{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:49:50Z","timestamp":1792705790163,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1124\/jpet.106.111690","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T21:00:15Z","timestamp":1159390815000},"page":"376-385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["D2-Like Dopamine Receptors Depolarize Dorsal Raphe Serotonin Neurons through the Activation of Nonselective Cationic Conductance"],"prefix":"10.1016","volume":"320","author":[{"given":"Teresa K.","family":"Aman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roh-Yu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Haj-Dahmane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.106.111690_bib1","doi-asserted-by":"crossref","unstructured":"Aghajanian GK and Vandermaelen CP (1982) Intracellular recordings from serotoninergic dorsal raphe neurons: pacemaker potentials and the effect of LSD. Brain Res 238: 463\u2013469.","DOI":"10.1016\/0006-8993(82)90124-X"},{"key":"10.1124\/jpet.106.111690_bib2","doi-asserted-by":"crossref","unstructured":"Arango V, Underwood MD, and Mann JJ (2002) Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 136: 443\u2013453.","DOI":"10.1016\/S0079-6123(02)36037-0"},{"key":"10.1124\/jpet.106.111690_bib3","doi-asserted-by":"crossref","unstructured":"Clapham DE, Runnels LW, and Str\u00fcbing C (2001) The TRP ion channel family. Nat Rev Neurosci 2: 7\u2013396.","DOI":"10.1038\/35077544"},{"key":"10.1124\/jpet.106.111690_bib4","doi-asserted-by":"crossref","unstructured":"Cr\u00e9pel V, Aniksztein L, Ben-Ari Y, and Hammond C (1994) Glutamate metabotropic receptors increase a Ca2+-activated nonspecific cationic current in CA1 hippocampal neurons. J Neurophysiol 72: 1561\u20131569.","DOI":"10.1152\/jn.1994.72.4.1561"},{"key":"10.1124\/jpet.106.111690_bib5","doi-asserted-by":"crossref","unstructured":"Faber ESL, Sedlak P, Vidovic M, and Sah P (2006) Synaptic activation of transient receptor potential channels by metabotropic glutamate receptors in the lateral amygdale. Neuroscience 137: 781\u2013794.","DOI":"10.1016\/j.neuroscience.2005.09.027"},{"key":"10.1124\/jpet.106.111690_bib6","doi-asserted-by":"crossref","unstructured":"Ferr\u00e9 S, Cort\u00e9s R, and Artigas F (1994) Dopaminergic regulation of the serotoninergic raphe-striatal pathway: microdialysis studies in freely moving rats. J Neurosci 14: 4839\u20134846.","DOI":"10.1523\/JNEUROSCI.14-08-04839.1994"},{"key":"10.1124\/jpet.106.111690_bib7","doi-asserted-by":"crossref","unstructured":"Greengard P (2001) The neurobiology of dopamine signaling. Biosci Rep 21: 247\u2013269.","DOI":"10.1023\/A:1013205230142"},{"key":"10.1124\/jpet.106.111690_bib8","doi-asserted-by":"crossref","unstructured":"Haj-Dahmane S (2001) D2-like dopamine receptor activation excites rat dorsal raphe 5-HT neurons in vitro. Eur J Neurosci 14: 125\u2013134.","DOI":"10.1046\/j.0953-816x.2001.01616.x"},{"key":"10.1124\/jpet.106.111690_bib9","doi-asserted-by":"crossref","unstructured":"Haj-Dahmane S and Andrade R (1996) Muscrainic activation of a voltage-dependent cation nonselective current in rat association cortex. J Neurosci 16: 3848\u20133861.","DOI":"10.1523\/JNEUROSCI.16-12-03848.1996"},{"key":"10.1124\/jpet.106.111690_bib10","doi-asserted-by":"crossref","unstructured":"Harteneck C, Plant TD, and Schultz G (2000) From worm to man: three subfamilies of TRP channels. Trends Neurol Sci 23: 159\u2013166.","DOI":"10.1016\/S0166-2236(99)01532-5"},{"key":"10.1124\/jpet.106.111690_bib11","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Lopez S, Tkatch T, Perez-Garci E, Galarraga E, Bargas J, Hamm H, and Surmeier DJ (2000) D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC\u03b21-IP3-calcineurin-signaling cascade. J Neurosci 20: 8987\u20138995.","DOI":"10.1523\/JNEUROSCI.20-24-08987.2000"},{"key":"10.1124\/jpet.106.111690_bib12","doi-asserted-by":"crossref","unstructured":"Higashi H, Inanaga K, Nishi S, and Uchimura N (1989) Enhancement of dopamine actions on rat nucleus Accumbens neurons in vitro after methamphetamine pretreatment. J Physiol (Lond) 408: 587\u2013603.","DOI":"10.1113\/jphysiol.1989.sp017478"},{"key":"10.1124\/jpet.106.111690_bib13","doi-asserted-by":"crossref","unstructured":"Hofmann T, Schaefer M, Schultz G, and Gudermann T (2002) Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci