{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:48:17Z","timestamp":1771951697593,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1124\/jpet.104.080465","type":"journal-article","created":{"date-parts":[[2005,4,14]],"date-time":"2005-04-14T00:35:17Z","timestamp":1113438917000},"page":"613-620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Effects of 4\u2032-Chloro-3\u03b1-(diphenylmethoxy)-tropane on Mesostriatal, Mesocortical, and Mesolimbic Dopamine Transmission: Comparison with Effects of Cocaine"],"prefix":"10.1016","volume":"313","author":[{"given":"Gianluigi","family":"Tanda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Ebbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy H.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.104.080465_bib1","doi-asserted-by":"crossref","unstructured":"Baker LE, Riddle EE, Saunders RB, and Appel JB (1993) The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds. Behav Pharmacol 4: 69\u201379.","DOI":"10.1097\/00008877-199302000-00008"},{"key":"10.1124\/jpet.104.080465_bib2","doi-asserted-by":"crossref","unstructured":"Balster RL and Schuster CR (1973) Fixed-interval schedule of cocaine reinforcement: effect of dose and infusion duration. J Exp Anal Behav 20: 119\u2013129.","DOI":"10.1901\/jeab.1973.20-119"},{"key":"10.1124\/jpet.104.080465_bib3","doi-asserted-by":"crossref","unstructured":"Callahan PM, de la Garza R 2nd, and Cunningham KA (1997) Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacol Biochem Behav 57: 601\u2013607.","DOI":"10.1016\/S0091-3057(96)00434-0"},{"key":"10.1124\/jpet.104.080465_bib4","doi-asserted-by":"crossref","unstructured":"David DJ, Zahniser NR, Hoffer BJ, and Gerhardt GA (1998) In vivo electrochemical studies of dopamine clearance in subregions of rat nucleus accumbens: differential properties of the core and shell. Exp Neurol 153: 277\u2013286.","DOI":"10.1006\/exnr.1998.6898"},{"key":"10.1124\/jpet.104.080465_bib5","doi-asserted-by":"crossref","unstructured":"De La Garza R 2nd, Callahan PM, and Cunningham KA (1998) The discriminative stimulus properties of cocaine: effects of microinfusion of cocaine, a 5-HT1A agonist or antagonist, into the ventral tegmental area. Psychopharmacology 137: 1\u20136.","DOI":"10.1007\/s002130050586"},{"key":"10.1124\/jpet.104.080465_bib6","doi-asserted-by":"crossref","unstructured":"Di Chiara G, Tanda G, Bassareo V, Pontieri F, Acquas E, Fenu S, Cadoni C, and Carboni E (1999) Drug addiction as a disorder of associative learning: role of nucleus accumbens shell\/extended amygdala dopamine. Ann NY Acad Sci 877: 461\u2013485.","DOI":"10.1111\/j.1749-6632.1999.tb09283.x"},{"key":"10.1124\/jpet.104.080465_bib7","unstructured":"Di Chiara G, Tanda GL, Frau R, and Carboni E (1992) Heterologous monoamine reuptake: lack of transmitter specificity of neuron-specific carriers. Neurochem Int 20 (Suppl): 231S\u2013235S."},{"key":"10.1124\/jpet.104.080465_bib8","doi-asserted-by":"crossref","unstructured":"Filip M, Thomas ML, and Cunningham KA (2000) Dopamine D5 receptors in nucleus accumbens contribute to the detection of cocaine in rats. J Neurosci 20: RC98.","DOI":"10.1523\/JNEUROSCI.20-19-j0003.2000"},{"key":"10.1124\/jpet.104.080465_bib9","unstructured":"Finney DJ (1964) Statistical Method in Biological Assay, 2nd ed, Hafner, New York."