{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:37:31Z","timestamp":1789987051285,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1124\/jpet.105.091462","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T04:48:32Z","timestamp":1137646112000},"page":"530-538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adenosine A1 Receptor Antagonist Blunts Urinary Potassium Excretion, but Not Renal Hemodynamic Effects, Induced by Carbonic Anhydrase Inhibitor in Rats"],"prefix":"10.1016","volume":"316","author":[{"given":"Xiaosun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Curtis K.","family":"Kost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.105.091462_bib1","doi-asserted-by":"crossref","unstructured":"Bell PD, Lapointe JY, Sabirov R, Hayashi S, Peti-Peterdi J, Manabe K, Kovacs G, and Okada Y (2003) Macula densa cell signaling involves ATP release through a maxi anion channel. Proc Natl Acad Sci USA 100: 4322-4327.","DOI":"10.1073\/pnas.0736323100"},{"key":"10.1124\/jpet.105.091462_bib2","doi-asserted-by":"crossref","unstructured":"Brater DC (1998) Diuretic therapy. N Engl J Med 339: 387-395.","DOI":"10.1056\/NEJM199808063390607"},{"key":"10.1124\/jpet.105.091462_bib3","doi-asserted-by":"crossref","unstructured":"Brown R, Ollerstam A, Johansson B, Skott O, Gebre-Medhin S, Fredholm B, and Persson AE (2001) Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice. Am J Physiol 281: R1362-R1367.","DOI":"10.1152\/ajpregu.00470.2001"},{"key":"10.1124\/jpet.105.091462_bib4","doi-asserted-by":"crossref","unstructured":"Castrop H, Huang Y, Hashimoto S, Mizel D, Hansen P, Theilig F, Bachmann S, Deng C, Briggs J, and Schnermann J (2004) Impairment of tubuloglomerular feedback regulation of GFR in ecto-5\u2032-nucleotidase\/CD73-deficient mice. J Clin Investig 114: 634-642.","DOI":"10.1172\/JCI200421851"},{"key":"10.1124\/jpet.105.091462_bib5","doi-asserted-by":"crossref","unstructured":"Chang RS, Siegl PK, Clineschmidt BV, Mantlo NB, Chakravarty PK, Greenlee WJ, Patchett AA, and Lotti VJ (1992) In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist. J Pharmacol Exp Ther 262: 133-138.","DOI":"10.1016\/S0022-3565(25)10725-8"},{"key":"10.1124\/jpet.105.091462_bib6","doi-asserted-by":"crossref","unstructured":"Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, et al. (2003) Seventh report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. Hypertension 42: 1206-1252.","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"10.1124\/jpet.105.091462_bib7","doi-asserted-by":"crossref","unstructured":"Cholewa BC, Meister CJ, and Mattson DL (2005) Importance of the reninangiotensin system in the regulation of arterial blood pressure in conscious mice and rats. Acta Physiol Scand 183: 309-320.","DOI":"10.1111\/j.1365-201X.2004.01401.x"},{"key":"10.1124\/jpet.105.091462_bib8","doi-asserted-by":"crossref","unstructured":"Deng A, Hammes JS, and Thomson SC (2002) Hemodynamics of early tubuloglomerular feedback resetting during reduced proximal reabsorption. Kidney Int 62: 2136-2143.","DOI":"10.1046\/j.1523-1755.2002.00682.x"},{"key":"10.1124\/jpet.105.091462_bib9","doi-asserted-by":"crossref","unstructured":"Deng A, Wead LM, and Blantz RC (2004) Temporal adaptation of tubuloglomerular feedback: effects of COX-2. Kidney Int 