{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:28:08Z","timestamp":1761708488625,"version":"3.37.3"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1124\/jpet.109.160184","type":"journal-article","created":{"date-parts":[[2010,3,10]],"date-time":"2010-03-10T01:53:58Z","timestamp":1268186038000},"page":"758-763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Uric Acid Does Not Affect the Acetylcholine-Induced Relaxation of Aorta from Normotensive and Deoxycorticosterone Acetate-Salt Hypertensive Rats"],"prefix":"10.1016","volume":"333","author":[{"given":"Theodora","family":"Szasz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie W.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.109.160184_bib1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0891-5849(93)90143-I","article-title":"Towards the physiological function of uric acid","volume":"14","author":"Becker","year":"1993","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/jpet.109.160184_bib2","doi-asserted-by":"crossref","first-page":"C1424","DOI":"10.1152\/ajpcell.1996.271.5.C1424","article-title":"Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly","volume":"271","author":"Beckman","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1124\/jpet.109.160184_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1113\/jphysiol.2003.055913","article-title":"Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications","volume":"555","author":"Berry","year":"2004","journal-title":"J Physiol"},{"key":"10.1124\/jpet.109.160184_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2174\/0929867023371229","article-title":"Progress towards the discovery of xanthine oxidase inhibitors","volume":"9","author":"Borges","year":"2002","journal-title":"Curr Med Chem"},{"key":"10.1124\/jpet.109.160184_bib5","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/01.HYP.35.3.746","article-title":"Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension","volume":"35","author":"Butler","year":"2000","journal-title":"Hypertension"},{"key":"10.1124\/jpet.109.160184_bib6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.RES.87.10.840","article-title":"Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress","volume":"87","author":"Cai","year":"2000","journal-title":"Circ Res"},{"key":"10.1124\/jpet.109.160184_bib7","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra0800885","article-title":"Uric acid and cardiovascular risk","volume":"359","author":"Feig","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.109.160184_bib8","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1016\/S0021-9258(18)97351-5","article-title":"The competitive inhibition of uricase by oxonate and by related derivatives of S-triazines","volume":"240","author":"Fridovich","year":"1965","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.109.160184_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/CIRCULATIONAHA.106.650671","article-title":"Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice","volume":"115","author":"Gao","year":"2007","journal-title":"Circulation"},{"key":"10.1124\/jpet.109.160184_bib10","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1161\/CIRCULATIONAHA.106.651117","article-title":"High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid","volume":"114","author":"George","year":"2006","journal-title":"Circulation"},{"key":"10.1124\/jpet.109.160184_bib11","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/15257770802257952","article-title":"Inactivation of nitric oxide by uric acid","volume":"27","author":"Gersch","year":"2008","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1124\/jpet.109.160184_bib12","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1161\/hc4601.099485","article-title":"Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease","volume":"104","author":"Heitzer","year":"2001","journal-title":"Circulation"},{"key":"10.1124\/jpet.109.160184_bib13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0895-7061(01)02317-2","article-title":"Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals","volume":"15","author":"Higashi","year":"2002","journal-title":"Am J Hypertens"},{"key":"10.1124\/jpet.109.160184_bib14","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/01.HYP.0000069700.62727.C5","article-title":"Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?","volume":"41","author":"Johnson","year":"2003","journal-title":"Hypertension"},{"key":"10.1124\/jpet.109.160184_bib15","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/j.1523-1755.2005.00273.x","article-title":"Hyperuricemia induces endothelial dysfunction","volume":"67","author":"Khosla","year":"2005","journal-title":"Kidney Int"},{"key":"10.1124\/jpet.109.160184_bib16","first-page":"S115","article-title":"Gout and mortality","volume":"26","author":"Kim","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"10.1124\/jpet.109.160184_bib17","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/01.HYP.0000254480.64564.b6","article-title":"Hyperuricemia and incidence of hypertension among men without metabolic