{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:07:51Z","timestamp":1791479271472,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1124\/jpet.109.159657","type":"journal-article","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T01:43:08Z","timestamp":1252633388000},"page":"1025-1032","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effect of Intra-articular 4-(S)-Amino-5-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl} piperazino)-5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a Kinin B2 Receptor Antagonist, on Nociceptive Response in Monosodium Iodoacetate-Induced Experimental Osteoarthritis in Rats"],"prefix":"10.1016","volume":"331","author":[{"given":"Cecilia","family":"Cialdai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Giuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Valenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Tramontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alberto","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.109.159657_bib1","first-page":"ES21","article-title":"Managing osteoarthritic knee pain.","volume":"107","author":"Barron","year":"2007","journal-title":"J Am Osteopath Assoc"},{"issue":"2","key":"10.1124\/jpet.109.159657_bib2","first-page":"CD005328","article-title":"Intraarticular corticosteroid for treatment of osteoarthritis of the knee.","author":"Bellamy","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1124\/jpet.109.159657_bib3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0306-4522(93)90273-I","article-title":"Prostanoid-induced potentiation of the excitatory and sensitizing effects of bradykinin on articular mechanonociceptors in the rat ankle joint.","volume":"54","author":"Birrell","year":"1993","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.109.159657_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0162-3109(97)00023-4","article-title":"Generation of kinins in synovial fluid from patients with arthropathy.","volume":"36","author":"Bond","year":"1997","journal-title":"Immunopharmacology"},{"key":"10.1124\/jpet.109.159657_bib5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1063-4584(03)00163-8","article-title":"Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis.","volume":"11","author":"Bove","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1124\/jpet.109.159657_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0162-3109(97)00010-6","article-title":"Immunolocalization of bradykinin receptors on human synovial tissue.","volume":"36","author":"Cassim","year":"1997","journal-title":"Immunopharmacology"},{"key":"10.1124\/jpet.109.159657_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2005.10.014","article-title":"MEN16132, a novel potent and selective nonpeptide antagonist for the human bradykinin B2 receptor. In vitro pharmacology and molecular characterization.","volume":"528","author":"Cucchi","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.109.159657_bib8","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1139\/Y97-068","article-title":"Kinins and their receptors in hyperalgesia.","volume":"75","author":"Dray","year":"1997","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1124\/jpet.109.159657_bib9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0166-2236(93)90133-7","article-title":"Bradykinin and inflammatory pain.","volume":"16","author":"Dray","year":"1993","journal-title":"Trends Neurosci"},{"key":"10.1124\/jpet.109.159657_bib10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/BF01965014","article-title":"Bradykinin activates peripheral capsaicin-sensitive fibres via a second messenger system.","volume":"25","author":"Dray","year":"1988","journal-title":"Agents Actions"},{"key":"10.1124\/jpet.109.159657_bib11","first-page":"204","article-title":"Inflammatory synovitis in degenerative joint disease.","volume":"9","author":"Goldenberg","year":"1982","journal-title":"J Rheumatol"},{"key":"10.1124\/jpet.109.159657_bib12","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/jcp.21258","article-title":"Osteoarthritis.","volume":"213","author":"Goldring","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1124\/jpet.109.159657_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-2999(94)90587-8","article-title":"Effect of E-type prostaglandins on bradykinin-induced plasma extravasation in the knee joint of the rat.","volume":"252","author":"Green","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.109.159657_bib14","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.1780400917","article-title":"Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry.","volume":"40","author":"Guingamp","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1124\/jpet.109.159657_bib15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/01926230390241800","article-title":"Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis.","volume":"31","author":"Guzman","year":"2003","journal-title":"Toxicol Pathol"},{"key":"10.1124\/jpet.109.159657_bib16","first-page":"841","article-title":"Osteoarthritis: diagnosis and therapeutic considerations.","volume":"65","author":"Hinton","year":"2002","journal-title":"Am Fam Physician"},{"key":"10.1124\/jpet.109.159657_bib17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1476-5381.1991.tb12248.x","article-title":"Hoe 140 a new potent and long acting bradykinin antagonist: in vitro studies.","volume":"102","author":"Hock","year":"1991","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.109.159657_bib18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pain.2006.12.022","article-title":"Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation.","volume":"128","author":"Ivanavicius","year":"2007","journal-title":"Pain"},{"key":"10.1124\/jpet.109.159657_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0006-8993(85)91501-X","article-title":"Activation of fine articular afferent units by bradykinin.","volume":"327","author":"Kanaka","year":"1985","journal-title":"Brain Res"},{"key":"10.1124\/jpet.109.159657_bib20","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1097\/00001756-199912160-00018","article-title":"Bradykinin-induced neurogenic migration of neutrophils into the rat knee joint.","volume":"10","author":"Lo","year":"1999","journal-title":"Neuroreport"},{"key":"10.1124\/jpet.109.159657_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000147091","article-title":"Intrinsic innervation of the rat knee joint articular capsule and