},{"key":"10.1124\/jpet.104.080465_bib10","doi-asserted-by":"crossref","unstructured":"Haber SN and McFarland NR (1999) The concept of the ventral striatum in nonhuman primates. Ann NY Acad Sci 877: 33\u201348.","DOI":"10.1111\/j.1749-6632.1999.tb09259.x"},{"key":"10.1124\/jpet.104.080465_bib11","doi-asserted-by":"crossref","unstructured":"Ikemoto S (2002) Ventral striatal anatomy of locomotor activity induced by cocaine, D-amphetamine, dopamine and D1\/D2 agonists. Neuroscience 113: 939\u2013955.","DOI":"10.1016\/S0306-4522(02)00247-6"},{"key":"10.1124\/jpet.104.080465_bib12","doi-asserted-by":"crossref","unstructured":"Izenwasser S, Terry P, Heller B, Witkin JM, and Katz JL (1994) Differential relationships among dopamine transporter affinities and stimulant potencies of various uptake inhibitors. Eur J Pharmacol 263: 277\u2013283.","DOI":"10.1016\/0014-2999(94)90723-4"},{"key":"10.1124\/jpet.104.080465_bib13","doi-asserted-by":"crossref","unstructured":"Katz JL, Agoston GE, Alling KL, Kline RH, Forster MJ, Woolverton WL, Kopajtic TA, and Newman AH (2001) Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents. Psychopharmacology 154: 362\u2013374.","DOI":"10.1007\/s002130000667"},{"key":"10.1124\/jpet.104.080465_bib14","doi-asserted-by":"crossref","unstructured":"Katz JL, Izenwasser S, Kline RH, Allen AC, and Newman AH (1999) Novel 3alpha-diphenylmethoxytropane analogs: selective dopamine uptake inhibitors with behavioral effects distinct from those of cocaine. J Pharmacol Exp Ther 288: 302\u2013315.","DOI":"10.1016\/S0022-3565(24)37956-X"},{"key":"10.1124\/jpet.104.080465_bib15","doi-asserted-by":"crossref","unstructured":"Katz JL, Izenwasser S, and Terry P (2000) Relationships among dopamine transporter affinities and cocaine-like discriminative-stimulus effects. Psychopharmacology 148: 90\u201398.","DOI":"10.1007\/s002130050029"},{"key":"10.1124\/jpet.104.080465_bib16","doi-asserted-by":"crossref","unstructured":"Katz JL, Kopajtic TA, Agoston GE, and Newman AH (2004) Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands. J Pharmacol Exp Ther 309: 650\u2013660.","DOI":"10.1124\/jpet.103.060525"},{"key":"10.1124\/jpet.104.080465_bib17","doi-asserted-by":"crossref","unstructured":"Katz JL, Newman AH, and Izenwasser S (1997) Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacol Biochem Behav 57: 505\u2013512.","DOI":"10.1016\/S0091-3057(96)00441-8"},{"key":"10.1124\/jpet.104.080465_bib18","doi-asserted-by":"crossref","unstructured":"Koob GF (1999) The role of the striatopallidal and extended amygdala systems in drug addiction. Ann NY Acad Sci 877: 445\u2013460.","DOI":"10.1111\/j.1749-6632.1999.tb09282.x"},{"key":"10.1124\/jpet.104.080465_bib19","doi-asserted-by":"crossref","unstructured":"Kuczenski R, Segal DS, and Aizenstein ML (1991) Amphetamine, cocaine and fencamfamine: relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics. J Neurosci 11: 2703\u20132712.","DOI":"10.1523\/JNEUROSCI.11-09-02703.1991"},{"key":"10.1124\/jpet.104.080465_bib20","doi-asserted-by":"crossref","unstructured":"Kuhar MJ, Ritz MC, and Boja JW (1991) The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci 14: 299\u2013302.","DOI":"10.1016\/0166-2236(91)90141-G"},{"key":"10.1124\/jpet.104.080465_bib21","doi-asserted-by":"crossref","unstructured":"Moron JA, Brockington A, Wise RA, Rocha BA, and Hope BT (2002) Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J Neurosci 22: 