{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:35:46Z","timestamp":1790634946620,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1124\/jpet.111.181727","type":"journal-article","created":{"date-parts":[[2011,5,28]],"date-time":"2011-05-28T02:11:13Z","timestamp":1306548673000},"page":"758-766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Delayed Administration of Suramin Attenuates the Progression of Renal Fibrosis in Obstructive Nephropathy"],"prefix":"10.1016","volume":"338","author":[{"given":"Na","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Tolbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murugavel","family":"Ponnusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shougang","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.111.181727_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0304-3835(99)00260-8","article-title":"Suramin blocks growth-stimulatory effects of platelet-derived growth factor on malignant fibrous histiocytomas in vitro","volume":"146","author":"Abdiu","year":"1999","journal-title":"Cancer Lett"},{"key":"10.1124\/jpet.111.181727_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cytogfr.2004.03.006","article-title":"Regulation of PDGF and its receptors in fibrotic diseases","volume":"15","author":"Bonner","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1124\/jpet.111.181727_bib3","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1093\/ndt\/gfm393","article-title":"Treatment targets in renal fibrosis","volume":"22","author":"Boor","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1124\/jpet.111.181727_bib4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1152\/japplphysiol.00915.2002","article-title":"Antifibrotic effects of suramin in injured skeletal muscle after laceration","volume":"95","author":"Chan","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1124\/jpet.111.181727_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jcp.1041320120","article-title":"Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells","volume":"132","author":"Coffey","year":"1987","journal-title":"J Cell Physiol"},{"key":"10.1124\/jpet.111.181727_bib6","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1111\/j.1523-1755.2004.00905.x","article-title":"The renin-angiotensin system blockade does not prevent renal interstitial fibrosis induced by aristolochic acids","volume":"66","author":"Debelle","year":"2004","journal-title":"Kidney Int"},{"key":"10.1124\/jpet.111.181727_bib7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000227677","article-title":"Suramin inhibits the growth of non-small-cell lung cancer cells that express the epidermal growth factor receptor","volume":"54","author":"Fujiuchi","year":"1997","journal-title":"Oncology"},{"key":"10.1124\/jpet.111.181727_bib8","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/sj.ki.5001804","article-title":"The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice","volume":"70","author":"Gon\u00e7alves","year":"2006","journal-title":"Kidney Int"},{"key":"10.1124\/jpet.111.181727_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/ar1197","article-title":"Signaling by STATs","volume":"6","author":"Ivashkiv","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1124\/jpet.111.181727_bib10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological roles of MAPK signaling pathways in human diseases","volume":"1802","author":"Kim","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.111.181727_bib11","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/0959-8049(94)90544-4","article-title":"Suramin inhibits growth and transforming growth factor-\u03b21 (TGF-\u03b21) binding in osteosarcoma cell lines","volume":"30A","author":"Kloen","year":"1994","journal-title":"Eur J Cancer"},{"key":"10.1124\/jpet.111.181727_bib12","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm1275","article-title":"Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach","volume":"11","author":"Lautrette","year":"2005","journal-title":"Nat Med"},{"key":"10.1124\/jpet.111.181727_bib13","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.2353\/ajpath.2009.090037","article-title":"Involvement of sphingosine 1-phosphate (SIP)\/S1P3 signaling in cholestasis-induced liver fibrosis","volume":"175","author":"Li","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1124\/jpet.111.181727_bib14","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1681\/ASN.2010090956","article-title":"Suramin inhibits renal fibrosis in chronic kidney disease","volume":"22","author":"Liu","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/jpet.111.181727_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ki.5000054","article-title":"Renal fibrosis: new insights into the pathogenesis and therapeutics","volume":"69","author":"Liu","year":"2006","journal-title":"Kidney Int"},{"key":"10.1124\/jpet.111.181727_bib16","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1158\/0008-5472.CAN-07-0575","article-title":"Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression","volume":"67","author":"Lo","year":"2007","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.111.181727_bib17","doi-asserted-by":"crossref","first-page":"c286","DOI":"10.1159\/000235946","article-title":"Inhibition of the renin-angiotensin system in chronic kidney disease: a critical look to single and dual blockade","volume":"113","author":"Locatelli","year":"2009","journal-title":"Nephron Clin Pract"},{"key":"10.1124\/jpet.111.181727_bib18","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1097\/01.ASN.0000130623.66271.67","article-title":"Activation of the extracellular-signal regulated protein