{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:31:12Z","timestamp":1776288672291,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1124\/jpet.108.147124","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T02:09:16Z","timestamp":1229998156000},"page":"1007-1018","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Discriminative Stimulus and Subject-Rated Effects of Methamphetamine, d-Amphetamine, Methylphenidate, and Triazolam in Methamphetamine-Trained Humans"],"prefix":"10.1016","volume":"328","author":[{"given":"Rajkumar J.","family":"Sevak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Stoops","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lon R.","family":"Hays","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig R.","family":"Rush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.108.147124_bib1","doi-asserted-by":"crossref","unstructured":"Abreu ME and Griffiths RR (1996) Drug tasting may confound human drug discrimination studies. Psychopharmacology (Berl) 125: 255-257.","DOI":"10.1007\/BF02247336"},{"key":"10.1124\/jpet.108.147124_bib2","doi-asserted-by":"crossref","unstructured":"Carboni E and Silvagni A (2004) Experimental investigations on dopamine transmission can provide clues on the mechanism of the therapeutic effect of amphetamine and methylphenidate in ADHD. Neural Plast 11: 77-95.","DOI":"10.1155\/NP.2004.77"},{"key":"10.1124\/jpet.108.147124_bib3","doi-asserted-by":"crossref","unstructured":"Clemens KJ, Cornish JL, Hunt GE, and McGregor IS (2006) Intravenous methamphetamine self-administration in rats: effects of intravenous or intraperitoneal MDMA co-administration. Pharmacol Biochem Behav 85: 454-463.","DOI":"10.1016\/j.pbb.2006.09.015"},{"key":"10.1124\/jpet.108.147124_bib4","doi-asserted-by":"crossref","unstructured":"Czoty PW, Makriyannis A, and Bergman J (2004a) Methamphetamine discrimination and in vivo microdialysis in squirrel monkeys. Psychopharmacology (Berl) 175: 170-178.","DOI":"10.1007\/s00213-004-1798-6"},{"key":"10.1124\/jpet.108.147124_bib5","doi-asserted-by":"crossref","unstructured":"Czoty PW, Ramanathan CR, Mutschler NH, Makriyannis A, and Bergman J (2004b) Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors. J Pharmacol Exp Ther 311: 720-727.","DOI":"10.1124\/jpet.104.071035"},{"key":"10.1124\/jpet.108.147124_bib6","doi-asserted-by":"crossref","unstructured":"Danks RR, Wibbenmeyer LA, Faucher LD, Sihler KC, Kealey GP, Chang P, Amelon M, and Lewis RW 3rd (2004) Methamphetamine-associated burn injuries: a retrospective analysis. J Burn Care Rehabil 25: 425-429.","DOI":"10.1097\/01.BCR.0000138298.30449.AA"},{"key":"10.1124\/jpet.108.147124_bib7","doi-asserted-by":"crossref","unstructured":"Degenhardt L, Baker A, and Maher L (2008) Methamphetamine: geographic areas and populations at risk, and emerging evidence for effective interventions. Drug Alcohol Rev 27: 217-219.","DOI":"10.1080\/09595230801956538"},{"key":"10.1124\/jpet.108.147124_bib8","doi-asserted-by":"crossref","unstructured":"De La Garza R 2nd, Mahoney JJ 3rd, Culbertson C, Shoptaw S, and Newton TF (2008) The acetylcholinesterase inhibitor rivastigmine does not alter total choices for methamphetamine, but may reduce positive subjective effects, in a laboratory model of intravenous self-administration in human volunteers. Pharmacol Biochem Behav 89: 200-208.","DOI":"10.1016\/j.pbb.2007.12.010"},{"key":"10.1124\/jpet.108.147124_bib9","doi-asserted-by":"crossref","unstructured":"Desai RI, Paronis CA, Makriyannis A, Thakur GA, and Bergman J (2007) Discriminative-stimulus effects of methamphetamine and in vivo microdialysis in rats. FASEB J 21: 715.3.","DOI":"10.1096\/fasebj.21.6.A776-b"},{"key":"10.1124\/jpet.108.147124_bib10","unstructured":"Di Marino ME, Haberny KA, Felch LJ, Walsh SL, Preston KL, and Bigelow GE (1998) Development of a subjective rating scale sensitive to acute cocaine administration, in Problems of Drug Dependence 1997: Proceedings of the 59th Annual Scientific Meeting of the College on Problems of Drug Dependence. National Institute on Drug Abuse Research Monograph Series no. 178 (Harris LS ed) pp 139. National Institute on Drug Abuse, Rockville, MD."