{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:11:56Z","timestamp":1791259916565,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1124\/jpet.103.064006","type":"journal-article","created":{"date-parts":[[2004,6,18]],"date-time":"2004-06-18T17:28:53Z","timestamp":1087579733000},"page":"177-184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Blood-Brain Barrier Permeability of Novel [d-Arg2]Dermorphin (1-4) Analogs: Transport Property Is Related to the Slow Onset of Antinociceptive Activity in the Central Nervous System"],"prefix":"10.1016","volume":"310","author":[{"given":"Yoshiharu","family":"Deguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumio","family":"Ohtsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Miyakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Hosoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Sakurada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Terasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.103.064006_bib1","doi-asserted-by":"crossref","unstructured":"Banks WA and Kastin AJ (1990) Peptide transport systems for opiates across the blood-brain barrier. Am J Physiol 259: E1-E10.","DOI":"10.1152\/ajpendo.1990.259.1.E1"},{"key":"10.1124\/jpet.103.064006_bib2","doi-asserted-by":"crossref","unstructured":"Blasberg RG, Fenstermacher JD, and Patlak CS (1983) Transport of \u03b1-aminoisobutyric acid across brain capillary and cellular membrane. J Cereb Blood Flow Metab 3: 8-32.","DOI":"10.1038\/jcbfm.1983.2"},{"key":"10.1124\/jpet.103.064006_bib3","doi-asserted-by":"crossref","unstructured":"Boado RJ, Li JY, Nagaya M, Zhang C, and Pardridge WM (1999) Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc Natl Acad Sci USA 96: 12079-12084.","DOI":"10.1073\/pnas.96.21.12079"},{"key":"10.1124\/jpet.103.064006_bib4","doi-asserted-by":"crossref","unstructured":"Chaki K, Kawamura S, Kisara K, Sakurada S, Sakurada T, Sasaki Y, Sato T, and Suzuki K (1988a) Antinociception and physical dependence produced by [D-Arg2]dermorphin tetrapeptide analogues and morphine in rats. Br J Pharmacol 95: 15-22.","DOI":"10.1111\/j.1476-5381.1988.tb16543.x"},{"key":"10.1124\/jpet.103.064006_bib5","doi-asserted-by":"crossref","unstructured":"Chaki K, Sakurada S, Sakurada T, Kisara K, and Suzuki K (1990) N-Terminal tetrapeptide of dermorphin and D-Arg-substituted tetrapeptides: inactivation process of the antinociceptive activity by peptidase. Life Sci 46: 1671-1678.","DOI":"10.1016\/0024-3205(90)90382-2"},{"key":"10.1124\/jpet.103.064006_bib6","doi-asserted-by":"crossref","unstructured":"Chaki K, Sakurada S, Sakurada T, Sato T, Kawamura S, Kisara K, Watanabe H, and Suzuki K (1988b) Comparison of the antinociceptive effects of new [D-Arg2]-dermorphin tetrapeptide analogs and morphine in mice. Pharmacol Biochem Behav 31: 439-444.","DOI":"10.1016\/0091-3057(88)90371-1"},{"key":"10.1124\/jpet.103.064006_bib7","doi-asserted-by":"crossref","unstructured":"Dagenais C, Ducharme J, and Pollack GM (2001) Uptake and efflux of the peptidic delta-opioid receptor agonist. Neurosci Lett 301: 155-158.","DOI":"10.1016\/S0304-3940(01)01640-8"},{"key":"10.1124\/jpet.103.064006_bib8","doi-asserted-by":"crossref","unstructured":"Deguchi Y, Miyakawa Y, Sakurada S, Naito Y, Morimoto K, Ohtsuki S, Hosoya K, and Terasaki T (2003) Blood-brain barrier transport of a novel \u03bc1-specific opioid peptide, H-Tyr-D-Arg-Phe-\u03b2-Ala-OH (TAPA). J Neurochem 84: 1154-1161.","DOI":"10.1046\/j.1471-4159.2003.01582.x"},{"key":"10.1124\/jpet.103.064006_bib9","doi-asserted-by":"crossref","unstructured":"Fiori A, Cardelli P, Negri L, Savi MR, Strom R, and Erspamer V (1997) Deltorphin transport across the blood-brain barrier. Proc Natl Acad Sci USA 94: 9469-9474.","DOI":"10.1073\/pnas.94.17.9469"},{"key":"10.1124\/jpet.103.064006_bib10","doi-asserted-by":"crossref","unstructured":"Hosoya