{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:19:43Z","timestamp":1788574783716,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1124\/jpet.114.212795","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T09:52:40Z","timestamp":1396000360000},"page":"417-426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and Inflammation in Rats"],"prefix":"10.1016","volume":"349","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-8938","authenticated-orcid":false,"given":"Yong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiran","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad U.","family":"Bilal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunwei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.114.212795_bib1","doi-asserted-by":"crossref","first-page":"L1118","DOI":"10.1152\/ajplung.00232.2011","article-title":"Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement","volume":"302","author":"Alrashdan","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1124\/jpet.114.212795_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1385\/CT:6:2:111","article-title":"The NF-kappaB regulatory network","volume":"6","author":"Brasier","year":"2006","journal-title":"Cardiovasc Toxicol"},{"key":"10.1124\/jpet.114.212795_bib3","doi-asserted-by":"crossref","first-page":"e61944","DOI":"10.1371\/journal.pone.0061944","article-title":"Amelioration of IFN-\u03b3 and TNF-\u03b1-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCK-MLC phosphorylation signaling pathway","volume":"8","author":"Cao","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1124\/jpet.114.212795_bib4","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/bjs.9131","article-title":"Prevention of postsurgical adhesions using an ultrapure alginate-based gel","volume":"100","author":"Chaturvedi","year":"2013","journal-title":"Br J Surg"},{"key":"10.1124\/jpet.114.212795_bib5","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1124\/jpet.109.154179","article-title":"c-Jun NH2-terminal kinase is crucially involved in renal tubulo-interstitial inflammation","volume":"331","author":"de Borst","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.114.212795_bib6","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1128\/JVI.02576-13","article-title":"Inhibition of NF-\u03baB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival","volume":"88","author":"DeDiego","year":"2014","journal-title":"J Virol"},{"key":"10.1124\/jpet.114.212795_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/SLA.0b013e3182854949","article-title":"Use of bioresorbable membranes to reduce abdominal and perihepatic adhesions in 2-stage hepatectomy of liver metastases from colorectal cancer: results of a prospective, randomized controlled phase II trial","volume":"258","author":"Dupr\u00e9","year":"2013","journal-title":"Ann Surg"},{"key":"10.1124\/jpet.114.212795_bib8","first-page":"5","article-title":"The clinical significance of adhesions: focus on intestinal obstruction","volume":"577","author":"Ellis","year":"1997","journal-title":"Eur J Surg Suppl"},{"key":"10.1124\/jpet.114.212795_bib9","first-page":"410","article-title":"Polypropylene meshes to prevent abdominal herniation","volume":"37","author":"Emans","year":"2009","journal-title":"Can stable coatings prevent adhesions in the long term? Ann Biomed Eng"},{"key":"10.1124\/jpet.114.212795_bib10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.intimp.2011.11.009","article-title":"Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPAR\u03b3 pathway during acute endotoxemia","volume":"12","author":"Feng","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"10.1124\/jpet.114.212795_bib11","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/sj.bjp.0707634","article-title":"Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29)","volume":"153","author":"Gallicchio","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.114.212795_bib12","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s00464-007-9575-3","article-title":"Laparoscopic approach to acute small bowel obstruction: review of 1061 cases","volume":"21","author":"Ghosheh","year":"2007","journal-title":"Surg Endosc"},{"key":"10.1124\/jpet.114.212795_bib13","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1038\/nn.3531","article-title":"A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation","volume":"16","author":"Goldmann","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1124\/jpet.114.212795_bib14","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.taap.2013.08.011","article-title":"Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-\u03baB-mediated inflammatory responses in kidney tubular cells","volume":"272","author":"Gonz\u00e1lez-Guerrero","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.114.212795_bib15","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/1771182b0","article-title":"Assimilation of berberine by bacteria","volume":"177","author":"Gray","year":"1956","journal-title":"Nature"},{"key":"10.1124\/jpet.114.212795_bib16","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/art.30271","article-title":"JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis","volume":"63","author":"Guma","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1124\/jpet.114.212795_bib17","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1080\/110241599750007810","article-title":"The role of cytokines, coagulation, and fibrinolysis in peritoneal tissue