{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:24:00Z","timestamp":1780485840667,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1124\/jpet.109.162271","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T04:52:41Z","timestamp":1263963161000},"page":"140-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Nuclear Factor Erythroid 2-Related Factor 2 Deletion Impairs Glucose Tolerance and Exacerbates Hyperglycemia in Type 1 Diabetic Mice"],"prefix":"10.1016","volume":"333","author":[{"given":"Lauren M.","family":"Aleksunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Reisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie L.","family":"Yeager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Goedken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis D.","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.109.162271_bib1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/01926230701311344","article-title":"Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease.","volume":"35","author":"Aleksunes","year":"2007","journal-title":"Toxicol Pathol"},{"key":"10.1124\/jpet.109.162271_bib2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.taap.2007.08.022","article-title":"Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.","volume":"226","author":"Aleksunes","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.109.162271_bib3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/hep.21769","article-title":"Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway.","volume":"46","author":"Bae","year":"2007","journal-title":"Hepatology"},{"key":"10.1124\/jpet.109.162271_bib4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/sj.emboj.7601950","article-title":"Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin\/IGF-1 resistance.","volume":"27","author":"Beyer","year":"2008","journal-title":"EMBO J"},{"key":"10.1124\/jpet.109.162271_bib5","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1194\/jlr.M600289-JLR200","article-title":"ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells.","volume":"47","author":"da Silva Xavier","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1124\/jpet.109.162271_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/toxsci\/59.1.169","article-title":"High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.","volume":"59","author":"Enomoto","year":"2001","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.109.162271_bib7","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2337\/db08-0057","article-title":"Oxidative stress as a major culprit in kidney disease in diabetes.","volume":"57","author":"Forbes","year":"2008","journal-title":"Diabetes"},{"key":"10.1124\/jpet.109.162271_bib8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj20020430","article-title":"New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c.","volume":"366","author":"Foufelle","year":"2002","journal-title":"Biochem J"},{"key":"10.1124\/jpet.109.162271_bib9","doi-asserted-by":"crossref","first-page":"6258","DOI":"10.1073\/pnas.87.16.6258","article-title":"Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element.","volume":"87","author":"Friling","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.109.162271_bib10","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1111\/j.1742-4658.2006.05224.x","article-title":"Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase\/Akt pathway and the Nrf2 transcription factor in renal cells.","volume":"273","author":"Harrison","year":"2006","journal-title":"FEBS J"},{"key":"10.1124\/jpet.109.162271_bib11","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0090-9556(24)15107-0","article-title":"Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology.","volume":"28","author":"Hartley","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.109.162271_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2008.10.007","article-title":"Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes.","volume":"46","author":"He","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.109.162271_bib13","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1507\/endocrj.K07E-110","article-title":"ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome.","volume":"55","author":"Iizuka","year":"2008","journal-title":"Endocr J"},{"key":"10.1124\/jpet.109.162271_bib14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.","volume":"13","author":"Itoh","year":"1999","journal-title":"Genes Dev"},{"key":"10.1124\/jpet.109.162271_bib15","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1073\/pnas.0730817100","article-title":"Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver.","volume":"100","author":"Kabashima","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.109.162271_bib16","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.freeradbiomed.2008.09.013","article-title":"Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose.","volume":"45","author":"Langston","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/jpet.109.162271_bib17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0891-5849(96)02051-5","article-title":"Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.","volume":"20","author":"Lenzen","year":"1996","journal-title":"Free Radic Biol Med"},{"key":"10.1124\/jpet.109.162271_bib18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1126\/science.180605","article-title":"Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus.","volume":"193","author":"Like","year":"1976","journal-title":"Science"},{"key":"10.1124\/jpet.109.162271_bib19","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1194\/jlr.M700090-JLR200","article-title":"Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver.","volume":"48","author":"Morral","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1124\/jpet.109.162271_bib20","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.0712162105","article-title":"Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction.","volume":"105","author":"Pearson","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.109.162271_bib21","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2337\/db06-1601","article-title":"Reactive oxygen species as a signal in glucose-stimulated insulin secretion.","volume":"56","author":"Pi","year":"2007","journal-title":"Diabetes"},{"key":"10.1124\/jpet.109.162271_bib22","article-title":"ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.","author":"Pi","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.109.162271_bib23","first-page":"4319","article-title":"Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases.","volume":"55","author":"Primiano","year":"1995","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.109.162271_bib24","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1073\/pnas.051618798","article-title":"Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.","volume":"98","author":"Ramos-Gomez","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.109.162271_bib25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1464-5491.2005.01499.x","article-title":"Animal models of diabetes mellitus.","volume":"22","author":"Rees","year":"2005","journal-title":"Diabet Med"},{"key":"10.1124\/jpet.109.162271_bib26","doi-asserted-by":"crossref","first-page":"11632","DOI":"10.1016\/S0021-9258(18)99004-6","article-title":"The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.","volume":"266","author":"Rushmore","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.109.162271_bib27","doi-asserted-by":"crossref","first-page":"21991","DOI":"10.1074\/jbc.270.37.21991","article-title":"Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription.","volume":"270","author":"Shih","year":"1995","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"10.1124\/jpet.109.162271_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jcp.1030660405","article-title":"Insulin-dependent synthesis of glucokinase.","volume":"66","author":"Sols","year":"1965","journal-title":"J Cell Physiol"},{"key":"10.1124\/jpet.109.162271_bib29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2008.11.007","article-title":"Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway.","volume":"235","author":"Song","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.109.162271_bib30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1124\/jpet.107.135822","article-title":"NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet.","volume":"325","author":"Tanaka","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.109.162271_bib31","first-page":"5196","article-title":"Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.","volume":"62","author":"Thimmulappa","year":"2002","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.109.162271_bib32","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2337\/diab.46.11.1733","article-title":"Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells.","volume":"46","author":"Tiedge","year":"1997","journal-title":"Diabetes"},{"key":"10.1124\/jpet.109.162271_bib33","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1007\/s00125-006-0295-3","article-title":"Signalling mechanisms linking hepatic glucose and lipid metabolism.","volume":"49","author":"Weickert","year":"2006","journal-title":"Diabetologia"},{"key":"10.1124\/jpet.109.162271_bib34","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/labinvest.2008.75","article-title":"The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis.","volume":"88","author":"Xu","year":"2008","journal-title":"Lab Invest"},{"key":"10.1124\/jpet.109.162271_bib35","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/j.1365-2443.2008.01234.x","article-title":"Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice.","volume":"13","author":"Yoh","year":"2008","journal-title":"Genes Cells"},{"key":"10.1124\/jpet.109.162271_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/35093050","article-title":"Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.","volume":"413","author":"Yoon","year":"2001","journal-title":"Nature"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524457340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524457340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.109.162271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T02:09:05Z","timestamp":1740017345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524457340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0022356524457340"],"URL":"https:\/\/doi.org\/10.1124\/jpet.109.162271","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear Factor Erythroid 2-Related Factor 2 Deletion Impairs Glucose Tolerance and Exacerbates Hyperglycemia in Type 1 Diabetic Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.109.162271","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2010 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}