{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:33:21Z","timestamp":1769078001876,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1124\/jpet.108.143040","type":"journal-article","created":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T02:11:41Z","timestamp":1229393501000},"page":"682-691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Characterization of Serotonin Receptors in Pregnant Human Myometrium"],"prefix":"10.1016","volume":"328","author":[{"given":"Yolande","family":"Cordeaux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharmintra","family":"Pasupathy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Stephen","family":"Charnock-Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon C.S.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.108.143040_bib1","doi-asserted-by":"crossref","unstructured":"Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, and Branchek TA (1993) Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A 15: 408-412.","DOI":"10.1073\/pnas.90.2.408"},{"key":"10.1124\/jpet.108.143040_bib2","doi-asserted-by":"crossref","unstructured":"Agosti RM (2007) 5HT1F- and 5HT7-receptor agonists for the treatment of migraines. CNS Neurol Disord Drug Targets 6: 235-237.","DOI":"10.2174\/187152707781387242"},{"key":"10.1124\/jpet.108.143040_bib3","doi-asserted-by":"crossref","unstructured":"Alexander SP, Mathie A, and Peters JA (2008) Guide to receptors and channels (GRAC) 3rd ed. Br J Pharmacol 153 (Suppl 2): S1-S209.","DOI":"10.1038\/sj.bjp.0707746"},{"key":"10.1124\/jpet.108.143040_bib4","doi-asserted-by":"crossref","unstructured":"Bard JA, Zgombick J, Adham N, Vaysse P, Branchek TA, and Weinshank RL (1993) Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylyl cyclase. J Biol Chem 268: 23422-23426.","DOI":"10.1016\/S0021-9258(19)49479-9"},{"key":"10.1124\/jpet.108.143040_bib5","doi-asserted-by":"crossref","unstructured":"Bardou M, Cortijo J, Loustalot C, Taylor S, Perales-Mar\u00edn A, Mercier FJ, Dumas M, Deneux-Tharaux C, Frydman R, Morcillo EJ, et al. (1999) Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium. Naunyn Schmiedebergs Arch Pharmacol 360: 457-463.","DOI":"10.1007\/s002109900092"},{"key":"10.1124\/jpet.108.143040_bib6","doi-asserted-by":"crossref","unstructured":"Barnes NM and Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38: 1083-1152.","DOI":"10.1016\/S0028-3908(99)00010-6"},{"key":"10.1124\/jpet.108.143040_bib7","doi-asserted-by":"crossref","unstructured":"Castillo C, Ibarra M, M\u00e1rquez JA, Villalobos-Molina R, and Hong E (1993) Pharmacological evidence for interactions between 5-HT1A receptor agonists and subtypes of alpha-adrenoceptors on rabbit aorta. Eur J Pharmacol 241: 141-148.","DOI":"10.1016\/0014-2999(93)90195-N"},{"key":"10.1124\/jpet.108.143040_bib8","doi-asserted-by":"crossref","unstructured":"Chemel BR, Roth BL, Armbruster B, Watts VJ, and Nichols DE (2006) WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl) 188: 244-251.","DOI":"10.1007\/s00213-006-0490-4"},{"key":"10.1124\/jpet.108.143040_bib9","doi-asserted-by":"crossref","unstructured":"Cohen ML, Schenck KW, Colbert W, and Wittenauer L (1985) Role of 5-HT2 receptors in serotonin-induced contractions of nonvascular smooth muscle. J Pharmacol Exp Ther 232: 770-774.","DOI":"10.1016\/S0022-3565(25)20915-6"},{"key":"10.1124\/jpet.108.143040_bib10","unstructured":"Contractor SF, Jones JJ, Lee J, and Morris NF (1968) The responses of the human myometrium to 5-hydroxytryptamine (5-HT) and oxytocin (Syntocinon) and its monoamine oxidase (MAO) activity during gestation. J Physiol 195: 16P-17P."