{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:31:15Z","timestamp":1790069475198,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1124\/jpet.107.131888","type":"journal-article","created":{"date-parts":[[2008,1,9]],"date-time":"2008-01-09T03:53:38Z","timestamp":1199850818000},"page":"10-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Anti-Inflammatory and Analgesic Potency of Carboxyamidotriazole, a Tumorostatic Agent"],"prefix":"10.1016","volume":"325","author":[{"given":"Lei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dechang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.107.131888_bib1","doi-asserted-by":"crossref","unstructured":"Arend WP and Dayer JM (1995) Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum 38: 151\u2013160.","DOI":"10.1002\/art.1780380202"},{"key":"10.1124\/jpet.107.131888_bib2","unstructured":"Bauer KS, Figg WD, Hamilton JM, Jones EC, Premkumar A, Steinberg SM, Dyer V, Linehan WM, Pluda JM, and Reed E (1999) A pharmacokinetically guided Phase II study of carboxyamido-triazole in androgen-independent prostate cancer. Clin Cancer Res 5: 2324\u20132329."},{"key":"10.1124\/jpet.107.131888_bib3","unstructured":"Berlin J, Tutsch KD, Arzoomanian RZ, Alberti D, Binger K, Feierabend C, Dresen A, Marnocha R, Pluda J, and Wilding G (2002) Phase I and pharmacokinetic study of a micronized formulation of carboxyamidotriazole, a calcium signal transduction inhibitor: toxicity, bioavailability and the effect of food. Clin Cancer Res 8: 86\u201394."},{"key":"10.1124\/jpet.107.131888_bib4","doi-asserted-by":"crossref","unstructured":"Berlin J, Tutsch KD, Hutson P, Cleary J, Rago RP, Arzoomanian RZ, Alberti D, Feierabend C, and Wilding G (1997) Phase I clinical and pharmacokinetic study of oral carboxyamidotriazole, a signal transduction inhibitor. J Clin Oncol 15: 781\u2013789.","DOI":"10.1200\/JCO.1997.15.2.781"},{"key":"10.1124\/jpet.107.131888_bib5","unstructured":"Claffey KP, Brown LF, del Aguila LF, Tognazzi K, Yeo KT, Manseau EJ, and Dvorak HF (1996) Expression of vascular permeability factor\/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res 56: 172\u2013181."},{"key":"10.1124\/jpet.107.131888_bib6","doi-asserted-by":"crossref","unstructured":"Collier HO, Dinneen LC, Johnson CA, and Schneider C (1968) The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 32: 295\u2013310.","DOI":"10.1111\/j.1476-5381.1968.tb00973.x"},{"key":"10.1124\/jpet.107.131888_bib7","doi-asserted-by":"crossref","unstructured":"Coussens LM and Werb Z (2002) Inflammation and cancer. Nature 420: 860\u2013867.","DOI":"10.1038\/nature01322"},{"key":"10.1124\/jpet.107.131888_bib8","doi-asserted-by":"crossref","unstructured":"Dubuisson D and Dennis SG (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4: 161\u2013174.","DOI":"10.1016\/0304-3959(77)90130-0"},{"key":"10.1124\/jpet.107.131888_bib9","doi-asserted-by":"crossref","unstructured":"Enfissi A, Prigent S, Colosetti P, and Capiod T (2004) The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells. Cell Calcium 36: 459\u2013467.","DOI":"10.1016\/j.ceca.2004.04.004"},{"key":"10.1124\/jpet.107.131888_bib10","doi-asserted-by":"crossref","unstructured":"Felder CC, Ma AL, Liotta LA, and Kohn EC (1991) The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J Pharmacol Exp Ther 257: 967\u2013971.","DOI":"10.1016\/S0022-3565(25)24706-1"},{"key":"10.1124\/jpet.107.131888_bib11","doi-asserted-by":"crossref","unstructured":"Feldmann M, Andreakos E, Smith C, Bondeson J, Yoshimura S, Kiriakidis S, Monaco C, Gasparini C, Sacre S, Lundberg A, et al. (2002) Is NF-\u03baB a useful therapeutic target in rheumatoid arthritis? Ann Rheum Dis 61: 13\u201318.","DOI":"10.1136\/ard.61.suppl_2.ii13"},{"key":"10.1124\/jpet.107.131888_bib12","doi-asserted-by":"crossref","unstructured":"Griffioen AW and Molema G (2000) Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 52: 237\u2013268.","DOI":"10.1016\/S0031-6997(24)01448-0"},{"key":"10.1124\/jpet.107.131888_bib13","doi-asserted-by":"crossref","unstructured":"Hunskaar S and Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30: 103\u2013114.","DOI":"10.1016\/0304-3959(87)90088-1"},{"key":"10.1124\/jpet.107.131888_bib14","doi-asserted-by":"crossref","unstructured":"Hupe