan P, Bible RH, et al. (1988) Difference in metabolic profile of potassium canrenoate and spironolactone in the rat: mutagenic metabolites unique to potassium canrenoate. Arch Toxicol 61: 201-212.","DOI":"10.1007\/BF00316635"},{"key":"10.1124\/jpet.103.063388_bib8","doi-asserted-by":"crossref","unstructured":"Dhalla KS, Rupp H, Beamish RE, and Dhalla NS (1996) Mechanisms of alterations in cardiac membrane Ca2+ transport due to excess catecholamines. Cardiovasc Drugs Ther 10 (Suppl 1): 231-238.","DOI":"10.1007\/BF00120492"},{"key":"10.1124\/jpet.103.063388_bib9","doi-asserted-by":"crossref","unstructured":"DiBianco R (1990) ACE inhibitors in the treatment of heart failure. Clin Cardiol 13 (6 Suppl 7): VII32-VII38.","DOI":"10.1002\/clc.4960131407"},{"key":"10.1124\/jpet.103.063388_bib10","doi-asserted-by":"crossref","unstructured":"Funck RC, Wilke A, Rupp H, and Brilla CG (1997) Regulation and role of myocardial collagen matrix remodeling in hypertensive heart disease. Adv Exp Med Biol 432: 35-44.","DOI":"10.1007\/978-1-4615-5385-4_4"},{"key":"10.1124\/jpet.103.063388_bib11","doi-asserted-by":"crossref","unstructured":"Gallego M, Espina L, Vegas L, Echevarria E, Iriarte MM, and Casis O (2001) Spironolactone and captopril attenuates isoproterenol-induced cardiac remodelling in rats. Pharmacol Res 44: 311-315.","DOI":"10.1006\/phrs.2001.0865"},{"key":"10.1124\/jpet.103.063388_bib12","doi-asserted-by":"crossref","unstructured":"Gomez-Sanchez CE, Zhou MY, Cozza EN, Morita H, Foecking MF, and Gomez-Sanchez EP (1997) Aldosterone biosynthesis in the rat brain. Endocrinology 138: 3369-3373.","DOI":"10.1210\/en.138.8.3369"},{"key":"10.1124\/jpet.103.063388_bib13","doi-asserted-by":"crossref","unstructured":"Grimm D, Elsner D, Schunkert H, Pfeifer M, Griese D, Bruckschlegel G, Muders F, Riegger GA, and Kromer EP (1998) Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system. Cardiovasc Res 37: 91-100.","DOI":"10.1016\/S0008-6363(97)00212-5"},{"key":"10.1124\/jpet.103.063388_bib14","doi-asserted-by":"crossref","unstructured":"Hart G (1994) Cellular electrophysiology in cardiac hypertrophy and failure. Cardiovasc Res 28: 933-946.","DOI":"10.1093\/cvr\/28.7.933"},{"key":"10.1124\/jpet.103.063388_bib15","doi-asserted-by":"crossref","unstructured":"Junqueira LC, Cossermelli W, and Brentani R (1978) Differential staining of collagens type I, II and III by Sirius Red and polarization microscopy. Arch Histol Jpn 41: 267-274.","DOI":"10.1679\/aohc1950.41.267"},{"key":"10.1124\/jpet.103.063388_bib16","doi-asserted-by":"crossref","unstructured":"Kahn DS, Rona G, and Chappel CI (1969) Isoproterenol-induced cardiac necrosis. Ann NY Acad Sci 156: 285-293.","DOI":"10.1111\/j.1749-6632.1969.tb16735.x"},{"key":"10.1124\/jpet.103.063388_bib17","doi-asserted-by":"crossref","unstructured":"Martelli A, Carrozzino R, Mattioli F, Bucci G, Lamarino G, and Brambilla G (2002) DNA damage in tissues of rat treated with potassium canrenoate. Toxicology 171: 95-103.","DOI":"10.1016\/S0300-483X(01)00562-5"},{"key":"10.1124\/jpet.103.063388_bib18","doi-asserted-by":"crossref","unstructured":"Martelli A, Mattioli F, Carrozzino R, Ferraris E, Marchese M, Angiola M, and Brambilla G (1999) Genotoxicity testing of potassium canrenoate in