{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:13:00Z","timestamp":1784801580142,"version":"3.55.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1124\/jpet.104.073668","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T01:08:50Z","timestamp":1103159330000},"page":"220-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":155,"title":["Comparison of Pharmacological Activities of Three Distinct \u03ba Ligands (Salvinorin A, TRK-820 and 3FLB) on \u03ba Opioid Receptors in Vitro and Their Antipruritic and Antinociceptive Activities in Vivo"],"prefix":"10.1016","volume":"312","author":[{"given":"Yulin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadet","family":"Inan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Holzgrabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Y.W.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Guo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Cowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee-Yuan","family":"Liu-Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.104.073668_bib1","doi-asserted-by":"crossref","unstructured":"Adapa ID and Toll L (1997) Relationship between binding affinity and functional activity of nociceptin\/orphanin FQ. Neuropeptides 31: 403-408.","DOI":"10.1016\/S0143-4179(97)90032-9"},{"key":"10.1124\/jpet.104.073668_bib2","doi-asserted-by":"crossref","unstructured":"Barber A, Bartoszyk GD, Bender HM, Gottschlich R, Greiner HE, Harting J, Mauler F, Minck KO, Murray RD, and Simon M (1994) A pharmacological profile of the novel, peripherally-selective kappa- opioid receptor agonist, EMD 61753. Br J Pharmacol 113: 1317-1327.","DOI":"10.1111\/j.1476-5381.1994.tb17142.x"},{"key":"10.1124\/jpet.104.073668_bib3","doi-asserted-by":"crossref","unstructured":"Befort K, Tabbara L, and Kieffer BL (1996) [35S]GTP\u03b3S binding: a tool to evaluate functional activity of a cloned opioid receptor transiently expressed in COS cells. Neurochem Res 21: 1301-1307.","DOI":"10.1007\/BF02532371"},{"key":"10.1124\/jpet.104.073668_bib4","doi-asserted-by":"crossref","unstructured":"Bhargava HN and Gulati A (1988) Kappa-opioid receptor activity in spontaneously hypertensive rats. J Pharmacol Exp Ther 245: 460-465.","DOI":"10.1016\/S0022-3565(25)22631-3"},{"key":"10.1124\/jpet.104.073668_bib5","doi-asserted-by":"crossref","unstructured":"Blake AD, Bot G, Li SX, Freeman JC, and Reisine T (1997) Differential agonist regulation of the human kappa-opioid receptor. J Neurochem 68: 1846-1852.","DOI":"10.1046\/j.1471-4159.1997.68051846.x"},{"key":"10.1124\/jpet.104.073668_bib6","doi-asserted-by":"crossref","unstructured":"Butelman ER, Harris TJ, and Kreek MJ (2004) The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys. Psychopharmacology (Berl) 172: 220-224.","DOI":"10.1007\/s00213-003-1638-0"},{"key":"10.1124\/jpet.104.073668_bib7","unstructured":"Chang K-J (1984) Opioid receptors: multiplicity and sequelae of ligand-receptor interactions, in The Receptors, 1st vol, (Conn PM ed) pp 1-81, Academic Press, Inc., New York."