{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:54:50Z","timestamp":1792065290907,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1124\/jpet.110.176883","type":"journal-article","created":{"date-parts":[[2010,12,24]],"date-time":"2010-12-24T03:21:19Z","timestamp":1293160879000},"page":"2-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["BeKm-1, a Peptide Inhibitor of Human ether-a-go-go-Related Gene Potassium Currents, Prolongs QTc Intervals in Isolated Rabbit Heart"],"prefix":"10.1016","volume":"337","author":[{"given":"Yusheng","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BaoXi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray W.","family":"Chui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo M.","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.110.176883_bib1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/00005344-199109000-00014","article-title":"Effects of new and potent methanesulfonanilide class III antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle","volume":"18","author":"Baskin","year":"1991","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.110.176883_bib2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/00005344-199310000-00006","article-title":"Comparative assessment of ibutilide, d-sotalol, clofilium, E-4031, and UK-68,798 in a rabbit model of proarrhythmia","volume":"22","author":"Buchanan","year":"1993","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.110.176883_bib3","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0022-3565(25)10827-6","article-title":"Voltage- and time-dependent of the delayed K+ current in cardiac myocytes by dofetilide","volume":"262","author":"Carmeliet","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.110.176883_bib4","doi-asserted-by":"crossref","first-page":"13673","DOI":"10.1074\/jbc.M108211200","article-title":"Regulation of an ERG K+ current by Src tyrosine kinase","volume":"277","author":"Cayabyab","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.110.176883_bib5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.vascn.2006.01.002","article-title":"Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT interval","volume":"54","author":"Cheng","year":"2006","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1124\/jpet.110.176883_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00424-007-0418-9","article-title":"Localization of the ergtoxin-1 receptors on the voltage sensing domain of hERG K+ channel by AFM recognition imaging","volume":"456","author":"Chtcheglova","year":"2008","journal-title":"Pflugers Arch"},{"key":"10.1124\/jpet.110.176883_bib7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0002-9149(00)01044-4","article-title":"Positive atrial inotropic effect of dofetilide following cardioversion of atrial fibrillation or flutter","volume":"86","author":"DeCara","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1124\/jpet.110.176883_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1124\/mol.64.1.59","article-title":"APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go-related gene potassium channels","volume":"64","author":"Diochot","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.110.176883_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0014-5793(96)00333-X","article-title":"M-type K+ current inhibition by a toxin from the scorpion Buthus eupeus","volume":"384","author":"Filippov","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.110.176883_bib10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1096\/fasebj.13.8.953","article-title":"A toxin to nervous, cardiac, and endocrine ERG K channels isolated from Centruroides noxius scorpion venom","volume":"13","author":"Gurrola","year":"1999","journal-title":"FASEB J"},{"key":"10.1124\/jpet.110.176883_bib11","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0022-3565(25)23172-X","article-title":"UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells","volume":"256","author":"Gwilt","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.110.176883_bib12","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.vascn.2005.04.013","article-title":"Assessment of drug-induced QT interval prolongation in conscious rabbits","volume":"53","author":"Kijtawornrat","year":"2006","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1124\/jpet.110.176883_bib13","doi-asserted-by":"crossref","first-page":"9868","DOI":"10.1074\/jbc.M005973200","article-title":"An ERG channel inhibitor from the scorpion Buthus eupeus","volume":"276","author":"Korolkova","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.110.176883_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jmr.667","article-title":"Unique interaction of scorpion toxins with the hERG channel","volume":"17","author":"Korolkova","year":"2004","journal-title":"J Mol Recognit"},{"key":"10.1124\/jpet.110.176883_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF01812150","article-title":"Untersuchungen am \u00fcberlebenden S\u00e4ugethierherzen","volume":"61","author":"Langendorff","year":"1895","journal-title":"Pflugers Arch"},{"key":"10.1124\/jpet.110.176883_bib16","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/sj.bjp.0706894","article-title":"A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsade de Pointes","volume":"149","author":"Lawrence","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.110.176883_bib17","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1523\/JNEUROSCI.22-09-03414.2002","article-title":"Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release","volume":"22","author":"Lecchi","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.110.176883_bib18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1113\/expphysiol.1996.sp003972","article-title":"Two components of the delayed rectifier potassium current, IK, in rabbit sino-atrial node cells","volume":"81","author":"Lei","year":"1996","journal-title":"Exp Physiol"},{"key":"10.1124\/jpet.110.176883_bib19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1469-7793.2001.t01-1-00703.x","article-title":"Heterogeneous expression of the delayed rectifier K+ currents, i(K,r) and i(K,s), in rabbit sinoatrial node cells","volume":"535","author":"Lei","year":"2001","journal-title":"J Physiol"},{"key":"10.1124\/jpet.110.176883_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/sj.bjp.0703777","article-title":"Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QTc