66: 2348-2353.","DOI":"10.1111\/j.1523-1755.2004.66033.x"},{"key":"10.1124\/jpet.105.091462_bib10","doi-asserted-by":"crossref","unstructured":"Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, and Linden J (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53: 527-552.","DOI":"10.1016\/S0031-6997(24)01511-4"},{"key":"10.1124\/jpet.105.091462_bib11","doi-asserted-by":"crossref","unstructured":"Gellai M, Schreiner GF, Ruffolo RR Jr, Fletcher T, DeWolf R, and Brooks DP (1998) CVT-124, a novel adenosine A1 receptor antagonist with unique diuretic activity. J Pharmacol Exp Ther 286: 1191-1196.","DOI":"10.1016\/S0022-3565(24)37711-0"},{"key":"10.1124\/jpet.105.091462_bib12","doi-asserted-by":"crossref","unstructured":"Gottlieb SS, Brater DC, Thomas I, Havranek E, Bourge R, Goldman S, Dyer F, Gomez M, Bennett D, Ticho B, et al. (2002) BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 105: 1348-1353.","DOI":"10.1161\/hc1102.105264"},{"key":"10.1124\/jpet.105.091462_bib13","doi-asserted-by":"crossref","unstructured":"Hashimoto S, Huang YG, Castrop H, Hansen PB, Mizel D, Briggs J, and Schnermann J (2004a) Effect of carbonic anhydrase inhibition on GFR and renal hemodynamics in adenosine-1 receptor-deficient mice. Pflueg Arch Eur J Physiol 448: 621-628.","DOI":"10.1007\/s00424-004-1330-1"},{"key":"10.1124\/jpet.105.091462_bib14","doi-asserted-by":"crossref","unstructured":"Hashimoto S, Huang Y, Mizel D, Briggs J, and Schnermann J (2004b) Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR. Acta Physiol Scand 181: 455-462.","DOI":"10.1111\/j.1365-201X.2004.01318.x"},{"key":"10.1124\/jpet.105.091462_bib15","doi-asserted-by":"crossref","unstructured":"Hawkins RG and Houston MC (2005) Is population-wide diuretic use directly associated with the incidence of end-stage renal disease in the United States? A hypothesis. Am J Hypertens 18: 744-749.","DOI":"10.1016\/j.amjhyper.2004.12.007"},{"key":"10.1124\/jpet.105.091462_bib16","doi-asserted-by":"crossref","unstructured":"Jackson EK, Kost CK Jr, Herzer WA, Smits GJ, and Tofovic SP (2001) A(1) receptor blockade induces natriuresis with a favorable renal hemodynamic profile in SHHF\/Mcc-fa(cp) rats chronically treated with salt and furosemide. J Pharmacol Exp Ther 299: 978-987.","DOI":"10.1016\/S0022-3565(24)29220-X"},{"key":"10.1124\/jpet.105.091462_bib17","doi-asserted-by":"crossref","unstructured":"Kim GH (2004) Long-term adaptation of renal ion transporters to chronic diuretic treatment. Am J Nephrol 24: 595-605.","DOI":"10.1159\/000082314"},{"key":"10.1124\/jpet.105.091462_bib18","doi-asserted-by":"crossref","unstructured":"Knight RJ, Bowmer CJ, and Yates MS (1993) The diuretic action of 8-cyclopentyl-1,3-dipropylxanthine, a selective A1 adenosine receptor antagonist. Br J Pharmacol 109: 271-277.","DOI":"10.1111\/j.1476-5381.1993.tb13564.x"},{"key":"10.1124\/jpet.105.091462_bib19","doi-asserted-by":"crossref","unstructured":"Kost CK Jr, Herzer WA, Rominski BR, Mi Z, and Jackson EK (2000) Diuretic response to adenosine A(1) receptor blockade in normotensive and spontaneously hypertensive rats: role of pertussis toxin-sensitive G-proteins. J Pharmacol Exp Ther 292: 752-760.","DOI":"10.1016\/S0022-3565(24)35348-0"},{"key":"10.1124\/jpet.105.091462_bib20","doi-asserted-by":"crossref","unstructured":"Kramer