K, Tetuka K, Nagase K, Tomi M, Saeki S, Ohtsuki S, Takanaga H, Yanai N, Obinata M, Kikuchi A, et al. (2000) Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive simian virus 40 large T-antigen gene. AAPS PharmSci 2: E27 available at http:\/\/www.aapspharmsci.org\/","DOI":"10.1208\/ps020328"},{"key":"10.1124\/jpet.103.064006_bib11","doi-asserted-by":"crossref","unstructured":"Kastin AJ, Akerstrom V, Hackler L, and Pan W (2003) Different mechanisms influencing permeation of PDGF-AA and PDGF-BB across the blood-brain barrier. J Neurochem 87: 7-12.","DOI":"10.1046\/j.1471-4159.2003.01933.x"},{"key":"10.1124\/jpet.103.064006_bib12","doi-asserted-by":"crossref","unstructured":"Kastin AJ, Pan W, Maness LM, and Banks WA (1999) Peptides crossing the blood-brain barrier: some unusual observations. Brain Res 848: 96-100.","DOI":"10.1016\/S0006-8993(99)01961-7"},{"key":"10.1124\/jpet.103.064006_bib13","doi-asserted-by":"crossref","unstructured":"King M, Su W, Chang A, Zuckerman A, and Pasternak GW (2001) Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs. Nat Neurosci 4: 268-274.","DOI":"10.1038\/85115"},{"key":"10.1124\/jpet.103.064006_bib14","doi-asserted-by":"crossref","unstructured":"Narita M, Funada M, and Suzuki T (2001) Regulations of opioid dependence by opioid receptor types. Pharmacol Ther 89: 1-15.","DOI":"10.1016\/S0163-7258(00)00099-1"},{"key":"10.1124\/jpet.103.064006_bib15","doi-asserted-by":"crossref","unstructured":"Oehlke J. Scheller A, Wiesner B, Krause E, Beyermann M, Klauschenz E, Melzig M, and Bienert M (1998) Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior nonendocytically. Biochim Biophys Acta 1414: 127-139.","DOI":"10.1016\/S0005-2736(98)00161-8"},{"key":"10.1124\/jpet.103.064006_bib16","doi-asserted-by":"crossref","unstructured":"Ogawa T, Miyamae T, Murayama K, Okuyama K, Okayama T, Hagiwara M, Sakurada S, and Morikawa T (2002) Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N\u03b1-amidino-Tyr-D-Arg-Phe-Me\u03b2Ala-OH (ADAMB). J Med Chem 45: 5081-5089.","DOI":"10.1021\/jm010357t"},{"key":"10.1124\/jpet.103.064006_bib17","doi-asserted-by":"crossref","unstructured":"Oude Elferink RP and Zadina J (2001) MDR1 P-glycoprotein transports endogenous opioid peptides. Peptides 22: 2015-2020.","DOI":"10.1016\/S0196-9781(01)00564-2"},{"key":"10.1124\/jpet.103.064006_bib18","doi-asserted-by":"crossref","unstructured":"Paakkari P, Paakkari I, Vonhof S, Feuerstein G, and Siren AL (1993) Dermorphin analog Tyr-D-Arg2-Phe-sarcosine-induced opioid analgesia and respiratory stimulation: the role of mu 1-receptors? J Pharmacol Exp Ther 266: 544-550.","DOI":"10.1016\/S0022-3565(25)38418-1"},{"key":"10.1124\/jpet.103.064006_bib19","doi-asserted-by":"crossref","unstructured":"Pasternak GW (2001) Insights into mu opioid pharmacology the role of mu opioid receptor subtypes. Life Sci 68: 2213-2219.","DOI":"10.1016\/S0024-3205(01)01008-6"},{"key":"10.1124\/jpet.103.064006_bib20","doi-asserted-by":"crossref","unstructured":"Patlak CS, Blasberg RG, and Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3: 1-7.","DOI":"10.1038\/jcbfm.1983.1"},{"key":"10.1124\/jpet.103.064006_bib21","doi-asserted-by":"crossref","unstructured":"Ray E and Samanta AK (1996) Dansylcadaverine regulates ligand induced endocytosis of interleukin-8 receptor in human polymorphonuclear neutrophils. FEBS Lett 378: 235-239.","DOI":"10.1016\/0014-5793(95)01462-4"},{"key":"10.1124\/jpet.103.064006_bib22","doi-asserted-by":"crossref","unstructured":"Richard JP, Melikov K, Vives E, Ramos C, Verbeure B, Gait MJ, Chernomordik LV, and Lebleu B (2003) Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J Biol Chem 278: 585-590.","DOI":"10.1074\/jbc.M209548200"},{"key":"10.1124\/jpet.103.064006_bib23","doi-asserted-by":"crossref","unstructured":"Sakurada S, Takeda S, Sato T, Hayashi T, Yuki M, Kutsuwa M, Tan-no K, Sakurada