{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:10:38Z","timestamp":1791202238228,"version":"4.2.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1124\/jpet.113.204958","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:17:05Z","timestamp":1372810625000},"page":"381-392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Novel Anticancer Agent JNJ-26854165 Induces Cell Death through Inhibition of Cholesterol Transport and Degradation of ABCA1"],"prefix":"10.1016","volume":"346","author":[{"given":"Richard J.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad C.","family":"Bjorklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isere","family":"Kuiatse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan T.","family":"Remaley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarig","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Vreys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Z.","family":"Orlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.113.204958_bib1","unstructured":"Arts J, Page M, Valckx A, Blattner C, Kulikov R, Floren W, van Nuffel L, Janssen L, King P, Masure S, et al. (2008) JNJ-26854165\u2014a novel hdm2 antagonist in clinical development showing broad-spectrum preclinical antitumor activity against solid malignancies, in AACR Meeting Abstracts 2008 (1_Annual_Meeting): 1592."},{"key":"10.1124\/jpet.113.204958_bib2","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"2053","article-title":"Familial high density lipoprotein deficiency: Tangier disease","author":"Assmann","year":"1995"},{"key":"10.1124\/jpet.113.204958_bib3","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1158\/1541-7786.MCR-07-2079","article-title":"Mdm2 and Mdm4 loss regulates distinct p53 activities","volume":"6","author":"Barboza","year":"2008","journal-title":"Mol Cancer Res"},{"key":"10.1124\/jpet.113.204958_bib4","first-page":"110","article-title":"Staining of cholesterol with the fluorescent antibiotic \u201cfilipin\u201d","volume":"50","author":"B\u00f6rnig","year":"1974","journal-title":"Acta Histochem"},{"key":"10.1124\/jpet.113.204958_bib5","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1074\/mcp.M800515-MCP200","article-title":"Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma","volume":"8","author":"Boyd","year":"2009","journal-title":"Mol Cell Proteomics"},{"issue":"3B","key":"10.1124\/jpet.113.204958_bib6","first-page":"1441","article-title":"Neutral lipids production, transport, utilization","volume":"16","author":"Cantafora","year":"1996","journal-title":"Anticancer Res"},{"key":"10.1124\/jpet.113.204958_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11745-009-3305-7","article-title":"Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes","volume":"44","author":"Cenedella","year":"2009","journal-title":"Lipids"},{"key":"10.1124\/jpet.113.204958_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.canlet.2011.08.011","article-title":"Preclinical assessment of JNJ-26854165 (Serdemetan), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts","volume":"312","author":"Chargari","year":"2011","journal-title":"Cancer Lett"},{"key":"10.1124\/jpet.113.204958_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1046\/j.1365-2796.1999.00418.x","article-title":"Asthma and leukotrienes: antileukotrienes as novel anti-asthmatic drugs","volume":"245","author":"Claesson","year":"1999","journal-title":"J Intern Med"},{"key":"10.1124\/jpet.113.204958_bib10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ijc.20885","article-title":"DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis","volume":"115","author":"Di Stasi","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1124\/jpet.113.204958_bib11","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1161\/01.ATV.0000148706.15947.8a","article-title":"Probucol inhibits ABCA1-mediated cellular lipid efflux","volume":"24","author":"Favari","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/jpet.113.204958_bib12","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/S0022-2275(20)34418-7","article-title":"Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol","volume":"25","author":"Goldstein","year":"1984","journal-title":"J Lipid Res"},{"key":"10.1124\/jpet.113.204958_bib13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"10.1124\/jpet.113.204958_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00280-003-0692-y","article-title":"Metabolism of a cholesterol-rich microemulsion (LDE) in patients with multiple myeloma and a preliminary clinical study of LDE as a drug vehicle for the treatment of the disease","volume":"53","author":"Hungria","year":"2004","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1124\/jpet.113.204958_bib15","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1158\/1078-0432.CCR-08-0150","article-title":"Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage\u2014independent p53 phosphorylation in mantle cell lymphoma","volume":"14","author":"Jones","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1124\/jpet.113.204958_bib16","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1158\/1535-7163.MCT-10-0337","article-title":"The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias","volume":"9","author":"Kojima","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"10.1124\/jpet.113.204958_bib17","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1182\/blood-2006-08-044446","article-title":"Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study","volume":"109","author":"Kornblau","year":"2007","journal-title":"Blood"},{"key":"10.1124\/jpet.113.204958_bib18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/tpj.2009.62","article-title":"Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol","volume":"10","author":"Kristiana","year":"2010","journal-title":"Pharmacogenomics