{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:07:05Z","timestamp":1789913225361,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1124\/jpet.112.194357","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T22:56:41Z","timestamp":1340060201000},"page":"835-842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Vaccination with Platelet-Derived Growth Factor B Kinoids Inhibits CCl4-Induced Hepatic Fibrosis in Mice"],"prefix":"10.1016","volume":"342","author":[{"given":"Zhi-Ming","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Bao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hou-Qiang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.112.194357_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02890000","article-title":"Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis","volume":"56","author":"Ballardini","year":"1988","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"10.1124\/jpet.112.194357_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cytogfr.2004.03.006","article-title":"Regulation of PDGF and its receptors in fibrotic diseases","volume":"15","author":"Bonner","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1124\/jpet.112.194357_bib3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0014-5793(97)01446-4","article-title":"A cyclic peptide analogue of loop III of PDGF-BB causes apoptosis in human fibroblasts","volume":"419","author":"Brennand","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.112.194357_bib4","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/labinvest.3700094","article-title":"Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis","volume":"84","author":"Borkham-Kamphorst","year":"2004","journal-title":"Lab Invest"},{"key":"10.1124\/jpet.112.194357_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbrc.2004.06.153","article-title":"Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis","volume":"32","author":"Borkham-Kamphorst","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.112.194357_bib6","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.jhep.2007.01.029","article-title":"Pro-fibrogenic potential of PDGF-D in liver fibrosis","volume":"46","author":"Borkham-Kamphorst","year":"2007","journal-title":"J Hepatol"},{"key":"10.1124\/jpet.112.194357_bib7","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/labinvest.2008.71","article-title":"Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury","volume":"88","author":"Borkham-Kamphorst","year":"2008","journal-title":"Lab Invest"},{"key":"10.1124\/jpet.112.194357_bib8","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1073\/pnas.0409722102","article-title":"Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma","volume":"102","author":"Campbell","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.112.194357_bib9","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(01)00260-4","article-title":"Hepatic stellate cell\/myofibroblast subpopulations in fibrotic human and rat livers","volume":"36","author":"Cassiman","year":"2002","journal-title":"J Hepatol"},{"key":"10.1124\/jpet.112.194357_bib10","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/gt.2008.93","article-title":"Targeted inhibition of platelet-derived growth factor receptor-beta subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats","volume":"15","author":"Chen","year":"2008","journal-title":"Gene Ther"},{"key":"10.1124\/jpet.112.194357_bib11","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.vaccine.2005.11.064","article-title":"Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis","volume":"24","author":"Cheong","year":"2006","journal-title":"Vaccine"},{"key":"10.1124\/jpet.112.194357_bib12","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jhep.2006.04.010","article-title":"Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice","volume":"45","author":"Czochra","year":"2006","journal-title":"J Hepatol"},{"key":"10.1124\/jpet.112.194357_bib13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1046\/j.1365-2133.2001.04443.x","article-title":"Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts","volume":"145","author":"Czuwara-Ladykowska","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1124\/jpet.112.194357_bib14","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/10878","article-title":"Therapeutic antibodies elicited by immunization against TNF-alpha","volume":"17","author":"Dalum","year":"1999","journal-title":"Nat Biotechnol"},{"key":"10.1124\/jpet.112.194357_bib15","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1136\/ard.2007.079137","article-title":"Early and long-lasting protection from arthritis in tumour necrosis factor alpha (TNFalpha) transgenic mice vaccinated against TNFalpha","volume":"67","author":"Delavall\u00e9e","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1124\/jpet.112.194357_bib16","doi-asserted-by":"crossref","first-page":"16581","DOI":"10.1016\/S0021-9258(18)42042-X","article-title":"Identification of a peptide antagonist for platelet-derived growth factor","volume":"267","author":"Engstr\u00f6m","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.112.194357_bib17","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1124\/jpet.112.194357_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4161\/hv.3.1.3537","article-title":"Therapeutic vaccination with epidermal growth factor (EGF) in advanced lung cancer: analysis of pooled data from three clinical trials","volume":"3","author":"Gonz\u00e1lez","year":"2007","journal-title":"Human Vaccines"},{"key":"10.1124\/jpet.112.194357_bib19","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1124\/jpet.106.114496","article-title":"Local inhibition of liver fibrosis by specific delivery of a platelet-derived growth factor kinase inhibitor to hepatic stellate cells","volume":"321","author":"Gonzalo","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.112.194357_bib20","doi-asserted-by":"crossref","first-page":"9208","DOI":"10.1073\/pnas.0603110103","article-title":"A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth","volume":"103","author":"Holmgren","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.112.194357_bib21","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"10.1124\/jpet.112.194357_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/01.LAB.0000054178.01162.E4","article-title":"The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis","volume":"83","author":"Kinnman","year":"2003","journal-title":"Lab Invest"},{"key":"10.1124\/jpet.112.194357_bib23","first-page":"3538","article-title":"Immunochemical localization of the epitope for a monoclonal antibody that neutralizes human platelet-derived growth factor mitogenic activity","volume":"9","author":"LaRochelle","year":"1989","journal-title":"Mol