},{"key":"10.1124\/jpet.104.073668_bib8","doi-asserted-by":"crossref","unstructured":"Chavkin C, Sud S, Jin W, Stewart J, Zjawiony JK, Siebert DJ, Toth BA, Hufeisen SJ, and Roth BL (2004) Salvinorin A, an active component of the hallucinogenic sage S. alvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. J Pharmacol Exp Ther 308: 1197-1203.","DOI":"10.1124\/jpet.103.059394"},{"key":"10.1124\/jpet.104.073668_bib9","doi-asserted-by":"crossref","unstructured":"Chen C, Xue JC, Zhu J, Chen YW, Kunapuli S, de Riel JK, Yu L, and Liu-Chen L-Y (1995) Characterization of irreversible binding of beta-funaltrexamine to the cloned rat mu opioid receptor. J Biol Chem 270: 17866-17870.","DOI":"10.1074\/jbc.270.30.17866"},{"key":"10.1124\/jpet.104.073668_bib10","doi-asserted-by":"crossref","unstructured":"Cheng Y-C and Prusoff WH (1973) Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (I50) of an enzymatic reaction. Biochem Pharmcol 22: 3099-3108.","DOI":"10.1016\/0006-2952(73)90196-2"},{"key":"10.1124\/jpet.104.073668_bib11","doi-asserted-by":"crossref","unstructured":"Chu P, Murray S, Lissin D, and von Zastrow M (1997) Delta and kappa-opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. J Biol Chem 272: 27124-27130.","DOI":"10.1074\/jbc.272.43.27124"},{"key":"10.1124\/jpet.104.073668_bib12","doi-asserted-by":"crossref","unstructured":"Dykstra LA, Gmerek DE, Winger G, and Woods JH (1987) Kappa-opioids in Rhesus monkeys: I. Diuresis, sedation, analgesia and discriminative stimulus effects. J Pharmacol Exp Ther 242: 413-420.","DOI":"10.1016\/S0022-3565(25)39097-X"},{"key":"10.1124\/jpet.104.073668_bib13","doi-asserted-by":"crossref","unstructured":"Endoh T, Matsuura H, Tajima A, Izumimoto N, Tajima C, Suzuki T, Saitoh A, Suzuki T, Narita M, Tseng L, et al. (1999) Potent antinociceptive effects of TRK-820, a novel kappa-opioid receptor agonist. Life Sci 65: 1685-1694.","DOI":"10.1016\/S0024-3205(99)00417-8"},{"key":"10.1124\/jpet.104.073668_bib14","doi-asserted-by":"crossref","unstructured":"Endoh T, Tajima A, Izumimoto N, Suzuki T, Saitoh A, Suzuki T, Narita M, Kamei J, Tseng LF, Mizoguchi H, et al. (2001) TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys. Jpn J Pharmacol 85: 282-290.","DOI":"10.1254\/jjp.85.282"},{"key":"10.1124\/jpet.104.073668_bib15","doi-asserted-by":"crossref","unstructured":"Endoh T, Tajima A, Suzuki T, Kamei J, Narita M, Tseng L, and Nagase H (2000) Characterization of the antinociceptive effects of TRK-820 in the rat. Eur J Pharmacol 387: 133-140.","DOI":"10.1016\/S0014-2999(99)00815-8"},{"key":"10.1124\/jpet.104.073668_bib16","doi-asserted-by":"crossref","unstructured":"Ghozland S, Matthes HW, Simonin F, Filliol D, Kieffer BL, and Maldonado R (2002) Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors. J Neurosci 22: 1146-1154.","DOI":"10.1523\/JNEUROSCI.22-03-01146.2002"},{"key":"10.1124\/jpet.104.073668_bib17","doi-asserted-by":"crossref","unstructured":"Gmerek DE and Cowan A (1984) In vivo evidence for benzomorphan-selective receptors in rats. J Pharmacol Exp Ther 230: 110-115.","DOI":"10.1016\/S0022-3565(25)21347-7"},{"key":"10.1124\/jpet.104.073668_bib18","doi-asserted-by":"crossref","unstructured":"Gmerek DE and Cowan A (1988) Role of opioid receptors in bombesin-induced grooming. Ann NY Acad Sci 525: 291-300.","DOI":"10.1111\/j.1749-6632.1988.tb38614.x"},{"key":"10.1124\/jpet.104.073668_bib19","doi-asserted-by":"crossref","unstructured":"Huang P, Kehner GB, Cowan A, and Liu-Chen L-Y (2001) Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist. J Pharmacol Exp Ther 297: 688-695.","DOI":"10.1016\/S0022-3565(24)29586-0"},{"key":"10.1124\/jpet.104.073668_bib20","doi-asserted-by":"crossref","unstructured":"Huang