{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:57:33Z","timestamp":1790143053376,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1124\/jpet.108.143925","type":"journal-article","created":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:44:44Z","timestamp":1223513084000},"page":"193-200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Effects of Atypical \u03ba-Opioid Receptor Agonists on Intrathecal Morphine-Induced Itch and Analgesia in Primates"],"prefix":"10.1016","volume":"328","author":[{"given":"Mei-Chuan","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Husbands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.108.143925_bib1","doi-asserted-by":"crossref","unstructured":"Bailey PL, Rhondeau S, Schafer PG, Lu JK, Timmins BS, Foster W, Pace NL, and Stanley TH (1993) Dose-response pharmacology of intrathecal morphine in human volunteers. Anesthesiology 79: 49-59.","DOI":"10.1097\/00000542-199307000-00010"},{"key":"10.1124\/jpet.108.143925_bib2","doi-asserted-by":"crossref","unstructured":"Butelman ER, Ko MC, Sobczyk-Kojiro K, Mosberg HI, Van Bemmel B, Zernig G, and Woods JH (1998) Kappa-opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception. J Pharmacol Exp Ther 285: 595-601.","DOI":"10.1016\/S0022-3565(24)37419-1"},{"key":"10.1124\/jpet.108.143925_bib3","doi-asserted-by":"crossref","unstructured":"Butelman ER, Ko MC, Traynor JR, Vivian JA, Kreek MJ, and Woods JH (2001) GR89,696: a potent \u03ba-opioid agonist with subtype selectivity in rhesus monkeys. J Pharmacol Exp Ther 298: 1049-1059.","DOI":"10.1016\/S0022-3565(24)29474-X"},{"key":"10.1124\/jpet.108.143925_bib4","doi-asserted-by":"crossref","unstructured":"Butelman ER, Negus SS, Ai Y, de Costa BR, and Woods JH (1993) Kappa opioid antagonist effects of systemically administered nor-binaltorphimine in a thermal antinociception assay in rhesus monkeys. J Pharmacol Exp Ther 267: 1269-1276.","DOI":"10.1016\/S0022-3565(25)39577-7"},{"key":"10.1124\/jpet.108.143925_bib5","doi-asserted-by":"crossref","unstructured":"Cohen SE, Ratner EF, Kreitzman TR, Archer JH, and Mignano LR (1992) Nalbuphine is better than naloxone for treatment of side effects after epidural morphine. Anesth Analg 75: 747-752.","DOI":"10.1213\/00000539-199211000-00016"},{"key":"10.1124\/jpet.108.143925_bib6","doi-asserted-by":"crossref","unstructured":"Cousins MJ and Mather LE (1984) Intrathecal and epidural administration of opioids. Anesthesiology 61: 276-310.","DOI":"10.1097\/00000542-198409000-00008"},{"key":"10.1124\/jpet.108.143925_bib7","doi-asserted-by":"crossref","unstructured":"Cowan A and Gmerek DE (1986) In vivo studies on kappa opioid receptors. Trends Pharmacol Sci 7: 69-72.","DOI":"10.1016\/0165-6147(86)90257-9"},{"key":"10.1124\/jpet.108.143925_bib8","doi-asserted-by":"crossref","unstructured":"Davidson S, Zhang X, Yoon CH, Khasabov SG, Simone DA, and Giesler GJ Jr (2007) The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci 27: 10007-10014.","DOI":"10.1523\/JNEUROSCI.2862-07.2007"},{"key":"10.1124\/jpet.108.143925_bib9","doi-asserted-by":"crossref","unstructured":"DeBalli P and Breen TW (2003) Intrathecal opioids for combined spinal-epidural analgesia during labour. CNS Drugs 17: 889-904.","DOI":"10.2165\/00023210-200317120-00003"},{"key":"10.1124\/jpet.108.143925_bib10","doi-asserted-by":"crossref","unstructured":"Emmerson PJ, Liu MR, Woods JH, and Medzihradsky F (1994) Binding affinity and selectivity of opioids at mu, delta