{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:53:01Z","timestamp":1758127981768,"version":"3.37.3"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1124\/jpet.106.103366","type":"journal-article","created":{"date-parts":[[2006,4,29]],"date-time":"2006-04-29T00:49:28Z","timestamp":1146271768000},"page":"725-734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Angiotensin-Converting Enzyme and Angiotensin II Receptor Subtype 1 Inhibitors Restitute Hypertensive Internal Anal Sphincter in the Spontaneously Hypertensive Rats"],"prefix":"10.1016","volume":"318","author":[{"given":"M\u00e1rcio A.F.","family":"De Godoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Rattan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.106.103366_bib1","doi-asserted-by":"crossref","unstructured":"Aihara H, Ogawa H, Kasuya A, Yoshida M, Suzuki-Kusaba M, Hisa H, and Satoh S (1999) Intrarenal angiotensin converting enzyme inhibition in spontaneously hypertensive rats. Eur J Pharmacol 373: 35-40.","DOI":"10.1016\/S0014-2999(99)00266-6"},{"key":"10.1124\/jpet.106.103366_bib2","doi-asserted-by":"crossref","unstructured":"Azpiroz F and Whitehead WE (2002) Anorectal functional testing: review of collective experience. Am J Gastroenterol 97: 232-240.","DOI":"10.1016\/S0002-9270(01)04012-6"},{"key":"10.1124\/jpet.106.103366_bib3","doi-asserted-by":"crossref","unstructured":"Bagby SP, McDonald WJ, and Mass RD (1979) Serial renin-angiotensin studies in spontaneously hypertensive and Wistar Kyoto normotensive rats: transition from normal-to high-renin status during the established phase of spontaneous hypertension. Hypertension 4: 347-354.","DOI":"10.1161\/01.HYP.1.4.347"},{"key":"10.1124\/jpet.106.103366_bib4","doi-asserted-by":"crossref","unstructured":"Bataller R, Sancho-Bru P, Gin\u00e9s P, Lora JM, Al-Garawi A, Sol\u00e9 M, Colmenero J, Nicol\u00e1s JM, Jimen\u00e9z W, Weich N, et al. (2003) Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology 125: 117-125.","DOI":"10.1016\/S0016-5085(03)00695-4"},{"key":"10.1124\/jpet.106.103366_bib5","doi-asserted-by":"crossref","unstructured":"Biancani P, Walsh JH, and Behar J (1985) Vasoactive intestinal polypeptide: a neurotransmitter for relaxation of the rabbit internal anal sphincter. Gastroenterology 89: 867-874.","DOI":"10.1016\/0016-5085(85)90585-2"},{"key":"10.1124\/jpet.106.103366_bib6","doi-asserted-by":"crossref","unstructured":"Bolterman RJ, Manriquez MC, Ruiz MCO, Juncos LA, and Romero JC (2005) Effects of captopril on the renin angiotensin system, oxidative stress and endothelin in normal and hypertensive rats. Hypertension 46: 943-947.","DOI":"10.1161\/01.HYP.0000174602.59935.d5"},{"key":"10.1124\/jpet.106.103366_bib7","doi-asserted-by":"crossref","unstructured":"Celik AF, Katsinelos P, Read NW, Khan MI, and Donnelly TC (1995) Hereditary proctalgia fugax and constipation: report of a second family. Gut 36: 581-584.","DOI":"10.1136\/gut.36.4.581"},{"key":"10.1124\/jpet.106.103366_bib8","doi-asserted-by":"crossref","unstructured":"Chomczynski P and Sacchi N (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159.","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"10.1124\/jpet.106.103366_bib9","doi-asserted-by":"crossref","unstructured":"Cook TA, Brading AF, and Mortensen NJ (2001) The pharmacology of the internal anal sphincter and new treatments of ano-rectal disorders. Aliment Pharmacol Ther 15: 887-898.","DOI":"10.1046\/j.1365-2036.2001.00995.x"},{"key":"10.1124\/jpet.106.103366_bib10","doi-asserted-by":"crossref","unstructured":"Cosentino F, Savoia C, De Paolis P, Francia P, Russo A, Maffei A, Venturelli V, Schiavoni M, Lembo M, and Volpe M (2005) Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin type 1 receptor antagonists. Am J Hypertens 18: 493-499.","DOI":"10.1016\/j.amjhyper.2004.11.007"},{"key":"10.1124\/jpet.106.103366_bib11","doi-asserted-by":"crossref","unstructured":"De