syndrome","volume":"49","author":"Krishnan","year":"2007","journal-title":"Hypertension"},{"key":"10.1124\/jpet.109.160184_bib18","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/hy1101.092839","article-title":"Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism","volume":"38","author":"Mazzali","year":"2001","journal-title":"Hypertension"},{"key":"10.1124\/jpet.109.160184_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00005344-200401000-00014","article-title":"Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension","volume":"43","author":"Mitchell","year":"2004","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.109.160184_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1440-1797.2004.00292.x","article-title":"Impaired nitric oxide- and endothelium-derived hyperpolarizing factor-dependent dilation of renal afferent arteriole in Dahl salt-sensitive rats","volume":"9","author":"Ozawa","year":"2004","journal-title":"Nephrology (Carlton)"},{"key":"10.1124\/jpet.109.160184_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1124\/pr.58.1.6","article-title":"Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol","volume":"58","author":"Pacher","year":"2006","journal-title":"Pharmacol Rev"},{"key":"10.1124\/jpet.109.160184_bib22","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1681\/ASN.2006030264","article-title":"Human vascular smooth muscle cells express a urate transporter","volume":"17","author":"Price","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/jpet.109.160184_bib23","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1089\/ars.2007.1989","article-title":"Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension","volume":"10","author":"Schulz","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.109.160184_bib24","doi-asserted-by":"crossref","first-page":"24491","DOI":"10.1074\/jbc.273.38.24491","article-title":"Nitrosation of uric acid by peroxynitrite. Formation of a vasoactive nitric oxide donor","volume":"273","author":"Skinner","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.109.160184_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/ar2509","article-title":"Developments in the scientific and clinical understanding of gout","volume":"10","author":"So","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1124\/jpet.109.160184_bib26","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1073\/pnas.95.8.4754","article-title":"Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats","volume":"95","author":"Suzuki","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.109.160184_bib27","doi-asserted-by":"crossref","first-page":"H1341","DOI":"10.1152\/ajpheart.00569.2008","article-title":"A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidase","volume":"295","author":"Szasz","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/jpet.109.160184_bib28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00418-004-0696-7","article-title":"Reactive oxygen species in vascular biology: implications in hypertension","volume":"122","author":"Touyz","year":"2004","journal-title":"Histochem Cell Biol"},{"key":"10.1124\/jpet.109.160184_bib29","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1096\/fasebj.2.15.3192041","article-title":"Uricase protein sequences: conserved during vertebrate evolution but absent in humans","volume":"2","author":"Varela-Echavarr\u00eda","year":"1988","journal-title":"FASEB J"},{"key":"10.1124\/jpet.109.160184_bib30","doi-asserted-by":"crossref","first-page":"H281","DOI":"10.1152\/ajpheart.00304.2008","article-title":"Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats","volume":"295","author":"Viel","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1124\/jpet.109.160184_bib31","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.2337\/db06-0283","article-title":"Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers","volume":"55","author":"Waring","year":"2006","journal-title":"Diabetes"},{"key":"10.1124\/jpet.109.160184_bib32","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1007\/s00125-007-0817-7","article-title":"Lowering serum urate does not improve endothelial function in patients with type 2 diabetes","volume":"50","author":"Waring","year":"2007","journal-title":"Diabetologia"},{"key":"10.1124\/jpet.109.160184_bib33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0378-1119(91)90622-I","article-title":"Molecular evolution of the urate oxidase-encoding gene in hominoid primates: nonsense mutations","volume":"109","author":"Yeldandi","year":"1991","journal-title":"Gene"},{"key":"10.1124\/jpet.109.160184_bib34","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1161\/01.CIR.0000089082.40285.C3","article-title":"Gene transfer of human guanosine 5\u2032-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension","volume":"108","author":"Zheng","year":"2003","journal-title":"Circulation"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524458187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524458187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.109.160184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T02:12:04Z","timestamp":1740017524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524458187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0022356524458187"],"URL":"https:\/\/doi.org\/10.1124\/jpet.109.160184","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uric Acid Does Not Affect the Acetylcholine-Induced Relaxation of Aorta from Normotensive and Deoxycorticosterone Acetate-Salt Hypertensive Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.109.160184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}