{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:56:52Z","timestamp":1762541812375,"version":"3.37.3"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1124\/jpet.108.148478","type":"journal-article","created":{"date-parts":[[2009,2,14]],"date-time":"2009-02-14T12:32:21Z","timestamp":1234614741000},"page":"615-624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Involution of Collagen-Induced Arthritis with an Angiogenesis Inhibitor, PPI-2458"],"prefix":"10.1016","volume":"329","author":[{"given":"Ernest","family":"Brahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Schoettler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona L.","family":"Banquerigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.108.148478_bib1","doi-asserted-by":"crossref","unstructured":"Bainbridge J, Madden L, Essex D, Binks M, Malhotra R, and Paleolog EM (2007) Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition. Arthritis Res Ther 9: R127.","DOI":"10.1186\/ar2340"},{"key":"10.1124\/jpet.108.148478_bib2","unstructured":"Bendele AM, McComb J, Gould T, Frazier J, Chlipala E, Seely J, Kieft G, and Edwards CK 3rd (1999) Effects of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) alone and in combination with methotrexate in adjuvant arthritic rats. Clin Exp Rheumatol 17: 553-560."},{"key":"10.1124\/jpet.108.148478_bib3","doi-asserted-by":"crossref","unstructured":"Benny O, Fainaru O, Adini A, Cassiola F, Bazinet L, Adini I, Pravda E, Nahmias Y, Koirala S, Corfas G, et al. (2008) An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. Nat Biotechnol 26: 799-807.","DOI":"10.1038\/nbt1415"},{"key":"10.1124\/jpet.108.148478_bib4","doi-asserted-by":"crossref","unstructured":"Bernier SG, Lazarus DD, Clark E, Doyle B, Labenski MT, Thompson CD, Westlin WF, and Hannig G (2004) A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis. Proc Natl Acad Sci U S A 101: 10768-10773.","DOI":"10.1073\/pnas.0404105101"},{"key":"10.1124\/jpet.108.148478_bib5","doi-asserted-by":"crossref","unstructured":"Bernier SG, Taghizadeh N, Thompson CD, Westlin WF, and Hannig G (2005) Methionine aminopeptidases type I and type II are essential to control cell proliferation. J Cell Biochem 95: 1191-1203.","DOI":"10.1002\/jcb.20493"},{"key":"10.1124\/jpet.108.148478_bib6","unstructured":"Bhargava P, Marshall JL, Rizvi N, Dahut W, Yoe J, Figuera M, Phipps K, Ong VS, Kato A, and Hawkins MJ (1999) A Phase I and pharmacokinetic study of TNP-470 administered weekly to patients with advanced cancer. Clin Cancer Res 5: 1989-1995."},{"key":"10.1124\/jpet.108.148478_bib7","doi-asserted-by":"crossref","unstructured":"Brahn E, Peacock DJ, and Banquerigo ML (1991) Suppression of collagen-induced arthritis by combination cyclosporin A and methotrexate therapy. Arthritis Rheum 34: 1282-1288.","DOI":"10.1002\/art.1780341012"},{"key":"10.1124\/jpet.108.148478_bib8","doi-asserted-by":"crossref","unstructured":"Brahn E, Tang C, and Banquerigo ML (1994) Regression of collagen-induced arthritis with taxol, a microtubule stabilizer. Arthritis Rheum 37: 839-845.","DOI":"10.1002\/art.1780370611"},{"key":"10.1124\/jpet.108.148478_bib9","doi-asserted-by":"crossref","unstructured":"Brahn E and Trentham DE (1984a) Antigen-specific suppression of collagen arthritis by adoptive transfer of spleen cells. Clin Immunol Immunopathol 31: 124-131.","DOI":"10.1016\/0090-1229(84)90197-1"},{"key":"10.1124\/jpet.108.148478_bib10","doi-asserted-by":"crossref","unstructured":"Brahn E and Trentham DE (1984b) Effect of antithymocyte serum on collagen arthritis in rats: evidence that T cells are involved in its pathogenesis. Cell Immunol 86: 421-428.","DOI":"10.1016\/0008-8749(84)90397-6"},{"key":"10.1124\/jpet.108.148478_bib11","doi-asserted-by":"crossref","unstructured":"Campagnuolo G, Bolon B, and Feige U (2002) Kinetics of bone protection by recombinant osteoprotegerin therapy in Lewis rats with adjuvant arthritis. Arthritis Rheum 46: 1926-1936.","DOI":"10.1002\/art.10369"},{"key":"10.1124\/jpet.108.148478_bib12","doi-asserted-by":"crossref","unstructured":"Carmeliet P (2005) Angiogenesis in life, disease and medicine. Nature 438: 932-936.","DOI":"10.1038\/nature04478"},{"key":"10.1124\/jpet.108.148478_bib13","unstructured":"Caulfield JP, Hein A, Dynesius-Trentham R, and Trentham DE (1982) Morphologic demonstration of two stages in the development of type II collagen-induced arthritis. Lab Invest 46: 321-343."