P, Steplock D, Weinman EJ, Hall RA, Ding Z, Li J, Wang Y, and Liu-Chen LY (2004) kappa-Opioid receptor interacts with Na(+)\/H(+)-exchanger regulatory factor-1\/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1\/EBP50) to stimulate Na(+)\/H(+) exchange independent of G(i)\/G(o) proteins. J Biol Chem 279: 25002-25009.","DOI":"10.1074\/jbc.M313366200"},{"key":"10.1124\/jpet.104.073668_bib21","unstructured":"Kehner GB, Gaul F, Zang WY, Daubert JD,. Cassel JA, DeHaven RN, DeHaven-Hudkins DL, and Cowan A (1999) Stereoselective antipruritic effects of enadoline and GR 94839 in mice. FASEB J 13: A801."},{"key":"10.1124\/jpet.104.073668_bib22","doi-asserted-by":"crossref","unstructured":"Kieffer BL (1995) Recent advances in molecular recognition and signal transduction of active peptides: receptors for opioid peptides. Cell Mol Neurobiol 15: 615-635.","DOI":"10.1007\/BF02071128"},{"key":"10.1124\/jpet.104.073668_bib23","doi-asserted-by":"crossref","unstructured":"Knapp RJ, Malatynska E, Collins N, Fang L, Wang JY, Hruby VJ, Roeske WR, and Yamamura HI (1995) Molecular biology and pharmacology of cloned opioid receptors. FASEB J 9: 516-525.","DOI":"10.1096\/fasebj.9.7.7737460"},{"key":"10.1124\/jpet.104.073668_bib24","doi-asserted-by":"crossref","unstructured":"Ko MCH, Lee H, Song MS, Sobczyk-Kojiro K, Mosberg HI, Kishioka S, Woods JH, and Naughton NN (2003) Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. J Pharmacol Exp Ther 305: 173-179.","DOI":"10.1124\/jpet.102.044909"},{"key":"10.1124\/jpet.104.073668_bib25","doi-asserted-by":"crossref","unstructured":"Kogel B, Christoph T, Friderichs E, Hennies H-H, Matthiesen T, Schneider J, and Holzgrabe U (1998) HZ2, a selective kappa-opioid agonist. CNS Drug Rev 4: 54-70.","DOI":"10.1111\/j.1527-3458.1998.tb00041.x"},{"key":"10.1124\/jpet.104.073668_bib26","doi-asserted-by":"crossref","unstructured":"Kuraishi Y, Nagasawa T, Hayashi K, and Satoh M (1995) Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol 275: 229-233.","DOI":"10.1016\/0014-2999(94)00780-B"},{"key":"10.1124\/jpet.104.073668_bib27","doi-asserted-by":"crossref","unstructured":"Lai HW, Minami M, Satoh M, and Wong YH (1995) Gz coupling to the rat kappa-opioid receptor. FEBS Lett 360: 97-99.","DOI":"10.1016\/0014-5793(95)00088-Q"},{"key":"10.1124\/jpet.104.073668_bib28","doi-asserted-by":"crossref","unstructured":"Law P-Y, Wong YH, and Loh HH (2000) Molecular mechanisms and regulation of opioid receptor signaling. Annu Rev Pharmacol Toxicol 40: 389-430.","DOI":"10.1146\/annurev.pharmtox.40.1.389"},{"key":"10.1124\/jpet.104.073668_bib29","doi-asserted-by":"crossref","unstructured":"Lee JW, Joshi S, Chan JS, and Wong YH (1998) Differential coupling of mu-, delta- and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. J Neurochem 70: 2203-2211.","DOI":"10.1046\/j.1471-4159.1998.70052203.x"},{"key":"10.1124\/jpet.104.073668_bib30","doi-asserted-by":"crossref","unstructured":"Li J, Li J-G, Chen C, Zhang F, and Liu-Chen L-Y (2002) Molecular basis of differences in (trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzeneacetamide-induced desensitization and phosphorylation between human and rat \u03ba-opioid receptors expressed in Chinese hamster ovary cells. Mol Pharmacol 61: 73-84.","DOI":"10.1124\/mol.61.1.73"},{"key":"10.1124\/jpet.104.073668_bib31","doi-asserted-by":"crossref","unstructured":"Li