{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:00:33Z","timestamp":1787241633685,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1124\/jpet.106.116665","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T20:51:12Z","timestamp":1169067072000},"page":"187-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Carbon Monoxide-Mediated Activation of Large-Conductance Calcium-Activated Potassium Channels Contributes to Mesenteric Vasodilatation in Cirrhotic Rats"],"prefix":"10.1016","volume":"321","author":[{"given":"Massimo","family":"Bolognesi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sacerdoti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Piva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Di Pascoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Zampieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santina","family":"Quarta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Motterlini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Merkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Gatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.106.116665_bib1","doi-asserted-by":"crossref","unstructured":"Amberg GC, Bonev AD, Rossow CF, Nelson MT, and Santana LF (2003b) Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension. J Clin Investig 112: 717\u2013724.","DOI":"10.1172\/JCI18684"},{"key":"10.1124\/jpet.106.116665_bib2","doi-asserted-by":"crossref","unstructured":"Amberg GC and Santana LF (2003a) Downregulation of the BK channel \u03b21 subunit in genetic hypertension. Circ Res 93: 965\u2013971.","DOI":"10.1161\/01.RES.0000100068.43006.36"},{"key":"10.1124\/jpet.106.116665_bib3","doi-asserted-by":"crossref","unstructured":"Archer SL, Gragasin FS, Wu X, Wang S, McMurtry S, Kim DH, Platonov M, Koshal A, Hashimoto K, Campbell WB, et al. (2003) Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BKCa channels. Circulation 107: 769\u2013776.","DOI":"10.1161\/01.CIR.0000047278.28407.C2"},{"key":"10.1124\/jpet.106.116665_bib4","doi-asserted-by":"crossref","unstructured":"Barkoudah E, Jaggar JH, and Leffler CW (2004) The permissive role of endothelial NO in CO-induced cerebrovascular dilation. Am J Physiol 287: H1459\u2013H1465.","DOI":"10.1152\/ajpheart.00369.2004"},{"key":"10.1124\/jpet.106.116665_bib5","doi-asserted-by":"crossref","unstructured":"Barriere E, Tazi KA, Pessione F, Heller J, Poirel O, Lebrec D, and Moreau R (2001) Role of small-conductance Ca2+-dependent K+ channels in in vitro nitric oxide-mediated aortic hyporeactivity to alpha-adrenergic vasoconstriction in rats with cirrhosis. J Hepatol 35: 350\u2013357.","DOI":"10.1016\/S0168-8278(01)00141-6"},{"key":"10.1124\/jpet.106.116665_bib6","doi-asserted-by":"crossref","unstructured":"Bolognesi M, Sacerdoti D, Di Pascoli M, Angeli P, Quarta S, Sticca A, Pontisso P, Merkel C, and Gatta A (2005) Haeme oxygenase mediates hyporeactivity to phenylephrine in the mesenteric vessels of cirrhotic rats with ascites. Gut 54: 1630\u20131636.","DOI":"10.1136\/gut.2004.063735"},{"key":"10.1124\/jpet.106.116665_bib7","doi-asserted-by":"crossref","unstructured":"Bratz IN, Dick GM, Partridge LD, and Kanagy NL (2005) Reduced molecular expression of K+ channel proteins in vascular smooth muscle from rats made hypertensive with N-omega-nitro-l-arginine. Am J Physiol 289: H1284\u2013H1290.","DOI":"10.1152\/ajpheart.01053.2004"},{"key":"10.1124\/jpet.106.116665_bib8","doi-asserted-by":"crossref","unstructured":"Clapp