DJ, Boltz R, Cohen CJ, Felix J, Ham E, Miller D, Soderman D, and van Skiver D (1991) The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582. J Biol Chem 266: 10136\u201310142.","DOI":"10.1016\/S0021-9258(18)99200-8"},{"key":"10.1124\/jpet.107.131888_bib15","doi-asserted-by":"crossref","unstructured":"Jacobs W, Mikkelsen T, Smith R, Nelson K, Rosenblum ML, and Kohn EC (1997) Inhibitory effects of CAI in glioblastoma growth and invasion. J Neurooncol 32: 93\u2013101.","DOI":"10.1023\/A:1005777711567"},{"key":"10.1124\/jpet.107.131888_bib16","doi-asserted-by":"crossref","unstructured":"Kohn EC, Alessandro R, Spoonster J, Wersto RP, and Liotta LA (1995) Angiogenesis: role of calcium-mediated signal transduction. Proc Natl Acad Sci U S A 92: 1307\u20131311.","DOI":"10.1073\/pnas.92.5.1307"},{"key":"10.1124\/jpet.107.131888_bib17","doi-asserted-by":"crossref","unstructured":"Kohn EC, Figg WD, Sarosy GA, Bauer KS, Davis PA, Soltis MJ, Thompkins A, Liotta LA, and Reed E (1997) Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations. J Clin Oncol 15: 1985\u20131993.","DOI":"10.1200\/JCO.1997.15.5.1985"},{"key":"10.1124\/jpet.107.131888_bib18","doi-asserted-by":"crossref","unstructured":"Kohn EC and Liotta LA (1990) L651582: a novel antiproliferative and antimetastasis agent. J Natl Cancer Inst 82: 54\u201360.","DOI":"10.1093\/jnci\/82.1.54"},{"key":"10.1124\/jpet.107.131888_bib19","unstructured":"Kohn EC, Reed E, Sarosy GA, Minasian L, Bauer KS, Bostick-Bruton F, Kulpa V, Fuse E, Tompkins A, Noone M, et al. (2001) A phase I trial of carboxyamidotriazole and paclitaxel for relapsed solid tumors: potential efficacy of the combination and demonstration of pharmacokinetic interaction. Clin Cancer Res 7: 1600\u20131609."},{"key":"10.1124\/jpet.107.131888_bib20","doi-asserted-by":"crossref","unstructured":"Kollias G, Douni E, Kassiotis G, and Kontoyiannis D (1999) On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Immunol Rev 169: 175\u2013194.","DOI":"10.1111\/j.1600-065X.1999.tb01315.x"},{"key":"10.1124\/jpet.107.131888_bib21","doi-asserted-by":"crossref","unstructured":"Lambert PA, Somers KD, Kohn EC, and Perry RR (1997) Antiproliferative and antiinvasive effects of carboxyamido-triazole on breast cancer cell lines. Surgery 122: 372\u2013378.","DOI":"10.1016\/S0039-6060(97)90029-5"},{"key":"10.1124\/jpet.107.131888_bib22","doi-asserted-by":"crossref","unstructured":"Lu H, Ouyang W, and Huang C (2006) Inflammation, a key event in cancer development. Mol Cancer Res 4: 221\u2013233.","DOI":"10.1158\/1541-7786.MCR-05-0261"},{"key":"10.1124\/jpet.107.131888_bib23","doi-asserted-by":"crossref","unstructured":"Luzzi KJ, Varghese HJ, MacDonald IC, Kohn EC, Schmidt EE, Morris VL, Chambers AF, and Groom AC (1998) Inhibition of angiogenesis in liver metastases by carboxyamidotriazole (CAI): computer assisted analysis. Angiogenesis 2: 373\u2013379.","DOI":"10.1023\/A:1009259521092"},{"key":"10.1124\/jpet.107.131888_bib24","doi-asserted-by":"crossref","unstructured":"Majno G (1998) Chronic inflammation: links with angiogenesis and wound healing. Am J Pathol 153: 1035\u20131039.","DOI":"10.1016\/S0002-9440(10)65648-9"},{"key":"10.1124\/jpet.107.131888_bib25","doi-asserted-by":"crossref","unstructured":"Miles AA and Miles EM (1952) Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of guinea pigs. J Physiol 118: 228\u2013257.","DOI":"10.1113\/jphysiol.1952.sp004789"},{"key":"10.1124\/jpet.107.131888_bib26","doi-asserted-by":"crossref","unstructured":"Moody TW, Chiles J, Moody E, Sieczkiewicz GJ, and Kohn EC (2003) CAI inhibits the growth of small cell lung cancer cells. Lung Cancer 39: 279\u2013288.","DOI":"10.1016\/S0169-5002(02)00525-1"},{"key":"10.1124\/jpet.107.131888_bib27","doi-asserted-by":"crossref","unstructured":"Newbould BB (1963) Chemotherapy of arthritis induced in rats by mycobacterial adjuvant. Br J Pharmacol Chemother 21: 127\u2013136.","DOI":"10.1111\/j.1476-5381.1963.tb01508.x"},{"key":"10.1124\/jpet.107.131888_bib28","doi-asserted-by":"crossref","unstructured":"Olajide OA, Makinde JM, Okpako DT, and Awe SO (2000) Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark. J Ethnopharmacol 71: 153\u2013160.","DOI":"10.1016\/S0378-8741(99)00201-9"},{"key":"10.1124\/jpet.107.131888_bib29","unstructured":"Perabo FG, Wirger A, Kamp S, Lindner H, Schmidt DH, Muller SC, and Kohn EC (2004) Carboxyamido-triazole (CAI), a signal transduction inhibitor induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2. Anticancer Res 24: 2869\u20132877."