J-G, Benovic JL, and Liu-Chen L-Y (2000) Mechanisms of agonist-induced down-regulation of the human kappa-opioid receptor: internalization is required for down-regulation. Mol Pharmacol 58: 795-801.","DOI":"10.1124\/mol.58.4.795"},{"key":"10.1124\/jpet.104.073668_bib32","doi-asserted-by":"crossref","unstructured":"Li J-G, Luo LY, Krupnick JG, Benovic JL, and Liu-Chen L-Y (1999) U50,488H-induced internalization of the human kappa opioid receptor involves a beta-arrestin- and dynamin-dependent mechanism. Kappa receptor internalization is not required for mitogen-activated protein kinase activation. J Biol Chem 274: 12087-12094.","DOI":"10.1074\/jbc.274.17.12087"},{"key":"10.1124\/jpet.104.073668_bib33","doi-asserted-by":"crossref","unstructured":"Li JG, Zhang F, Jin XL, and Liu-Chen LY (2003) Differential regulation of the human kappa opioid receptor by agonists: etorphine and levorphanol reduced dynorphin A- and U50,488H-induced internalization and phosphorylation. J Pharmacol Exp Ther 305: 531-540.","DOI":"10.1124\/jpet.102.045559"},{"key":"10.1124\/jpet.104.073668_bib34","doi-asserted-by":"crossref","unstructured":"Mansour A, Khachaturian H, Lewis ME, Akil H, and Watson SJ (1988) Anatomy of CNS opioid receptors. Trends Neurosci 11: 308-314.","DOI":"10.1016\/0166-2236(88)90093-8"},{"key":"10.1124\/jpet.104.073668_bib35","doi-asserted-by":"crossref","unstructured":"Marie N, Lecoq I, Jauzac P, and Allouche S (2003) Differential sorting of human delta-opioid receptors after internalization by peptide and alkaloid agonists. J Biol Chem 278: 22795-22804.","DOI":"10.1074\/jbc.M300084200"},{"key":"10.1124\/jpet.104.073668_bib36","doi-asserted-by":"crossref","unstructured":"Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B, et al. (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature (Lond) 377: 532-535.","DOI":"10.1038\/377532a0"},{"key":"10.1124\/jpet.104.073668_bib37","doi-asserted-by":"crossref","unstructured":"Mizoguchi H, Hung KC, Leitermann R, Narita M, Nagase H, Suzuki T, and Tseng LF (2003) Blockade of mu-opioid receptor-mediated G-protein activation and antinociception by TRK-820 in mice. Eur J Pharmacol 461: 35-39.","DOI":"10.1016\/S0014-2999(03)01299-8"},{"key":"10.1124\/jpet.104.073668_bib38","doi-asserted-by":"crossref","unstructured":"Nagase H, Hayakawa J, Kawamura K, Kawai K, Takezawa Y, Matsuura H, Tajima C, and Endo T (1998) Discovery of a structurally novel opioid kappa-agonist derived from 4,5-epoxymorphinan. Chem Pharm Bull (Tokyo) 46: 366-369.","DOI":"10.1248\/cpb.46.366"},{"key":"10.1124\/jpet.104.073668_bib39","doi-asserted-by":"crossref","unstructured":"Pfeiffer A, Brantl V, Herz A, and Emrich HM (1986) Psychotomimesis mediated by kappa opiate receptors. Science (Wash DC) 233: 774-776.","DOI":"10.1126\/science.3016896"},{"key":"10.1124\/jpet.104.073668_bib40","doi-asserted-by":"crossref","unstructured":"Quock RM, Hosohata Y, Knapp RJ, Burkey TH, Hosohata K, Zhang X, Rice KC, Nagase H, Hruby VJ, Porreca F, et al. (1997) Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor. Eur J Pharmacol 326: 101-104.","DOI":"10.1016\/S0014-2999(97)83488-7"},{"key":"10.1124\/jpet.104.073668_bib41","doi-asserted-by":"crossref","unstructured":"Reece PA, Sedman AJ, Rose S, Wright DS, Dawkins R, and Rajagopalan R (1994) Diuretic