},{"key":"10.1124\/jpet.108.147124_bib11","doi-asserted-by":"crossref","unstructured":"Fleckenstein AE, Gibb JW, and Hanson GR (2000) Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. Eur J Pharmacol 406: 1-13.","DOI":"10.1016\/S0014-2999(00)00639-7"},{"key":"10.1124\/jpet.108.147124_bib12","doi-asserted-by":"crossref","unstructured":"Fone KC and Nutt DJ (2005) Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder. Curr Opin Pharmacol 5: 87-93.","DOI":"10.1016\/j.coph.2004.10.001"},{"key":"10.1124\/jpet.108.147124_bib13","doi-asserted-by":"crossref","unstructured":"Fustero S, Gonz\u00e1lez J, and del Pozo C (2006) 1,4-Benzodiazepine N-nitrosoamidines: useful intermediates in the synthesis of tricyclic benzodiazepines. Molecules 11: 583-588.","DOI":"10.3390\/11080583"},{"key":"10.1124\/jpet.108.147124_bib14","doi-asserted-by":"crossref","unstructured":"Gonsalves VM, Sapp JL, and Huss MT (2007) A comparison of methamphetamine and nonamphetamine users in a dual diagnosis facility. Addict Res Theory 15: 277-284.","DOI":"10.1080\/16066350701407021"},{"key":"10.1124\/jpet.108.147124_bib15","doi-asserted-by":"crossref","unstructured":"Halkitis PN, Parsons JT, and Stirratt MJ (2001) A double epidemic: crystal methamphetamine drug use in relation to HIV transmission among gay men. J Homosex 41: 17-35.","DOI":"10.1300\/J082v41n02_02"},{"key":"10.1124\/jpet.108.147124_bib16","doi-asserted-by":"crossref","unstructured":"Hart CL, Haney M, Foltin RW, and Fischman MW (2002) Effects of the NMDA antagonist memantine on human methamphetamine discrimination. Psychopharmacology (Berl) 164: 376-384.","DOI":"10.1007\/s00213-002-1225-9"},{"key":"10.1124\/jpet.108.147124_bib17","doi-asserted-by":"crossref","unstructured":"Hart CL, Ward AS, Haney M, Foltin RW, and Fischman MW (2001) Methamphetamine self-administration by humans. Psychopharmacology (Berl) 157: 75-81.","DOI":"10.1007\/s002130100738"},{"key":"10.1124\/jpet.108.147124_bib18","doi-asserted-by":"crossref","unstructured":"Holtzman SG (2001) Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine. Psychopharmacology (Berl) 155: 180-186.","DOI":"10.1007\/s002130100684"},{"key":"10.1124\/jpet.108.147124_bib19","doi-asserted-by":"crossref","unstructured":"Huang JT and Ho BT (1974) Discriminative stimulus properties of d-amphetamine and related compounds in rats. Pharmacol Biochem Behav 2: 669-673.","DOI":"10.1016\/0091-3057(74)90036-7"},{"key":"10.1124\/jpet.108.147124_bib20","doi-asserted-by":"crossref","unstructured":"Jasinski D (1977) Assessment of the abuse potentiality of morphine-like drugs (methods used in man), in Drug Addiction I (Martin WR ed) pp 197-258, Springer-Verlag New York Inc., New York.","DOI":"10.1007\/978-3-642-66612-4_4"},{"key":"10.1124\/jpet.108.147124_bib21","doi-asserted-by":"crossref","unstructured":"Johanson CE, Lundahl LH, Lockhart N, and Schubiner H (2006) Intravenous cocaine discrimination in humans. Exp Clin Psychopharmacol 14: 99-108.","DOI":"10.1037\/1064-1297.14.2.99"},{"key":"10.1124\/jpet.108.147124_bib22","doi-asserted-by":"crossref","unstructured":"Lamb RJ and Henningfield JE (1994) Human d-amphetamine drug discrimination: methamphetamine and hydromorphone. J Exp Anal Behav 61: 169-180.","DOI":"10.1901\/jeab.1994.61-169"},{"key":"10.1124\/jpet.108.147124_bib23","doi-asserted-by":"crossref","unstructured":"Lile JA, Stoops WW, Durell TM, Glaser PE, and Rush CR (2006) Discriminative-stimulus, self-reported, performance, and cardiovascular effects of atomoxetine in methylphenidate-trained humans. Exp Clin Psychopharmacol 14: 136-147.","DOI":"10.1037\/1064-1297.14.2.136"},{"key":"10.1124\/jpet.108.147124_bib24","doi-asserted-by":"crossref","unstructured":"Martin WR, Sloan JW, Sapira JD, and Jasinski DR (1971) Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man. Clin Pharmacol Ther 12: 245-258.","DOI":"10.1002\/cpt1971122part1245"},{"key":"10.1124\/jpet.108.147124_bib25","doi-asserted-by":"crossref","unstructured":"Maxwell JC and Rutkowski BA (2008) The prevalence of methamphetamine and amphetamine abuse in North America: a review of the indicators, 1992-2007. Drug Alcohol Rev 27: 229-235.","DOI":"10.1080\/09595230801919460"},{"key":"10.1124\/jpet.108.147124_bib26","doi-asserted-by":"crossref","unstructured":"Mayfield DG (1973) The effect of intravenous methamphetamine on mood. Int J Addict 8: 565-568.","DOI":"10.3109\/10826087309062056"},{"key":"10.1124\/jpet.108.147124_bib27","doi-asserted-by":"crossref","unstructured":"McLeod DR, Griffiths RR, Bigelow GE, and Yingling JE (1982) An automated version of the digit symbol substitution test (DSST). Behav Res Methods Instr 14: 463-466.","DOI":"10.3758\/BF03203313"},{"key":"10.1124\/jpet.108.147124_bib28","doi-asserted-by":"crossref","unstructured":"Newton