{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:44:00Z","timestamp":1777445040634,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1124\/jpet.108.149625","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T09:02:34Z","timestamp":1233997354000},"page":"479-485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Localization of Multidrug Resistance-Associated Protein 2 in the Nonpigmented Ciliary Epithelium of the Eye"],"prefix":"10.1016","volume":"329","author":[{"given":"Ryan M.","family":"Pelis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Shahidullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sikha","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Coca-Prados","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A.","family":"Delamere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.108.149625_bib1","doi-asserted-by":"crossref","unstructured":"Brubaker RF, Nagataki S, Townsend DJ, Burns RR, Higgins RG, and Wentworth W (1981) The effect of age on aqueous humor formation in man. Ophthalmology 88: 283-288.","DOI":"10.1016\/S0161-6420(81)35037-4"},{"key":"10.1124\/jpet.108.149625_bib2","doi-asserted-by":"crossref","unstructured":"Coffey KL, Krushinsky A, Green CR, and Donaldson PJ (2002) Molecular profiling and cellular localization of connexin isoforms in the rat ciliary epithelium. Exp Eye Res 75: 9-21.","DOI":"10.1006\/exer.2002.1187"},{"key":"10.1124\/jpet.108.149625_bib3","doi-asserted-by":"crossref","unstructured":"Cunha-Vaz J (1979) The blood-ocular barriers. Surv Ophthalmol 23: 279-296.","DOI":"10.1016\/0039-6257(79)90158-9"},{"key":"10.1124\/jpet.108.149625_bib4","doi-asserted-by":"crossref","unstructured":"Dallas S, Miller DS, and Bendayan R (2006) Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol Rev 58: 140-161.","DOI":"10.1124\/pr.58.2.3"},{"key":"10.1124\/jpet.108.149625_bib5","doi-asserted-by":"crossref","unstructured":"Dantzler WH and Wright SH (2003) The molecular and cellular physiology of basolateral organic anion transport in mammalian renal tubules. Biochim Biophys Acta 1618: 185-193.","DOI":"10.1016\/j.bbamem.2003.08.015"},{"key":"10.1124\/jpet.108.149625_bib6","doi-asserted-by":"crossref","unstructured":"Deeley RG, Westlake C, and Cole SP (2006) Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 86: 849-899.","DOI":"10.1152\/physrev.00035.2005"},{"key":"10.1124\/jpet.108.149625_bib7","doi-asserted-by":"crossref","unstructured":"Do CW and Civan MM (2004) Basis of chloride transport in ciliary epithelium. J Membr Biol 200: 1-13.","DOI":"10.1007\/s00232-004-0688-5"},{"key":"10.1124\/jpet.108.149625_bib8","doi-asserted-by":"crossref","unstructured":"Doshi M, Marcus C, Bejjani BA, and Edward DP (2006) Immunolocalization of CYP1B1 in normal, human, fetal and adult eyes. Exp Eye Res 82: 24-32.","DOI":"10.1016\/j.exer.2005.04.016"},{"key":"10.1124\/jpet.108.149625_bib9","doi-asserted-by":"crossref","unstructured":"El-Sheikh AA, van den Heuvel JJ, Koenderink JB, and Russel FG (2007) Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2\/ABCC2- and MRP4\/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther 320: 229-235.","DOI":"10.1124\/jpet.106.110379"},{"key":"10.1124\/jpet.108.149625_bib10","doi-asserted-by":"crossref","unstructured":"Evers R, Kool M, Smith AJ, van Deemter L, de Haas M, and Borst P (2000) Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport. Br J Cancer 83: 366-374.","DOI":"10.1054\/bjoc.2000.1260"},{"key":"10.1124\/jpet.108.149625_bib11","doi-asserted-by":"crossref","unstructured":"Folmer Y, Schneider M, Blum HE, and Hafkemeyer P (2007) Reversal of drug resistance of hepatocellular carcinoma cells by adenoviral delivery of anti-ABCC2 antisense constructs. Cancer Gene Ther 14: 875-884.","DOI":"10.1038\/sj.cgt.7701082"},{"key":"10.1124\/jpet.108.149625_bib12","doi-asserted-by":"crossref","unstructured":"F\u00f6rster F, Volz A, and Fricker G (2008) Compound profiling for ABCC2 (MRP2) using a fluorescent microplate assay system. Eur J Pharm Biopharm 69: 396-403.","DOI":"10.1016\/j.ejpb.2007.10.003"},{"key":"10.1124\/jpet.108.149625_bib13","doi-asserted-by":"crossref","unstructured":"Freddo TF (2001) Shifting the paradigm of the blood-aqueous barrier. Exp Eye Res 73: 581-592.","DOI":"10.1006\/exer.2001.1056"},{"key":"10.1124\/jpet.108.149625_bib14","unstructured":"Freddo TF, Bartels SP, Barsotti MF, and Kamm RD (1990) The source of proteins in the aqueous humor of the normal rabbit. Invest Ophthalmol Vis Sci 31: 125-137."