{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:47:32Z","timestamp":1791082052432,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1124\/jpet.113.204933","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T11:55:21Z","timestamp":1374839721000},"page":"80-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Rolipram Attenuates Bile Duct Ligation\u2013Induced Liver Injury in Rats: A Potential Pathogenic Role of PDE4"],"prefix":"10.1016","volume":"347","author":[{"given":"Leila","family":"Gobejishvili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirish","family":"Barve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Breitkopf-Heinlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingWen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana V.","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Dooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"McClain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.113.204933_bib1","doi-asserted-by":"crossref","unstructured":"Aoyama T, Paik YH, Seki E (2010) Toll-like receptor signaling and liver fibrosis. Gastroenterol Res Pract 2010: DOI: 10.1155\/2010\/192543 [Epub].","DOI":"10.1155\/2010\/192543"},{"key":"10.1124\/jpet.113.204933_bib2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/hep.20051","article-title":"Apoptosis: the nexus of liver injury and fibrosis","volume":"39","author":"Canbay","year":"2004","journal-title":"Hepatology"},{"key":"10.1124\/jpet.113.204933_bib3","doi-asserted-by":"crossref","first-page":"G334","DOI":"10.1152\/ajpgi.00517.2003","article-title":"Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis","volume":"287","author":"Cullen","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.113.204933_bib4","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0168-8278(99)80192-5","article-title":"Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells","volume":"30","author":"Desmouli\u00e8re","year":"1999","journal-title":"J Hepatol"},{"key":"10.1124\/jpet.113.204933_bib5","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/0006-2952(93)90219-M","article-title":"Protection by phosphodiesterase inhibitors against endotoxin-induced liver injury in galactosamine-sensitized mice","volume":"45","author":"Fischer","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.113.204933_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/bbrc.1997.6214","article-title":"Fas\/APO-1(CD95)-induced apoptosis of primary hepatocytes is inhibited by cAMP","volume":"232","author":"Fladmark","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.113.204933_bib7","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.113.204933_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0022-3565(24)36389-X","article-title":"Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors","volume":"280","author":"Gantner","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.113.204933_bib9","doi-asserted-by":"crossref","first-page":"G681","DOI":"10.1152\/ajpgi.00098.2006","article-title":"Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease","volume":"291","author":"Gobejishvili","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.113.204933_bib10","doi-asserted-by":"crossref","first-page":"G718","DOI":"10.1152\/ajpgi.90232.2008","article-title":"Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease","volume":"295","author":"Gobejishvili","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.113.204933_bib11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1124\/jpet.110.174268","article-title":"S-Adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP\/protein kinase A pathway","volume":"337","author":"Gobejishvili","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.113.204933_bib12","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1172\/JCI119291","article-title":"Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133","volume":"99","author":"Houglum","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.113.204933_bib13","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1073\/pnas.122041599","article-title":"Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses","volume":"99","author":"Jin","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.113.204933_bib14","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.4049\/jimmunol.175.3.1523","article-title":"Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages","volume":"175","author":"Jin","year":"2005","journal-title":"J Immunol"},{"key":"10.1124\/jpet.113.204933_bib15","doi-asserted-by":"crossref","first-page":"G385","DOI":"10.1152\/ajpgi.00430.2010","article-title":"cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase","volume":"301","author":"Johnston","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.113.204933_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3181\/0707-MR-190","article-title":"Mechanisms of fibrogenesis","volume":"233","author":"Kisseleva","year":"2008","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1124\/jpet.113.204933_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bpg.2011.02.011","article-title":"Anti-fibrogenic strategies and the regression of fibrosis","volume":"25","author":"Kisseleva","year":"2011","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1124\/jpet.113.204933_bib18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/371346a0","article-title":"Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE","volume":"371","author":"Lazebnik","year":"1994","journal-title":"Nature"},{"key":"10.1124\/jpet.113.204933_bib19","doi-asserted-by":"crossref","first-page":"13026","DOI":"10.1074\/jbc.275.17.13026","article-title":"Cyclic nucleotides suppress tumor necrosis factor alpha-mediated apoptosis by inhibiting caspase activation and cytochrome c release in primary hepatocytes via a mechanism independent of Akt activation","volume":"275","author":"Li","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.113.204933_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00535-008-2180-y","article-title":"Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies","volume":"43","author":"Li","year":"2008","journal-title":"J