and kappa receptors in monkey brain membranes. J Pharmacol Exp Ther 271: 1630-1637.","DOI":"10.1016\/S0022-3565(25)24051-4"},{"key":"10.1124\/jpet.108.143925_bib11","doi-asserted-by":"crossref","unstructured":"Endoh T, Tajima A, Izumimoto N, Suzuki T, Saitoh A, Suzuki T, Narita M, Kamei J, Tseng LF, Mizoguchi H, et al. (2001) TRK-820, a selective \u03ba-opioid agonist, produces potent antinociception in cynomolgus monkeys. Jpn J Pharmacol 85: 282-290.","DOI":"10.1254\/jjp.85.282"},{"key":"10.1124\/jpet.108.143925_bib12","doi-asserted-by":"crossref","unstructured":"France CP, Medzihradsky F, and Woods JH (1994) Comparison of kappa opioids in rhesus monkeys: behavioral effects and receptor binding affinities. J Pharmacol Exp Ther 268: 47-58.","DOI":"10.1016\/S0022-3565(25)38497-1"},{"key":"10.1124\/jpet.108.143925_bib13","doi-asserted-by":"crossref","unstructured":"Ganesh A and Maxwell LG (2007) Pathophysiology and management of opioid-induced pruritus. Drugs 67: 2323-2333.","DOI":"10.2165\/00003495-200767160-00003"},{"key":"10.1124\/jpet.108.143925_bib14","doi-asserted-by":"crossref","unstructured":"Gmerek DE, Dykstra LA, and Woods JH (1987) Kappa opioids in rhesus monkeys: III. Dependence associated with chronic administration. J Pharmacol Exp Ther 242: 428-436.","DOI":"10.1016\/S0022-3565(25)39099-3"},{"key":"10.1124\/jpet.108.143925_bib15","doi-asserted-by":"crossref","unstructured":"Heishman SJ, Stitzer ML, Bigelow GE, and Liebson IA (1989) Acute opioid physical dependence in postaddict humans: naloxone dose effects after brief morphine exposure. J Pharmacol Exp Ther 248: 127-134.","DOI":"10.1016\/S0022-3565(25)23620-5"},{"key":"10.1124\/jpet.108.143925_bib16","doi-asserted-by":"crossref","unstructured":"Inan S and Cowan A (2006) Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats. Pharmacol Biochem Behav 85: 39-43.","DOI":"10.1016\/j.pbb.2006.07.004"},{"key":"10.1124\/jpet.108.143925_bib17","unstructured":"Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals, 7th ed, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council and National Academy Press, Washington, DC."},{"key":"10.1124\/jpet.108.143925_bib18","doi-asserted-by":"crossref","unstructured":"Kamei J and Nagase H (2001) Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice. Eur J Pharmacol 418: 141-145.","DOI":"10.1016\/S0014-2999(01)00941-4"},{"key":"10.1124\/jpet.108.143925_bib19","doi-asserted-by":"crossref","unstructured":"Kishioka S, Paronis CA, and Woods JH (2000) Acute dependence on, but not tolerance to, heroin and morphine as measured by respiratory effects in rhesus monkeys. Eur J Pharmacol 398: 121-130.","DOI":"10.1016\/S0014-2999(00)00279-X"},{"key":"10.1124\/jpet.108.143925_bib20","doi-asserted-by":"crossref","unstructured":"Ko MC, Butelman ER, Traynor JR, and Woods JH (1998) Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys. J Pharmacol Exp Ther 285: 518-526.","DOI":"10.1016\/S0022-3565(24)37416-6"},{"key":"10.1124\/jpet.108.143925_bib21","doi-asserted-by":"crossref","unstructured":"Ko MC, Johnson MD, Butelman ER, Willmont KJ, Mosberg HI, and Woods JH (1999) Intracisternal nor-binaltorphimine distinguishes central and peripheral \u03ba-opioid antinociception in rhesus monkeys. J Pharmacol Exp Ther 291: 1113-1120.","DOI":"10.1016\/S0022-3565(24)35216-4"},{"key":"10.1124\/jpet.108.143925_bib22","doi-asserted-by":"crossref","unstructured":"Ko MCH and Naughton NN (2000) An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception. Anesthesiology 