{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:00:30Z","timestamp":1759683630997,"version":"3.37.3"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1124\/jpet.105.083394","type":"journal-article","created":{"date-parts":[[2005,6,17]],"date-time":"2005-06-17T02:07:56Z","timestamp":1118974076000},"page":"170-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Discriminative Stimulus Effects of \u03b3-Hydroxybutyrate (GHB) in Rats Discriminating GHB from Baclofen and Diazepam"],"prefix":"10.1016","volume":"314","author":[{"given":"Wouter","family":"Koek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence P.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Coop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles P.","family":"France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.105.083394_bib1","doi-asserted-by":"crossref","unstructured":"Baker LE, Pynnonen D, and Poling A (2004) Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats. Psychopharmacology 174: 220-227.","DOI":"10.1007\/s00213-003-1744-z"},{"key":"10.1124\/jpet.105.083394_bib2","doi-asserted-by":"crossref","unstructured":"Beardsley PM, Balster RL, and Harris LS (1996) Evaluation of the discriminative stimulus and reinforcing effects of gammahydroxybutyrate (GHB). Psychopharmacology 127: 315-322.","DOI":"10.1007\/s002130050092"},{"key":"10.1124\/jpet.105.083394_bib3","doi-asserted-by":"crossref","unstructured":"Boja JW and Schechter MD (1990) Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training. Psychopharmacology 102: 221-226.","DOI":"10.1007\/BF02245925"},{"key":"10.1124\/jpet.105.083394_bib4","doi-asserted-by":"crossref","unstructured":"Bonanno G, Carita F, Cavazzani P, Munari C, and Raiteri M (1999) Selective block of rat and human neocortex GABA(B) receptors regulating somatostatin release by a GABA(B) antagonist endowed with cognition enhancing activity. Neuropharmacology 38: 1789-1795.","DOI":"10.1016\/S0028-3908(99)00084-2"},{"key":"10.1124\/jpet.105.083394_bib5","doi-asserted-by":"crossref","unstructured":"Bowen CA, Gatto GJ, and Grant KA (1997) Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats. Behav Pharmacol 8: 339-352.","DOI":"10.1097\/00008877-199708000-00007"},{"key":"10.1124\/jpet.105.083394_bib6","doi-asserted-by":"crossref","unstructured":"Carai MA, Agabio R, Lobina C, Reali R, Vacca G, Colombo G, and Gessa GL (2002) GABA(B)-receptor mediation of the inhibitory effect of gamma-hydroxybutyric acid on intestinal motility in mice. Life Sci 70: 3059-3067.","DOI":"10.1016\/S0024-3205(02)01553-9"},{"key":"10.1124\/jpet.105.083394_bib7","doi-asserted-by":"crossref","unstructured":"Carai MA, Colombo G, Brunetti G, Melis S, Serra S, Vacca G, Mastinu S, Pistuddi AM, Solinas C, Cignarella G, et al. (2001) Role of GABA(B) receptors in the sedative\/hypnotic effect of gamma-hydroxybutyric acid. Eur J Pharmacol 428: 315-321.","DOI":"10.1016\/S0014-2999(01)01334-6"},{"key":"10.1124\/jpet.105.083394_bib8","doi-asserted-by":"crossref","unstructured":"Carai MA, Vacca G, Serra S, Colombo G, Froestl W, and Gessa GL (2004) Suppression of GABA(B) receptor function in vivo by disulfide reducing agent, dl-dithiothreitol (DTT). Psychopharmacology 174: 283-290.","DOI":"10.1007\/s00213-003-1737-y"},{"key":"10.1124\/jpet.105.083394_bib9","doi-asserted-by":"crossref","unstructured":"Carter LP, Flores LR, Wu H, Chen W, Unzeitig AW, Coop A, and France CP (2003) The role of GABAB receptors in the discriminative stimulus effects of \u03b3-hydroxybutyrate in rats: time course and antagonism studies. J Pharmacol Exp Ther 305: 