{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:43:40Z","timestamp":1792626220584,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1124\/jpet.106.111559","type":"journal-article","created":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T20:41:53Z","timestamp":1158612113000},"page":"1376-1385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":391,"title":["A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat"],"prefix":"10.1016","volume":"319","author":[{"given":"Prisca","family":"Honore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Donnelly-Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian T.","family":"Namovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Z.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe P.","family":"Mikusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gricelda","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Gauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasant","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo Perez","family":"Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kennan","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie R.","family":"Faltynek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.106.111559_bib1","doi-asserted-by":"crossref","unstructured":"Anderson CM and Nedergaard M (2006) Emerging challenges of assigning P2X (7) receptor function and immunoreactivity in neurons. Trends Neurosci 29: 257\u2013262.","DOI":"10.1016\/j.tins.2006.03.003"},{"key":"10.1124\/jpet.106.111559_bib2","doi-asserted-by":"crossref","unstructured":"Armstrong JN, Brust TB, Lewis RG, and MacViar BA (2002) Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase. J Neurosci 22: 5938\u20135945.","DOI":"10.1523\/JNEUROSCI.22-14-05938.2002"},{"key":"10.1124\/jpet.106.111559_bib3","doi-asserted-by":"crossref","unstructured":"Baraldi PG, del Carmen Nunez M, Morelli A, Flazoni S, Di Virglio F, and Romagnoli R (2003) Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor. J Med Chem 45: 1318\u20131329.","DOI":"10.1021\/jm021049d"},{"key":"10.1124\/jpet.106.111559_bib4","doi-asserted-by":"crossref","unstructured":"Beigi RD, Kertesy SB, Aquilina G, and Dubyak GR (2003) Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms. Br J Pharmacol 140: 507\u2013519.","DOI":"10.1038\/sj.bjp.0705470"},{"key":"10.1124\/jpet.106.111559_bib5","doi-asserted-by":"crossref","unstructured":"Bennett GJ and Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33: 87\u2013107.","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"10.1124\/jpet.106.111559_bib6","doi-asserted-by":"crossref","unstructured":"Bianchi BR, Lynch KJ, Touma E, Niforatos W, Burgard EC, Alexander KM, Park HS, Yu H, Metzger R, Kowaluk E, et al. (1999) Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur J Pharmacol 376: 127\u2013138.","DOI":"10.1016\/S0014-2999(99)00350-7"},{"key":"10.1124\/jpet.106.111559_bib7","doi-asserted-by":"crossref","unstructured":"Bianchi M, Dib B, and Panerai AE (1998) Interleukin-1 and nociception in the rat. J Neurosci Res 53: 645\u2013650.","DOI":"10.1002\/(SICI)1097-4547(19980915)53:6<645::AID-JNR2>3.0.CO;2-5"},{"key":"10.1124\/jpet.106.111559_bib8","doi-asserted-by":"crossref","unstructured":"Burnstock G (2006) Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol Rev 58: 58\u201378.","DOI":"10.1124\/pr.58.1.5"},{"key":"10.1124\/jpet.106.111559_bib9","doi-asserted-by":"crossref","unstructured":"Burnstock G and Wood JN (1996) Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr Opin Neurobiol 6: 526\u2013532.","DOI":"10.1016\/S0959-4388(96)80060-2"},{"key":"10.1124\/jpet.106.111559_bib10","doi-asserted-by":"crossref","unstructured":"Chakfe