USA 99: 7461\u20137466.","DOI":"10.1073\/pnas.102596199"},{"key":"10.1124\/jpet.106.111690_bib14","doi-asserted-by":"crossref","unstructured":"Innis RB, Nestler EJ, and Aghajanian GK (1988) Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain Res 459: 27\u201336.","DOI":"10.1016\/0006-8993(88)90282-X"},{"key":"10.1124\/jpet.106.111690_bib15","doi-asserted-by":"crossref","unstructured":"Jacobs BL and Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72: 165\u2013229.","DOI":"10.1152\/physrev.1992.72.1.165"},{"key":"10.1124\/jpet.106.111690_bib16","doi-asserted-by":"crossref","unstructured":"Kitahama K, Nagatsu I, Geffard M, and Maeda T (2000) Distribution of dopamine-immunoreactive fibers in the rat brainstem. J Chem Neuroanat 18: 1\u20139.","DOI":"10.1016\/S0891-0618(99)00047-2"},{"key":"10.1124\/jpet.106.111690_bib17","doi-asserted-by":"crossref","unstructured":"Kim SJ, Kim YS, Yuan JP, Petralia RS, Worley PF, and Linden DJ (2003) Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature (Lond) 426: 285\u2013291.","DOI":"10.1038\/nature02162"},{"key":"10.1124\/jpet.106.111690_bib18","doi-asserted-by":"crossref","unstructured":"Lacey MG, Mercuri NB, North RA (1987) Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta. J Physiol (Lond) 392: 397\u2013416.","DOI":"10.1113\/jphysiol.1987.sp016787"},{"key":"10.1124\/jpet.106.111690_bib19","doi-asserted-by":"crossref","unstructured":"Li HS, Xu XZ, and Montell C (1999) Activation of TRPC3-dependent cation current through the neurotrophin BDNF. Neuron 24: 261\u2013273.","DOI":"10.1016\/S0896-6273(00)80838-7"},{"key":"10.1124\/jpet.106.111690_bib20","doi-asserted-by":"crossref","unstructured":"Liu RJ, van den Pol AN, and Aghajanian GK (2002) Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J Neurosci 22: 9453\u20139464.","DOI":"10.1523\/JNEUROSCI.22-21-09453.2002"},{"key":"10.1124\/jpet.106.111690_bib21","doi-asserted-by":"crossref","unstructured":"MacKenzie RG, VanLeeuwen D, Pugsley TA, Shih YH, Demattos S, Tang L, Todd RD, and O\u2019Malley KL (1994) Characterization of the human dopamine D3 receptor expressed in transfected cell lines. Eur J Pharmacol 266: 79\u201385.","DOI":"10.1016\/0922-4106(94)90212-7"},{"key":"10.1124\/jpet.106.111690_bib22","doi-asserted-by":"crossref","unstructured":"Mansour A, Meador-Woodruff JH, Bunzow JR, Civelli O, Akil H, and Watson SJ (1990) Localization of D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J Neurosci 10: 2587\u20132600.","DOI":"10.1523\/JNEUROSCI.10-08-02587.1990"},{"key":"10.1124\/jpet.106.111690_bib23","doi-asserted-by":"crossref","unstructured":"Matsumoto M, Yoshioka M, Togashi H, Ikeda T, and Saito H (1996) Functional regulation by dopamine receptors of serotonin release from the rat hippocampus: In vivo microdialysis study. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 353: 621\u2013629.","DOI":"10.1007\/BF00167181"},{"key":"10.1124\/jpet.106.111690_bib24","doi-asserted-by":"crossref","unstructured":"Missale K, Nash SR, Robinson SW, Jaber M, and Caron MG (1998) Dopamine receptors: from structure to function. Physiol Rev 78: 189\u2013225.","DOI":"10.1152\/physrev.1998.78.1.189"},{"key":"10.1124\/jpet.106.111690_bib25","doi-asserted-by":"crossref","unstructured":"Munsch T, Yanagawa Y, Obata K, and Pape H-C (2005) Dopamine control of local interneuron activity in the thalamus. Eur J Neurosci 21: 290\u2013294.","DOI":"10.1111\/j.1460-9568.2004.03842.x"},{"key":"10.1124\/jpet.106.111690_bib26","doi-asserted-by":"crossref","unstructured":"Nemeroff CB (2003) Anxiolytics: past, present, and future agents. J Clin Psychiatry 64 (Suppl 3): 3\u20136.","DOI":"10.4088\/JCP.v64n0506"},{"key":"10.1124\/jpet.106.111690_bib27","doi-asserted-by":"crossref","unstructured":"Pan ZZ, Grudt TJ, and Williams JT (1994) \u03b11-Adrenoceptors in rat dorsal raphe neurons: regulation of two potassium conductances. J Physiol (Lond) 478: 437\u2013447.","DOI":"10.1113\/jphysiol.1994.sp020263"},{"key":"10.1124\/jpet.106.111690_bib28","doi-asserted-by":"crossref","unstructured":"Partridge LD, Muller TH, and Swandulla D (1994) Calcium-activated non-selective channels in the nervous system. Brain Res Brain Res Rev 19: 319\u2013325.","DOI":"10.1016\/0165-0173(94)90017-5"},{"key":"10.1124\/jpet.106.111690_bib29","doi-asserted-by":"crossref","unstructured":"Peyron C, Luppi