TF, De La Garza R 2nd, Kalechstein AD, and Nestor L (2005) Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects. Pharmacol Biochem Behav 82: 90-97.","DOI":"10.1016\/j.pbb.2005.07.012"},{"key":"10.1124\/jpet.108.147124_bib29","doi-asserted-by":"crossref","unstructured":"Oliveto AH, Bickel WK, Hughes JR, Shea PJ, Higgins ST, and Fenwick JW (1992) Caffeine drug discrimination in humans: acquisition, specificity and correlation with self-reports. J Pharmacol Exp Ther 261: 885-894.","DOI":"10.1016\/S0022-3565(25)11160-9"},{"key":"10.1124\/jpet.108.147124_bib30","doi-asserted-by":"crossref","unstructured":"Patrick KS and Markowitz JS (1997) Pharmacology of methylphenidate, amphetamine enantiomers and pemoline in attention-deficit hyperactivity disorder. Hum Psychopharmacol Clin Exp 12: 527-546.","DOI":"10.1002\/(SICI)1099-1077(199711\/12)12:6<527::AID-HUP932>3.0.CO;2-U"},{"key":"10.1124\/jpet.108.147124_bib31","doi-asserted-by":"crossref","unstructured":"Rush CR and Baker RW (2001) Behavioral pharmacological similarities between methylphenidate and cocaine in cocaine abusers. Exp Clin Psychopharmacol 9: 59-73.","DOI":"10.1037\/\/1064-1297.9.1.59"},{"key":"10.1124\/jpet.108.147124_bib32","doi-asserted-by":"crossref","unstructured":"Rush CR, Essman WD, Simpson CA, and Baker RW (2001) Reinforcing and subjectrated effects of methylphenidate and d-amphetamine in non-drug-abusing humans. J Clin Psychopharmacol 21: 273-286.","DOI":"10.1097\/00004714-200106000-00005"},{"key":"10.1124\/jpet.108.147124_bib33","doi-asserted-by":"crossref","unstructured":"Rush CR, Kollins SH, and Pazzaglia PJ (1998) Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans. Exp Clin Psychopharmacol 6: 32-44.","DOI":"10.1037\/\/1064-1297.6.1.32"},{"key":"10.1124\/jpet.108.147124_bib34","doi-asserted-by":"crossref","unstructured":"Rush CR, Stoops WW, Hays LR, Glaser PE, and Hays LS (2003) Risperidone attenuates the discriminative-stimulus effects of d-amphetamine in humans. J Pharmacol Exp Ther 306: 195-204.","DOI":"10.1124\/jpet.102.048439"},{"key":"10.1124\/jpet.108.147124_bib35","doi-asserted-by":"crossref","unstructured":"Stoops WW, Lile JA, Glaser PE, and Rush CR (2005) Discriminative stimulus and self-reported effects of methylphenidate, d-amphetamine, and triazolam in methylphenidate-trained humans. Exp Clin Psychopharmacol 13: 56-64.","DOI":"10.1037\/1064-1297.13.1.56"},{"key":"10.1124\/jpet.108.147124_bib36","unstructured":"Substance Abuse and Mental Health Service Administration (2006) Results from the National Survey on Drug Use and Health. NSDUH Series H-32, DHHS Publication No. SMA 07-4293, National Findings Office of Applied Sciences, Rockville, MD."},{"key":"10.1124\/jpet.108.147124_bib37","unstructured":"Substance Abuse and Mental Health Service Administration. Drug Abuse Warning Network (2005) National Estimates of Drug-Related Emergency Department visits Office of Applied Studies, DAWN Series D-29, DHHS Publication No (SMA) 07-4256, Rockville, MD."},{"key":"10.1124\/jpet.108.147124_bib38","unstructured":"Substance Abuse and Mental Health Service Administration Drug and Alcohol Services Information System (2004) Primary methamphetamine\/amphetamin treatment admissions increase: 1992-2002 report, Office of Applied Studies Publications and Data Dissemination, Rockville, MD."},{"key":"10.1124\/jpet.108.147124_bib39","doi-asserted-by":"crossref","unstructured":"Sun J, Xu X, Wang C, and You T (2008) Analysis of amphetamines in urine with liquid-liquid extraction by capillary electrophoresis with simultaneous electrochemical and electrochemiluminescence detection. Electrophoresis 29: 3999-4007.","DOI":"10.1002\/elps.200700875"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524348566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524348566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.108.147124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T22:53:07Z","timestamp":1740005587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524348566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0022356524348566"],"URL":"https:\/\/doi.org\/10.1124\/jpet.108.147124","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discriminative Stimulus and Subject-Rated Effects of Methamphetamine, d-Amphetamine, Methylphenidate, and Triazolam in Methamphetamine-Trained Humans","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.108.147124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}