Y, Seguin R, Antel JP, Morissette C, Malo D, Henderson D, and Seguela P (2002) ADP and AMP induce interleukin-1 beta release from microglia cells through activation of ATP-primed P2X7 receptor channels, J Neurosci 22: 3061\u20133069.","DOI":"10.1523\/JNEUROSCI.22-08-03061.2002"},{"key":"10.1124\/jpet.106.111559_bib11","doi-asserted-by":"crossref","unstructured":"Chessell IP, Hatcher J, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, et al. (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114: 386\u2013396.","DOI":"10.1016\/j.pain.2005.01.002"},{"key":"10.1124\/jpet.106.111559_bib12","doi-asserted-by":"crossref","unstructured":"Collo G, Neidhart S, Kawashima E, Kosco-Vibois M, North RA, and Buell G (1997) Tissue distribution of the P2X7 receptor. Neuropharmacology 36: 1277\u20131283.","DOI":"10.1016\/S0028-3908(97)00140-8"},{"key":"10.1124\/jpet.106.111559_bib13","doi-asserted-by":"crossref","unstructured":"Dell\u2019Antonio A, Quattrini A, Dal Cin E, Fulgenzi A, and Ferrero ME (2002a) Antinociceptive effect of a new P2Z\/P2X7 antagonist, oxidized ATP, in arthritic rats. Neurosci Lett 327: 87\u201390.","DOI":"10.1016\/S0304-3940(02)00385-3"},{"key":"10.1124\/jpet.106.111559_bib14","doi-asserted-by":"crossref","unstructured":"Dell\u2019Antonio A, Quattrini A, Dal Cin E, Fulgenzi A, and Ferrero ME (2002b) Relief of inflammatory pain in rats by local use of the selective P2X7 ATP receptor inhibitor, oxidized ATP. Arthritis Rheum 46: 3378\u20133385.","DOI":"10.1002\/art.10678"},{"key":"10.1124\/jpet.106.111559_bib15","doi-asserted-by":"crossref","unstructured":"Di Virgilio F (2006) Novel data point to a broader mechanism of action of oxidized ATP: the P2X7 receptor is not the only target. Br J Pharmacol 140: 441\u2013443.","DOI":"10.1038\/sj.bjp.0705469"},{"key":"10.1124\/jpet.106.111559_bib16","doi-asserted-by":"crossref","unstructured":"Donnelly-Roberts DL, Namovic M, Faltynek CR, and Jarvis MF (2004) Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells. J Pharmacol Exp Ther 308: 1053\u20131061.","DOI":"10.1124\/jpet.103.059600"},{"key":"10.1124\/jpet.106.111559_bib17","doi-asserted-by":"crossref","unstructured":"Evans RJ, Lewis C, Buell G, Vlaera S, North RA, and Surprenant A (1995) Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2X purinoceptors). Mol Pharmacol 48: 178\u2013183.","DOI":"10.1016\/S0026-895X(25)10232-0"},{"key":"10.1124\/jpet.106.111559_bib18","doi-asserted-by":"crossref","unstructured":"Ferrari D, Pizzirani C, Adinolfi E, Lemoli RM, Curti A, Idzko M, Panther E, and DiVirgilio F (2006) The P2X7 receptor: a key player in IL-1 processing and release. J Immunol 176: 3877\u20133883.","DOI":"10.4049\/jimmunol.176.7.3877"},{"key":"10.1124\/jpet.106.111559_bib19","doi-asserted-by":"crossref","unstructured":"Ferreira S, Lorenzetti B, Bristow A, and Poole S (1988) Interleukin-1\u03b2 as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature (Lond) 334: 698\u2013700.","DOI":"10.1038\/334698a0"},{"key":"10.1124\/jpet.106.111559_bib20","doi-asserted-by":"crossref","unstructured":"Honore P, Wade CL, Zhong C, Harris RR, Wu C, Ghayur T, Iwakura Y, Decker MW, Faltynek C, Sullivan J, et al. (2006). Interleukin-1\u03b1\u03b2 gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain Behav Brain Res 167: 355\u2013364.","DOI":"10.1016\/j.bbr.2005.09.024"},{"key":"10.1124\/jpet.106.111559_bib21","doi-asserted-by":"crossref","unstructured":"Horai R, Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, Ikuse T, Asano M, and Iwakura Y (2000) Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 191: 