Cell Biol"},{"key":"10.1124\/jpet.112.194357_bib24","doi-asserted-by":"crossref","first-page":"17074","DOI":"10.1016\/S0021-9258(18)41894-7","article-title":"Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule","volume":"267","author":"LaRochelle","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.112.194357_bib25","doi-asserted-by":"crossref","first-page":"19442","DOI":"10.1073\/pnas.0604827103","article-title":"TNFalpha kinoid vaccination-induced neutralizing antibodies to TNFalpha protect mice from autologous TNFalpha-driven chronic and acute inflammation","volume":"103","author":"Le Buanec","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.112.194357_bib26","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/ijc.25469","article-title":"Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis","volume":"128","author":"Maass","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1124\/jpet.112.194357_bib27","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1200\/JCO.2007.11.5980","article-title":"Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non\u2013small-cell lung cancer","volume":"26","author":"Neninger Vinageras","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1124\/jpet.112.194357_bib28","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.1872-034X.2010.00718.x","article-title":"Anti-PDGF-B monoclonal antibody reduces liver fibrosis development","volume":"40","author":"Ogawa","year":"2010","journal-title":"Hepatol Res"},{"key":"10.1124\/jpet.112.194357_bib29","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.LAB.0000017365.18894.D3","article-title":"Effects and regulation of connective tissue growth factor on hepatic stellate cells","volume":"82","author":"Paradis","year":"2002","journal-title":"Lab Invest"},{"key":"10.1124\/jpet.112.194357_bib30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1399-3011.1999.tb01618.x","article-title":"A cyclic peptide analogue of the loop III region of platelet-derived growth factor-BB is a synthetic antigen for the native protein","volume":"53","author":"Patel","year":"1999","journal-title":"J Pept Res"},{"key":"10.1124\/jpet.112.194357_bib31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/hep.1840190323","article-title":"Expression of platelet-derived growth factor in a model of acute liver injury","volume":"19","author":"Pinzani","year":"1994","journal-title":"Hepatology"},{"key":"10.1124\/jpet.112.194357_bib32","first-page":"785","article-title":"Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis","volume":"148","author":"Pinzani","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1124\/jpet.112.194357_bib33","doi-asserted-by":"crossref","first-page":"d1720","DOI":"10.2741\/pinzani","article-title":"PDGF and signal transduction in hepatic stellate cells","volume":"7","author":"Pinzani","year":"2002","journal-title":"Front Biosci"},{"key":"10.1124\/jpet.112.194357_bib34","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1073\/pnas.0611022104","article-title":"VEGF kinoid vaccine, a therapeutic approach against tumor angiogenesis and metastases","volume":"104","author":"Rad","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.112.194357_bib35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","article-title":"A simplified method for the analysis of hydroxyproline in biological tissues","volume":"29","author":"Reddy","year":"1996","journal-title":"Clin Biochem"},{"key":"10.1124\/jpet.112.194357_bib36","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.4049\/jimmunol.178.11.7450","article-title":"A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis","volume":"178","author":"Spohn","year":"2007","journal-title":"J Immunol"},{"key":"10.1124\/jpet.112.194357_bib37","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/eji.200737989","article-title":"Active immunization with IL-1 displayed on virus-like particles protects from autoimmune arthritis","volume":"38","author":"Spohn","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1124\/jpet.112.194357_bib38","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0140-6736(08)60381-5","article-title":"Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study","volume":"371","author":"Tissot","year":"2008","journal-title":"Lancet"},{"key":"10.1124\/jpet.112.194357_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.gene.2008.05.022","article-title":"Spontaneous hepatic fibrosis in transgenic mice overexpressing PDGF-A","volume":"423","author":"Thieringer","year":"2008","journal-title":"Gene"},{"key":"10.1124\/jpet.112.194357_bib40","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/gt.2008.112","article-title":"A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sepsis","volume":"15","author":"Tohyama","year":"2008","journal-title":"Gene Ther"},{"key":"10.1124\/jpet.112.194357_bib41","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1172\/JCI117497","article-title":"Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture","volume":"94","author":"Wong","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.112.194357_bib42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0753-3322(99)80065-1","article-title":"Anti-IFN alpha immunization raises the IFN alpha-neutralizing capacity of serum\u2013an adjuvant to antiretroviral tritherapy","volume":"53","author":"Zagury","year":"1999","journal-title":"Biomed Pharmacother"},{"key":"10.1124\/jpet.112.194357_bib43","doi-asserted-by":"crossref","first-page":"8024","DOI":"10.1073\/pnas.141224798","article-title":"Toward a new generation of vaccines: the anti-cytokine therapeutic vaccines","volume":"98","author":"Zagury","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.112.194357_bib44","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1359-6101(03)00004-2","article-title":"Active versus passive anti-cytokine antibody therapy against cytokine-associated chronic diseases","volume":"14","author":"Zagury","year":"2003","journal-title":"Cytokine Growth Factor Rev"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524183358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524183358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.112.194357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T12:11:06Z","timestamp":1739967066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524183358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0022356524183358"],"URL":"https:\/\/doi.org\/10.1124\/jpet.112.194357","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vaccination with Platelet-Derived Growth Factor B Kinoids Inhibits CCl4-Induced Hepatic Fibrosis in Mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.112.194357","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2012 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}