},{"key":"10.1124\/jpet.108.149625_bib15","doi-asserted-by":"crossref","unstructured":"Gao B, Huber RD, Wenzel A, Vavricka SR, Ismair MG, Rem\u00e9 C, and Meier PJ (2005) Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium. Exp Eye Res 80: 61-72.","DOI":"10.1016\/j.exer.2004.08.013"},{"key":"10.1124\/jpet.108.149625_bib16","doi-asserted-by":"crossref","unstructured":"George RL, Huang W, Naggar HA, Smith SB, and Ganapathy V (2004) Transport of N-acetylaspartate via murine sodium\/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse. Biochim Biophys Acta 1690: 63-69.","DOI":"10.1016\/j.bbadis.2004.05.009"},{"key":"10.1124\/jpet.108.149625_bib17","unstructured":"Hooijberg JH, Broxterman HJ, Kool M, Assaraf YG, Peters GJ, Noordhuis P, Scheper RJ, Borst P, Pinedo HM, and Jansen G (1999) Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res 59: 2532-2535."},{"key":"10.1124\/jpet.108.149625_bib18","doi-asserted-by":"crossref","unstructured":"Leier I, Hummel-Eisenbeiss J, Cui Y, and Keppler D (2000) ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int 57: 1636-1642.","DOI":"10.1046\/j.1523-1755.2000.00007.x"},{"key":"10.1124\/jpet.108.149625_bib19","doi-asserted-by":"crossref","unstructured":"Madon J, Hagenbuch B, Landmann L, Meier PJ, and Stieger B (2000) Transport function and hepatocellular localization of mrp6 in rat liver. Mol Pharmacol 57: 634-641.","DOI":"10.1124\/mol.57.3.634"},{"key":"10.1124\/jpet.108.149625_bib20","doi-asserted-by":"crossref","unstructured":"Mendelsohn ME, Abramson DH, Madden T, Tong W, Tran HT, and Dunkel IJ (1998) Intraocular concentrations of chemotherapeutic agents after systemic or local administration. Arch Ophthalmol 116: 1209-1212.","DOI":"10.1001\/archopht.116.9.1209"},{"key":"10.1124\/jpet.108.149625_bib21","doi-asserted-by":"crossref","unstructured":"Shahidullah M, Tamiya S, and Delamere NA (2007) Primary culture of porcine nonpigmented ciliary epithelium. Curr Eye Res 32: 511-522.","DOI":"10.1080\/02713680701434899"},{"key":"10.1124\/jpet.108.149625_bib22","unstructured":"Smith RS and Rudt LA (1975) Ocular vascular and epithelial barriers to microperoxidase. Invest Ophthalmol 14: 556-560."},{"key":"10.1124\/jpet.108.149625_bib23","doi-asserted-by":"crossref","unstructured":"Takikawa H (2002) Hepatobiliary transport of bile acids and organic anions. J Hepatobiliary Pancreat Surg 9: 443-447.","DOI":"10.1007\/s005340200055"},{"key":"10.1124\/jpet.108.149625_bib24","doi-asserted-by":"crossref","unstructured":"Tian X, Zamek-Gliszczynski MJ, Zhang P, and Brouwer KL (2004) Modulation of multidrug resistance-associated protein 2 (Mrp2) and Mrp3 expression and function with small interfering RNA in sandwich-cultured rat hepatocytes. Mol Pharmacol 66: 1004-1010.","DOI":"10.1124\/mol.66.4.1004"},{"key":"10.1124\/jpet.108.149625_bib25","doi-asserted-by":"crossref","unstructured":"van Aubel RA, van Kuijck MA, Koenderink JB, Deen PM, van Os CH, and Russel FG (1998) Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein mrp2 expressed in insect cells. Mol Pharmacol 53: 1062-1067.","DOI":"10.1016\/S0026-895X(24)13277-4"},{"key":"10.1124\/jpet.108.149625_bib26","doi-asserted-by":"crossref","unstructured":"van de Water FM, Masereeuw R, and Russel FG (2005) Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions. Drug Metab Rev 37: 443-471.","DOI":"10.1080\/03602530500205275"},{"key":"10.1124\/jpet.108.149625_bib27","doi-asserted-by":"crossref","unstructured":"Zhao C and Shichi H (1995) Immunocytochemical study of cytochrome P450 (1A1\/1A2) induction in murine ocular tissues. Exp Eye Res 60: 143-152.","DOI":"10.1016\/S0014-4835(95)80004-2"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524384125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524384125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.108.149625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T01:28:37Z","timestamp":1740014917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524384125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0022356524384125"],"URL":"https:\/\/doi.org\/10.1124\/jpet.108.149625","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Localization of Multidrug Resistance-Associated Protein 2 in the Nonpigmented Ciliary Epithelium of the Eye","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.108.149625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}