},{"key":"10.1124\/jpet.108.148478_bib14","doi-asserted-by":"crossref","unstructured":"de Bandt M, Grossin M, Weber AJ, Chopin M, Elbim C, Pla M, Gougerot-Pocidalo MA, and Gaudry M (2000) Suppression of arthritis and protection from bone destruction by treatment with TNP-470\/AGM-1470 in a transgenic mouse model of rheumatoid arthritis. Arthritis Rheum 43: 2056-2063.","DOI":"10.1002\/1529-0131(200009)43:9<2056::AID-ANR17>3.0.CO;2-2"},{"key":"10.1124\/jpet.108.148478_bib15","doi-asserted-by":"crossref","unstructured":"Griffith EC, Su Z, Turk BE, Chen S, Chang YH, Wu Z, Biemann K, and Liu JO (1997) Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem Biol 4: 461-471.","DOI":"10.1016\/S1074-5521(97)90198-8"},{"key":"10.1124\/jpet.108.148478_bib16","doi-asserted-by":"crossref","unstructured":"Hannig G, Bernier SG, Hoyt JG, Doyle B, Clark E, Karp RM, Lorusso J, and Westlin WF (2007) Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458. Arthritis Rheum 56: 850-860.","DOI":"10.1002\/art.22402"},{"key":"10.1124\/jpet.108.148478_bib17","doi-asserted-by":"crossref","unstructured":"Herbst RS, Madden TL, Tran HT, Blumenschein GR Jr, Meyers CA, Seabrooke LF, Khuri FR, Puduvalli VK, Allgood V, Fritsche HA Jr, et al. (2002) Safety and pharmacokinetic effects of TNP-470, an angiogenesis inhibitor, combined with paclitaxel in patients with solid tumors: evidence for activity in non-small-cell lung cancer. J Clin Oncol 20: 4440-4447.","DOI":"10.1200\/JCO.2002.04.006"},{"key":"10.1124\/jpet.108.148478_bib18","doi-asserted-by":"crossref","unstructured":"Hisadome M, Fukuda T, Adachi K, and Komatsu H (2004) Combination benefit of a pyrimidylpiperazine derivative (Y-40138) and methotrexate in arthritic rats. Eur J Pharmacol 497: 351-359.","DOI":"10.1016\/j.ejphar.2004.07.058"},{"key":"10.1124\/jpet.108.148478_bib19","doi-asserted-by":"crossref","unstructured":"Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Brem H, and Folkman J (1990) Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348: 555-557.","DOI":"10.1038\/348555a0"},{"key":"10.1124\/jpet.108.148478_bib20","unstructured":"Kudelka AP, Levy T, Verschraegen CF, Edwards CL, Piamsomboon S, Termrungruanglert W, Freedman RS, Kaplan AL, Kieback DG, Meyers CA, et al. (1997) A phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix. Clin Cancer Res 3: 1501-1505."},{"key":"10.1124\/jpet.108.148478_bib21","doi-asserted-by":"crossref","unstructured":"Lainer DT and Brahn E (2005) New antiangiogenic strategies for the treatment of proliferative synovitis. Expert Opin Investig Drugs 14: 1-17.","DOI":"10.1517\/13543784.14.1.1"},{"key":"10.1124\/jpet.108.148478_bib22","doi-asserted-by":"crossref","unstructured":"Lainer-Carr D and Brahn E (2007) Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis. Nat Clin Pract Rheumatol 3: 434-442.","DOI":"10.1038\/ncprheum0559"},{"key":"10.1124\/jpet.108.148478_bib23","doi-asserted-by":"crossref","unstructured":"Lazarus DD, Doyle EG, Bernier SG, Rogers AB, Labenski MT, Wakefield JD, Karp RM, Clark EJ, Lorusso J, Hoyt JG, et al. (2008) An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis. Inflamm Res 57: 18-27.","DOI":"10.1007\/s00011-007-7075-5"},{"key":"10.1124\/jpet.108.148478_bib24","unstructured":"Logothetis CJ, Wu KK, Finn LD, Daliani D, Figg W, Ghaddar H, and Gutterman JU (2001) Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer. Clin Cancer Res 7: 1198-1203."