{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:15:37Z","timestamp":1791274537286,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1124\/jpet.110.177378","type":"journal-article","created":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T00:15:29Z","timestamp":1303431329000},"page":"345-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"title":["The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise?"],"prefix":"10.1016","volume":"338","author":[{"given":"Stacey J.","family":"Sukoff Rizzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Dollings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Neal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey N.","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Lock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Kowal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Randall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Huselton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthick","family":"Vishwanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna Y.","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Butera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Rosenzweig-Lipson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zo\u00eb A.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dunlop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.110.177378_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF01062139","article-title":"Testing for the equality of area under the curves when using destructive measurement techniques","volume":"16","author":"Bailer","year":"1988","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1124\/jpet.110.177378_bib2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1471-4159.2000.0750889.x","article-title":"Regulation of neurotransmitter release by metabotropic glutamate receptors","volume":"75","author":"Cartmell","year":"2000","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.110.177378_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1073\/pnas.0510051103","article-title":"mGluR7\u2019s lucky number","volume":"103","author":"Conn","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.110.177378_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.pharmtox.37.1.205","article-title":"Pharmacology and functions of metabotropic glutamate receptors","volume":"37","author":"Conn","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/jpet.110.177378_bib5","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1046\/j.1460-9568.2003.02667.x","article-title":"Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7","volume":"17","author":"Cryan","year":"2003","journal-title":"Eur J Neurosci"},{"key":"10.1124\/jpet.110.177378_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0223-5234(03)00012-6","article-title":"High throughput artificial membrane permeability assay for blood-brain barrier","volume":"38","author":"Di","year":"2003","journal-title":"Eur J Med Chem"},{"key":"10.1124\/jpet.110.177378_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2006.10.039","article-title":"Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS","volume":"335","author":"Di","year":"2007","journal-title":"Int J Pharm"},{"key":"10.1124\/jpet.110.177378_bib8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijpharm.2006.03.007","article-title":"High throughput microsomal stability assay for insoluble compounds","volume":"317","author":"Di","year":"2006","journal-title":"Int J Pharm"},{"key":"10.1124\/jpet.110.177378_bib9","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/FBP.0b013e32832ec5d1","article-title":"The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat","volume":"20","author":"Dolan","year":"2009","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.110.177378_bib10","series-title":"Pharmacokinetics","author":"Gibaldi","year":"1982"},{"key":"10.1124\/jpet.110.177378_bib11","series-title":"The Metabotropic Glutamate Receptors","first-page":"147","article-title":"Acute regulation of synaptic transmission by metabotropic glutamate receptors","author":"Glaum","year":"1997"},{"key":"10.1124\/jpet.110.177378_bib12","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1124\/jpet.109.162115","article-title":"Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson\u2019s disease","volume":"332","author":"Greco","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.110.177378_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainresrev.2009.05.005","article-title":"Emerging role of glutamate in the pathophysiology of major depressive disorder","volume":"61","author":"Hashimoto","year":"2009","journal-title":"Brain Res Rev"},{"key":"10.1124\/jpet.110.177378_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2005.01.018","article-title":"Neurochemical evaluation of the novel 5-HT1A receptor partial agonist\/serotonin reuptake inhibitor, vilazodone","volume":"510","author":"Hughes","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.110.177378_bib15","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/(SICI)1096-9861(19980413)393:3<332::AID-CNE6>3.0.CO;2-2","article-title":"Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: a light and electron microscopic study","volume":"393","author":"Kinoshita","year":"1998","journal-title":"J Comp Neurol"},{"key":"10.1124\/jpet.110.177378_bib16","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1017\/S1092852900010403","article-title":"Beyond monoamines: glutamatergic function in mood disorders","volume":"10","author":"Kugaya","year":"2005","journal-title":"CNS Spectr"},{"key":"10.1124\/jpet.110.177378_bib17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuropharm.2006.03.020","article-title":"Comparison of in vivo and ex vivo [3H]flumazenil binding assays to determine occupancy at the benzodiazepine binding site of rat brain GABAA receptors","volume":"51","author":"Li","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.110.177378_bib18","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1038\/npp.2008.236","article-title":"Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism","volume":"34","author":"Li","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.110.177378_bib19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1523\/JNEUROSCI.19-03-00955.1999","article-title":"Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion","volume":"19","author":"Masugi","year":"1999","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.110.177378_bib20","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/nn1971","article-title":"New insights into BDNF function in depression and anxiety","volume":"10","author":"Martinowich","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1124\/jpet.110.177378_bib21","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1176\/appi.ajp.161.5.826","article-title":"Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study","volume":"161","author":"Meyer","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1124\/jpet.110.177378_bib22","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/sj.npp.1300926","article-title":"Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders","volume":"31","author":"Mitsukawa","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1124\/jpet.110.177378_bib23","doi-asserted-by":"crossref","first-page":"18712","DOI":"10.1073\/pnas.0508063102","article-title":"A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo","volume":"102","author":"Mitsukawa","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.110.177378_bib24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00213-007-0856-2","article-title":"Activation of the mGlu7 receptor elicits antidepressant-like effects in mice","volume":"194","author":"Palucha","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.110.177378_bib25","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1124\/jpet.110.169730","article-title":"The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N\u2032-bis (diphenylmethyl)-1,2-ethanediamine (AMN082), is serotonin-dependent","volume":"334","author":"Pa\u0142ucha-Poniewiera","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.110.177378_bib26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pbb.2008.06.006","article-title":"Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082","volume":"91","author":"Salling","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.110.177378_bib27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1124\/jpet.110.177378_bib28","series-title":"2005 Neuroscience Meeting; 2005 Nov 12\u201316; Washington, DC","article-title":"siRNA-induced knockdown of the group III metabotropic glutamate receptor mGluR7 in the adult mouse brain induces anxiolytic-like responses","author":"Thakker","year":"2005"},{"key":"10.1124\/jpet.110.177378_bib29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0969-8051(02)00316-5","article-title":"In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography","volume":"29","author":"Wilson","year":"2002","journal-title":"Nucl Med Biol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524464562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524464562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.110.177378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T02:32:28Z","timestamp":1740018748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524464562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0022356524464562"],"URL":"https:\/\/doi.org\/10.1124\/jpet.110.177378","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise?","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.110.177378","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}