repair","volume":"165","author":"Holmdahl","year":"1999","journal-title":"Eur J Surg"},{"key":"10.1124\/jpet.114.212795_bib18","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.surg.2006.12.010","article-title":"Cross-linked poly (gamma-glutamic acid) attenuates peritoneal adhesion in a rat model","volume":"141","author":"Izumi","year":"2007","journal-title":"Surgery"},{"key":"10.1124\/jpet.114.212795_bib19","doi-asserted-by":"crossref","first-page":"E955","DOI":"10.1152\/ajpendo.90599.2008","article-title":"Berberine suppresses proinflammatory responses through AMPK activation in macrophages","volume":"296","author":"Jeong","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1124\/jpet.114.212795_bib20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mce.2010.07.023","article-title":"Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-\u03baB signaling pathway","volume":"331","author":"Jiang","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1124\/jpet.114.212795_bib21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2567.2012.03618.x","volume":"137","author":"Jung","year":"2012","journal-title":"Immunology"},{"key":"10.1124\/jpet.114.212795_bib22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1476-5381.2011.01353.x","article-title":"Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats","volume":"164","author":"Kim","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.114.212795_bib23","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm1135","article-title":"Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins","volume":"10","author":"Kong","year":"2004","journal-title":"Nat Med"},{"key":"10.1124\/jpet.114.212795_bib24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nm1733","article-title":"Interferon-gamma is a therapeutic target molecule for prevention of postoperative adhesion formation","volume":"14","author":"Kosaka","year":"2008","journal-title":"Nat Med"},{"key":"10.1124\/jpet.114.212795_bib25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000314805","article-title":"Abdominal adhesion prevention: still a sticky subject?","volume":"27","author":"Lauder","year":"2010","journal-title":"Dig Surg"},{"key":"10.1124\/jpet.114.212795_bib26","doi-asserted-by":"crossref","first-page":"F1410","DOI":"10.1152\/ajprenal.00018.2011","article-title":"TGF-\u03b21-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney","volume":"300","author":"Ma","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/jpet.114.212795_bib27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.imbio.2011.01.001","article-title":"Macrophages in skin injury and repair","volume":"216","author":"Mahdavian Delavary","year":"2011","journal-title":"Immunobiology"},{"key":"10.1124\/jpet.114.212795_bib28","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1440-1681.2012.05670.x","article-title":"Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention","volume":"39","author":"Meng","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1124\/jpet.114.212795_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0002-9610(00)00407-4","article-title":"Etiology of small bowel obstruction","volume":"180","author":"Miller","year":"2000","journal-title":"Am J Surg"},{"key":"10.1124\/jpet.114.212795_bib30","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/ars.2012.5116","article-title":"The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice","volume":"20","author":"Mo","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1124\/jpet.114.212795_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1124\/jpet.111.188599","article-title":"Modulation of inflammation by Cicaderma ointment accelerates skin wound healing","volume":"343","author":"Morin","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.114.212795_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating cell-signalling pathways with NF-kappaB and IKK function","volume":"8","author":"Perkins","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1124\/jpet.114.212795_bib33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1600-065X.2011.01033.x","article-title":"Epithelial cells and airway diseases","volume":"242","author":"Proud","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1124\/jpet.114.212795_bib34","first-page":"5034","article-title":"A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 1986","volume":"186","author":"Rothlein","year":"2011","journal-title":"137: 1270-1274. J Immunol"},{"key":"10.1124\/jpet.114.212795_bib35","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s10753-007-9043-1","article-title":"The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions)","volume":"30","author":"Sahin","year":"2007","journal-title":"Inflammation"},{"key":"10.1124\/jpet.114.212795_bib36","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/cvr\/cvp130","article-title":"Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines","volume":"83","author":"Shan","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1124\/jpet.114.212795_bib37","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4049\/jimmunol.165.1.442","article-title":"The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment","volume":"165","author":"Sigal","year":"2000","journal-title":"J Immunol"},{"key":"10.1124\/jpet.114.212795_bib38","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7150\/ijms.5607","article-title":"Novel powdered anti-adhesion material: preventing postoperative intra-abdominal adhesions in a rat model","volume":"10","author":"Takagi","year":"2013","journal-title":"Int