Gastroenterol"},{"key":"10.1124\/jpet.113.204933_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1440-1746.2004.03512.x","article-title":"Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats","volume":"20","author":"Matsuhashi","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1124\/jpet.113.204933_bib22","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1055\/s-0030-1255352","article-title":"Cell death and fibrogenesis","volume":"30","author":"Mehal","year":"2010","journal-title":"Semin Liver Dis"},{"key":"10.1124\/jpet.113.204933_bib23","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s10620-005-2711-9","article-title":"Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates aspirin-induced gastric mucosal injury in rats","volume":"50","author":"Odashima","year":"2005","journal-title":"Dig Dis Sci"},{"key":"10.1124\/jpet.113.204933_bib24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1053\/j.gastro.2003.09.044","article-title":"Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine\/threonine phosphorylation of CD95","volume":"126","author":"Reinehr","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1124\/jpet.113.204933_bib25","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1038\/sj.bjp.0704644","article-title":"Rolipram inhibits leukocyte-endothelial cell interactions in vivo through P- and E-selectin downregulation","volume":"135","author":"Sanz","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.113.204933_bib26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1053\/jhep.2001.25349","article-title":"The role of Smad3 in mediating mouse hepatic stellate cell activation","volume":"34","author":"Schnabl","year":"2001","journal-title":"Hepatology"},{"key":"10.1124\/jpet.113.204933_bib27","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat Med"},{"key":"10.1124\/jpet.113.204933_bib28","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1002\/jcp.22529","article-title":"The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion","volume":"226","author":"Selige","year":"2011","journal-title":"J Cell Physiol"},{"key":"10.1124\/jpet.113.204933_bib29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1124\/jpet.111.184325","article-title":"Copper deficiency exacerbates bile duct ligation-induced liver injury and fibrosis in rats","volume":"339","author":"Song","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.113.204933_bib30","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s000110050475","article-title":"Protection by a cyclic AMP-specific phosphodiesterase inhibitor, rolipram, and dibutyryl cyclic AMP against Propionibacterium acnes and lipopolysaccharide-induced mouse hepatitis","volume":"48","author":"Taguchi","year":"1999","journal-title":"Inflamm Res"},{"key":"10.1124\/jpet.113.204933_bib31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/toxsci\/kfm209","article-title":"The role of tumor necrosis factor alpha in lipopolysaccharide\/ranitidine-induced inflammatory liver injury","volume":"100","author":"Tukov","year":"2007","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.113.204933_bib32","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1124\/jpet.105.090837","article-title":"Selective inhibition of phosphodiesterase-4 ameliorates chronic colitis and prevents intestinal fibrosis","volume":"316","author":"Videla","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.113.204933_bib33","doi-asserted-by":"crossref","first-page":"G727","DOI":"10.1152\/ajpgi.00410.2001","article-title":"cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release","volume":"283","author":"Webster","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.113.204933_bib34","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/hep.21135","article-title":"Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells","volume":"43","author":"Wiercinska","year":"2006","journal-title":"Hepatology"},{"key":"10.1124\/jpet.113.204933_bib35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0306-3623(96)00314-X","article-title":"Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis","volume":"29","author":"Windmeier","year":"1997","journal-title":"Gen Pharmacol"},{"key":"10.1124\/jpet.113.204933_bib36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0014-2999(98)00901-7","article-title":"Prevention by rolipram of concanavalin A-induced T-cell-dependent hepatitis in mice","volume":"367","author":"Xiang","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.113.204933_bib37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/(SICI)1096-9896(199709)183:1<90::AID-PATH1105>3.0.CO;2-J","article-title":"Gene expression and synthesis of fibronectin isoforms in rat hepatic stellate cells. Comparison with liver parenchymal cells and skin fibroblasts","volume":"183","author":"Xu","year":"1997","journal-title":"J Pathol"},{"key":"10.1124\/jpet.113.204933_bib38","first-page":"319","article-title":"Adenosine-cyclic AMP pathways and cytokine expression","volume":"10","author":"Zidek","year":"1999","journal-title":"Eur Cytokine Netw"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524287656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524287656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.113.204933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:17:10Z","timestamp":1739996230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524287656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0022356524287656"],"URL":"https:\/\/doi.org\/10.1124\/jpet.113.204933","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rolipram Attenuates Bile Duct Ligation\u2013Induced Liver Injury in Rats: A Potential Pathogenic Role of PDE4","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.113.204933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government work not protected by U.S. copyright","name":"copyright","label":"Copyright"}]}}