92: 795-805.","DOI":"10.1097\/00000542-200003000-00023"},{"key":"10.1124\/jpet.108.143925_bib23","doi-asserted-by":"crossref","unstructured":"Ko MC, Lee H, Song MS, Sobczyk-Kojiro K, Mosberg HI, Kishioka S, Woods JH, and Naughton NN (2003a) Activation of \u03ba-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. J Pharmacol Exp Ther 305: 173-179.","DOI":"10.1124\/jpet.102.044909"},{"key":"10.1124\/jpet.108.143925_bib24","doi-asserted-by":"crossref","unstructured":"Ko MC, Willmont KJ, Lee H, Flory GS, and Woods JH (2003b) Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys. Brain Res 982: 38-44.","DOI":"10.1016\/S0006-8993(03)02938-X"},{"key":"10.1124\/jpet.108.143925_bib25","doi-asserted-by":"crossref","unstructured":"Ko MC, Song MS, Edwards T, Lee H, and Naughton NN (2004) The role of central \u03bc opioid receptors in opioid-induced itch in primates. J Pharmacol Exp Ther 310: 169-176.","DOI":"10.1124\/jpet.103.061101"},{"key":"10.1124\/jpet.108.143925_bib26","doi-asserted-by":"crossref","unstructured":"Lee H, Naughton NN, Woods JH, and Ko MCH (2003) Characterization of scratching responses in rats following centrally administered morphine or bombesin. Behav Pharmacol 14: 501-508.","DOI":"10.1097\/00008877-200311000-00002"},{"key":"10.1124\/jpet.108.143925_bib27","doi-asserted-by":"crossref","unstructured":"Lee H, Naughton NN, Woods JH, and Ko MC (2007) Effects of butorphanol on morphine-induced itch and analgesia in primates. Anesthesiology 107: 478-485.","DOI":"10.1097\/01.anes.0000278876.20263.a7"},{"key":"10.1124\/jpet.108.143925_bib28","doi-asserted-by":"crossref","unstructured":"Li J, Li JG, Chen C, Zhang F, and Liu-Chen LY (2002) Molecular basis of differences in (-)(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzeneacetamide-induced desensitization and phosphorylation between human and rat kappa-opioid receptors expressed in chinese hamster ovary cells. Mol Pharmacol 61: 73-84.","DOI":"10.1124\/mol.61.1.73"},{"key":"10.1124\/jpet.108.143925_bib29","doi-asserted-by":"crossref","unstructured":"Liu-Chen LY (2004) Agonist-induced regulation and trafficking of kappa opioid receptors. Life Sci 75: 511-536.","DOI":"10.1016\/j.lfs.2003.10.041"},{"key":"10.1124\/jpet.108.143925_bib30","doi-asserted-by":"crossref","unstructured":"Mizoguchi H, Hung KC, Leitermann R, Narita M, Nagase H, Suzuki T, and Tseng LF (2003) Blockade of \u03bc-opioid receptor-mediated G-protein activation and antinociception by TRK-820 in mice. Eur J Pharmacol 461: 35-39.","DOI":"10.1016\/S0014-2999(03)01299-8"},{"key":"10.1124\/jpet.108.143925_bib31","doi-asserted-by":"crossref","unstructured":"Palmer CM, Emerson S, Volgoropolous D, and Alves D (1999) Dose-response relationship of intrathecal morphine for postcesarean analgesia. Anesthesiology 90: 437-444.","DOI":"10.1097\/00000542-199902000-00018"},{"key":"10.1124\/jpet.108.143925_bib32","doi-asserted-by":"crossref","unstructured":"Rawal N, Sch\u00f6tt U, Dahlstr\u00f6m B, Inturrisi CE, Tandon B, Sj\u00f6strand U, and Wennhager M (1986) Influence of naloxone infusion on analgesia and respiratory depression following epidural morphine. Anesthesiology 64: 194-201.","DOI":"10.1097\/00000542-198602000-00011"},{"key":"10.1124\/jpet.108.143925_bib33","doi-asserted-by":"crossref","unstructured":"Simonin F, Gav\u00e9riaux-Ruff C, Befort K, Matthes H, Lannes B, Micheletti G, Matt\u00e9i MG, Charron G, Bloch B, and Kieffer B (1995) \u03ba-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc Natl Acad Sci U S A 92: 7006-7010.","DOI":"10.1073\/pnas.92.15.7006"},{"key":"10.1124\/jpet.108.143925_bib34","doi-asserted-by":"crossref","unstructured":"Tallarida RJ (2000) Drug Synergism and Dose-Effect Data Analysis, CRC Press, Boca Raton, FL.","DOI":"10.1201\/9781420036107"},{"key":"10.1124\/jpet.108.143925_bib35","doi-asserted-by":"crossref","unstructured":"Togashi Y, Umeuchi H, Okano K, Ando N, Yoshizawa Y, Honda T, Kawamura K, Endoh T, Utsumi J, Kamei J, et al. (2002) Antipruritic activity of the \u03ba-opioid receptor agonist, TRK-820. Eur J Pharmacol 435: 259-264.","DOI":"10.1016\/S0014-2999(01)01588-6"},{"key":"10.1124\/jpet.108.143925_bib36","unstructured":"Toll L, Berzetei-Gurske IP, Polgar WE, Brandt SR, Adapa ID, Rodriguez L, Schwartz RW, Haggart D, O\u2019Brien A, White A, et al. (1998) Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA Res Monogr 178: 440-466."},{"key":"10.1124\/jpet.108.143925_bib37","doi-asserted-by":"crossref","unstructured":"Umeuchi H, Togashi Y, Honda T, Nakao K, Okano K, Tanaka T, and Nagase H (2003) Involvement of central \u03bc-opioid system in the scratching behavior in mice, and the suppression of it by the activation of \u03ba-opioid system. Eur J Pharmacol 477: 29-35.","DOI":"10.1016\/j.ejphar.2003.08.007"},{"key":"10.1124\/jpet.108.143925_bib38","doi-asserted-by":"crossref","unstructured":"Wakasa Y, Fujiwara A, Umeuchi H, Endoh T, Okano K, Tanaka T, and Nagase H (2004) Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys. Life Sci 75: 2947-2957.","DOI":"10.1016\/j.lfs.2004.05.033"},{"key":"10.1124\/jpet.108.143925_bib39","doi-asserted-by":"crossref","unstructured":"Wang JJ, Ho ST, and Tzeng JI (1998) Comparison of intravenous nalbuphine infusion versus naloxone in the prevention of epidural morphine-related side effects. Reg Anesth Pain Med 23: 479-484.","DOI":"10.1097\/00115550-199823050-00009"},{"key":"10.1124\/jpet.108.143925_bib40","doi-asserted-by":"crossref","unstructured":"Wang Y, Tang K, Inan S, Siebert D, Holzgrabe U, Lee DY, Huang P, Li JG, Cowan A, and Liu-Chen LY (2005) Comparison of pharmacologic activities of three distinct \u03ba ligands (salvinorin A, TRK-820 and 3FLB) on \u03ba opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo. J Pharmacol Exp Ther 312: 220-230.","DOI":"10.1124\/jpet.104.073668"},{"key":"10.1124\/jpet.108.143925_bib41","doi-asserted-by":"crossref","unstructured":"Wikstr\u00f6m B, Gellert R, Ladefoged SD, Danda Y, Akai M, Ide K, Ogasawara M, Kawashima Y, Ueno K, Mori A, et al. (2005) Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blinded, placebo-controlled clinical studies. J Am Soc Nephrol 16: 3742-3747.","DOI":"10.1681\/ASN.2005020152"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652434755X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235652434755X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.108.143925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T22:49:52Z","timestamp":1740005392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235652434755X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S002235652434755X"],"URL":"https:\/\/doi.org\/10.1124\/jpet.108.143925","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Atypical \u03ba-Opioid Receptor Agonists on Intrathecal Morphine-Induced Itch and Analgesia in Primates","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.108.143925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}