J Med Sci"},{"key":"10.1124\/jpet.114.212795_bib39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/humupd\/dms032","article-title":"Different surgical techniques to reduce post-operative adhesion formation: a systematic review and meta-analysis","volume":"19","author":"Ten Broek","year":"2013","journal-title":"Hum Reprod Update"},{"key":"10.1124\/jpet.114.212795_bib40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/bjs.8994","article-title":"Comparison of operative notes with real-time observation of adhesiolysis-related complications during surgery","volume":"100","author":"ten Broek","year":"2013","journal-title":"Br J Surg"},{"key":"10.1124\/jpet.114.212795_bib41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000102591","article-title":"Prevention of abdominal adhesions\u2014present state and what\u2019s beyond the horizon?","volume":"39","author":"Tingstedt","year":"2007","journal-title":"Eur Surg Res"},{"key":"10.1124\/jpet.114.212795_bib42","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1016\/j.jss.2009.09.024","article-title":"A novel hydrogel-coated polyester mesh prevents postsurgical adhesions in a rat model","volume":"167","author":"Townsend","year":"2011","journal-title":"J Surg Res"},{"key":"10.1124\/jpet.114.212795_bib43","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/jbm.10040","article-title":"The role of Seprafilm bioresorbable membrane in the prevention and therapy of endometrial synechiae","volume":"63","author":"Tsapanos","year":"2002","journal-title":"J Biomed Mater Res"},{"issue":"Suppl 2","key":"10.1124\/jpet.114.212795_bib44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1463-1318.2007.01358.x","article-title":"Consequences and complications of peritoneal adhesions","volume":"9","author":"van Goor","year":"2007","journal-title":"Colorectal Dis"},{"key":"10.1124\/jpet.114.212795_bib45","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1080\/000000000000003","article-title":"Mesh repair of incisional hernia: comparison of laparoscopic and open repair","volume":"168","author":"van't","year":"2002","journal-title":"Eur J Surg"},{"key":"10.1124\/jpet.114.212795_bib46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jss.2009.09.015","article-title":"Abdominal adhesions: current and novel therapies","volume":"165","author":"Ward","year":"2011","journal-title":"J Surg Res"},{"key":"10.1124\/jpet.114.212795_bib47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2012.01.039","article-title":"Glutamate potentiates lipopolysaccharide-stimulated interleukin-10 release from neonatal rat spinal cord astrocytes","volume":"207","author":"Werry","year":"2012","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.114.212795_bib48","first-page":"325","article-title":"Metaanalysis of the safety and efficacy of an adhesion barrier (Interceed TC7) in laparotomy","volume":"44","author":"Wiseman","year":"1999","journal-title":"J Reprod Med"},{"key":"10.1124\/jpet.114.212795_bib49","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1124\/jpet.113.208009","article-title":"Pharmacologic suppression of inflammation by a diphenyldifluoroketone, EF24, in a rat model of fixed-volume hemorrhage improves survival","volume":"347","author":"Yadav","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.114.212795_bib50","doi-asserted-by":"crossref","unstructured":"Yao J, Kong W, and Jiang J (2013) Learning from berberine: treating chronic diseases through multiple targets. Sci China Life Sci [published ahead of print]","DOI":"10.1007\/s11427-013-4568-z"},{"key":"10.1124\/jpet.114.212795_bib51","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.6061\/clinics\/2012(11)14","article-title":"Adhesion-preventing properties of 4% icodextrin and canola oil: a comparative experimental study","volume":"67","author":"Yigitler","year":"2012","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1124\/jpet.114.212795_bib52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbr.2011.07.006","article-title":"Pro- and anti-inflammatory cytokines expression in rat\u2019s brain and spleen exposed to chronic mild stress: involvement in depression","volume":"225","author":"You","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1124\/jpet.114.212795_bib53","doi-asserted-by":"crossref","first-page":"455","DOI":"10.7150\/ijbs.4630","article-title":"Overexpression of microRNA-1 causes atrioventricular block in rodents","volume":"9","author":"Zhang","year":"2013","journal-title":"Int J Biol Sci"},{"key":"10.1124\/jpet.114.212795_bib54","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1159\/000324012","article-title":"Tanshinone IIA inhibits miR-1 expression through p38 MAPK signal pathway in post-infarction rat cardiomyocytes","volume":"26","author":"Zhang","year":"2010","journal-title":"Cell Physiol Biochem"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524187009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524187009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.114.212795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T17:23:58Z","timestamp":1739985838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524187009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0022356524187009"],"URL":"https:\/\/doi.org\/10.1124\/jpet.114.212795","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and Inflammation in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.114.212795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}