J"},{"key":"10.1124\/jpet.113.204958_bib19","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1182\/blood-2007-01-065888","article-title":"Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma","volume":"110","author":"Kuhn","year":"2007","journal-title":"Blood"},{"key":"10.1124\/jpet.113.204958_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00041433-199804000-00009","article-title":"Niemann-Pick disease type C","volume":"9","author":"Liscum","year":"1998","journal-title":"Curr Opin Lipidol"},{"key":"10.1124\/jpet.113.204958_bib21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2172-10-2","article-title":"High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes","volume":"10","author":"Mahshid","year":"2009","journal-title":"BMC Immunol"},{"key":"10.1124\/jpet.113.204958_bib22","doi-asserted-by":"crossref","first-page":"27584","DOI":"10.1074\/jbc.M103264200","article-title":"Cellular localization and trafficking of the human ABCA1 transporter","volume":"276","author":"Neufeld","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.113.204958_bib23","doi-asserted-by":"crossref","first-page":"15571","DOI":"10.1074\/jbc.M314160200","article-title":"The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease","volume":"279","author":"Neufeld","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.113.204958_bib24","first-page":"102","article-title":"Lysosomal storage disease: revealing lysosomal function and physiology","volume":"25","author":"Parkinson-Lawrence","year":"2010","journal-title":"Physiology (Bethesda)"},{"key":"10.1124\/jpet.113.204958_bib25","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1517\/13543780802493366","article-title":"Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer","volume":"17","author":"Patel","year":"2008","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1124\/jpet.113.204958_bib26","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1016\/j.febslet.2010.04.047","article-title":"Defective cholesterol trafficking in Niemann-Pick C-deficient cells","volume":"584","author":"Peake","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.113.204958_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0304-4157(87)90013-X","article-title":"Mechanisms and consequences of cellular cholesterol exchange and transfer","volume":"906","author":"Phillips","year":"1987","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.113.204958_bib28","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/MOL.0b013e328352c4dd","article-title":"The role of cholesterol efflux in mechanisms of endothelial protection by HDL","volume":"23","author":"Prosser","year":"2012","journal-title":"Curr Opin Lipidol"},{"key":"10.1124\/jpet.113.204958_bib29","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.ejca.2010.03.041","article-title":"Severe hypocholesterolaemia is often neglected in haematological malignancies","volume":"46","author":"Pugliese","year":"2010","journal-title":"Eur J Cancer"},{"key":"10.1124\/jpet.113.204958_bib30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/039463200601900210","article-title":"Low levels of serum cholesterol\/phospholipids are associated with the antiphospholipid antibodies in monoclonal gammopathy","volume":"19","author":"Pugliese","year":"2006","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1124\/jpet.113.204958_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0005-2760(90)90284-5","article-title":"Abnormal cholesterol metabolism in imipramine-treated fibroblast cultures. Similarities with Niemann-Pick type C disease","volume":"1043","author":"Rodriguez-Lafrasse","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.113.204958_bib32","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1158\/1541-7786.MCR-10-0008","article-title":"High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent mechanism","volume":"8","author":"Sekine","year":"2010","journal-title":"Mol Cancer Res"},{"key":"10.1124\/jpet.113.204958_bib33","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-065X.2009.00836.x","article-title":"Comprehending the complex connection between PKCbeta, TAK1, and IKK in BCR signaling","volume":"232","author":"Shinohara","year":"2009","journal-title":"Immunol Rev"},{"key":"10.1124\/jpet.113.204958_bib34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/pbc.23319","article-title":"Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program","volume":"59","author":"Smith","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1124\/jpet.113.204958_bib35","doi-asserted-by":"crossref","first-page":"6313","DOI":"10.1158\/1078-0432.CCR-11-1101","article-title":"A phase I first-in-human pharmacokinetic and pharmacodynamic study of serdemetan in patients with advanced solid tumors","volume":"17","author":"Tabernero","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1124\/jpet.113.204958_bib36","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1016\/S0022-2275(20)30028-6","article-title":"Decreased feedback regulation