effects, pharmacokinetics and safety of a new centrally acting kappa-opioid agonist (CI-977) in humans. J Clin Pharmacol 34: 1126-1132.","DOI":"10.1002\/j.1552-4604.1994.tb01991.x"},{"key":"10.1124\/jpet.104.073668_bib42","doi-asserted-by":"crossref","unstructured":"Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJJ, and Civelli O (1995) Orphanin FQ: a neuropeptide that activates an opioid like G protein-coupled receptor. Science (Wash DC) 270: 792-794.","DOI":"10.1126\/science.270.5237.792"},{"key":"10.1124\/jpet.104.073668_bib43","doi-asserted-by":"crossref","unstructured":"Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, and Rothman RB (2002) Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proc Natl Acad Sci USA 99: 11934-11939.","DOI":"10.1073\/pnas.182234399"},{"key":"10.1124\/jpet.104.073668_bib44","unstructured":"Schwartz TW and Holst B (2002) Molecular structure of G protein-coupled receptors, in Textbook of Receptor Pharmacology (Foreman JC and Johansen T eds) pp 81-110, CRC Press, New York."},{"key":"10.1124\/jpet.104.073668_bib45","unstructured":"Scrip (2003) Fujisawa\/Toray Europe pruritus deal. Scrip 2821: 13."},{"key":"10.1124\/jpet.104.073668_bib46","doi-asserted-by":"crossref","unstructured":"Seki T, Awamura S, Kimura C, Ide S, Sakano K, Minami M, Nagase H, and Satoh M (1999) Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor. Eur J Pharmacol 376: 159-167.","DOI":"10.1016\/S0014-2999(99)00369-6"},{"key":"10.1124\/jpet.104.073668_bib47","doi-asserted-by":"crossref","unstructured":"Sheffler DJ and Roth BL (2003) Salvinorin A: the \u201cmagic mint\u201d hallucinogen finds a molecular target in the kappa opioid receptor. Trends Pharmacol Sci 24: 107-109.","DOI":"10.1016\/S0165-6147(03)00027-0"},{"key":"10.1124\/jpet.104.073668_bib48","doi-asserted-by":"crossref","unstructured":"Siebert DJ (1994) Salvia divinorum and salvinorin A: new pharmacologic findings. J Ethnopharmacol 43: 53-56.","DOI":"10.1016\/0378-8741(94)90116-3"},{"key":"10.1124\/jpet.104.073668_bib49","doi-asserted-by":"crossref","unstructured":"Siener T, Cambareri A, Kuhl U, Englberger W, Haurand M, Kogel B, and Holzgrabe U (2000) Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones. J Med Chem 43: 3746-3751.","DOI":"10.1021\/jm0009484"},{"key":"10.1124\/jpet.104.073668_bib50","doi-asserted-by":"crossref","unstructured":"Simonin F, Valverde O, Smadja C, Slowe S, Kitchen I, Dierich A, Le M, Roques BP, Maldonado R, and Kieffer BL (1998) Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. EMBO (Eur Mol Biol Organ) J 17: 886-897.","DOI":"10.1093\/emboj\/17.4.886"},{"key":"10.1124\/jpet.104.073668_bib51","doi-asserted-by":"crossref","unstructured":"Sorbera LA, Castaner J, and Leeson PA (2003) Nalfurafine hydrochloride. Drugs Future 28: 237-242.","DOI":"10.1358\/dof.2003.028.03.723584"},{"key":"10.1124\/jpet.104.073668_bib52","doi-asserted-by":"crossref","unstructured":"Szmuszkovicz J (1999) U-50,488 and the kappa receptor: II. 1991-1998. Prog Drug Res 53: 1-51.","DOI":"10.1007\/978-3-0348-8735-9_1"},{"key":"10.1124\/jpet.104.073668_bib53","doi-asserted-by":"crossref","unstructured":"Togashi Y, Umeuchi H, Okano K, Ando N, Yoshizawa Y, Honda T, Kawamura K, Endoh T, Utsumi J, Kamei J, et al. (2002) Antipruritic activity of the kappa-opioid receptor agonist, TRK-820. Eur J Pharmacol 435: 