{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T05:22:59Z","timestamp":1740028979729,"version":"3.37.3"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1124\/jpet.107.129940","type":"journal-article","created":{"date-parts":[[2007,9,14]],"date-time":"2007-09-14T00:38:58Z","timestamp":1189730338000},"page":"868-876","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-Term Changes in the Muscarinic M1 Receptor Induced by Instantaneous Formation of Wash-Resistant Xanomeline-Receptor Complex"],"prefix":"10.1016","volume":"323","author":[{"given":"Kayla C.","family":"De Lorme","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne K.O.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith J.","family":"Noetzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonya B.","family":"Polson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esam E.","family":"El-Fakahany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.107.129940_bib1","doi-asserted-by":"crossref","unstructured":"Birdsall NJ and Lazareno S (2005) Allosterism at muscarinic receptors: ligands and mechanisms. Mini Rev Med Chem 5: 523\u2013543.","DOI":"10.2174\/1389557054023251"},{"key":"10.1124\/jpet.107.129940_bib2","doi-asserted-by":"crossref","unstructured":"Bodick NC, Offen WW, Levey AI, Cutler NR, Gauthier SG, Satlin A, Shannon HE, Tollefson GD, Rasmussen K, Bymaster FP, et al. (1997) Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease. Arch Neurol 54: 465\u2013473.","DOI":"10.1001\/archneur.1997.00550160091022"},{"key":"10.1124\/jpet.107.129940_bib3","unstructured":"Bonner TI, Modi WS, Seuanez HN, and O\u2019Brien SJ (1991) Chromosomal mapping of the five human genes encoding muscarinic acetylcholine receptors. Cytogenet Cell Genet 58: 1850\u20131851."},{"key":"10.1124\/jpet.107.129940_bib4","doi-asserted-by":"crossref","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248\u2013254.","DOI":"10.1006\/abio.1976.9999"},{"key":"10.1124\/jpet.107.129940_bib5","doi-asserted-by":"crossref","unstructured":"Bunemann M and Hosey MM (1999) G-protein coupled receptor kinases as modulators of G-protein signalling. J Physiol (Lond) 517: 5\u201323.","DOI":"10.1111\/j.1469-7793.1999.0005z.x"},{"key":"10.1124\/jpet.107.129940_bib6","doi-asserted-by":"crossref","unstructured":"Bymaster FP, Carter PA, Peters SC, Zhang W, Ward JS, Mitch CH, Calligaro DO, Whitesitt CA, DeLapp N, Shannon HE, et al. (1998) Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects. Brain Res 795: 179\u2013190.","DOI":"10.1016\/S0006-8993(98)00267-4"},{"key":"10.1124\/jpet.107.129940_bib7","doi-asserted-by":"crossref","unstructured":"Bymaster FP, Whitesitt CA, Shannon HE, DeLapp N, Ward JS, Calligaro DO, Shipley LA, Buelke-Sam JL, Bodick NC, Farde L, et al. (1997) Xanomeline: a selective muscarinic agonist for the treatment of Alzheimer\u2019s disease. Drug Dev Res 40: 158\u2013170.","DOI":"10.1002\/(SICI)1098-2299(199702)40:2<158::AID-DDR6>3.0.CO;2-K"},{"key":"10.1124\/jpet.107.129940_bib8","doi-asserted-by":"crossref","unstructured":"Christopoulos A and El-Fakahany EE (1997) Novel persistent activation of muscarinic M1 receptors by xanomeline. Eur J Pharmacol 334: R3\u2013R4.","DOI":"10.1016\/S0014-2999(97)01162-X"},{"key":"10.1124\/jpet.107.129940_bib9","doi-asserted-by":"crossref","unstructured":"Christopoulos A, Pierce TL, Sorman JL, and El-Fakahany EE (1998) On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor. Mol Pharmacol 53: 1120\u20131130.","DOI":"10.1016\/S0026-895X(24)13285-3"},{"key":"10.1124\/jpet.107.129940_bib10","doi-asserted-by":"crossref","unstructured":"De Lorme KC, Sikorski KL, Grant MK, and El-Fakahany EE (2006) Long-term wash-resistant effects of brief interaction of xanomeline at the M1 muscarinic receptor. Neurosci Lett 410: 11\u201314.","DOI":"10.1016\/j.neulet.2006.09.062"},{"key":"10.1124\/jpet.107.129940_bib11","doi-asserted-by":"crossref","unstructured":"Espinoza-Fonseca LM, and Trujillo-Ferrara JG (2006) The existence of a second allosteric site on the M1 muscarinic acetylcholine receptor and its implications for drug design. Bioorg Med Chem Lett 16: 1217\u20131220.","DOI":"10.1016\/j.bmcl.2005.11.097"},{"key":"10.1124\/jpet.107.129940_bib12","doi-asserted-by":"crossref","unstructured":"Feigenbaum P and El-Fakahany EE (1985) Regulation of muscarinic cholinergic receptor density in neuroblastoma cells by brief exposure to agonist: possible involvement in desensitization of receptor function. J Pharmacol Exp Ther 233: 134\u2013140.","DOI":"10.1016\/S0022-3565(25)21131-4"},{"key":"10.1124\/jpet.107.129940_bib13","doi-asserted-by":"crossref","unstructured":"Ferguson SS (2001) Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev 53: 1\u201324.","DOI":"10.1016\/S0031-6997(24)01478-9"},{"key":"10.1124\/jpet.107.129940_bib14","unstructured":"Furchgott RF (1966) The use of beta-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes, in Advances in Drug Research (Harper NJ and Simmonds AB eds) pp 21\u201355, Academic Press, New York."