{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:12:04Z","timestamp":1783696324407,"version":"3.55.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1124\/jpet.114.217372","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T04:50:32Z","timestamp":1406004632000},"page":"134-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cyclooxygenase 2 Inhibitor Celecoxib Inhibits Glutamate Release by Attenuating the PGE2\/EP2 Pathway in Rat Cerebral Cortex Endings"],"prefix":"10.1016","volume":"351","author":[{"given":"Tzu-Yu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Kuei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Jane","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.114.217372_bib1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/01480545.2012.749270","article-title":"Effect of celecoxib and L-NAME on global ischemia-reperfusion injury in the rat hippocampus","volume":"36","author":"Abd El-Aal","year":"2013","journal-title":"Drug Chem Toxicol"},{"key":"10.1124\/jpet.114.217372_bib2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1471-4159.1987.tb04128.x","article-title":"Ionic dependence of membrane potential and glutamate receptor-linked responses in synaptoneurosomes as measured with a cyanine dye, DiS-C2-(5)","volume":"48","author":"Akerman","year":"1987","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.114.217372_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuropharm.2012.09.010","article-title":"Neuroprotection mediated by the EP\u2084 receptor avoids the detrimental side effects of COX-2 inhibitors following ischaemic injury","volume":"65","author":"Akram","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.114.217372_bib4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0896-6273(93)90145-H","article-title":"Nonvesicular release of neurotransmitter","volume":"11","author":"Attwell","year":"1993","journal-title":"Neuron"},{"key":"10.1124\/jpet.114.217372_bib5","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1111\/j.1471-4159.1991.tb08306.x","article-title":"An ion channel locus for the protein kinase C potentiation of transmitter glutamate release from guinea pig cerebrocortical synaptosomes","volume":"57","author":"Barrie","year":"1991","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.114.217372_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)80510-3","article-title":"Neuronal calcium signaling","volume":"21","author":"Berridge","year":"1998","journal-title":"Neuron"},{"key":"10.1124\/jpet.114.217372_bib7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1146\/annurev.pharmtox.41.1.661","article-title":"Prostanoid receptors: subtypes and signaling","volume":"41","author":"Breyer","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/jpet.114.217372_bib8","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1152\/jn.2002.87.6.2851","article-title":"Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity","volume":"87","author":"Chen","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1124\/jpet.114.217372_bib9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/35070000","article-title":"Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex","volume":"3","author":"Chheda","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1124\/jpet.114.217372_bib10","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1111\/j.1460-9568.2008.06251.x","article-title":"COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning in vivo","volume":"27","author":"Cowley","year":"2008","journal-title":"Eur J Neurosci"},{"key":"10.1124\/jpet.114.217372_bib11","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.7901908","article-title":"Oxidative stress, glutamate, and neurodegenerative disorders","volume":"262","author":"Coyle","year":"1993","journal-title":"Science"},{"key":"10.1124\/jpet.114.217372_bib12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/ana.10374","article-title":"Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS","volume":"52","author":"Drachman","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1124\/jpet.114.217372_bib13","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1111\/j.1476-5381.2011.01483.x","article-title":"Characteristics and molecular basis of celecoxib modulation on K(v)7 potassium channels","volume":"164","author":"Du","year":"2011","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.114.217372_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuroscience.2013.02.041","article-title":"Celecoxib attenuates systemic lipopolysaccharide-induced brain inflammation and white matter injury in the neonatal rats","volume":"240","author":"Fan","year":"2013","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.114.217372_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.1984.tb09689.x","article-title":"Glutamate: a neurotransmitter in mammalian brain","volume":"42","author":"Fonnum","year":"1984","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.114.217372_bib16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuropharm.2012.07.030","article-title":"In vitro characterisation of the novel positive allosteric modulators of the mGlu\u2085 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat","volume":"64","author":"Gilmour","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.114.217372_bib17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neuroscience.2004.01.045","article-title":"Post-treatment, but not pre-treatment, with the selective cyclooxygenase-2 inhibitor celecoxib markedly enhances functional recovery from kainic acid-induced neurodegeneration","volume":"125","author":"Gobbo","year":"2004","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.114.217372_bib18","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1111\/j.1460-9568.2007.05873.x","article-title":"Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca(2+) signalling in hippocampal neurons","volume":"26","author":"Gonz\u00e1lez","year":"2007","journal-title":"Eur J Neurosci"},{"issue":"11, Suppl 8","key":"10.1124\/jpet.114.217372_bib19","first-page":"S7","article-title":"Anatomy and physiology of glutamate in the CNS","volume":"44","author":"Greenamyre","year":"1994","journal-title":"Neurology"},{"key":"10.1124\/jpet.114.217372_bib20","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuropharm.2007.10.003","article-title":"Dendritic and mitochondrial changes during glutamate excitotoxicity","volume":"53","author":"Greenwood","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.114.217372_bib21","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.114.217372_bib22","doi-asserted-by":"crossref","first-page":"30554","DOI":"10.1074\/jbc.271.48.30554","article-title":"cAMP-dependent facilitation of glutamate release by beta-adrenergic receptors in cerebrocortical nerve terminals","volume":"271","author":"Herrero","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.114.217372_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1749-6632.1989.tb22600.x","article-title":"Formation