},{"key":"10.1124\/jpet.108.143040_bib11","doi-asserted-by":"crossref","unstructured":"Cordeaux Y, Missfelder-Lobos H, Charnock-Jones DS, and Smith GCS (2008) Stimulation of contractions in human myometrium by serotonin is unmasked by smooth muscle relaxants. Reprod Sci 15: 727-734.","DOI":"10.1177\/1933719108317582"},{"key":"10.1124\/jpet.108.143040_bib12","doi-asserted-by":"crossref","unstructured":"De Ponti F (2004) Pharmacology of serotonin: what a clinician should know. Gut 53: 1520-1535.","DOI":"10.1136\/gut.2003.035568"},{"key":"10.1124\/jpet.108.143040_bib13","doi-asserted-by":"crossref","unstructured":"Freyburger WA, Graham BE, Rapport MM, Seay PH, Govier WM, Swoap OF, and Vander Brook MJ (1952) The pharmacology of 5-hydroxytryptamine (serotonin). J Pharmacol Exp Ther 105: 80-86.","DOI":"10.1016\/S0022-3565(25)05010-4"},{"key":"10.1124\/jpet.108.143040_bib14","doi-asserted-by":"crossref","unstructured":"Hoyer D, Hannon JP, and Martin GR (2002) Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71: 533-554.","DOI":"10.1016\/S0091-3057(01)00746-8"},{"key":"10.1124\/jpet.108.143040_bib15","doi-asserted-by":"crossref","unstructured":"K\u00e4ll\u00e9n B and Lygner PE (2001) Delivery outcome in women who used drugs for migraine during pregnancy with special reference to sumatriptan. Headache 41: 351-356.","DOI":"10.1046\/j.1526-4610.2001.111006351.x"},{"key":"10.1124\/jpet.108.143040_bib16","doi-asserted-by":"crossref","unstructured":"Katz A, Wu D, and Simon MI (1992) Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C. Nature 360: 686-689.","DOI":"10.1038\/360686a0"},{"key":"10.1124\/jpet.108.143040_bib17","doi-asserted-by":"crossref","unstructured":"Kaumann AJ and Levy FO (2006) 5-hydroxytryptamine receptors in the human cardiovascular system. Pharmacol Ther 111: 674-706.","DOI":"10.1016\/j.pharmthera.2005.12.004"},{"key":"10.1124\/jpet.108.143040_bib18","doi-asserted-by":"crossref","unstructured":"Kelly CR and Sharif NA (2006) Pharmacological evidence for a functional serotonin-2B receptor in a human uterine smooth muscle cell line. J Pharmacol Exp Ther 317: 1254-1261.","DOI":"10.1124\/jpet.105.100172"},{"key":"10.1124\/jpet.108.143040_bib19","doi-asserted-by":"crossref","unstructured":"Kimura T, Takemura M, Nomura S, Nobunaga T, Kubota Y, Inoue T, Hashimoto K, Kumazawa I, Ito Y, Ohashi K, et al. (1996) Expression of oxytocin receptor in human pregnant myometrium. Endocrinology 137: 780-785.","DOI":"10.1210\/endo.137.2.8593830"},{"key":"10.1124\/jpet.108.143040_bib20","doi-asserted-by":"crossref","unstructured":"Kitazawa T, Kubo O, Satoh M, and Taneike T (1998) Involvement of 5-hydroxytryptamine 7 receptors in inhibition of porcine myometrial contractility by 5-hydroxytryptamine. Br J Pharmacol 123: 173-182.","DOI":"10.1038\/sj.bjp.0701583"},{"key":"10.1124\/jpet.108.143040_bib21","doi-asserted-by":"crossref","unstructured":"Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, and Bickerdike M (2004) Pharmacological characterisation of the agonist radioligand binding sites of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol 370: 114-123.","DOI":"10.1007\/s00210-004-0951-4"},{"key":"10.1124\/jpet.108.143040_bib22","doi-asserted-by":"crossref","unstructured":"Krobert KA, Bach T, Syversveen T, Kvingedal AM, and Levy FO (2001) The cloned human 5-HT7 receptor slice variants: a comparative characterization of their pharmacology, function and distribution. Naunyn Schmiedebergs Arch Pharmacol 363: 620-632.","DOI":"10.1007\/s002100000369"},{"key":"10.1124\/jpet.108.143040_bib23","doi-asserted-by":"crossref","unstructured":"Lindstr\u00f6m TM and Bennett PR (2005) The role of nuclear factor kappa B in human labour. Reproduction 130: 569-581.","DOI":"10.1530\/rep.1.00197"},{"key":"10.1124\/jpet.108.143040_bib24","doi-asserted-by":"crossref","unstructured":"McLean PG and Coupar IM (1996) Stimulation of cyclic AMP formation in the circular smooth muscle of human colon by activation of 5HT4-like receptors. Br J Pharmacol 117: 238-239.","DOI":"10.1111\/j.1476-5381.1996.tb15182.x"},{"key":"10.1124\/jpet.108.143040_bib25","doi-asserted-by":"crossref","unstructured":"Mih\u00e1lyi