{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:23:00Z","timestamp":1767666180364,"version":"3.40.3"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1124\/jpet.111.188250","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T05:55:53Z","timestamp":1324014953000},"page":"742-749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quantitative Analyses of Antagonism: Combinations of Midazolam and Either Flunitrazepam or Pregnanolone in Rhesus Monkeys Discriminating Midazolam"],"prefix":"10.1016","volume":"340","author":[{"given":"Lisa R.","family":"Gerak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles P.","family":"France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.111.188250_bib1","first-page":"48","article-title":"Some quantitative uses of drug antagonists","volume":"14","author":"Arunlakshana","year":"1959","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.111.188250_bib2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0014-2999(82)90355-7","article-title":"Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist","volume":"81","author":"Dantzer","year":"1982","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.111.188250_bib3","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/FBP.0b013e32833fa79d","article-title":"Tolerance to the rate-increasing and not rate-decreasing effects of pregnanolone in rats","volume":"21","author":"Eppolito","year":"2010","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.111.188250_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0022-3565(24)35305-4","article-title":"Differential change in neuroactive steroid sensitivity during ethanol withdrawal","volume":"292","author":"Finn","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.111.188250_bib5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1124\/jpet.111.180422","article-title":"Anticonflict and reinforcing effects of triazolam + pregnanolone combinations in rhesus monkeys","volume":"337","author":"Fischer","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.111.188250_bib6","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0028-3908(99)00190-2","article-title":"Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate","volume":"39","author":"Gasior","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.111.188250_bib7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00213-009-1497-4","article-title":"Selective changes in sensitivity to benzodiazepines, and not other positive GABAA modulators, in rats receiving flunitrazepam chronically","volume":"204","author":"Gerak","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.111.188250_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/FBP.0b013e3283425aa0","article-title":"Chronic benzodiazepine treatment does not alter interactions between positive GABAA modulators and flumazenil or pentylenetetrazole in monkeys","volume":"22","author":"Gerak","year":"2011","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.111.188250_bib9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0006-8993(87)90993-0","article-title":"Time course for development of anticonvulsant tolerance and GABAergic subsensitivity after chronic diazepam","volume":"405","author":"Gonsalves","year":"1987","journal-title":"Brain Res"},{"year":"1996","series-title":"Guide for the Care and Use of Laboratory Animals","key":"10.1124\/jpet.111.188250_bib10"},{"year":"1993","series-title":"Pharmacologic Analysis of Drug-Receptor Interaction","author":"Kenakin","key":"10.1124\/jpet.111.188250_bib11"},{"key":"10.1124\/jpet.111.188250_bib12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s002130000374","article-title":"In vivo estimates of efficacy at 5-HT1A receptors: effects of EEDQ on the ability of agonists to produce lower-lip retraction in rats","volume":"149","author":"Koek","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.111.188250_bib13","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0022-3565(25)22531-9","article-title":"Anticonvulsant activity of neurosteroids: correlation with \u03b3-aminobutyric acid-evoked chloride current potentiation","volume":"270","author":"Kokate","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.111.188250_bib14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0022-3565(24)37827-9","article-title":"Lack of anticonvulsant tolerance to the neuroactive steroid pregnanolone in mice","volume":"287","author":"Kokate","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.111.188250_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/sleep\/22.1.33","article-title":"Role of GABAA receptors in the regulation of sleep: initial sleep responses to peripherally administered modulators and agonists","volume":"22","author":"Lancel","year":"1999","journal-title":"Sleep"},{"key":"10.1124\/jpet.111.188250_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00008877-199902000-00004","article-title":"Discriminative-stimulus effects of triazolam and midazolam in rhesus monkeys","volume":"10","author":"Lelas","year":"1999","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.111.188250_bib17","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0022-3565(24)39151-7","article-title":"Antagonism of the discriminative stimulus effects of positive \u03b3-aminobutyric acidA modulators in rhesus monkeys discriminating midazolam","volume":"294","author":"Lelas","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.111.188250_bib18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0022-3565(25)21163-6","article-title":"Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil","volume":"279","author":"L\u00f6scher","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.111.188250_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0091-3057(96)00132-3","article-title":"Development of tolerance in mice to the sedative effects of the neuroactive steroid minaxolone following chronic exposure","volume":"58","author":"Marshall","year":"1997","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1124\/jpet.111.188250_bib20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00008877-200211000-00004","article-title":"Acute and chronic effects of the neuroactive steroid pregnanolone on schedule-controlled responding in rhesus monkeys","volume":"13","author":"McMahon","year":"2002","journal-title":"Behav Pharmacol"},{"key":"10.1124\/jpet.111.188250_bib21","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1124\/jpet.300.3.1017","article-title":"Daily treatment with diazepam differentially modifies sensitivity to the effects of \u03b3-aminobutyric acidA modulators on schedule-controlled responding in rhesus monkeys","volume":"300","author":"McMahon","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.111.188250_bib22","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s00213-004-2022-4","article-title":"Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys","volume":"178","author":"McMahon","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.111.188250_bib23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1124\/jpet.300.2.505","article-title":"Discriminative stimulus effects of benzodiazepine (BZ)1 receptor-selective ligands in rhesus monkeys","volume":"300","author":"McMahon","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.111.188250_bib24","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0022-3565(24)39026-3","article-title":"Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself","volume":"295","author":"Reddy","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.111.188250_bib25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1528-1157.2001.10200.x","article-title":"Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy","volume":"42","author":"Reddy","year":"2001","journal-title":"Epilepsia"},{"key":"10.1124\/jpet.111.188250_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00213-005-0228-8","article-title":"Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors","volume":"184","author":"Rowlett","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.111.188250_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.neuroscience.2005.12.031","article-title":"Tolerance development to Morris water maze test impairments induced by acute allopregnanolone","volume":"139","author":"T\u00fcrkmen","year":"2006","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.111.188250_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s002130050809","article-title":"Positive allosteric modulators of the GABAA receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol","volume":"141","author":"Vanover","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1124\/jpet.111.188250_bib29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s002130050424","article-title":"Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3\u20130593","volume":"134","author":"Wieland","year":"1997","journal-title":"Psychopharmacology"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524467748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524467748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.111.188250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T23:03:47Z","timestamp":1743203027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524467748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0022356524467748"],"URL":"https:\/\/doi.org\/10.1124\/jpet.111.188250","relation":{},"ISSN":["0022-3565"],"issn-type":[{"type":"print","value":"0022-3565"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Analyses of Antagonism: Combinations of Midazolam and Either Flunitrazepam or Pregnanolone in Rhesus Monkeys Discriminating Midazolam","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.111.188250","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}