Godoy MAF, Dunn SR, and Rattan S (2004) Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone. Gastroenterology 127: 127-138.","DOI":"10.1053\/j.gastro.2004.03.056"},{"key":"10.1124\/jpet.106.103366_bib12","doi-asserted-by":"crossref","unstructured":"De Godoy MAF and Rattan S (2005) Autocrine regulation of internal anal sphincter tone by renin-angiotensin system: comparison with phasic smooth muscle. Am J Physiol 289: G1164-G1175.","DOI":"10.1152\/ajpgi.00115.2005"},{"key":"10.1124\/jpet.106.103366_bib13","doi-asserted-by":"crossref","unstructured":"Dzau VJ, Burt DW, and Pratt RE (1988) Molecular biology of the renin-angiotensin system. Am J Physiol 255: F563-F573.","DOI":"10.1152\/ajprenal.1988.255.4.F563"},{"key":"10.1124\/jpet.106.103366_bib14","doi-asserted-by":"crossref","unstructured":"Dzau VJ, Ellison KE, Brody T, Ingelfinger J, and Pratt RE (1987) A comparative study of the distributions of renin and angiotensinogen messenger ribonucleic acids in rat and mouse tissues. Endocrinology 120: 2334-2338.","DOI":"10.1210\/endo-120-6-2334"},{"key":"10.1124\/jpet.106.103366_bib15","doi-asserted-by":"crossref","unstructured":"Eggena P, Krall F, Eggena MP, Clegg K, Fittingoff M, and Barret JD (1990) Production of angiotensinogen by cultured rat aortic smooth muscle cells. Clin Exp Hypertens 12: 1175-1189.","DOI":"10.3109\/10641969009074747"},{"key":"10.1124\/jpet.106.103366_bib16","doi-asserted-by":"crossref","unstructured":"Engel SI, Schaeffer TR, Gold BI, and Rubin B (1972) Inhibition of pressor effects of angiotensin I and augmentation of the depressor effects of bradykinin by synthetic peptides. Proc Soc Exp Biol Med 140: 240-244.","DOI":"10.3181\/00379727-140-36433"},{"key":"10.1124\/jpet.106.103366_bib17","doi-asserted-by":"crossref","unstructured":"Fan Y-P, Puri RN, and Rattan S (2002) Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action. Am J Physiol 282: G461-G469.","DOI":"10.1152\/ajpgi.00207.2001"},{"key":"10.1124\/jpet.106.103366_bib18","doi-asserted-by":"crossref","unstructured":"Fukada SY, Tirapelli CR, De Godoy MAF, and De Oliveira AM (2005) Mechanisms underlying the endothelium-independent relaxation induced by angiotensin II in rat aorta. J Cardiovasc Pharmacol 45: 136-143.","DOI":"10.1097\/01.fjc.0000151929.34896.c3"},{"key":"10.1124\/jpet.106.103366_bib19","doi-asserted-by":"crossref","unstructured":"Griendling KK, Murphy TJ, and Alexander RW (1993) Molecular biology of the renin-angiotensin system. Circulation 87: 1816-1828.","DOI":"10.1161\/01.CIR.87.6.1816"},{"key":"10.1124\/jpet.106.103366_bib20","doi-asserted-by":"crossref","unstructured":"Horita Y, Tadokoro M, Taura K, Suyama N, Taguchi T, Miyasaki M, and Kohno S (2004) Low-dose combination therapy with temocapril and losartan reduces proteinuria in normotensive patients with immunoglobulin A nephropathy. Hypertension Res 27: 963-970.","DOI":"10.1291\/hypres.27.963"},{"key":"10.1124\/jpet.106.103366_bib21","doi-asserted-by":"crossref","unstructured":"Hubner N, Kreutz R, Takahashi S, Ganten D, and Lindpaintner K (1995) Altered angiotensinogen amino acid sequence and plasma angiotensin II levels in genetically hypertensive rats: a study on cause and effect. Hypertension 26: 279-284.","DOI":"10.1161\/01.HYP.26.2.279"},{"key":"10.1124\/jpet.106.103366_bib22","doi-asserted-by":"crossref","unstructured":"Katwa LC, Tyagi SC, Campbell SE, Lee SJ, Cicila GT, and Weber KT (1996) Valvular interstitial cells express angiotensinogen and cathepsin D and generate angiotensin peptides. Int J Biochem Cell Biol 28: 807-821.","DOI":"10.1016\/1357-2725(96)00012-X"},{"key":"10.1124\/jpet.106.103366_bib23","doi-asserted-by":"crossref","unstructured":"Lee RM, Berecek KH, Tsoporis J, McKenzie R, and Triggle CR (1991) Prevention of hypertension and vascular changes