313\u2013320.","DOI":"10.1084\/jem.191.2.313"},{"key":"10.1124\/jpet.106.111559_bib22","doi-asserted-by":"crossref","unstructured":"Humphrey BD and Dubyak GR (1996) Induction of the P2z\/P2X7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and IFN-\u03b3 in the human THP-1 monocytic cell line. J Immunol 157: 5627\u20135637.","DOI":"10.4049\/jimmunol.157.12.5627"},{"key":"10.1124\/jpet.106.111559_bib23","doi-asserted-by":"crossref","unstructured":"Jacobson KA, Jarvis MF, and Williams M (2002) Perspective: purine and pyrimidine: II. Receptors as drug targets. J Med Chem 45: 4057\u20134093.","DOI":"10.1021\/jm020046y"},{"key":"10.1124\/jpet.106.111559_bib24","doi-asserted-by":"crossref","unstructured":"Jarvis MF, Bianchi B, Uchic JT, Cartmell J, Lee C-H, Williams M, and Faltynek C (2004) [3H]A-317491, a novel high-affinity non-nucleotide antagonist the specifically labels human P2X2\/3 and P2X3 receptors. J Pharmacol Exp Ther 310: 407\u2013416.","DOI":"10.1124\/jpet.103.064907"},{"key":"10.1124\/jpet.106.111559_bib25","doi-asserted-by":"crossref","unstructured":"Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biessen T, Cartmell J, Bianchi B, et al. (2002) A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2\/3 receptors, reduces chronic inflammatory and neuropathic pain in rats. Proc Natl Acad Sci USA 99: 17179\u201317184.","DOI":"10.1073\/pnas.252537299"},{"key":"10.1124\/jpet.106.111559_bib26","doi-asserted-by":"crossref","unstructured":"Kahlenberg J and Dubyak GW (2004) Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Cell Physiol 286: C1100\u2013C1108.","DOI":"10.1152\/ajpcell.00494.2003"},{"key":"10.1124\/jpet.106.111559_bib27","doi-asserted-by":"crossref","unstructured":"Kim SH and Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50: 355\u2013363.","DOI":"10.1016\/0304-3959(92)90041-9"},{"key":"10.1124\/jpet.106.111559_bib28","doi-asserted-by":"crossref","unstructured":"Labasi JM, Petrushova N, Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, and Gabel CA (2002) Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 168: 6436\u20136445.","DOI":"10.4049\/jimmunol.168.12.6436"},{"key":"10.1124\/jpet.106.111559_bib29","doi-asserted-by":"crossref","unstructured":"Lakshmi S and Joshi PG (2005) Co-activation of P2Y2 receptor and TRPV channel by ATP: implications for ATP induced pain. Cell Mol Neurobiol 25: 819\u201332.","DOI":"10.1007\/s10571-005-4936-8"},{"key":"10.1124\/jpet.106.111559_bib30","unstructured":"Lappin SC, Winyard LA, Clayton N, Chambers LJ, Demont EH, Chessell IP, Richardson JC, and Gunthorpe MJ (2005) Reversal of mechanical hyperalgesia in a rat model of inflammatory pain by a potent and selective P2X7 antagonist, in Abstract 958.2 of the 35th Annual Society for Neuroscience Meeting; 2005 Nov 12\u201316; Washington, DC. Society for Neuroscience, Washington, DC."},{"key":"10.1124\/jpet.106.111559_bib31","doi-asserted-by":"crossref","unstructured":"Lynch JJ 3rd, Wade CL, Mikusa JP, Decker MW, and Honore P (2005) ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. Eur J Pharmacol 509: 43\u201348.","DOI":"10.1016\/j.ejphar.2004.12.034"},{"key":"10.1124\/jpet.106.111559_bib32","doi-asserted-by":"crossref","unstructured":"Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biessen T, Kowaluk EA, and Jarvis MF (1999) Molecular and functional characterization of human P2X(2) receptors. Mol Pharmacol 56: 1171\u20131181.","DOI":"10.1124\/mol.56.6.1171"},{"key":"10.1124\/jpet.106.111559_bib33","doi-asserted-by":"crossref","unstructured":"Maier SF, Wietelak EP, Martin D, and Watkins LR (1993) Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res 623: 