BK, Schweda F, and Riegger GA (1999) Diuretic treatment and diuretic resistance in heart failure. Am J Med 106: 90-96.","DOI":"10.1016\/S0002-9343(98)00365-9"},{"key":"10.1124\/jpet.105.091462_bib21","doi-asserted-by":"crossref","unstructured":"Kuan CJ, Herzer WA, and Jackson EK (1993) Cardiovascular and renal effects of blocking A1 adenosine receptors. J Cardiovasc Pharmacol 21: 822-828.","DOI":"10.1097\/00005344-199305000-00020"},{"key":"10.1124\/jpet.105.091462_bib22","doi-asserted-by":"crossref","unstructured":"Leyssac PP, Karlsen FM, Holstein-Rathlou NH, and Skott O (1994) On determinants of glomerular filtration rate after inhibition of proximal tubular reabsorption. Am J Physiol 266: R1544-R1550.","DOI":"10.1152\/ajpregu.1994.266.5.R1544"},{"key":"10.1124\/jpet.105.091462_bib23","doi-asserted-by":"crossref","unstructured":"Lorenz JN, Schultheis PJ, Traynor T, Shull GE, and Schnermann J (1999) Micropuncture analysis of single-nephron function in NHE3-deficient mice. Am J Physiol 277: F447-F453.","DOI":"10.1152\/ajprenal.1999.277.3.F447"},{"key":"10.1124\/jpet.105.091462_bib24","doi-asserted-by":"crossref","unstructured":"Macala LJ and Hayslett JP (2002) Basolateral and apical A1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells. Am J Physiol 283: F1216-F1225.","DOI":"10.1152\/ajprenal.00085.2002"},{"key":"10.1124\/jpet.105.091462_bib25","doi-asserted-by":"crossref","unstructured":"Ma H and Ling BN (1996) Luminal adenosine receptors regulate amiloride-sensitive Na+ channels in A6 distal nephron cells. Am J Physiol 270: F798-F805.","DOI":"10.1152\/ajprenal.1996.270.5.F798"},{"key":"10.1124\/jpet.105.091462_bib26","doi-asserted-by":"crossref","unstructured":"Na KY, Oh YK, Han JS, Joo KW, Lee JS, Earm JH, Knepper MA, and Kim GH (2003) Upregulation of Na+ transporter abundances in response to chronic thiazide or loop diuretic treatment in rats. Am J Physiol 284: F133-F143.","DOI":"10.1152\/ajprenal.00227.2002"},{"key":"10.1124\/jpet.105.091462_bib27","doi-asserted-by":"crossref","unstructured":"Nishiyama A, Majid DS, Taher KA, Miyatake A, and Navar LG (2000) Relation between renal interstitial ATP concentrations and autoregulation-mediated changes in renal vascular resistance. Circ Res 86: 656-662.","DOI":"10.1161\/01.RES.86.6.656"},{"key":"10.1124\/jpet.105.091462_bib28","doi-asserted-by":"crossref","unstructured":"Nishiyama A and Navar LG (2002) ATP mediates tubuloglomerular feedback. Am J Physiol 283: R273-R275; discussion R278-R279.","DOI":"10.1152\/ajpregu.00071.2002"},{"key":"10.1124\/jpet.105.091462_bib29","doi-asserted-by":"crossref","unstructured":"Nomura H, Nagashima K, Kusaka H, and Karasawa A (1995) Antihypertensive effects of KW-3902, an adenosine A1-receptor antagonist, in Dahl salt-sensitive rats. Jpn J Pharmacol 68: 389-396.","DOI":"10.1254\/jjp.68.389"},{"key":"10.1124\/jpet.105.091462_bib30","unstructured":"Osswald H, Hermes HH, and Nabakowski G (1982) Role of adenosine in signal transmission of tubuloglomerular feedback. Kidney Int Suppl 12: S136-S142."