A, Ducza E, G\u00e1sp\u00e1r R, and Falkay G (2003) Investigation of the role of the serotonergic activity of certain subtype-selective alpha1A antagonists in the relaxant effect on the pregnant rat uterus in vitro. Mol Hum Reprod 9: 475-480.","DOI":"10.1093\/molehr\/gag061"},{"key":"10.1124\/jpet.108.143040_bib26","doi-asserted-by":"crossref","unstructured":"Minosyan TY, Lu R, Eghbali M, Toro L, and Stefani E (2007) Increased 5-HT contractile response in late pregnant rat myometrium is associated with a higher density of 5-HT2A receptors. J Physiol 581: 91-97.","DOI":"10.1113\/jphysiol.2007.129726"},{"key":"10.1124\/jpet.108.143040_bib27","doi-asserted-by":"crossref","unstructured":"Newman-Tancredi A, Wootton R, and Strange PG (1992) High-level stable expression of recombinant 5-HT1A 5-hydroxytryptamine receptors in Chinese hamster ovary cells. Biochem J 285: 933-938.","DOI":"10.1042\/bj2850933"},{"key":"10.1124\/jpet.108.143040_bib28","doi-asserted-by":"crossref","unstructured":"Olesen C, Steffensen FH, Sorensen HT, Nielsen GL, and Olsen J (2000) Pregnancy outcome following prescription for sumatriptan. Headache 40: 20-24.","DOI":"10.1046\/j.1526-4610.2000.00003.x"},{"key":"10.1124\/jpet.108.143040_bib29","doi-asserted-by":"crossref","unstructured":"Perez-Garc\u00eda GS and Meneses A (2005) Effects of the potential 5-HT7 receptor agonist AS19 in an autoshaping learning task. Behav Brain Res 163: 136-140.","DOI":"10.1016\/j.bbr.2005.04.014"},{"key":"10.1124\/jpet.108.143040_bib30","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Garc\u00eda G, Gonzalez-Espinosa C, and Meneses A (2006) An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. Behav Brain Res 169: 83-92.","DOI":"10.1016\/j.bbr.2005.12.013"},{"key":"10.1124\/jpet.108.143040_bib31","doi-asserted-by":"crossref","unstructured":"Roth BL, Nakaki T, Chuang DM, and Costa E (1984) Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover. Neuropharmacology 23: 1223-1225.","DOI":"10.1016\/0028-3908(84)90244-2"},{"key":"10.1124\/jpet.108.143040_bib32","doi-asserted-by":"crossref","unstructured":"Rudolph MI, Reinicke K, Cruz MA, Gallardo V, Gonzalez C, and Bardisa L (1993) Distribution of mast cells and the effects of their mediators on contractility in human myometrium. Br J Obstet Gynaecol 100: 1125-1130.","DOI":"10.1111\/j.1471-0528.1993.tb15178.x"},{"key":"10.1124\/jpet.108.143040_bib33","doi-asserted-by":"crossref","unstructured":"Soldin OP, Dahlin J, and O\u2019Mara DM (2008) Triptans in Pregnancy. Ther Drug Monit 30: 5-9.","DOI":"10.1097\/FTD.0b013e318162c89b"},{"key":"10.1124\/jpet.108.143040_bib34","doi-asserted-by":"crossref","unstructured":"Woolley DW (1958) A probable mechanism of action of serotonin. Proc Natl Acad Sci U S A 44: 197-201.","DOI":"10.1073\/pnas.44.2.197"},{"key":"10.1124\/jpet.108.143040_bib35","doi-asserted-by":"crossref","unstructured":"Wu C, Yoder EJ, Shih J, Chen K, Dias P, Shi L, Ji XD, Wei J, Conner JM, Kumar S, et al. (1998) Development and characterisation of monoclonal antibodies specific to the serotonin 5-HT2A receptor. J Histochem Cytochem 46: 811-824.","DOI":"10.1177\/002215549804600704"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524348190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524348190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.108.143040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T22:51:46Z","timestamp":1740005506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524348190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0022356524348190"],"URL":"https:\/\/doi.org\/10.1124\/jpet.108.143040","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of Serotonin Receptors in Pregnant Human Myometrium","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.108.143040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}