},{"key":"10.1124\/jpet.107.129940_bib15","doi-asserted-by":"crossref","unstructured":"Hulme EC, Birdsall NJ, and Buckley NJ (1990) Muscarinic receptor subtypes. Annu Rev Pharmacol Toxicol 30: 633\u2013673.","DOI":"10.1146\/annurev.pa.30.040190.003221"},{"key":"10.1124\/jpet.107.129940_bib16","doi-asserted-by":"crossref","unstructured":"Jakub\u00edk J, El-Fakahany EE, and Dolezal V (2006) Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors. Mol Pharmacol 70: 656\u2013666.","DOI":"10.1124\/mol.106.023762"},{"key":"10.1124\/jpet.107.129940_bib17","doi-asserted-by":"crossref","unstructured":"Jakub\u00edk J, Tucek S, and El-Fakahany EE (2002) Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor. J Pharmacol Exp Ther 301: 1033\u20131041.","DOI":"10.1124\/jpet.301.3.1033"},{"key":"10.1124\/jpet.107.129940_bib18","doi-asserted-by":"crossref","unstructured":"Jakub\u00edk J, Tucek S, and El-Fakahany EE (2004) Role of receptor protein and membrane lipids in xanomeline wash-resistant binding to muscarinic M1 receptors. J Pharmacol Exp Ther 308: 105\u2013110.","DOI":"10.1124\/jpet.103.058594"},{"key":"10.1124\/jpet.107.129940_bib19","doi-asserted-by":"crossref","unstructured":"Ladner CJ and Lee JM (1998) Pharmacological drug treatment of Alzheimer disease: the cholinergic hypothesis revisited. J Neuropathol Exp Neurol 57: 719\u2013731.","DOI":"10.1097\/00005072-199808000-00001"},{"key":"10.1124\/jpet.107.129940_bib20","doi-asserted-by":"crossref","unstructured":"McKinney M and Coyle JT (1991) The potential for muscarinic receptor subtype-specific pharmacotherapy for Alzheimer\u2019s disease. Mayo Clin Proc 66: 1225\u20131237.","DOI":"10.1016\/S0025-6196(12)62474-4"},{"key":"10.1124\/jpet.107.129940_bib21","doi-asserted-by":"crossref","unstructured":"Messer WS Jr (2002) Cholinergic agonists and the treatment of Alzheimer\u2019s disease. Curr Top Med Chem 2: 353\u2013358.","DOI":"10.2174\/1568026024607553"},{"key":"10.1124\/jpet.107.129940_bib22","doi-asserted-by":"crossref","unstructured":"Nitsch RM, Slack BE, Farber SA, Schultz JG, Deng M, Kim C, Borghesani PR, Korver W, Wurman RJ, and Growdon JH (1994) Regulation of proteolytic processing of the amyloid beta-protein precursor of Alzheimer\u2019s disease in transfected cell lines and in brain slices. J Neural Transm Suppl 44: 21\u201327.","DOI":"10.1007\/978-3-7091-9350-1_2"},{"key":"10.1124\/jpet.107.129940_bib23","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Puertas R, Pascual J, Vilar\u00f3 T, and Pazos A (1997) Autoradiographic distribution of M1, M2, M3, and M4 muscarinic receptor subtypes in Alzheimer\u2019s disease. Synapse 26: 341\u2013350.","DOI":"10.1002\/(SICI)1098-2396(199708)26:4<341::AID-SYN2>3.0.CO;2-6"},{"key":"10.1124\/jpet.107.129940_bib24","doi-asserted-by":"crossref","unstructured":"Shannon HE, Bymaster FP, Calligaro DO, Greenwood B, Mitch CH, Sawyer BD, Ward JS, Wong DT, Olesen PH, Sheardown MJ, et al. (1994) Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors. J Pharmacol Exp Ther 269: 271\u2013281.","DOI":"10.1016\/S0022-3565(25)38667-2"},{"key":"10.1124\/jpet.107.129940_bib25","doi-asserted-by":"crossref","unstructured":"Spalding TA, Trotter C, Skjaerbaerk N, Messier TL, Currier EA, Burstein ES, Li D, Hacksell U, and Brann MR (2002) Discovery of an ectopic activation site on the M1 muscarinic receptor. Mol Pharmacol 61: 1297\u20131302.","DOI":"10.1124\/mol.61.6.1297"},{"key":"10.1124\/jpet.107.129940_bib26","unstructured":"Van Rossum JM (1968) Drug receptor theories, in Recent Advances in Pharmacology (Robson JM and Stacey RS eds) pp 99\u2013133, Churchill, London, UK."},{"key":"10.1124\/jpet.107.129940_bib27","doi-asserted-by":"crossref","unstructured":"Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, and Delon MR (1982) Alzheimer\u2019s disease and senile dementia: loss of neurons in the basal forebrain. Science 215: 1237\u20131239.","DOI":"10.1126\/science.7058341"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524341837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524341837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.107.129940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T22:27:45Z","timestamp":1740004065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524341837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0022356524341837"],"URL":"https:\/\/doi.org\/10.1124\/jpet.107.129940","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-Term Changes in the Muscarinic M1 Receptor Induced by Instantaneous Formation of Wash-Resistant Xanomeline-Receptor Complex","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.107.129940","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2007 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}