389\u2013395.","DOI":"10.1523\/JNEUROSCI.22-02-00389.2002"},{"key":"10.1124\/jpet.104.080465_bib22","doi-asserted-by":"crossref","unstructured":"Newman AH, Allen AC, Izenwasser S, and Katz JL (1994) Novel 3 alpha-(diphenylmethoxy)-tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles. J Med Chem 37: 2258\u20132261.","DOI":"10.1021\/jm00041a002"},{"key":"10.1124\/jpet.104.080465_bib23","doi-asserted-by":"crossref","unstructured":"Newman AH and Kulkarni S (2002) Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic\u2014a focus on analogues of benztropine and rimcazole. Med Res Rev 22: 429\u2013464.","DOI":"10.1002\/med.10014"},{"key":"10.1124\/jpet.104.080465_bib24","unstructured":"Paxinos G and Watson C (1987) The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney, Australia."},{"key":"10.1124\/jpet.104.080465_bib25","doi-asserted-by":"crossref","unstructured":"Pontieri FE, Tanda G, and Di Chiara G (1995) Intravenous cocaine, morphine and amphetamine preferentially increase extracellular dopamine in the shell as compared with the core of the rat nucleus accumbens. Proc Natl Acad Sci USA 92: 12304\u201312308.","DOI":"10.1073\/pnas.92.26.12304"},{"key":"10.1124\/jpet.104.080465_bib26","doi-asserted-by":"crossref","unstructured":"Pontieri FE, Tanda G, Orzi F, and Di Chiara G (1996) Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature (Lond) 382: 255\u2013257.","DOI":"10.1038\/382255a0"},{"key":"10.1124\/jpet.104.080465_bib27","doi-asserted-by":"crossref","unstructured":"Raje S, Cao J, Newman AH, Gao H, and Eddington ND (2003) Evaluation of the blood-brain barrier transport, population pharmacokinetics and brain distribution of benztropine analogs and cocaine using in vitro and in vivo techniques. J Pharmacol Exp Ther 307: 801\u2013808.","DOI":"10.1124\/jpet.103.053504"},{"key":"10.1124\/jpet.104.080465_bib28","doi-asserted-by":"crossref","unstructured":"Ritz MC, Cone EJ, and Kuhar MJ (1990) Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study. Life Sci 46: 635\u2013645.","DOI":"10.1016\/0024-3205(90)90132-B"},{"key":"10.1124\/jpet.104.080465_bib29","doi-asserted-by":"crossref","unstructured":"Ritz MC, Lamb RJ, Goldberg SR, and Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science (Wash DC) 237: 1219\u20131223.","DOI":"10.1126\/science.2820058"},{"key":"10.1124\/jpet.104.080465_bib30","doi-asserted-by":"crossref","unstructured":"Sellings LH and Clarke PB (2003) Segregation of amphetamine reward and locomotor stimulation between nucleus accumbens medial shell and core. J Neurosci 23: 6295\u20136303.","DOI":"10.1523\/JNEUROSCI.23-15-06295.2003"},{"key":"10.1124\/jpet.104.080465_bib31","unstructured":"Snedecor GW and Cochran WG (1967) Statistical Methods, 6th ed, pp 135\u2013171, Iowa State University Press, Ames, Iowa."},{"key":"10.1124\/jpet.104.080465_bib32","unstructured":"Tanda G, Ebbs A, Kopajtic TA, and Katz JL (2004) Alteration of the neurochemical effects of cocaine by muscarinic m1 receptor antagonists. Program No. 573.15. 2004 Abstract Viewer\/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online."