of low density lipoprotein receptor activity by sterols in leukemic cells from patients with acute myelogenous leukemia","volume":"38","author":"Tatidis","year":"1997","journal-title":"J Lipid Res"},{"key":"10.1124\/jpet.113.204958_bib37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0304-3835(01)00592-4","article-title":"Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: suppressed levels of a circulating marker for bile acid synthesis","volume":"170","author":"Tatidis","year":"2001","journal-title":"Cancer Lett"},{"key":"10.1124\/jpet.113.204958_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00277-011-1246-8","article-title":"Low-density lipoprotein cholesterol suppresses apoptosis in human multiple myeloma cells","volume":"91","author":"Tirado-V\u00e9lez","year":"2012","journal-title":"Ann Hematol"},{"key":"10.1124\/jpet.113.204958_bib39","first-page":"233","article-title":"Reduced low-density-lipoprotein cholesterol causing low serum cholesterol levels in gastrointestinal cancer: a case control study","volume":"23","author":"Tomiki","year":"2004","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1124\/jpet.113.204958_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1388-1981(00)00061-5","article-title":"Apolipoprotein-mediated cellular cholesterol\/phospholipid efflux and plasma high density lipoprotein level in mice","volume":"1485","author":"Tsujita","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.113.204958_bib41","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1126\/science.1092472","article-title":"In vivo activation of the p53 pathway by small-molecule antagonists of MDM2","volume":"303","author":"Vassilev","year":"2004","journal-title":"Science"},{"key":"10.1124\/jpet.113.204958_bib42","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1046\/j.1365-2141.2002.03671.x","article-title":"Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma","volume":"118","author":"Villalva","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1124\/jpet.113.204958_bib43","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S0140-6736(85)92679-0","article-title":"Hypocholesterolaemia in malignancy due to elevated low-density-lipoprotein-receptor activity in tumour cells: evidence from studies in patients with leukaemia","volume":"2","author":"Vitols","year":"1985","journal-title":"Lancet"},{"key":"10.1124\/jpet.113.204958_bib44","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1182\/blood.V84.8.2689.2689","article-title":"Multilevel regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in normal and leukemic cells","volume":"84","author":"Vitols","year":"1994","journal-title":"Blood"},{"key":"10.1124\/jpet.113.204958_bib45","doi-asserted-by":"crossref","first-page":"9774","DOI":"10.1073\/pnas.0403506101","article-title":"ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins","volume":"101","author":"Wang","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.113.204958_bib46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/labinvest.3780421","article-title":"ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation","volume":"82","author":"Wellington","year":"2002","journal-title":"Lab Invest"},{"key":"10.1124\/jpet.113.204958_bib47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/ijc.24813","article-title":"Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target","volume":"126","author":"Wiklund","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1124\/jpet.113.204958_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0092-8674(84)90188-0","article-title":"The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA","volume":"39","author":"Yamamoto","year":"1984","journal-title":"Cell"},{"key":"10.1124\/jpet.113.204958_bib49","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/01.ATV.0000057572.97137.DD","article-title":"Importance of different pathways of cellular cholesterol efflux","volume":"23","author":"Yancey","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/jpet.113.204958_bib50","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00277-007-0375-6","article-title":"Cholesterol levels in patients with multiple myeloma","volume":"87","author":"Yavasoglu","year":"2008","journal-title":"Ann Hematol"},{"key":"10.1124\/jpet.113.204958_bib51","first-page":"4413","article-title":"Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis","volume":"59","author":"Yoshiji","year":"1999","journal-title":"Cancer Res"}],"updated-by":[{"DOI":"10.1124\/jpet.113.11er13","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000}}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524287334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524287334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.113.204958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T20:16:12Z","timestamp":1739996172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524287334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0022356524287334"],"URL":"https:\/\/doi.org\/10.1124\/jpet.113.204958","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Novel Anticancer Agent JNJ-26854165 Induces Cell Death through Inhibition of Cholesterol Transport and Degradation of ABCA1","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.113.204958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"U.S. Government work not protected by U.S. copyright","name":"copyright","label":"Copyright"}]}}