259-264.","DOI":"10.1016\/S0014-2999(01)01588-6"},{"key":"10.1124\/jpet.104.073668_bib54","doi-asserted-by":"crossref","unstructured":"Tomizawa M, Cowan A, and Casida JE (2001) Analgesic and toxic effects of neonicotinoid insecticides in mice. Toxicol Appl Pharmacol 177: 77-83.","DOI":"10.1006\/taap.2001.9292"},{"key":"10.1124\/jpet.104.073668_bib55","doi-asserted-by":"crossref","unstructured":"Traynor JR and Nahorski SR (1995) Modulation by mu-opioid agonists of guanosine-5\u2032-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol Pharmacol 47: 848-854.","DOI":"10.1016\/S0026-895X(25)08634-1"},{"key":"10.1124\/jpet.104.073668_bib56","doi-asserted-by":"crossref","unstructured":"Umeuchi H, Togashi Y, Honda T, Nakao K, Okano K, Tanaka T, and Nagase H (2003) Involvement of central mu-opioid system in the scratching behavior in mice and the suppression of it by the activation of kappa-opioid system. Eur J Pharmacol 477: 29-35.","DOI":"10.1016\/j.ejphar.2003.08.007"},{"key":"10.1124\/jpet.104.073668_bib57","doi-asserted-by":"crossref","unstructured":"VonVoigtlander PF, Lahti RA, and Ludens JH (1983) U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist. J Pharmacol Exp Ther 224: 7-12.","DOI":"10.1016\/S0022-3565(25)33422-1"},{"key":"10.1124\/jpet.104.073668_bib58","doi-asserted-by":"crossref","unstructured":"Wheeler-Aceto H and Cowan A (1991) Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacol (Berlin) 104: 35-44.","DOI":"10.1007\/BF02244551"},{"key":"10.1124\/jpet.104.073668_bib59","doi-asserted-by":"crossref","unstructured":"Zhang F, Li J, Li J-G, and Liu-Chen L-Y (2002) (-)U50,488H [(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneace tamide] induces internalization and down-regulation of the human, but not the rat, kappa-opioid receptor: structural basis for the differential regulation. J Pharmacol Exp Ther 302: 1184-1192.","DOI":"10.1124\/jpet.302.3.1184"},{"key":"10.1124\/jpet.104.073668_bib60","doi-asserted-by":"crossref","unstructured":"Zhu J, Luo L-Y, Chen C, and Liu-Chen L-Y (1997) Activation of the cloned human \u03ba opioid receptor by agonists enhances [35S]GTP\u03b3S binding to membranes: determination of potencies and efficacies of ligands. J Pharmacol Exp Ther 282: 676-684.","DOI":"10.1016\/S0022-3565(24)36877-6"},{"key":"10.1124\/jpet.104.073668_bib61","doi-asserted-by":"crossref","unstructured":"Zhu J, Luo LY, Mao GF, Ashby B, and Liu-Chen L-Y (1998) Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in CHO cells. J Pharmacol Exp Ther 285: 28-36.","DOI":"10.1016\/S0022-3565(24)37361-6"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524317446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524317446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.104.073668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T21:10:45Z","timestamp":1739999445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524317446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0022356524317446"],"URL":"https:\/\/doi.org\/10.1124\/jpet.104.073668","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Pharmacological Activities of Three Distinct \u03ba Ligands (Salvinorin A, TRK-820 and 3FLB) on \u03ba Opioid Receptors in Vitro and Their Antipruritic and Antinociceptive Activities in Vivo","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.104.073668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}