LH and Jabr RI (2003) The BK channel: protective or detrimental in genetic hypertension? Circ Res 93: 893\u2013895.","DOI":"10.1161\/01.RES.0000103309.55054.3E"},{"key":"10.1124\/jpet.106.116665_bib9","doi-asserted-by":"crossref","unstructured":"Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R, and Motterlini R (2003) Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ Res 93: e2\u2013e8.","DOI":"10.1161\/01.RES.0000084381.86567.08"},{"key":"10.1124\/jpet.106.116665_bib10","doi-asserted-by":"crossref","unstructured":"Dubuis E, Gautier M, Melin A, Rebocho M, Girardin C, Bonnet P, and Vandier C (2002) Chronic carbon monoxide enhanced IbTx-sensitive currents in rat resistance pulmonary artery smooth muscle cells. Am J Physiol 283: L120\u2013L129.","DOI":"10.1152\/ajplung.00004.2002"},{"key":"10.1124\/jpet.106.116665_bib11","doi-asserted-by":"crossref","unstructured":"Dubuis E, Potier M, Wang R, and Vandier C (2005) Continuous inhalation of carbon monoxide attenuates hypoxic pulmonary hypertension development presumably through activation of BKCa channels. Cardiovasc Res 65: 751\u2013761.","DOI":"10.1016\/j.cardiores.2004.11.007"},{"key":"10.1124\/jpet.106.116665_bib12","doi-asserted-by":"crossref","unstructured":"Fernandez M, Lambrecht RW, and Bonkovsky HL (2001) Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: role in modulating mesenteric vascular reactivity. J Hepatol 34: 812\u2013817.","DOI":"10.1016\/S0168-8278(01)00010-1"},{"key":"10.1124\/jpet.106.116665_bib13","doi-asserted-by":"crossref","unstructured":"Foresti R, Hammad J, Clark JE, Johnson TR, Mann BE, Friebe A, Green CJ, and Motterlini R (2004) Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol 142: 453\u2013460.","DOI":"10.1038\/sj.bjp.0705825"},{"key":"10.1124\/jpet.106.116665_bib14","doi-asserted-by":"crossref","unstructured":"Gonzales-Abraldes J, Garcia-Pagan JC, and Bosch J (2002) Nitric oxide and portal hypertension. Metab Brain Dis 17: 311\u2013324.","DOI":"10.1023\/A:1021957818240"},{"key":"10.1124\/jpet.106.116665_bib15","doi-asserted-by":"crossref","unstructured":"Jaggar JH, Leffler CW, Cheranov SY, Tcheranova D, E S, and Cheng X (2002) Carbon monoxide dilates cerebral arterioles by enhancing the coupling of Ca2+ sparks to Ca2+-activated K+ channels. Circ Res 91: 610\u2013617.","DOI":"10.1161\/01.RES.0000036900.76780.95"},{"key":"10.1124\/jpet.106.116665_bib16","doi-asserted-by":"crossref","unstructured":"Jaggar JH, Li A, Parfenova H, Liu J, Umstot ES, Dopico AM, and Leffler CW (2005) Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels. Circ Res 97: 805\u2013812.","DOI":"10.1161\/01.RES.0000186180.47148.7b"},{"key":"10.1124\/jpet.106.116665_bib17","doi-asserted-by":"crossref","unstructured":"Jaggar JH, Porter VA, Lederer WJ, and Nelson MT (2000) Calcium sparks in smooth muscle. Am J Physiol 278: C235\u2013C256.","DOI":"10.1152\/ajpcell.2000.278.2.C235"},{"key":"10.1124\/jpet.106.116665_bib18","doi-asserted-by":"crossref","unstructured":"Johnson FK, Durante W, Peyton KJ, and Johnson RA (2003a) Heme oxygenase inhibitor restores arteriolar nitric oxide function in Dahl rats. Hypertension 41: 149\u2013155.","DOI":"10.1161\/01.HYP.0000046923.52222.58"},{"key":"10.1124\/jpet.106.116665_bib19","doi-asserted-by":"crossref","unstructured":"Johnson FK and Johnson RA (2003b) Carbon monoxide promotes endothelium-dependent constriction of isolated