321\u2013324.","DOI":"10.1016\/0006-8993(93)91446-Y"},{"key":"10.1124\/jpet.106.111559_bib34","doi-asserted-by":"crossref","unstructured":"Murgia M, Hanau S, Pizzo P, Rippa M, and Di Virgilio F (1993) Oxidized ATP: an irreversible inhibitor of the macrophage purinergic P2Z receptor. J Biol Chem 268: 8199\u201381203.","DOI":"10.1016\/S0021-9258(18)53082-9"},{"key":"10.1124\/jpet.106.111559_bib35","unstructured":"Namovic MT, Jarvis MF, and Donnelly-Roberts DL (2005) C-terminus P451L mutation does not alter the function of mouse recombinant P2X7 receptors: a pharmacological comparison of mouse, rat and human P2X7 receptors, in Abstract 958.4 of the 35th Annual Society for Neuroscience Meeting; 2005 Nov 12\u201316; Washington, DC. Society for Neuroscience, Washington, DC."},{"key":"10.1124\/jpet.106.111559_bib36","doi-asserted-by":"crossref","unstructured":"Nelson DW, Gregg RJ, Kort ME, Perez-Medrano A, Voight EA, Wang Y, Namovic MT, Grayson G, Donnelly-Roberts DL, Niforatos W, et al. (2006) Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J Med Chem 49: 3659\u20133666.","DOI":"10.1021\/jm051202e"},{"key":"10.1124\/jpet.106.111559_bib37","doi-asserted-by":"crossref","unstructured":"North AR (2002) Molecular Physiology of P2X Receptors. Physiol Rev 82: 1013\u20131067.","DOI":"10.1152\/physrev.00015.2002"},{"key":"10.1124\/jpet.106.111559_bib38","doi-asserted-by":"crossref","unstructured":"Panenka W, Jijon H, Herx LM, Armstrong N, Feighan D, Wei T, Yong VW, Ranshoff RM, and Macvicar BA (2001) P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J Neurosci 21: 7135\u20137142.","DOI":"10.1523\/JNEUROSCI.21-18-07135.2001"},{"key":"10.1124\/jpet.106.111559_bib39","doi-asserted-by":"crossref","unstructured":"Pannicke T, Fisher W, Biefermann B, Schadlich H, Grosche J, Faude F, Wiedemann P, Allgaier C, Illes P, Burnstock G, et al. (2000) P2X7-receptors activation in Mueller glial cells from the human retina. J Neurosci 20: 5965\u20135972.","DOI":"10.1523\/JNEUROSCI.20-16-05965.2000"},{"key":"10.1124\/jpet.106.111559_bib40","doi-asserted-by":"crossref","unstructured":"Parvathenani LK, Svetlana T, Greco CR, Roberts SB, Robertson B, and Posmantur R (2003) P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer\u2019s disease. J Biol Chem 278: 13309\u201313317.","DOI":"10.1074\/jbc.M209478200"},{"key":"10.1124\/jpet.106.111559_bib41","doi-asserted-by":"crossref","unstructured":"Perregaux DG and Gabel CA (1994) Interleukin-1\u03b2 maturation and release in response to ATP and nigericin. J Biol Chem 269: 15195\u201315203.","DOI":"10.1016\/S0021-9258(17)36591-2"},{"key":"10.1124\/jpet.106.111559_bib42","doi-asserted-by":"crossref","unstructured":"Romagnoli R, Baraldi PG, Pavani MG, Tabrizi MA, Moorman AR, Di Virgilio F, Cattabriga E, Pancaldi C, Gessi S, and Borea PA (2004) Synthesis, radiolabeling, and preliminary biological evaluation of [3 H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor. Bioorg Med Chem Lett 14: 5709\u20135712.","DOI":"10.1016\/j.bmcl.2004.07.095"},{"key":"10.1124\/jpet.106.111559_bib43","doi-asserted-by":"crossref","unstructured":"Safieh-Garabedian B, Poole S, Allchorne A, Winter J, and Woolf CJ (1995) Contribution of interleukin-1 to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br J Pharmacol 115: 1265\u20131275.","DOI":"10.1111\/j.1476-5381.1995.tb15035.x"},{"key":"10.1124\/jpet.106.111559_bib44","doi-asserted-by":"crossref","unstructured":"Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, and Woolf CJ (2001) Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature (Lond) 410: 471\u201375.","DOI":"10.1038\/35068566"},{"key":"10.1124\/jpet.106.111559_bib45","doi-asserted-by":"crossref","unstructured":"Sim JA, Young