kinase pathway in human glomerulopathies","volume":"15","author":"Masaki","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/jpet.111.181727_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10157-009-0247-6","article-title":"Chronic kidney disease management in an academic internal medicine clinic","volume":"14","author":"Morrow","year":"2010","journal-title":"Clin Exp Nephrol"},{"key":"10.1124\/jpet.111.181727_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ncpneph0093","article-title":"Mechanisms of disease: fibroblasts\u2014a new look at an old problem","volume":"2","author":"Neilson","year":"2006","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1124\/jpet.111.181727_bib21","doi-asserted-by":"crossref","first-page":"F996","DOI":"10.1152\/ajprenal.00282.2009","article-title":"Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy","volume":"297","author":"Pang","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/jpet.111.181727_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/ki.2010.154","article-title":"A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy","volume":"78","author":"Pang","year":"2010","journal-title":"Kidney Int"},{"key":"10.1124\/jpet.111.181727_bib23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4049\/jimmunol.0801986","article-title":"TGF-\u03b2 promotes Th17 cell development through inhibition of SOCS3","volume":"183","author":"Qin","year":"2009","journal-title":"J Immunol"},{"key":"10.1124\/jpet.111.181727_bib24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0003-9861(03)00163-2","article-title":"Possible involvement of mitogen-activated protein kinase in the angiotensin II-induced fibronectin synthesis in renal interstitial fibroblasts","volume":"415","author":"Sekine","year":"2003","journal-title":"Arch Biochem Biophys"},{"key":"10.1124\/jpet.111.181727_bib25","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/sj.ki.5002149","article-title":"TGF-\u03b2 type II receptor deficiency prevents renal injury via decrease in ERK activity in crescentic glomerulonephritis","volume":"71","author":"Song","year":"2007","journal-title":"Kidney Int"},{"key":"10.1124\/jpet.111.181727_bib26","first-page":"2239","article-title":"Suramin: a novel antineoplastic agent with multiple potential mechanisms of action","volume":"53","author":"Stein","year":"1993","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.111.181727_bib27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1200\/JCO.1989.7.4.499","article-title":"Suramin: an anticancer drug with a unique mechanism of action","volume":"7","author":"Stein","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1124\/jpet.111.181727_bib28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s10157-004-0297-8","article-title":"Role of mitogen-activated protein kinase in the regulation of transforming growth factor-\u03b2-induced fibronectin accumulation in cultured renal interstitial fibroblasts","volume":"8","author":"Suzuki","year":"2004","journal-title":"Clin Exp Nephrol"},{"key":"10.1124\/jpet.111.181727_bib29","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1158\/0008-5472.CAN-06-3211","article-title":"Transforming growth factor \u03b2 signaling via Ras in mesenchymal cells requires p21-activated kinase 2 for extracellular signal-regulated kinase-dependent transcriptional responses","volume":"67","author":"Suzuki","year":"2007","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.111.181727_bib30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1172\/JCI8315","article-title":"Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury","volume":"106","author":"Terzi","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.111.181727_bib31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1536\/jhj.42.221","article-title":"Vascular smooth muscle cell proliferation is effectively suppressed by the non-specific growth factor inhibitor suramin","volume":"42","author":"Urasawa","year":"2001","journal-title":"Jpn Heart J"},{"key":"10.1124\/jpet.111.181727_bib32","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1128\/MCB.16.4.1759","article-title":"Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins","volume":"16","author":"Vignais","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1124\/jpet.111.181727_bib33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1440-1797.2005.00334.x","article-title":"Transforming growth factor-\u03b2 and Smad signalling in kidney diseases","volume":"10","author":"Wang","year":"2005","journal-title":"Nephrology"},{"key":"10.1124\/jpet.111.181727_bib34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"10.1124\/jpet.111.181727_bib35","first-page":"343","article-title":"Growth factors, cytokines and soluble forms of receptor molecules in cancer patients","volume":"15","author":"Zumkeller","year":"1995","journal-title":"Anticancer Res"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524465191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524465191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.111.181727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T02:34:32Z","timestamp":1740018872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524465191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0022356524465191"],"URL":"https:\/\/doi.org\/10.1124\/jpet.111.181727","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delayed Administration of Suramin Attenuates the Progression of Renal Fibrosis in Obstructive Nephropathy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.111.181727","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2011 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}