PH, Kitahama K, Fort P, Hermann DM, and Jouvet M (1995) Origin of the dopaminergic innervation of the rat dorsal raphe nucleus. Neuroreport 6: 2527\u20132531.","DOI":"10.1097\/00001756-199512150-00019"},{"key":"10.1124\/jpet.106.111690_bib30","doi-asserted-by":"crossref","unstructured":"Plant TD and Schaefer M (2003) TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels. Cell Calcium 33: 441\u2013450.","DOI":"10.1016\/S0143-4160(03)00055-1"},{"key":"10.1124\/jpet.106.111690_bib31","doi-asserted-by":"crossref","unstructured":"Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, and Pangalos MN (2002) mRNA distribution analysis of human TRPC family in the CNS and peripheral tissues. Brain Res Mol Brain Res 109: 95\u2013104.","DOI":"10.1016\/S0169-328X(02)00527-2"},{"key":"10.1124\/jpet.106.111690_bib32","doi-asserted-by":"crossref","unstructured":"Seeman P and Van Tol HHM (1994) Dopamine receptor pharmacology. Trends Pharmacol Sci 15: 264\u2013270.","DOI":"10.1016\/0165-6147(94)90323-9"},{"key":"10.1124\/jpet.106.111690_bib33","doi-asserted-by":"crossref","unstructured":"Sergeeva OA, Korotkova TM, Scherer A, Brown RE, and Haas HL (2003) Coexpression of non-selective channels of the transient receptor potential canonical family in central aminergic neurones. J Neurochem 85: 1547\u20131552.","DOI":"10.1046\/j.1471-4159.2003.01806.x"},{"key":"10.1124\/jpet.106.111690_bib34","doi-asserted-by":"crossref","unstructured":"Shen KZ and North RA (1992) Muscarine increases cation conductance and decrease potassium conductance in rat locus coeruleus neurons. J Physiol (Lond) 455: 471\u2013485.","DOI":"10.1113\/jphysiol.1992.sp019312"},{"key":"10.1124\/jpet.106.111690_bib35","doi-asserted-by":"crossref","unstructured":"Str\u00fcbing C, Krapivinsky G, and Krapivinsky L, and Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29: 645\u2013655.","DOI":"10.1016\/S0896-6273(01)00240-9"},{"key":"10.1124\/jpet.106.111690_bib36","doi-asserted-by":"crossref","unstructured":"Suzuki M, Hurd YL, Sokoloff P, Schwartz JC, and Sedvall G (1998) D3 dopamine receptor mRNA is widely expressed in the human brain. Brain Res 779: 58\u201374.","DOI":"10.1016\/S0006-8993(97)01078-0"},{"key":"10.1124\/jpet.106.111690_bib37","doi-asserted-by":"crossref","unstructured":"Swandulla D and Lux HD (1985) Activation of non-specific cation conductance by intracellular Ca2+ elevation in bursting pacemaker neurons of helix pomatia. J Neurophysiol 54: 1430\u20131443.","DOI":"10.1152\/jn.1985.54.6.1430"},{"key":"10.1124\/jpet.106.111690_bib38","doi-asserted-by":"crossref","unstructured":"Uchimura N, Higashi H, and Nishi S (1986) Hyperpolarizing and depolarizing actions of dopamine via D-1 and D-2 receptors on nucleus accumbens neurons. Brain Res 375: 368\u2013372.","DOI":"10.1016\/0006-8993(86)90760-2"},{"key":"10.1124\/jpet.106.111690_bib39","doi-asserted-by":"crossref","unstructured":"Vallar L, Muca C, Magni M, Albert P, Bunzo J, and Cevilli O (1990) Differential coupling of dopaminergic D2 receptors expressed in different cell types: stimulation of phosphatidylinositol 4,5-biphosphate hydrolysis in LtK-fibroblast, hyperpolarization and cytosolic-free Ca2+ concentration decrease in GH4C1 cells. J Biol Chem 265: 10320\u201310326.","DOI":"10.1016\/S0021-9258(18)86948-4"},{"key":"10.1124\/jpet.106.111690_bib40","doi-asserted-by":"crossref","unstructured":"Yang CR, Bourque CW, and Renaud LP (1991) Dopamine D2 receptor activation depolarizes rat supraoptic neurons in hypothalamic explants. J Physiol (Lond) 443: 405\u2013419.","DOI":"10.1113\/jphysiol.1991.sp018840"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524331416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524331416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.106.111690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T17:08:02Z","timestamp":1739984882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524331416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0022356524331416"],"URL":"https:\/\/doi.org\/10.1124\/jpet.106.111690","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"D2-Like Dopamine Receptors Depolarize Dorsal Raphe Serotonin Neurons through the Activation of Nonselective Cationic Conductance","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.106.111690","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}