gracilis muscle arterioles. Am J Physiol 285: R536\u2013R541.","DOI":"10.1152\/ajpregu.00624.2002"},{"key":"10.1124\/jpet.106.116665_bib20","doi-asserted-by":"crossref","unstructured":"Kaide JI, Zhang F, Wei Y, Wang W, Gopal VR, Falck JR, Laniado-Schwartzman M, and Nasjletti A (2004) Vascular CO counterbalances the sensitizing influence of 20-HETE on agonist-induced vasoconstriction. Hypertension 44: 1\u20137.","DOI":"10.1161\/01.HYP.0000135658.57547.bb"},{"key":"10.1124\/jpet.106.116665_bib21","doi-asserted-by":"crossref","unstructured":"Kotlikoff M and Hall I (2003) Hypertension: \u03b2 testing. J Clin Investig 112: 654\u2013656.","DOI":"10.1172\/JCI19580"},{"key":"10.1124\/jpet.106.116665_bib22","doi-asserted-by":"crossref","unstructured":"Kozma F, Johnson RA, Zhang F, Yu C, Tong X, and Nasjletti A (1999) Contribution of endogenous carbon monoxide to regulation of diameter in resistance vessels. Am J Physiol 276: R1087\u2013R1094.","DOI":"10.1152\/ajpregu.1999.276.4.R1087"},{"key":"10.1124\/jpet.106.116665_bib23","doi-asserted-by":"crossref","unstructured":"Liu Y, Hudetz AG, Knaus HG, and Rusch NJ (1998) Increased expression of Ca2+-sensitive K+ channels in the cerebral microcirculation of genetically hypertensive rats: evidence for their protection against cerebral vasospasm. Circ Res 82: 729\u2013737.","DOI":"10.1161\/01.RES.82.6.729"},{"key":"10.1124\/jpet.106.116665_bib24","doi-asserted-by":"crossref","unstructured":"Liu Y, Pleyte K, Knaus HG, and Rusch NJ (1997) Increased expression of Ca2+-sensitive K+ channels in aorta of hypertensive rats. Hypertension 30: 1403\u20131409.","DOI":"10.1161\/01.HYP.30.6.1403"},{"key":"10.1124\/jpet.106.116665_bib25","doi-asserted-by":"crossref","unstructured":"Motterlini R, Gonzales A, Foresti R, Clark JE, Green CJ, and Winslow RM (1998) Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo. Circ Res 83: 568\u2013577.","DOI":"10.1161\/01.RES.83.5.568"},{"key":"10.1124\/jpet.106.116665_bib26","doi-asserted-by":"crossref","unstructured":"Mulvany MJ and Aalkiaer C (1990) Structure and function of small arteries. Physiol Rev 70: 921\u2013961.","DOI":"10.1152\/physrev.1990.70.4.921"},{"key":"10.1124\/jpet.106.116665_bib27","doi-asserted-by":"crossref","unstructured":"Naik JS, O\u2019Donaughy TL, and Walker BR (2003a) Endogenous carbon monoxide is an endothelial-derived vasodilator factor in the mesenteric circulation. Am J Physiol 284: H838\u2013H845.","DOI":"10.1152\/ajpheart.00747.2002"},{"key":"10.1124\/jpet.106.116665_bib28","doi-asserted-by":"crossref","unstructured":"Naik JS and Walker BR (2003b) Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization. Am J Physiol 285: H220\u2013H228.","DOI":"10.1152\/ajpheart.01131.2002"},{"key":"10.1124\/jpet.106.116665_bib29","doi-asserted-by":"crossref","unstructured":"Sacerdoti D, Bolognesi M, Di Pascoli M, Gatta A, McGiff JC, Laniado Schwartzman M, and Abraham NG (2006) The rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid (EET) is mediated by activating heme oxygenase (HO). Am J Physiol 291: 1999\u20132002.","DOI":"10.1152\/ajpheart.00082.2006"},{"key":"10.1124\/jpet.106.116665_bib30","doi-asserted-by":"crossref","unstructured":"Schrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, and Rodes J (1988) Peripheral arterial vasodilation hypothesis: a proposal fort he initiation of renal sodium and water retention in cirrhosis. Hepatology 8: 