cultured rat and human cells. Mutagenesis 14: 463-472.","DOI":"10.1093\/mutage\/14.5.463"},{"key":"10.1124\/jpet.103.063388_bib19","doi-asserted-by":"crossref","unstructured":"Mason J, Kain H, Shiigai T, and Welsch J (1979) The early phase of experimental acute renal failure. V. The influence of suppressing the renin-angiotensin system. Pflueg Arch Eur J Physiol 380: 233-243.","DOI":"10.1007\/BF00582902"},{"key":"10.1124\/jpet.103.063388_bib20","doi-asserted-by":"crossref","unstructured":"Murphree SS and Saffitz JE (1989) Distribution of beta-adrenergic receptors in failing human myocardium. Implications for mechanisms of down-regulation. Circulation 79: 1214-1225.","DOI":"10.1161\/01.CIR.79.6.1214"},{"key":"10.1124\/jpet.103.063388_bib21","doi-asserted-by":"crossref","unstructured":"Ng Y, Goldspink DF, Burniston JG, Clark WA, Colyer J, and Tan LB (2002) Characterisation of isoprenaline myotoxicity on slow-twitch skeletal versus cardiac muscle. Int J Cardiol 86: 299-309.","DOI":"10.1016\/S0167-5273(02)00369-8"},{"key":"10.1124\/jpet.103.063388_bib22","doi-asserted-by":"crossref","unstructured":"RALES (Randomized Aldactone Evaluation Study) (1996) Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure (the Randomized Aldactone Evaluation Study [RALES]). Am J Cardiol 78: 902-907.","DOI":"10.1016\/S0002-9149(96)00465-1"},{"key":"10.1124\/jpet.103.063388_bib23","doi-asserted-by":"crossref","unstructured":"Remiao F, Carmo H, Carvalho F, and Bastos ML (2001) Copper enhances isoproterenol toxicity in isolated rat cardiomyocytes: effects on oxidative stress. Cardiovasc Toxicol 1: 195-204.","DOI":"10.1385\/CT:1:3:195"},{"key":"10.1124\/jpet.103.063388_bib24","doi-asserted-by":"crossref","unstructured":"Remme WJ (1986) Congestive heart failure-pathophysiology and medical treatment. J Cardiovasc Pharmacol 8 (Suppl 1): S36-S52.","DOI":"10.1097\/00005344-198600081-00009"},{"key":"10.1124\/jpet.103.063388_bib25","doi-asserted-by":"crossref","unstructured":"Robert V, Van Thiem N, Cheav SL, Mouas C, Swynghedauw B, and Delcayre C (1994) Increased cardiac types I and III collagen mRNAs in aldosterone-salt hypertension. Hypertension 24: 30-36.","DOI":"10.1161\/01.HYP.24.1.30"},{"key":"10.1124\/jpet.103.063388_bib26","doi-asserted-by":"crossref","unstructured":"Rocha R, Stier CT Jr, Kifor I, Ochoa-Maya MR, Rennke HG, Williams GH, and Adler GK (2000) Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. Endocrinology 141: 3871-3878.","DOI":"10.1210\/endo.141.10.7711"},{"key":"10.1124\/jpet.103.063388_bib27","doi-asserted-by":"crossref","unstructured":"Rothwell NJ, Stock MJ, and Sudera DK (1987) Changes in tissue blood flow and \u03b2-receptor density of skeletal muscle in rats treated with the \u03b22-adrenoceptor agonist clenbuterol. Br J Pharmacol 90: 601-607.","DOI":"10.1111\/j.1476-5381.1987.tb11211.x"},{"key":"10.1124\/jpet.103.063388_bib28","doi-asserted-by":"crossref","unstructured":"Schaison FH, Fernando Ramirez-Gil J, Ciferri S, Bernard M, Baudin B, Mougenot N, Carayon A, and Lechat P (1996) Acute and long-term dose-response study of quinapril on hormonal profile and tissue angiotensin-converting enzyme in Wistar rats. J Cardiovasc Pharmacol 28: 