},{"key":"10.1124\/jpet.104.080465_bib33","doi-asserted-by":"crossref","unstructured":"Tanda G, Pontieri FE, and Di Chiara G (1997a) Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism. Science (Wash DC) 276: 2048\u20132050.","DOI":"10.1126\/science.276.5321.2048"},{"key":"10.1124\/jpet.104.080465_bib34","doi-asserted-by":"crossref","unstructured":"Tanda G, Pontieri FE, Frau R, and Di Chiara G (1997b) Contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine. Eur J Neurosci 9: 2077\u20132085.","DOI":"10.1111\/j.1460-9568.1997.tb01375.x"},{"key":"10.1124\/jpet.104.080465_bib35","doi-asserted-by":"crossref","unstructured":"Tolliver BK, Newman AH, Katz JL, Ho LB, Fox LM, Hsu K Jr, and Berger SP (1999) Behavioral and neurochemical effects of the dopamine transporter ligand 4-chlorobenztropine alone and in combination with cocaine in vivo. J Pharmacol Exp Ther 289: 110\u2013122.","DOI":"10.1016\/S0022-3565(24)38113-3"},{"key":"10.1124\/jpet.104.080465_bib36","doi-asserted-by":"crossref","unstructured":"van der Zee P, Koger HS, Gooljes J, and Hespe W (1980) Aryl 1,4-dialk(en)ylpiperazines as selective and very potent inhibitors of dopamine uptake. Eur J Med Chem 15: 363\u2013370.","DOI":"10.1002\/chin.198102262"},{"key":"10.1124\/jpet.104.080465_bib37","doi-asserted-by":"crossref","unstructured":"Williams JM and Steketee JD (2004) Characterization of dopamine transport in crude synaptosomes prepared from rat medial prefrontal cortex. J Neurosci Methods 137: 161\u2013165.","DOI":"10.1016\/j.jneumeth.2004.02.022"},{"key":"10.1124\/jpet.104.080465_bib38","doi-asserted-by":"crossref","unstructured":"Wood DM and Emmett-Oglesby MW (1989) Mediation in the nucleus accumbens of the discriminative stimulus produced by cocaine. Pharmacol Biochem Behav 33: 453\u2013457.","DOI":"10.1016\/0091-3057(89)90529-7"},{"key":"10.1124\/jpet.104.080465_bib39","doi-asserted-by":"crossref","unstructured":"Woolverton WL, Hecht GS, Agoston GE, Katz JL, and Newman AH (2001) Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys. Psychopharmacology 154: 375\u2013382.","DOI":"10.1007\/s002130000616"},{"key":"10.1124\/jpet.104.080465_bib40","doi-asserted-by":"crossref","unstructured":"Woolverton WL, Rowlett JK, Wilcox KM, Paul IA, Kline RH, Newman AH, and Katz JL (2000) 3\u2032- and 4\u2032-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys. Psychopharmacology 147: 426\u2013435.","DOI":"10.1007\/s002130050012"},{"key":"10.1124\/jpet.104.080465_bib41","doi-asserted-by":"crossref","unstructured":"Wu Q, Reith ME, Kuhar MJ, Carroll FI, and Garris PA (2001) Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission. J Neurosci 21: 6338\u20136347.","DOI":"10.1523\/JNEUROSCI.21-16-06338.2001"},{"key":"10.1124\/jpet.104.080465_bib42","doi-asserted-by":"crossref","unstructured":"Zahm DS (1999) Functional-anatomical implications of the nucleus accumbens core and shell subterritories. Ann NY Acad Sci 877: 113\u2013128.","DOI":"10.1111\/j.1749-6632.1999.tb09264.x"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524319548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524319548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.104.080465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T21:22:24Z","timestamp":1740000144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524319548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0022356524319548"],"URL":"https:\/\/doi.org\/10.1124\/jpet.104.080465","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of 4\u2032-Chloro-3\u03b1-(diphenylmethoxy)-tropane on Mesostriatal, Mesocortical, and Mesolimbic Dopamine Transmission: Comparison with Effects of Cocaine","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.104.080465","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}