668-674.","DOI":"10.1124\/jpet.102.047860"},{"key":"10.1124\/jpet.105.083394_bib10","doi-asserted-by":"crossref","unstructured":"Carter LP, Unzeitig AW, Wu H, Chen W, Coop A, Koek W, and France CP (2004) The discriminative stimulus effects of \u03b3-hydroxybutyrate (GHB) and related compounds in rats discriminating baclofen or diazepam: the role of GABAB and GABAA receptors. J Pharmacol Exp Ther 309: 540-547.","DOI":"10.1124\/jpet.103.062950"},{"key":"10.1124\/jpet.105.083394_bib11","doi-asserted-by":"crossref","unstructured":"Carter LP, Wu H, Chen W, Matthews MM, Mehta AK, Hernandez J, Thompson JA, Ticku MK, Coop A, Koek W, et al. (2005) Novel \u03b3-hydroxybutyric acid (GHB) analogs share some, but not all, of the behavioral effects of GHB and GABAB receptor agonists. J Pharmacol Exp Ther, in press.","DOI":"10.1124\/jpet.104.077578"},{"key":"10.1124\/jpet.105.083394_bib12","doi-asserted-by":"crossref","unstructured":"Colombo G, Agabio R, Bourguignon J, Fadda F, Lobina C, Maitre M, Reali R, Schmitt M, and Gessa GL (1995a) Blockade of the discriminative stimulus effects of gamma-hydroxybutyric acid (GHB) by the GHB receptor antagonist NCS-382. Physiol Behav 58: 587-590.","DOI":"10.1016\/0031-9384(95)00086-X"},{"key":"10.1124\/jpet.105.083394_bib13","doi-asserted-by":"crossref","unstructured":"Colombo G, Agabio R, Lobina C, Reali R, Fadda F, and Gessa GL (1995b) Symmetrical generalization between the discriminative stimulus effects of gamma-hydroxybutyric acid and ethanol: occurrence within narrow dose ranges. Physiol Behav 57: 105-111.","DOI":"10.1016\/0031-9384(94)00215-Q"},{"key":"10.1124\/jpet.105.083394_bib14","doi-asserted-by":"crossref","unstructured":"Colombo G, Agabio R, Lobina C, Reali R, and Gessa GL (1998) Involvement of GABA(A) and GABA(B) receptors in the mediation of discriminative stimulus effects of gamma-hydroxybutyric acid. Physiol Behav 64: 293-302.","DOI":"10.1016\/S0031-9384(98)00062-6"},{"key":"10.1124\/jpet.105.083394_bib15","doi-asserted-by":"crossref","unstructured":"Colpaert FC and Balster RL (1988) Transduction Mechanisms of Drug Stimuli. Springer, Heidelberg, Germany.","DOI":"10.1007\/978-3-642-73223-2"},{"key":"10.1124\/jpet.105.083394_bib16","unstructured":"Colpaert FC and Janssen PA (1982) Factors regulating drug cue sensitivity: the effects of dose ratio and absolute dose level in the case of fentanyl dose-dose discrimination. Arch Int Pharmacodyn Ther 258: 283-299."},{"key":"10.1124\/jpet.105.083394_bib17","doi-asserted-by":"crossref","unstructured":"Colpaert FC and Janssen PA (1986) Agonist and antagonist effects of prototype opiate drugs in fentanyl dose-dose discrimination. Psychopharmacology 90: 222-228.","DOI":"10.1007\/BF00181246"},{"key":"10.1124\/jpet.105.083394_bib18","doi-asserted-by":"crossref","unstructured":"Cook CD, Aceto MD, Coop A, and Beardsley PM (2002) Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice. Psychopharmacology 160: 99-106.","DOI":"10.1007\/s00213-001-0951-8"},{"key":"10.1124\/jpet.105.083394_bib19","unstructured":"Edgington ES (1995) Randomization Tests, Marcel Dekker, New York."},{"key":"10.1124\/jpet.105.083394_bib20","doi-asserted-by":"crossref","unstructured":"Gatto GJ, Bowen CA, and Grant KA (1995) Assessment of the mixed discriminative stimulus effects of ethanol in a three-choice ethanol-dizocilpine-water discrimination in rats. Behav Pharmacol 6: 601-613.","DOI":"10.1097\/00008877-199508000-00020"},{"key":"10.1124\/jpet.105.083394_bib21","doi-asserted-by":"crossref","unstructured":"Grant KA (1994) Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels. Behav Pharmacol 5: 383-404.","DOI":"10.1097\/00008877-199408000-00003"},{"key":"10.1124\/jpet.105.083394_bib22","unstructured":"J\u00e4rbe TUC and Swedberg MDB (1982) A conceptualization of drug discrimination learning, in Drug Discrimination: Applications in CNS Pharmacology (Colpaert FC and Slangen JL eds) pp 327-341, Elsevier, Amsterdam."