},{"key":"10.1124\/jpet.105.091462_bib31","doi-asserted-by":"crossref","unstructured":"Schnermann J, Chou CL, Ma T, Traynor T, Knepper MA, and Verkman AS (1998) Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci USA 95: 9660-9664.","DOI":"10.1073\/pnas.95.16.9660"},{"key":"10.1124\/jpet.105.091462_bib32","doi-asserted-by":"crossref","unstructured":"Siegl PK, Chang RS, Mantlo NB, Chakravarty PK, Ondeyka DL, Greenlee WJ, Patchett AA, Sweet CS, and Lotti VJ (1992) In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist. J Pharmacol Exp Ther 262: 139-144.","DOI":"10.1016\/S0022-3565(25)10726-X"},{"key":"10.1124\/jpet.105.091462_bib33","doi-asserted-by":"crossref","unstructured":"Sun D, Samuelson LC, Yang T, Huang Y, Paliege A, Saunders T, Briggs J, and Schnermann J (2001) Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors. Proc Natl Acad Sci USA 98: 9983-9988.","DOI":"10.1073\/pnas.171317998"},{"key":"10.1124\/jpet.105.091462_bib34","doi-asserted-by":"crossref","unstructured":"Thomson S, Bao D, Deng A, and Vallon V (2000) Adenosine formed by 5\u2032-nucleotidase mediates tubuloglomerular feedback. J Clin Investig 106: 289-298.","DOI":"10.1172\/JCI8761"},{"key":"10.1124\/jpet.105.091462_bib35","doi-asserted-by":"crossref","unstructured":"Tucker BJ, Steiner RW, Gushwa LC, and Blantz RC (1978) Studies on the tubuloglomerular feedback system in the rat. The mechanism of reduction in filtration rate with benzolamide. J Clin Investig 62: 993-1004.","DOI":"10.1172\/JCI109229"},{"key":"10.1124\/jpet.105.091462_bib36","doi-asserted-by":"crossref","unstructured":"Uehara Y, Numabe A, Hirawa N, Kawabata Y, Nagoshi H, Kaneko H, Gomi T, Goto A, Toyo-oka T, and Omata M (1995) A new adenosine subtype-1 receptor antagonist, FK-838, attenuates salt-induced hypertension in Dahl salt-sensitive rats. Am J Hypertens 8: 1189-1199.","DOI":"10.1016\/0895-7061(95)00253-7"},{"key":"10.1124\/jpet.105.091462_bib37","doi-asserted-by":"crossref","unstructured":"van Buren M, Bijlsma JA, Boer P, van Rijn HJ, and Koomans HA (1993) Natriuretic and hypotensive effect of adenosine-1 blockade in essential hypertension. Hypertension 22: 728-734.","DOI":"10.1161\/01.HYP.22.5.728"},{"key":"10.1124\/jpet.105.091462_bib38","doi-asserted-by":"crossref","unstructured":"Welch WJ (2002) Adenosine A1 receptor antagonists in the kidney: effects in fluid-retaining disorders. Curr Opin Pharmacol 2: 165-170.","DOI":"10.1016\/S1471-4892(02)00134-0"},{"key":"10.1124\/jpet.105.091462_bib39","doi-asserted-by":"crossref","unstructured":"Wilcox CS, Welch WJ, Schreiner GF, and Belardinelli L (1999) Natriuretic and diuretic actions of a highly selective adenosine A1 receptor antagonist. J Am Soc Nephrol 10: 714-720.","DOI":"10.1681\/ASN.V104714"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524324619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524324619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.105.091462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T21:44:38Z","timestamp":1740001478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524324619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0022356524324619"],"URL":"https:\/\/doi.org\/10.1124\/jpet.105.091462","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenosine A1 Receptor Antagonist Blunts Urinary Potassium Excretion, but Not Renal Hemodynamic Effects, Induced by Carbonic Anhydrase Inhibitor in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.105.091462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}