{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T05:21:23Z","timestamp":1740028883949,"version":"3.37.3"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1124\/jpet.105.085027","type":"journal-article","created":{"date-parts":[[2005,7,16]],"date-time":"2005-07-16T03:57:40Z","timestamp":1121486260000},"page":"855-861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Rapid Elimination of Cefaclor from the Cerebrospinal Fluid Is Mediated by a Benzylpenicillin-Sensitive Mechanism Distinct from Organic Anion Transporter 3"],"prefix":"10.1016","volume":"314","author":[{"given":"Misaki","family":"Kuroda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kusuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Endou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.105.085027_bib1","doi-asserted-by":"crossref","unstructured":"Cserr HF and Berman BJ (1978) Iodide and thiocyanate efflux from brain following injection into rat caudate nucleus. Am J Physiol 235: F331-F337.","DOI":"10.1152\/ajprenal.1978.235.4.F331"},{"key":"10.1124\/jpet.105.085027_bib2","doi-asserted-by":"crossref","unstructured":"Dancer SJ (2001) The problem with cephalosporins. J Antimicrob Chemother 48: 463-478.","DOI":"10.1093\/jac\/48.4.463"},{"key":"10.1124\/jpet.105.085027_bib3","doi-asserted-by":"crossref","unstructured":"Daniel H and Kottra G (2004) The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch 447: 610-618.","DOI":"10.1007\/s00424-003-1101-4"},{"key":"10.1124\/jpet.105.085027_bib4","doi-asserted-by":"crossref","unstructured":"Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, and Leibach FH (1995) Differential recognition of \u03b2-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem 270: 25672-25677.","DOI":"10.1074\/jbc.270.43.25672"},{"key":"10.1124\/jpet.105.085027_bib5","doi-asserted-by":"crossref","unstructured":"Kikuchi R, Kusuhara H, Sugiyama D, and Sugiyama Y (2003) Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier. J Pharmacol Exp Ther 306: 51-58.","DOI":"10.1124\/jpet.103.049197"},{"key":"10.1124\/jpet.105.085027_bib6","doi-asserted-by":"crossref","unstructured":"Kusuhara H, He Z, Nagata Y, Nozaki Y, Ito T, Masuda H, Meier PJ, Abe T, and Sugiyama Y (2003) Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus. Pharm Res 20: 720-727.","DOI":"10.1023\/A:1023473216759"},{"key":"10.1124\/jpet.105.085027_bib7","doi-asserted-by":"crossref","unstructured":"Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, and Endou H (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274: 13675-13680.","DOI":"10.1074\/jbc.274.19.13675"},{"key":"10.1124\/jpet.105.085027_bib8","doi-asserted-by":"crossref","unstructured":"Levin VA (1980) Relationship of octanol\/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 23: 682-684.","DOI":"10.1021\/jm00180a022"},{"key":"10.1124\/jpet.105.085027_bib9","doi-asserted-by":"crossref","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with folin phenol reagent. J Biol Chem 193: 265-267.","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"10.1124\/jpet.105.085027_bib10","doi-asserted-by":"crossref","unstructured":"Matsushita H, Suzuki H, Sugiyama Y, Sawada Y, Iga T, Kawaguchi Y, and Hanano M (1991) Facilitated transport of cefodizime into the rat central nervous system. J Pharmacol Exp Ther 259: 620-625.","DOI":"10.1016\/S0022-3565(25)20476-1"},{"key":"10.1124\/jpet.105.085027_bib11","doi-asserted-by":"crossref","unstructured":"Nagata Y, Kusuhara H, Endou H, and Sugiyama Y (2002) Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol 61: 982-988.","DOI":"10.1124\/mol.61.5.982"},{"key":"10.1124\/jpet.105.085027_bib12","doi-asserted-by":"crossref","unstructured":"Nagata Y, Kusuhara H, Hirono S, Endou H, and Sugiyama Y (2004a) Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3. Drug Metab Dispos 32: 1040-1047.","DOI":"10.1016\/S0090-9556(24)02989-1"},{"key":"10.1124\/jpet.105.085027_bib13","doi-asserted-by":"crossref","unstructured":"Nagata Y, Kusuhara H, Imaoka T, Endou H, and Sugiyama Y (2004b) Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus. J Pharm Sci 93: 2724-2732.","DOI":"10.1002\/jps.20175"},{"key":"10.1124\/jpet.105.085027_bib14","doi-asserted-by":"crossref","unstructured":"Nohjoh T, Suzuki H, Sawada Y, Sugiyama Y, Iga T, and Hanano M (1989) Transport of cefodizime, a novel third generation cephalosporin antibiotic, in isolated rat choroid plexus. J Pharmacol Exp Ther 250: 324-328.","DOI":"10.1016\/S0022-3565(25)21367-2"},{"key":"10.1124\/jpet.105.085027_bib15","doi-asserted-by":"crossref","unstructured":"Novotny A, Xiang J, Stummer W, Teuscher NS, Smith