},{"key":"10.1124\/jpet.105.083394_bib23","unstructured":"Kenakin T (1997) Pharmacologic Analysis of Drug-Receptor Interaction, Lippincott-Raven Publishers, Philadelphia."},{"key":"10.1124\/jpet.105.083394_bib24","doi-asserted-by":"crossref","unstructured":"Kleven MS and Koek W (1997) Discriminative stimulus properties of cocaine: enhancement by beta-adrenergic receptor antagonists. Psychopharmacology 131: 307-312.","DOI":"10.1007\/s002130050297"},{"key":"10.1124\/jpet.105.083394_bib25","doi-asserted-by":"crossref","unstructured":"Koek W, Flores LR, Carter LP, Lamb RJ, Chen W, Wu H, Coop A, and France CP (2004) Discriminative stimulus effects of \u03b3-hydroxybutyrate (GHB) in pigeons: role of diazepam-sensitive and -insensitive GABAA receptors and of GABAB receptors. J Pharmacol Exp Ther 308: 904-911.","DOI":"10.1124\/jpet.103.056093"},{"key":"10.1124\/jpet.105.083394_bib26","doi-asserted-by":"crossref","unstructured":"Kostowski W and Bienkowski P (1999) Discriminative stimulus effects of ethanol: neuropharmacological characterization. Alcohol 17: 63-80.","DOI":"10.1016\/S0741-8329(98)00035-4"},{"key":"10.1124\/jpet.105.083394_bib27","doi-asserted-by":"crossref","unstructured":"Lamb RJ, Munn J, Duiker NJ, Coop A, Wu H, Koek W, and France CP (2003) Interactions of \u03b3-hydroxy butyrate with ethanol and NCS 382. Eur J Pharmacol 470: 157-162.","DOI":"10.1016\/S0014-2999(03)01791-6"},{"key":"10.1124\/jpet.105.083394_bib28","doi-asserted-by":"crossref","unstructured":"Lingenhoehl K, Brom R, Heid J, Beck P, Froestl W, Kaupmann K, Bettler B, and Mosbacher J (1999) Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors. Neuropharmacology 38: 1667-1673.","DOI":"10.1016\/S0028-3908(99)00131-8"},{"key":"10.1124\/jpet.105.083394_bib29","doi-asserted-by":"crossref","unstructured":"Ludbrook J (1998) Multiple comparison procedures updated. Clin Exp Pharmacol Physiol 25: 1032-1037.","DOI":"10.1111\/j.1440-1681.1998.tb02179.x"},{"key":"10.1124\/jpet.105.083394_bib30","doi-asserted-by":"crossref","unstructured":"Martellotta MC, Cossu G, Fattore L, Gessa GL, and Fratta W (1998) Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice. Eur Neuropsychopharmacol 8: 293-296.","DOI":"10.1016\/S0924-977X(97)00087-4"},{"key":"10.1124\/jpet.105.083394_bib31","doi-asserted-by":"crossref","unstructured":"Mehta AK, Muschaweck NM, Maeda DY, Coop A, and Ticku MK (2001) Binding characteristics of the \u03b3-hydroxybutyric acid receptor antagonist [3H](2 E)-(5-hydroxy-5,7,8,9-tetrahydro-6 H-benzo[a][7]annulen-6-ylidene) ethanoic acid in the rat brain. J Pharmacol Exp Ther 299: 1148-1153.","DOI":"10.1016\/S0022-3565(24)29240-5"},{"key":"10.1124\/jpet.105.083394_bib32","doi-asserted-by":"crossref","unstructured":"Metcalf BR, Stahl JM, Allen JD, Woolfolk DR, and Soto PL (2001) Discrimination of gamma-hydroxybutyrate and ethanol administered separately and as a mixture in rats. Pharmacol Biochem Behav 70: 31-41.","DOI":"10.1016\/S0091-3057(01)00579-2"},{"key":"10.1124\/jpet.105.083394_bib33","doi-asserted-by":"crossref","unstructured":"Nicholson KL and Balster RL (2001) GHB: a new and novel drug of abuse. Drug Alcohol Depend 63: 1-22.","DOI":"10.1016\/S0376-8716(00)00191-5"},{"key":"10.1124\/jpet.105.083394_bib34","doi-asserted-by":"crossref","unstructured":"Overton DA (1982) Multiple drug training as a method for increasing the specificity of the drug discrimination procedure. J