{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:39:06Z","timestamp":1777045146034,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1124\/jpet.109.157099","type":"journal-article","created":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T02:03:57Z","timestamp":1253585037000},"page":"1096-1103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["An Adipose Tissue-Independent Insulin-Sensitizing Action of Telmisartan: a Study in Lipodystrophic Mice"],"prefix":"10.1016","volume":"331","author":[{"given":"X.","family":"Rong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ebihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Aini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kusakabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.109.157099_bib1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.med.57.022605.114424","article-title":"Genetic basis of lipodystrophies and management of metabolic complications","volume":"57","author":"Agarwal","year":"2006","journal-title":"Annu Rev Med"},{"key":"10.1124\/jpet.109.157099_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/01.HYP.0000225402.69580.1d","article-title":"Telmisartan prevents obesity and increases the expression of uncoupling protein 1 in diet-induced obese mice","volume":"48","author":"Araki","year":"2006","journal-title":"Hypertension"},{"key":"10.1124\/jpet.109.157099_bib3","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.HYP.0000123072.34629.57","article-title":"Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity","volume":"43","author":"Benson","year":"2004","journal-title":"Hypertension"},{"key":"10.1124\/jpet.109.157099_bib4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000163635.62927.34","article-title":"Adipose tissue, inflammation, and cardiovascular disease","volume":"96","author":"Berg","year":"2005","journal-title":"Circ Res"},{"key":"10.1124\/jpet.109.157099_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1043-2760(00)00323-4","article-title":"Free fatty acids and pathogenesis of type 2 diabetes mellitus","volume":"11","author":"Bergman","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"10.1124\/jpet.109.157099_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2337\/diab.46.1.3","article-title":"Role of fatty acids in the pathogenesis of insulin resistance and NIDDM","volume":"46","author":"Boden","year":"1997","journal-title":"Diabetes"},{"key":"10.1124\/jpet.109.157099_bib7","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI11245","article-title":"Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones","volume":"106","author":"Chao","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.109.157099_bib8","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s001250050793","article-title":"The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study","volume":"40","author":"Charles","year":"1997","journal-title":"Diabetologia"},{"key":"10.1124\/jpet.109.157099_bib9","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.2337\/diabetes.47.7.1014","article-title":"Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins","volume":"47","author":"Cusin","year":"1998","journal-title":"Diabetes"},{"key":"10.1124\/jpet.109.157099_bib10","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.2337\/diabetes.50.6.1440","article-title":"Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes","volume":"50","author":"Ebihara","year":"2001","journal-title":"Diabetes"},{"key":"10.1124\/jpet.109.157099_bib11","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1357-2725(02)00311-4","article-title":"The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?","volume":"35","author":"Engeli","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1124\/jpet.109.157099_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nm1025","article-title":"PPARs and the complex journey to obesity","volume":"10","author":"Evans","year":"2004","journal-title":"Nat Med"},{"key":"10.1124\/jpet.109.157099_bib13","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1073\/pnas.94.9.4242","article-title":"Leptin expression and action: new experimental paradigms","volume":"94","author":"Flier","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/jpet.109.157099_bib14","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.febslet.2004.09.027","article-title":"An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3\u2013L1 adipocytes","volume":"576","author":"Fujimoto","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.109.157099_bib15","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1056\/NEJMra025261","article-title":"Acquired and inherited lipodystrophies","volume":"350","author":"Garg","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.109.157099_bib16","doi-asserted-by":"crossref","first-page":"34268","DOI":"10.1074\/jbc.M300043200","article-title":"Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass","volume":"278","author":"Gavrilova","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.109.157099_bib17","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.2337\/diabetes.51.7.2113","article-title":"Adrenalectomy improves diabetes in A-ZIP\/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity","volume":"51","author":"Haluzik","year":"2002","journal-title":"Diabetes"},{"key":"10.1124\/jpet.109.157099_bib18","doi-asserted-by":"crossref","first-page":"498","DOI":"10.2337\/diacare.28.2.498","article-title":"Possible