},{"key":"10.1124\/jpet.108.148478_bib25","doi-asserted-by":"crossref","unstructured":"Mankin HJ, Dorfman H, Lippiello L, and Zarins A (1971) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 53: 523-537.","DOI":"10.2106\/00004623-197153030-00009"},{"key":"10.1124\/jpet.108.148478_bib26","doi-asserted-by":"crossref","unstructured":"Peacock DJ, Banquerigo ML, and Brahn E (1992) Angiogenesis inhibition suppresses collagen arthritis. J Exp Med 175: 1135-1138.","DOI":"10.1084\/jem.175.4.1135"},{"key":"10.1124\/jpet.108.148478_bib27","doi-asserted-by":"crossref","unstructured":"Peacock DJ, Banquerigo ML, and Brahn E (1995) A novel angiogenesis inhibitor suppresses rat adjuvant arthritis. Cell Immunol 160: 178-184.","DOI":"10.1016\/0008-8749(95)80025-E"},{"key":"10.1124\/jpet.108.148478_bib28","doi-asserted-by":"crossref","unstructured":"Silva MA, Ishii-Iwamoto EL, Bracht A, Caparroz-Assef SM, Kimura E, Cuman RK, and Bersani-Amado CA (2005) Efficiency of combined methotrexate\/chloroquine therapy in adjuvant-induced arthritis. Fundam Clin Pharmacol 19: 479-489.","DOI":"10.1111\/j.1472-8206.2005.00346.x"},{"key":"10.1124\/jpet.108.148478_bib29","doi-asserted-by":"crossref","unstructured":"Sin N, Meng L, Wang MQ, Wen JJ, Bornmann WG, and Crews CM (1997) The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc Natl Acad Sci U S A 94: 6099-6103.","DOI":"10.1073\/pnas.94.12.6099"},{"key":"10.1124\/jpet.108.148478_bib30","doi-asserted-by":"crossref","unstructured":"Teitelbaum SL (2000) Bone resorption by osteoclasts. Science 289: 1504-1508.","DOI":"10.1126\/science.289.5484.1504"},{"key":"10.1124\/jpet.108.148478_bib31","doi-asserted-by":"crossref","unstructured":"Trentham DE, Townes AS, and Kang AH (1977) Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med 146: 857-868.","DOI":"10.1084\/jem.146.3.857"},{"key":"10.1124\/jpet.108.148478_bib32","doi-asserted-by":"crossref","unstructured":"Walsh DA (1999) Angiogenesis and arthritis. Rheumatology (Oxford) 38: 103-112.","DOI":"10.1093\/rheumatology\/38.2.103"},{"key":"10.1124\/jpet.108.148478_bib33","doi-asserted-by":"crossref","unstructured":"Wu Y, Liu J, Feng X, Yang P, Xu X, Hsu HC, and Mountz JD (2005) Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis. Arthritis Rheum 52: 3257-3268.","DOI":"10.1002\/art.21354"},{"key":"10.1124\/jpet.108.148478_bib34","unstructured":"Yanase T, Tamura M, Fujita K, Kodama S, and Tanaka K (1993) Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo. Cancer Res 53: 2566-2570."},{"key":"10.1124\/jpet.108.148478_bib35","doi-asserted-by":"crossref","unstructured":"Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, and Crews CM (2006) Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A 103: 10379-10384.","DOI":"10.1073\/pnas.0511313103"},{"key":"10.1124\/jpet.108.148478_bib36","doi-asserted-by":"crossref","unstructured":"Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, et al. (2006) A chemical and genetic approach to the mode of action of fumagillin. Chem Biol 13: 1001-1009.","DOI":"10.1016\/j.chembiol.2006.07.010"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524384113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524384113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.108.148478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T01:28:47Z","timestamp":1740014927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524384113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0022356524384113"],"URL":"https:\/\/doi.org\/10.1124\/jpet.108.148478","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involution of Collagen-Induced Arthritis with an Angiogenesis Inhibitor, PPI-2458","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.108.148478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}