Pharmacol Exp Ther 221: 166-172.","DOI":"10.1016\/S0022-3565(25)33033-8"},{"key":"10.1124\/jpet.105.083394_bib35","doi-asserted-by":"crossref","unstructured":"Overton DA, Shen CF, Ke GY, and Gazdick LP (1989) Discriminable effects of phencyclidine analogs evaluated by multiple drug (PCP versus OTHER) discrimination training. Psychopharmacology 97: 514-520.","DOI":"10.1007\/BF00439557"},{"key":"10.1124\/jpet.105.083394_bib36","doi-asserted-by":"crossref","unstructured":"Pan ZH and Lipton SA (1995) Multiple GABA receptor subtypes mediate inhibition of calcium influx at rat retinal bipolar cell terminals. J Neurosci 15: 2668-2679.","DOI":"10.1523\/JNEUROSCI.15-04-02668.1995"},{"key":"10.1124\/jpet.105.083394_bib37","unstructured":"Siegel S and Castellan NJ Jr (1988) Nonparametric Statistics for the Behavioral Sciences, McGraw-Hill Companies, New York."},{"key":"10.1124\/jpet.105.083394_bib38","doi-asserted-by":"crossref","unstructured":"Stolerman IP and Mariathasan EA (1990) Discrimination of an amphetamine-pentobarbitone mixture by rats in an AND-OR paradigm. Psychopharmacology 102: 557-560.","DOI":"10.1007\/BF02247142"},{"key":"10.1124\/jpet.105.083394_bib39","doi-asserted-by":"crossref","unstructured":"Tallarida RJ (2000) Drug Synergism and Dose-Effect Data Analysis, pp 44-50, Chapman & Hall\/CRC, Boca Raton, FL.","DOI":"10.1201\/9781420036107"},{"key":"10.1124\/jpet.105.083394_bib40","doi-asserted-by":"crossref","unstructured":"Vayer P, Mandel P, and Maitre M (1985) Conversion of gamma-hydroxybutyrate to gamma-aminobutyrate in vitro. J Neurochem 45: 810-814.","DOI":"10.1111\/j.1471-4159.1985.tb04065.x"},{"key":"10.1124\/jpet.105.083394_bib41","doi-asserted-by":"crossref","unstructured":"White JM and Holtzman SG (1981) Three-choice drug discrimination in the rat: morphine, cyclazocine and saline. J Pharmacol Exp Ther 217: 254-262.","DOI":"10.1016\/S0022-3565(25)32526-7"},{"key":"10.1124\/jpet.105.083394_bib42","doi-asserted-by":"crossref","unstructured":"Winter JC (1981) The stimulus properties of gamma-hydroxybutyrate. Psychopharmacology 73: 372-375.","DOI":"10.1007\/BF00426468"},{"key":"10.1124\/jpet.105.083394_bib43","doi-asserted-by":"crossref","unstructured":"Woolverton WL, Rowlett JK, Winger G, Woods JH, Gerak LR, and France CP (1999) Evaluation of the reinforcing and discriminative stimulus effects of gamma-hydroxybutyrate in rhesus monkeys. Drug Alcohol Depend 54: 137-143.","DOI":"10.1016\/S0376-8716(98)00153-7"},{"key":"10.1124\/jpet.105.083394_bib44","doi-asserted-by":"crossref","unstructured":"Wu H, Zink N, Carter LP, Mehta A, Hernandez R, Ticku MK, Lamb RJ, France CP, and Coop A (2003) A tertiary alcohol analog of \u03b3-hydroxybutyric acid as a specific \u03b3-hydroxybutyric acid receptor ligand. J Pharmacol Exp Ther 305: 675-679.","DOI":"10.1124\/jpet.102.046797"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524320713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524320713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.105.083394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T21:29:20Z","timestamp":1740000560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524320713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0022356524320713"],"URL":"https:\/\/doi.org\/10.1124\/jpet.105.083394","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2005,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discriminative Stimulus Effects of \u03b3-Hydroxybutyrate (GHB) in Rats Discriminating GHB from Baclofen and Diazepam","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.105.083394","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}