MT, Sung HY, North RA, and Surprenant A (2004) Reanalysis of P2X7 receptor expression in rodent brain. J Neurosci 24: 6307\u20136314.","DOI":"10.1523\/JNEUROSCI.1469-04.2004"},{"key":"10.1124\/jpet.106.111559_bib46","doi-asserted-by":"crossref","unstructured":"Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH, Griffiths RJ, and Gabel CA (2001) Altered cytokine production in mice lacking P2X7 receptors. J Biol Chem 276: 125\u2013132.","DOI":"10.1074\/jbc.M006781200"},{"key":"10.1124\/jpet.106.111559_bib47","doi-asserted-by":"crossref","unstructured":"Sommer C, Petrausch S, Lindenlaub T, and Toyka K (1999) Neutralizing antibodies to interleukin1-receptor reduce pain-associated behavior in mice with experimental neuropathy. Neurosci Lett 270: 25\u201328.","DOI":"10.1016\/S0304-3940(99)00450-4"},{"key":"10.1124\/jpet.106.111559_bib48","doi-asserted-by":"crossref","unstructured":"Surprenant A, Rassendren F, Kawashima E, North RA, and Buell G (1996) The cytolytic P2z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science (Wash DC) 272: 735\u2013738.","DOI":"10.1126\/science.272.5262.735"},{"key":"10.1124\/jpet.106.111559_bib49","doi-asserted-by":"crossref","unstructured":"Tominaga M, Wada M, and Masu M (2001) Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci USA 98: 6951\u20136956.","DOI":"10.1073\/pnas.111025298"},{"key":"10.1124\/jpet.106.111559_bib50","doi-asserted-by":"crossref","unstructured":"Touzani O, Boutin H, LeFeurve R, Parker L, Miller A, Luheshi G, and Rothwell N (2002) Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type 1 receptor. J Neurosci 22: 38\u201343.","DOI":"10.1523\/JNEUROSCI.22-01-00038.2002"},{"key":"10.1124\/jpet.106.111559_bib51","doi-asserted-by":"crossref","unstructured":"Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter M, and Inoue K (2003) P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature (Lond) 424: 778\u2013783.","DOI":"10.1038\/nature01786"},{"key":"10.1124\/jpet.106.111559_bib52","doi-asserted-by":"crossref","unstructured":"Verhoef PA, Estacion M, Schilling W, and Dubyak GR (2003) P2X7 Receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 release. J Immunol 170: 5728\u20135738.","DOI":"10.4049\/jimmunol.170.11.5728"},{"key":"10.1124\/jpet.106.111559_bib53","doi-asserted-by":"crossref","unstructured":"Wolf G, Yirmiya R, Goshen I, Iverfeldt K, Holmlund L, Takeda K, and Shavit Y (2004) Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects. Pain 104: 471\u2013480.","DOI":"10.1016\/S0304-3959(03)00067-8"},{"key":"10.1124\/jpet.106.111559_bib54","doi-asserted-by":"crossref","unstructured":"Woolf CJ, Allchorne A, Safieh-Garabedian B, and Poole S (1997) Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha. Br J Pharmacol 121: 417\u2013424.","DOI":"10.1038\/sj.bjp.0701148"},{"key":"10.1124\/jpet.106.111559_bib55","doi-asserted-by":"crossref","unstructured":"Zhang X-F, Han P, Faltynek CR, Jarvis MF, and Shieh C-C (2005) Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglion. Brain Res 1052: 63\u201370.","DOI":"10.1016\/j.brainres.2005.06.022"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524330812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524330812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.106.111559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T17:06:01Z","timestamp":1739984761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524330812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0022356524330812"],"URL":"https:\/\/doi.org\/10.1124\/jpet.106.111559","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.106.111559","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}