},{"key":"10.1124\/jpet.107.131888_bib30","doi-asserted-by":"crossref","unstructured":"Rotrosen D and Gallin JI (1986) Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin and promotes albumin diffusion across cultured endothelial monolayers. J Cell Biol 103: 2379\u20132387.","DOI":"10.1083\/jcb.103.6.2379"},{"key":"10.1124\/jpet.107.131888_bib31","doi-asserted-by":"crossref","unstructured":"Stefanovic-Racic M, Stadler J, and Evans CH (1993) Nitric oxide and arthritis. Arthritis Rheum 36: 1036\u20131044.","DOI":"10.1002\/art.1780360803"},{"key":"10.1124\/jpet.107.131888_bib32","doi-asserted-by":"crossref","unstructured":"Storgard CM, Stupack DG, Jonczyk A, Goodman SL, Fox RI, and Cheresh DA (1999) Decreased angiogenesis and arthritic disease in rabbits treated with an avb3 antagonist. J Clin Invest 103: 47\u201354.","DOI":"10.1172\/JCI3756"},{"key":"10.1124\/jpet.107.131888_bib33","doi-asserted-by":"crossref","unstructured":"Swingle KF and Shideman FE (1972) Phases of the inflammatory response to subcutaneous implantation of a cotton pellet and their modification by certain antiinflammatory agents. J Pharmacol Exp Ther 183: 226\u2013234.","DOI":"10.1016\/S0022-3565(25)29332-6"},{"key":"10.1124\/jpet.107.131888_bib34","doi-asserted-by":"crossref","unstructured":"Thurston G, Murphy TJ, Baluk P, Lindsey JR, and McDonald DM (1998) Strain dependent differences in angiogenesis in mice with chronic airway inflammation. Am J Pathol 153: 1099\u20131112.","DOI":"10.1016\/S0002-9440(10)65654-4"},{"key":"10.1124\/jpet.107.131888_bib35","doi-asserted-by":"crossref","unstructured":"Tj\u00f8lsen A, Berge O, Hunskaar S, Roseland JK, and Hole K (1992) The formalin test: an evaluation of the method. Pain 51: 5\u201317.","DOI":"10.1016\/0304-3959(92)90003-T"},{"key":"10.1124\/jpet.107.131888_bib36","doi-asserted-by":"crossref","unstructured":"Walz DT, Dimartino MJ, and Misher A (1971) Adjuvant-induced arthritis in rats. II. Drug effects on physiologic, biochemical and immunologic parameters. J Pharmacol Exp Ther 178: 223\u2013231.","DOI":"10.1016\/S0022-3565(25)28953-4"},{"key":"10.1124\/jpet.107.131888_bib37","doi-asserted-by":"crossref","unstructured":"Wasilenko WJ, Palad AJ, Somers KD, Blackmore PF, Kohn EC, Rhim JS, Wright GL Jr, and Schellhammer PF (1996) Effects of the calcium influx inhibitor carboxyamido-triazole on the proliferation and invasiveness of human prostate tumor cell lines. Int J Cancer 68: 259\u2013264.","DOI":"10.1002\/(SICI)1097-0215(19961009)68:2<259::AID-IJC20>3.0.CO;2-4"},{"key":"10.1124\/jpet.107.131888_bib38","doi-asserted-by":"crossref","unstructured":"Wu H, Yuan Y, Zawieja DC, Tinsley J, and Granger HJ (1999) Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability Am J Physiol Heart Circ Physiol 276: H535\u2013H542.","DOI":"10.1152\/ajpheart.1999.276.2.H535"},{"key":"10.1124\/jpet.107.131888_bib39","doi-asserted-by":"crossref","unstructured":"Yasui H, Butscher W, Cohen M, Spriggs N, Wersto R, Kohn EC, Liotta L, and Gardner K (1997) Selective inhibition of mitogen-induced transactivation of the HIV Long Terminal Repeat by carboxyamidotriazole. J Biol Chem 272: 28762\u201328770.","DOI":"10.1074\/jbc.272.45.28762"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524343551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524343551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.107.131888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T22:34:35Z","timestamp":1740004475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524343551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0022356524343551"],"URL":"https:\/\/doi.org\/10.1124\/jpet.107.131888","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-Inflammatory and Analgesic Potency of Carboxyamidotriazole, a Tumorostatic Agent","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.107.131888","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}