beneficial effect of telmisartan on glycemic control in diabetic subjects","volume":"28","author":"Honjo","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1124\/jpet.109.157099_bib19","doi-asserted-by":"crossref","first-page":"31160","DOI":"10.1074\/jbc.273.47.31160","article-title":"Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes","volume":"273","author":"Liu","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.109.157099_bib20","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1681\/ASN.V1351162","article-title":"Angiotensin III activates nuclear transcription factor-kappaB in cultured mesangial cells mainly via AT(2) receptors: studies with AT(1) receptor-knockout mice","volume":"13","author":"Lorenzo","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/jpet.109.157099_bib21","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2337\/diacare.28.3.757","article-title":"Replacement of valsartan and candesartan by telmisartan in hypertensive patients with type 2 diabetes: Metabolic and antiatherogenic consequences","volume":"28","author":"Miura","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1124\/jpet.109.157099_bib22","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1101\/gad.12.20.3168","article-title":"Life without white fat: a transgenic mouse","volume":"12","author":"Moitra","year":"1998","journal-title":"Genes Dev"},{"key":"10.1124\/jpet.109.157099_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cmet.2005.06.006","article-title":"Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice","volume":"2","author":"Neschen","year":"2005","journal-title":"Cell Metab"},{"key":"10.1124\/jpet.109.157099_bib24","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.2337\/diabetes.50.5.1158","article-title":"Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability","volume":"50","author":"Oakes","year":"2001","journal-title":"Diabetes"},{"key":"10.1124\/jpet.109.157099_bib25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2337\/diacare.27.4.1015","article-title":"Insulin-sensitizing effects of telmisartan: implications for treating insulin-resistant hypertension and cardiovascular disease","volume":"27","author":"Pershadsingh","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1124\/jpet.109.157099_bib26","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1146\/annurev.ph.54.030192.004321","article-title":"Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis","volume":"54","author":"Pilkis","year":"1992","journal-title":"Annu Rev Physiol"},{"key":"10.1124\/jpet.109.157099_bib27","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1161\/01.CIR.0000141736.76561.78","article-title":"Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome","volume":"110","author":"Prasad","year":"2004","journal-title":"Circulation"},{"key":"10.1124\/jpet.109.157099_bib28","doi-asserted-by":"crossref","first-page":"E227","DOI":"10.1152\/ajpendo.00090.2004","article-title":"Angiotensin II type 1 receptor blocker ameliorates overproduction and accumulation of triglyceride in the liver of Zucker fatty rats","volume":"287","author":"Ran","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1124\/jpet.109.157099_bib29","doi-asserted-by":"crossref","first-page":"E1465","DOI":"10.1152\/ajpendo.00516.2007","article-title":"Adrenocortical dysregulation as a major player in insulin resistance and onset of obesity","volume":"293","author":"Roberge","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1124\/jpet.109.157099_bib30","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1172\/JCI27300","article-title":"Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2","volume":"116","author":"Savage","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.109.157099_bib31","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1073\/pnas.94.9.4637","article-title":"Direct antidiabetic effect of leptin through triglyceride depletion of tissues","volume":"94","author":"Shimabukuro","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/jpet.109.157099_bib32","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1161\/01.HYP.0000215181.60228.f7","article-title":"Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis","volume":"47","author":"Sugimoto","year":"2006","journal-title":"Hypertension"},{"key":"10.1124\/jpet.109.157099_bib33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/01.HYP.0000255576.16089.b9","article-title":"Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function","volume":"49","author":"Takemori","year":"2007","journal-title":"Hypertension"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524455584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524455584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.109.157099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T02:01:52Z","timestamp":1740016912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524455584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0022356524455584"],"URL":"https:\/\/doi.org\/10.1124\/jpet.109.157099","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Adipose Tissue-Independent Insulin-Sensitizing Action of Telmisartan: a Study in Lipodystrophic Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.109.157099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}