C, Kisara K, and Sakurada T (2000) Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-\u03b2-Ala, a novel dermorphin analogue with high affinity at mu-opioid receptors. Eur J Pharmacol 395: 107-112.","DOI":"10.1016\/S0014-2999(00)00166-7"},{"key":"10.1124\/jpet.103.064006_bib24","doi-asserted-by":"crossref","unstructured":"Samii A, Bickel U, Stroth U, and Pardridge WM (1994) Blood-brain barrier transport of neuropeptides: analysis with a metabolically stable dermorphin analogue. Am J Physiol 267: E124-E131.","DOI":"10.1152\/ajpendo.1994.267.1.E124"},{"key":"10.1124\/jpet.103.064006_bib25","doi-asserted-by":"crossref","unstructured":"Sasaki Y, Matsui M, Taguchi M, Suzuki K, Sakurada S, Sato T, Sakurada T, and Kisara K (1984) D-Arg2-dermorphin tetrapeptide analogs: a potent and long-lasting analgesic activity after subcutaneous administration. Biochem Biophys Res Commun 16: 214-218.","DOI":"10.1016\/0006-291X(84)91435-9"},{"key":"10.1124\/jpet.103.064006_bib26","unstructured":"Smith QR and Stoll J (1999) Molecular characterization of amino acid transporters at the blood-brain barrier, in Alfred Benzon Symposium 45, Brain Barrier Systems (Paulson OB, Knudsen GM and Moos T eds) pp 303-320, Munksgaard, Copenhagen."},{"key":"10.1124\/jpet.103.064006_bib27","doi-asserted-by":"crossref","unstructured":"Tamai I, Sai Y, Kobayashi H, Kamata M, Wakamiya T, and Tsuji A (1997) Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier. J Pharmacol Exp Ther 280: 410-415.","DOI":"10.1016\/S0022-3565(24)36406-7"},{"key":"10.1124\/jpet.103.064006_bib28","doi-asserted-by":"crossref","unstructured":"Tanabe S, Shimohigashi Y, Nakayama Y, Makino T, Fujita T, Nose T, Tsujimoto G, Yokokura T, Naito M, Tsuruo T, et al. (1999) In vivo and in vitro evidence of blood-brain barrier transport of a novel cationic arginine-vasopressin fragment 4-9 analog. J Pharmacol Exp Ther 290: 561-568.","DOI":"10.1016\/S0022-3565(24)34935-3"},{"key":"10.1124\/jpet.103.064006_bib29","doi-asserted-by":"crossref","unstructured":"Terasaki T, Ohtsuki S, Hori S, Takanaga H, Nakashima E, and Hosoya K (2003) New approaches to in vivo models of blood-brain barrier drug transport. Drug Discov Today 8: 944-954.","DOI":"10.1016\/S1359-6446(03)02858-7"},{"key":"10.1124\/jpet.103.064006_bib30","doi-asserted-by":"crossref","unstructured":"Terasaki T, Takakuwa S, Saheki A, Moritani T, Shimura T, Tabata S, and Tsuji A (1992) Adsorptive-mediated endocytosis of an adrenocorticotropic hormone (ACTH) analogue, ebiratide, into the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells. Pharm Res (NY) 9: 529-534.","DOI":"10.1023\/A:1015848531603"},{"key":"10.1124\/jpet.103.064006_bib31","doi-asserted-by":"crossref","unstructured":"Urayama A, Yamada S, Ohmori Y, Deguchi Y, Uchida S, and Kimura R (2003) Blood-brain permeability of [3H]-(3-methyl-His2) thyrotropin-releasing hormone (MeTRH) in mice: effects of TRH and its analogues. Drug Metab Pharmacokinet 18: 310-311.","DOI":"10.2133\/dmpk.18.310"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524314247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524314247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.103.064006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:55:22Z","timestamp":1739998522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524314247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0022356524314247"],"URL":"https:\/\/doi.org\/10.1124\/jpet.103.064006","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood-Brain Barrier Permeability of Novel [d-Arg2]Dermorphin (1-4) Analogs: Transport Property Is Related to the Slow Onset of Antinociceptive Activity in the Central Nervous System","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.103.064006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2004 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}