{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:13:34Z","timestamp":1790936014240,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1124\/jpet.110.175018","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T04:44:43Z","timestamp":1290660283000},"page":"605-612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evidence That Botulinum Toxin Receptors on Epithelial Cells and Neuronal Cells Are Not Identical: Implications for Development of a Non-Neurotropic Vaccine"],"prefix":"10.1016","volume":"336","author":[{"given":"Md.","family":"Elias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fetweh","family":"al-Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Ancharski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zidoon","family":"Nasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance L.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.110.175018_bib1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jim.2008.01.015","article-title":"Hybridoma populations enriched for affinity-matured human IgGs yield high-affinity antibodies specific for botulinum neurotoxins","volume":"333","author":"Adekar","year":"2008","journal-title":"J Immunol Methods"},{"key":"10.1124\/jpet.110.175018_bib2","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1124\/jpet.105.092213","article-title":"Visualization of binding and transcytosis of botulinum toxin by human intestinal epithelial cells","volume":"315","author":"Ahsan","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.110.175018_bib3","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0022-3565(25)20272-5","article-title":"Lectins from Triticum vulgaris and Limax flavus are universal antagonists of botulinum neurotoxin and tetanus toxin","volume":"258","author":"Bakry","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.110.175018_bib4","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1523\/JNEUROSCI.22-16-06876.2002","article-title":"Complex gangliosides at the neuromuscular junction are membrane receptors for autoantibodies and botulinum neurotoxin but redundant for normal synaptic function","volume":"22","author":"Bullens","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.110.175018_bib5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0300-9084(00)01173-1","article-title":"Development of vaccines for prevention of botulism","volume":"82","author":"Byrne","year":"2000","journal-title":"Biochimie"},{"key":"10.1124\/jpet.110.175018_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1462-5822.2008.01253.x","article-title":"Differential entry of botulinum neurotoxin A into neuronal and intestinal cells","volume":"11","author":"Couesnon","year":"2009","journal-title":"Cell Microbiol"},{"key":"10.1124\/jpet.110.175018_bib7","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1126\/science.1123654","article-title":"SV2 is the protein receptor for botulinum neurotoxin A","volume":"312","author":"Dong","year":"2006","journal-title":"Science"},{"key":"10.1124\/jpet.110.175018_bib8","first-page":"1735","article-title":"Botulism caused by inhalation","volume":"57","author":"Holzer","year":"1962","journal-title":"Med Klin"},{"key":"10.1124\/jpet.110.175018_bib9","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1128\/iai.65.11.4586-4591.1997","article-title":"Induction of immune response by oral administration of recombinant botulinum toxin","volume":"65","author":"Kiyatkin","year":"1997","journal-title":"Infect Immun"},{"key":"10.1124\/jpet.110.175018_bib10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jmb.2008.12.027","article-title":"Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation","volume":"386","author":"Kumaran","year":"2009","journal-title":"J Mol Biol"},{"key":"10.1124\/jpet.110.175018_bib11","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/2338","article-title":"Crystal structure of botulinum neurotoxin type A and implications for toxicity","volume":"5","author":"Lacy","year":"1998","journal-title":"Nat Struct Biol"},{"key":"10.1124\/jpet.110.175018_bib12","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1124\/jpet.110.175018_bib13","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1242\/jcs.112.16.2715","article-title":"Functional characterisation of tetanus and botulinum neurotoxins binding domains","volume":"112","author":"Lalli","year":"1999","journal-title":"J Cell Sci"},{"key":"10.1124\/jpet.110.175018_bib14","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1128\/IAI.67.9.4708-4712.1999","article-title":"Pure botulinum toxin is absorbed from the stomach and small intestine and produces peripheral neuromuscular blockade","volume":"67","author":"Maksymowych","year":"1999","journal-title":"Infect Immun"},{"key":"10.1124\/jpet.110.175018_bib15","doi-asserted-by":"crossref","first-page":"21950","DOI":"10.1074\/jbc.273.34.21950","article-title":"Binding and transcytosis of botulinum neurotoxin by polarized human colon carcinoma cells","volume":"273","author":"Maksymowych","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.110.175018_bib16","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1124\/jpet.104.066845","article-title":"Structural features of the botulinum neurotoxin molecule that govern binding and transcytosis across polarized human intestinal epithelial cells","volume":"310","author":"Maksymowych","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.110.175018_bib17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0968-0004(86)90282-3","article-title":"How do tetanus and botulinum toxins bind to neuronal membranes?","volume":"11","author":"Montecucco","year":"1986","journal-title":"Trends Biochem Sci"},{"key":"10.1124\/jpet.110.175018_bib18","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1128\/IAI.01893-06","article-title":"Trivalent vaccine against botulinum toxin (serotypes A, B, and E) that can be administered by the mucosal route","volume":"75","author":"Ravichandran","year":"2007","journal-title":"Infect Immun"},{"key":"10.1124\/jpet.110.175018_bib19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1365-2958.2003.03872.x","article-title":"The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction","volume":"51","author":"Rummel","year":"2004","journal-title":"Mol Microbiol"},{"key":"10.1124\/jpet.110.175018_bib20","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1152\/physrev.2000.80.2.717","article-title":"Neurotoxins affecting neuroexocytosis","volume":"80","author":"Schiavo","year":"2000","journal-title":"Physiol Rev"},{"key":"10.1124\/jpet.110.175018_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0031-6997(25)06852-8","article-title":"The origin, structure, and pharmacological activity of botulinum toxin","volume":"33","author":"Simpson","year":"1981","journal-title":"Pharmacol Rev"},{"key":"10.1124\/jpet.110.175018_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.pharmtox.44.101802.121554","article-title":"Identification of the major steps in botulinum toxin action","volume":"44","author":"Simpson","year":"2004","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/jpet.110.175018_bib23","series-title":"Vaccines for Biodefense and Emerging and Neglected Diseases","first-page":"891","article-title":"Botulinum toxin","author":"Simpson","year":"2009"},{"key":"10.1124\/jpet.110.175018_bib24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/78005","article-title":"Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B","volume":"7","author":"Swaminathan","year":"2000","journal-title":"Nat Struct Biol"},{"key":"10.1124\/jpet.110.175018_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.toxicon.2004.03.016","article-title":"Isolation and characterization of a neutralizing antibody specific to internalization domain of Clostridium botulinum neurotoxin type B","volume":"44","author":"Yang","year":"2004","journal-title":"Toxicon"},{"key":"10.1124\/jpet.110.175018_bib26","doi-asserted-by":"crossref","first-page":"32815","DOI":"10.1074\/jbc.M205258200","article-title":"Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I","volume":"277","author":"Yowler","year":"2002","journal-title":"J Biol Chem"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524462472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524462472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.110.175018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T02:25:28Z","timestamp":1740018328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524462472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0022356524462472"],"URL":"https:\/\/doi.org\/10.1124\/jpet.110.175018","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence That Botulinum Toxin Receptors on Epithelial Cells and Neuronal Cells Are Not Identical: Implications for Development of a Non-Neurotropic Vaccine","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.110.175018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}