1151\u20131157.","DOI":"10.1002\/hep.1840080532"},{"key":"10.1124\/jpet.106.116665_bib31","doi-asserted-by":"crossref","unstructured":"Sieber C, Lopez-Talavera JC, and Groszmann RJ (1993) Role of nitric oxide in the in vitro splanchnic hyporeactivity in ascitic cirrhotic rats. Gastroenterology 104: 1750\u20131754.","DOI":"10.1016\/0016-5085(93)90655-V"},{"key":"10.1124\/jpet.106.116665_bib32","doi-asserted-by":"crossref","unstructured":"Sun D, Kaley G, and Koller A (1994) Characteristics and origin of myogenic response in isolated gracilis muscle arterioles. Am J Physiol 266: H1177\u2013H1183.","DOI":"10.1152\/ajpheart.1994.266.3.H1177"},{"key":"10.1124\/jpet.106.116665_bib33","doi-asserted-by":"crossref","unstructured":"Tanaka Y, Koike K, Alioua A, Stefani E, and Toro L (2004) \u03b21-subunit of maxiK channel in smooth muscle: a key molecule which tunes muscle mechanical activity. J Pharmacol Sci 94: 339\u2013347.","DOI":"10.1254\/jphs.94.339"},{"key":"10.1124\/jpet.106.116665_bib34","doi-asserted-by":"crossref","unstructured":"Villamor E, Perez-Vizcaino F, Cogolludo AL, Conde-Oviedo J, Zaragoza-Arnaez F, Lopez-Lopez JG, and Tamargo J (2000) Relaxant effects of carbon monoxide compared with nitric oxide in pulmonary and systemic vessels of newborn piglets. Pediatr Res 48: 546\u2013553.","DOI":"10.1203\/00006450-200010000-00021"},{"key":"10.1124\/jpet.106.116665_bib35","doi-asserted-by":"crossref","unstructured":"Wiest R and Groszmann RJ (1999) Nitric oxide and portal hypertension: its role in the regulation of intrahepatic and splanchnic vascular resistance. Semin Liver Dis 19: 411\u2013426.","DOI":"10.1055\/s-2007-1007129"},{"key":"10.1124\/jpet.106.116665_bib36","doi-asserted-by":"crossref","unstructured":"Wilkinson SP and Williams R (1980) Renin-angiotensin-aldosterone system in cirrhosis. Gut 21: 545\u2013554.","DOI":"10.1136\/gut.21.6.545"},{"key":"10.1124\/jpet.106.116665_bib37","doi-asserted-by":"crossref","unstructured":"Wu L, Cao K, Lu Y, and Wang R (2002) Different mechanisms underlying the stimulation of KCa channels by nitric oxide and carbon monoxide. J Clin Investig 110: 691\u2013700.","DOI":"10.1172\/JCI15316"},{"key":"10.1124\/jpet.106.116665_bib38","doi-asserted-by":"crossref","unstructured":"Wu L and Wang R (2005) Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol Rev 57: 585\u2013630.","DOI":"10.1124\/pr.57.4.3"},{"key":"10.1124\/jpet.106.116665_bib39","doi-asserted-by":"crossref","unstructured":"Zhang F, Kaide JI, Rodriguez-Mulero F, Abraham NG, and Nasjletti A (2001) Vasoregulatory function of heme-heme oxygenase-carbon monoxide system. Am J Hypertension 14: 62S\u201367S.","DOI":"10.1016\/S0895-7061(01)02071-4"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524337796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524337796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.106.116665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T17:13:13Z","timestamp":1739985193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524337796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0022356524337796"],"URL":"https:\/\/doi.org\/10.1124\/jpet.106.116665","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbon Monoxide-Mediated Activation of Large-Conductance Calcium-Activated Potassium Channels Contributes to Mesenteric Vasodilatation in Cirrhotic Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.106.116665","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}