DE, and Keep RF (2000) Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus. J Neurochem 75: 321-328.","DOI":"10.1046\/j.1471-4159.2000.0750321.x"},{"key":"10.1124\/jpet.105.085027_bib16","doi-asserted-by":"crossref","unstructured":"Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, and Smith DE (2004) Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice. J Pharmacol Exp Ther 308: 462-467.","DOI":"10.1124\/jpet.103.060400"},{"key":"10.1124\/jpet.105.085027_bib17","doi-asserted-by":"crossref","unstructured":"Ogawa M, Suzuki H, Sawada Y, Hanano M, and Sugiyama Y (1994) Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation. Am J Physiol 266: R392-R399.","DOI":"10.1152\/ajpregu.1994.266.2.R392"},{"key":"10.1124\/jpet.105.085027_bib18","doi-asserted-by":"crossref","unstructured":"Rothstein JD, Patel S, Regan MR, Haenggeli C, Huang YH, Bergles DE, Jin L, Dykes Hoberg M, Vidensky S, Chung DS, et al. (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature (Lond) 433: 73-77.","DOI":"10.1038\/nature03180"},{"key":"10.1124\/jpet.105.085027_bib19","doi-asserted-by":"crossref","unstructured":"Smith DE, Johanson CE, and Keep RF (2004) Peptide and peptide analog transport systems at the blood-CSF barrier. Adv Drug Deliv Rev 56: 1765-1791.","DOI":"10.1016\/j.addr.2004.07.008"},{"key":"10.1124\/jpet.105.085027_bib20","doi-asserted-by":"crossref","unstructured":"Spector R (1987) Ceftriaxone transport through the blood-brain barrier. J Infect Dis 156: 209-211.","DOI":"10.1093\/infdis\/156.1.209"},{"key":"10.1124\/jpet.105.085027_bib21","doi-asserted-by":"crossref","unstructured":"Spector R (1990) Advances in understanding the pharmacology of agents used to treat bacterial meningitis. Pharmacology 41: 113-118.","DOI":"10.1159\/000138706"},{"key":"10.1124\/jpet.105.085027_bib22","doi-asserted-by":"crossref","unstructured":"Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, and Sugiyama Y (2001) Characterization of the efflux transport of 17\u03b2-estradiol-d-17\u03b2-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther 298: 316-322.","DOI":"10.1016\/S0022-3565(24)29383-6"},{"key":"10.1124\/jpet.105.085027_bib23","doi-asserted-by":"crossref","unstructured":"Suzuki H, Sawada Y, Sugiyama Y, Iga T, and Hanano M (1987) Transport of benzylpenicillin by the rat choroid plexus in vitro. J Pharmacol Exp Ther 242: 660-665.","DOI":"10.1016\/S0022-3565(25)39133-0"},{"key":"10.1124\/jpet.105.085027_bib24","doi-asserted-by":"crossref","unstructured":"Suzuki H, Sawada Y, Sugiyama Y, Iga T, and Hanano M (1989a) Facilitated transport of benzylpenicillin through the blood-brain barrier in rats. J Pharmacobiodyn 12: 182-185.","DOI":"10.1248\/bpb1978.12.182"},{"key":"10.1124\/jpet.105.085027_bib25","doi-asserted-by":"crossref","unstructured":"Suzuki H, Sawada Y, Sugiyama Y, Iga T, Hanano M, and Spector R (1989b) Transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system. J Pharmacol Exp Ther 250: 979-984.","DOI":"10.1016\/S0022-3565(25)22850-6"},{"key":"10.1124\/jpet.105.085027_bib26","doi-asserted-by":"crossref","unstructured":"Suzuki H, Terasaki T, and Sugiyama Y (1997) Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system. Adv Drug Delivery Rev 25: 257-285.","DOI":"10.1016\/S0169-409X(97)00503-6"},{"key":"10.1124\/jpet.105.085027_bib27","unstructured":"Tunkel AR and Scheld WM (1997) Issues in the management of bacterial meningitis. Am Fam Physician 56: 1355-1362."},{"key":"10.1124\/jpet.105.085027_bib28","doi-asserted-by":"crossref","unstructured":"Yamaoka K, Tanigawara Y, Nakagawa T, and Uno T (1981) A pharmacokinetic analysis program (multi) for microcomputer. J Pharmacobiodyn 4: 879-885.","DOI":"10.1248\/bpb1978.4.879"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524321524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524321524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.105.085027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T21:32:09Z","timestamp":1740000729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524321524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0022356524321524"],"URL":"https:\/\/doi.org\/10.1124\/jpet.105.085027","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2005,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid Elimination of Cefaclor from the Cerebrospinal Fluid Is Mediated by a Benzylpenicillin-Sensitive Mechanism Distinct from Organic Anion Transporter 3","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.105.085027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2005 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}