and action potential duration","volume":"132","author":"Lengyel","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.110.176883_bib21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/FJC.0b013e31817532ee","article-title":"Additive effects of combined application of multiple hERG blockers","volume":"51","author":"Margulis","year":"2008","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.110.176883_bib22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0014-5793(03)00662-8","article-title":"Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin","volume":"547","author":"Milnes","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.110.176883_bib23","doi-asserted-by":"crossref","first-page":"12329","DOI":"10.1073\/pnas.210244497","article-title":"A structural basis for drug-induced long QT syndrome","volume":"97","author":"Mitcheson","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.110.176883_bib24","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0041-0101(02)00100-9","article-title":"A short-chain peptide toxin isolated from Centruroides sculpturatus scorpion venom inhibits ether-a-go-go-related gene K(+) channels","volume":"40","author":"Nastainczyk","year":"2002","journal-title":"Toxicon"},{"key":"10.1124\/jpet.110.176883_bib25","doi-asserted-by":"crossref","first-page":"16403","DOI":"10.1074\/jbc.M200460200","article-title":"Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel\u2019s outer vestibule","volume":"277","author":"Pardo-Lopez","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.110.176883_bib26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(95)90340-2","article-title":"A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel","volume":"81","author":"Sanguinetti","year":"1995","journal-title":"Cell"},{"key":"10.1124\/jpet.110.176883_bib27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1085\/jgp.96.1.195","article-title":"Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents","volume":"96","author":"Sanguinetti","year":"1990","journal-title":"J Gen Physiol"},{"key":"10.1124\/jpet.110.176883_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.tips.2005.01.003","article-title":"Predicting drug-hERG channel interactions that cause acquired long QT syndrome","volume":"26","author":"Sanguinetti","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.110.176883_bib29","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/0022-2828(89)91561-7","article-title":"Depression of the delayed outward K current by novel class III antiarrhythmi agent, E-4031, in guinea pig single ventricular cells","volume":"21","author":"Sawada","year":"1989","journal-title":"J Mol Cell Cardiol"},{"key":"10.1124\/jpet.110.176883_bib30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00005344-199009000-00008","article-title":"Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel Ik blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium","volume":"16","author":"Tande","year":"1990","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.110.176883_bib31","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1161\/01.RES.0000251717.98379.69","article-title":"Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit","volume":"99","author":"Tellez","year":"2006","journal-title":"Circ Res"},{"key":"10.1124\/jpet.110.176883_bib32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.vascn.2008.04.001","article-title":"Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics","volume":"58","author":"Vargas","year":"2008","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1124\/jpet.110.176883_bib33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/01.RES.76.4.607","article-title":"Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit","volume":"76","author":"Verheijck","year":"1995","journal-title":"Circ Res"},{"key":"10.1124\/jpet.110.176883_bib34","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00005344-199111000-00006","article-title":"Cardiac electrophysiologic and inotropic actions of new and potent methanesulfonanilide class III antiarrhythmic agents in anesthetized dogs","volume":"18","author":"Wallace","year":"1991","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1124\/jpet.110.176883_bib35","doi-asserted-by":"crossref","first-page":"13289","DOI":"10.1074\/jbc.C400025200","article-title":"Impairment of HERG K channel function by tumor necrosis factor-\u03b1","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.110.176883_bib36","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1073\/pnas.91.8.3438","article-title":"A family of potassium channel genes related to eag in Drosophila and mammals","volume":"91","author":"Warmke","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl 1","key":"10.1124\/jpet.110.176883_bib37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s003950050236","article-title":"Rate dependence of antiarrhythmic and proarrhythmic properties of class I and class III antiarrhythmic drugs","volume":"93","author":"Weirich","year":"1998","journal-title":"Basic Res Cardiol"},{"key":"10.1124\/jpet.110.176883_bib38","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/01.RES.80.2.261","article-title":"Tissue and species distribution of mRNA for the IKr-like K+ channel, erg","volume":"80","author":"Wymore","year":"1997","journal-title":"Circ Res"},{"key":"10.1124\/jpet.110.176883_bib39","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1016\/S0006-3495(03)70028-9","article-title":"BeKm-1 is a hERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1","volume":"84","author":"Zhang","year":"2003","journal-title":"Biophys J"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524462940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524462940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.110.176883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T02:27:03Z","timestamp":1740018423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524462940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0022356524462940"],"URL":"https:\/\/doi.org\/10.1124\/jpet.110.176883","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BeKm-1, a Peptide Inhibitor of Human ether-a-go-go-Related Gene Potassium Currents, Prolongs QTc Intervals in Isolated Rabbit Heart","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.110.176883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}