11-18.","DOI":"10.1097\/00005344-199607000-00003"},{"key":"10.1124\/jpet.103.063388_bib29","doi-asserted-by":"crossref","unstructured":"Silvestre JS, Robert V, Heymes C, Aupetit-Faisant B, Mouas C, Moalic JM, Swynghedauw B, and Delcayre C (1998) Myocardial production of aldosterone and corticosterone in the rat. Physiological regulation. J Biol Chem 273: 4883-4891.","DOI":"10.1074\/jbc.273.9.4883"},{"key":"10.1124\/jpet.103.063388_bib30","doi-asserted-by":"crossref","unstructured":"Sleight P (2002) Angiotensin II and trials of cardiovascular outcomes. Am J Cardiol 89: 11A-16A; discussion 16A-17A.","DOI":"10.1016\/S0002-9149(01)02322-0"},{"key":"10.1124\/jpet.103.063388_bib31","doi-asserted-by":"crossref","unstructured":"Takeda R, Hatakeyama H, Takeda Y, Iki K, Miyamori I, Sheng WP, Yamamoto H, and Blair IA (1995) Aldosterone biosynthesis and action in vascular cells. Steroids 60: 120-124.","DOI":"10.1016\/0039-128X(94)00026-9"},{"key":"10.1124\/jpet.103.063388_bib32","doi-asserted-by":"crossref","unstructured":"VanVleet JF, Tacker WA Jr, Bourland JD, Kallok MJ, and Schollmeyer MP (1983) Cardiac damage in dogs with chronically implanted automatic defibrillator electrode catheters and given four episodes of multiple shocks. Am Heart J 106: 300-307.","DOI":"10.1016\/0002-8703(83)90196-5"},{"key":"10.1124\/jpet.103.063388_bib33","unstructured":"van Zwieten PA and de Jonge A (1986) Interaction between the adrenergic and renin-angiotensin-aldosterone-systems. Postgrad Med J 62 (Suppl 1): 23-27."},{"key":"10.1124\/jpet.103.063388_bib34","doi-asserted-by":"crossref","unstructured":"Vatta MS, Bianciotti LG, Locatelli AS, Papouchado ML, and Fernandez BE (1992) Monophasic and biphasic effects of angiotensin II and III on norepinephrine uptake and release in rat adrenal medulla. Can J Physiol Pharmacol 70: 821-825.","DOI":"10.1139\/y92-110"},{"key":"10.1124\/jpet.103.063388_bib35","doi-asserted-by":"crossref","unstructured":"Weber KT, Janicki JS, Pick R, Capasso J, and Anversa P (1990) Myocardial fibrosis and pathologic hypertrophy in the rat with renovascular hypertension. Am J Cardiol 65: 1G-7G.","DOI":"10.1016\/0002-9149(90)90952-W"},{"key":"10.1124\/jpet.103.063388_bib36","unstructured":"Yamamoto T, Doi K, Ogihara T, Ichihara K, Hata T, and Kumahara Y (1976) Changes of blood pressure, plasma renin activity and plasma aldosterone concentration following the infusion of Sar1-Ile8-angiotensin II in hypertensive, fluid and electrolyte disorders. Prog Biochem Pharmacol 12: 174-189."}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524313850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524313850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.103.063388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:53:55Z","timestamp":1739998435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524313850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0022356524313850"],"URL":"https:\/\/doi.org\/10.1124\/jpet.103.063388","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potassium Canrenoate, an Aldosterone Receptor Antagonist, Reduces Isoprenaline-Induced Cardiac Fibrosis in the Rat","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.103.063388","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2004 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}