by captopril treatment. Hypertension 17: 141-150.","DOI":"10.1161\/01.HYP.17.2.141"},{"key":"10.1124\/jpet.106.103366_bib24","doi-asserted-by":"crossref","unstructured":"Leung PS, Chan WB, Wong TP, and Sernia C (1999) Expression and localization of the renin-angiotensin system in the rat pancreas. J Endocrinol 160: 13-19.","DOI":"10.1677\/joe.0.1600013"},{"key":"10.1124\/jpet.106.103366_bib25","doi-asserted-by":"crossref","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"10.1124\/jpet.106.103366_bib26","doi-asserted-by":"crossref","unstructured":"Moummi C and Rattan S (1988) Effect of methylene blue and N-ethylmaleimide on internal anal sphincter relaxation. Am J Physiol 255: G571-G578.","DOI":"10.1152\/ajpgi.1988.255.5.G571"},{"key":"10.1124\/jpet.106.103366_bib27","doi-asserted-by":"crossref","unstructured":"Rattan S (2005) The internal anal sphincter: regulation of smooth muscle tone and relaxation. Neurogastroenterol Motil 17: 50-59.","DOI":"10.1111\/j.1365-2982.2005.00659.x"},{"key":"10.1124\/jpet.106.103366_bib28","doi-asserted-by":"crossref","unstructured":"Rubin B, Antonaccio MJ, Goldberg ME, Harris DN, Itkin AG, Horovitz ZP, Panasevich RE, and Laffan RJ (1978) Chronic antihypertensive effects of captopril (SQ 14,225) and orally active angiotensin I-converting enzyme inhibitor, in conscious 2-kidney renal hypertensive rats. Eur J Pharmacol 51: 377-388.","DOI":"10.1016\/0014-2999(78)90429-6"},{"key":"10.1124\/jpet.106.103366_bib29","doi-asserted-by":"crossref","unstructured":"Sun WM, Peck RJ, Shorthouse AJ, and Read NW (1992) Haemorrhoids are associated not with hypertrophy of the internal anal sphincter, but with hypertension of the anal cushions. Br J Surg 79: 592-594.","DOI":"10.1002\/bjs.1800790642"},{"key":"10.1124\/jpet.106.103366_bib30","doi-asserted-by":"crossref","unstructured":"Terauchi A, Kobayashi D, and Mashimo H (2005) Distinct roles of constitutive nitric oxide synthases and interstitial cells of Cajal in rectoanal relaxation. Am J Physiol 289: G291-G299.","DOI":"10.1152\/ajpgi.00005.2005"},{"key":"10.1124\/jpet.106.103366_bib31","doi-asserted-by":"crossref","unstructured":"Tramontana M, Lecci A, Meini S, Montserrat X, Pascual J, Giuliani S, Quartara L, and Maggi CA (2001) Differences between peptide and nonpeptide B2 bradykinin receptor antagonist in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized guinea pigs. J Pharmacol Exp Ther 296: 1051-1057.","DOI":"10.1016\/S0022-3565(24)38850-0"},{"key":"10.1124\/jpet.106.103366_bib32","doi-asserted-by":"crossref","unstructured":"Zhu BT (1993) The competitive and noncompetitive antagonism of receptor-mediated drug actions in the presence of spare receptors. J Pharmacol Toxicol Methods 29: 85-91.","DOI":"10.1016\/1056-8719(93)90055-J"},{"key":"10.1124\/jpet.106.103366_bib33","doi-asserted-by":"crossref","unstructured":"Zhu ZS, Wang JM, and Chen SL (2004) Mesenteric artery remodeling and effects of imidapril and irbesartan on it in spontaneously hypertensive rats. World J Gastroenterol 10: 1471-1475.","DOI":"10.3748\/wjg.v10.i10.1471"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652432837X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652432837X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.106.103366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T21:57:35Z","timestamp":1740002255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235652432837X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S002235652432837X"],"URL":"https:\/\/doi.org\/10.1124\/jpet.106.103366","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin-Converting Enzyme and Angiotensin II Receptor Subtype 1 Inhibitors Restitute Hypertensive Internal Anal Sphincter in the Spontaneously Hypertensive Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.106.103366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}