ligaments.","volume":"141","author":"Marinozzi","year":"1991","journal-title":"Acta Anat"},{"key":"10.1124\/jpet.109.159657_bib22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/ar2069","article-title":"Arthritis and pain: neurogenic origin of joint pain.","volume":"8","author":"McDougall","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1124\/jpet.109.159657_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejphar.2009.04.057","article-title":"Pharmacological characterization of the bradykinin B2 receptor antagonist MEN16132 in rat in vitro bioassays.","volume":"615","author":"Meini","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.109.159657_bib24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00011-007-7204-1","article-title":"Knee osteoarthritis: a role for bradykinin?","volume":"57","author":"Meini","year":"2008","journal-title":"Inflamm Res"},{"key":"10.1124\/jpet.109.159657_bib25","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/BF00370884","article-title":"Sensitization of articular afferents to mechanical stimuli by bradykinin.","volume":"415","author":"Neugebauer","year":"1989","journal-title":"Pflugers Arch"},{"key":"10.1124\/jpet.109.159657_bib26","first-page":"63","article-title":"The activity of fine afferent nerve fibres of the rat knee joint and their modulation by inflammatory mediators.","volume":"10","author":"Pawlak","year":"2008","journal-title":"Ortop Traumatol Rehabil"},{"key":"10.1124\/jpet.109.159657_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.pain.2004.11.008","article-title":"Development and pharmacological characterization of a rat model of osteoarthritis pain.","volume":"114","author":"Pomonis","year":"2005","journal-title":"Pain"},{"key":"10.1124\/jpet.109.159657_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1749-6632.2002.tb04234.x","article-title":"Mechanisms of pain in arthritis.","volume":"966","author":"Schaible","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/jpet.109.159657_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1113\/jphysiol.1988.sp017240","article-title":"Excitation and sensitization of fine articular afferents from cat's knee joint by prostaglandin E2.","volume":"403","author":"Schaible","year":"1988","journal-title":"J Physiol"},{"key":"10.1124\/jpet.109.159657_bib30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0306-3623(95)00078-X","article-title":"Inhibition of rats adjuvant arthritis by a bradykinin antagonist Hoe 140 and its influence on kallikreins.","volume":"27","author":"Sharma","year":"1996","journal-title":"Gen Pharmacol"},{"key":"10.1124\/jpet.109.159657_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/ard.2007.080382","article-title":"Contrast-enhanced ultrasound in monitoring the efficacy of a bradykinin receptor 2 antagonist in painful knee osteoarthritis compared with MRI.","volume":"68","author":"Song","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1124\/jpet.109.159657_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1358\/dof.2006.031.02.970170","article-title":"Icatibant acetate.","volume":"31","author":"Sorbera","year":"2006","journal-title":"Drugs Fut"},{"key":"10.1124\/jpet.109.159657_bib33","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1073\/pnas.85.9.3245","article-title":"Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.","volume":"85","author":"Steranka","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1124\/jpet.109.159657_bib34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tvjl.2007.08.013","article-title":"The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis.","volume":"179","author":"Sutton","year":"2009","journal-title":"Vet J"},{"key":"10.1124\/jpet.109.159657_bib35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0014-2999(97)00153-2","article-title":"Bradykinin-induced knee joint incapacitation involves bradykinin B2 receptor mediated hyperalgesia and bradykinin B1 receptor-mediated nociception.","volume":"326","author":"Tonussi","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.109.159657_bib36","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0022-3565(24)38850-0","article-title":"Differences between peptide and nonpeptide B2 bradykinin receptor antagonists in blocking bronchoconstriction and hypotension induced by bradykinin in anesthetized guinea pigs.","volume":"296","author":"Tramontana","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.109.159657_bib37","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1124\/jpet.105.088252","article-title":"MEN16132, a novel potent and selective nonpeptide kinin B2 receptor antagonist: in vivo activity on bradykinin-induced bronchoconstriction and nasal mucosa microvascular leakage in anesthetized guinea pigs.","volume":"315","author":"Valenti","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.109.159657_bib38","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1016\/j.bmc.2008.09.050","article-title":"Site specific chemical delivery of NSAIDs to inflamed joints: synthesis, biological activity and \u03b3-imaging studies of quaternary ammonium salts of tropinol esters of some NSAIDs or their active metabolites.","volume":"16","author":"Yadav","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1124\/jpet.109.159657_bib39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/s10165-006-0490-6","article-title":"Cartilage destruction by matrix degradation products.","volume":"16","author":"Yasuda","year":"2006","journal-title":"Mod Rheumatol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524455687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524455687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.109.159657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T02:02:13Z","timestamp":1740016933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524455687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0022356524455687"],"URL":"https:\/\/doi.org\/10.1124\/jpet.109.159657","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Intra-articular 4-(S)-Amino-5-(4-{4-[2,4-dichloro-3-(2,4-dimethyl-8-quinolyloxymethyl)phenylsulfonamido]-tetrahydro-2H-4-pyranylcarbonyl} piperazino)-5-oxopentyl](trimethyl)ammonium chloride hydrochloride (MEN16132), a Kinin B2 Receptor Antagonist, on Nociceptive Response in Monosodium Iodoacetate-Induced Experimental Osteoarthritis in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.109.159657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2009 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}