and function of eicosanoids in the central nervous system","volume":"559","author":"Hertting","year":"1989","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/jpet.114.217372_bib24","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/j.1471-4159.2006.04327.x","article-title":"Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system","volume":"100","author":"Hunter","year":"2007","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.114.217372_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1742-2094-10-45","article-title":"Celecoxib reduces brain dopaminergic neuronaldysfunction, and improves sensorimotor behavioral performance in neonatal rats exposed to systemic lipopolysaccharide","volume":"10","author":"Kaizaki","year":"2013","journal-title":"J Neuroinflammation"},{"key":"10.1124\/jpet.114.217372_bib26","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.8396273","article-title":"Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase","volume":"261","author":"Li","year":"1993","journal-title":"Science"},{"key":"10.1124\/jpet.114.217372_bib27","doi-asserted-by":"crossref","first-page":"8726","DOI":"10.1074\/jbc.M805322200","article-title":"Nerve terminal GABAA receptors activate Ca2+\/calmodulin-dependent signaling to inhibit voltage-gated Ca2+ influx and glutamate release","volume":"284","author":"Long","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.114.217372_bib28","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ejps.2012.01.001","article-title":"Cytoprotective effect of nonsteroidal antiinflammatory drugs in rat brain slices subjected to reoxygenation after oxygen-glucose deprivation","volume":"45","author":"L\u00f3pez-Villodres","year":"2012","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/jpet.114.217372_bib29","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuint.2010.05.010","article-title":"Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: an NMDA receptor-independent mechanism","volume":"57","author":"Lu","year":"2010","journal-title":"Neurochem Int"},{"issue":"4S, Suppl","key":"10.1124\/jpet.114.217372_bib30","doi-asserted-by":"crossref","first-page":"1007S","DOI":"10.1093\/jn\/130.4.1007S","article-title":"Glutamate as a neurotransmitter in the brain: review of physiology and pathology","volume":"130","author":"Meldrum","year":"2000","journal-title":"J Nutr"},{"key":"10.1124\/jpet.114.217372_bib31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0165-6147(90)90184-A","article-title":"Excitatory amino acid neurotoxicity and neurodegenerative disease","volume":"11","author":"Meldrum","year":"1990","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.114.217372_bib32","doi-asserted-by":"crossref","first-page":"e54797","DOI":"10.1371\/journal.pone.0054797","article-title":"The role of potassium channel activation in celecoxib-induced analgesic action","volume":"8","author":"Mi","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1124\/jpet.114.217372_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0304-3940(02)00719-X","article-title":"Differential coupling of N- and P\/Q-type calcium channels to glutamate exocytosis in the rat cerebral cortex","volume":"330","author":"Mill\u00e1n","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.114.217372_bib34","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/jnen\/63.9.901","article-title":"Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases","volume":"63","author":"Minghetti","year":"2004","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1124\/jpet.114.217372_bib35","doi-asserted-by":"crossref","first-page":"19449","DOI":"10.1016\/S0021-9258(19)47321-3","article-title":"Fluorescent indicators for cytosolic sodium","volume":"264","author":"Minta","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.114.217372_bib36","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0028-3908(02)00375-1","article-title":"A role for COX-2 and p38 mitogen activated protein kinase in long-term depression in the rat dentate gyrus in vitro","volume":"44","author":"Murray","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.114.217372_bib37","doi-asserted-by":"crossref","first-page":"10954","DOI":"10.1073\/pnas.95.18.10954","article-title":"Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia","volume":"95","author":"Nakayama","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.114.217372_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0079-6123(08)60427-6","article-title":"Presynaptic modulation of glutamate release","volume":"116","author":"Nicholls","year":"1998","journal-title":"Prog Brain Res"},{"key":"10.1124\/jpet.114.217372_bib39","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/321772a0","article-title":"Synaptosomes possess an exocytotic pool of glutamate","volume":"321","author":"Nicholls","year":"1986","journal-title":"Nature"},{"key":"10.1124\/jpet.114.217372_bib40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1471-4159.1987.tb03393.x","article-title":"Calcium-dependent and -independent release of glutamate from synaptosomes monitored by continuous fluorometry","volume":"49","author":"Nicholls","year":"1987","journal-title":"J Neurochem"},{"key":"10.1124\/jpet.114.217372_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3940(95)11839-O","article-title":"Prostaglandin E2 stimulates glutamate release from synaptosomes of rat spinal cord","volume":"196","author":"Nishihara","year":"1995","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.114.217372_bib42","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1523\/JNEUROSCI.17-08-02746.1997","article-title":"Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage","volume":"17","author":"Nogawa","year":"1997","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.114.217372_bib43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2007.02.023","article-title":"Celecoxib inhibits Na+ currents in rat dorsal root ganglion neurons","volume":"1148","author":"Park","year":"2007","journal-title":"Brain Res"},{"key":"10.1124\/jpet.114.217372_bib44","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1096\/fasebj.5.2.2004663","article-title":"Voltage-gated K+ channels of the mammalian brain","volume":"5","author":"Rehm","year":"1991","journal-title":"FASEB J"},{"key":"10.1124\/jpet.114.217372_bib45","doi-asserted-by":"crossref","first-page":"9858","DOI":"10.1523\/JNEUROSCI.2392-05.2005","article-title":"Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor","volume":"25","author":"Sang","year":"2005","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.114.217372_bib46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.expneurol.2010.03.013","article-title":"Neuroprotection by glutamate receptor antagonists against seizure-induced excitotoxic cell death in the aging brain","volume":"224","author":"Schauwecker","year":"2010","journal-title":"Exp Neurol"},{"key":"10.1124\/jpet.114.217372_bib47","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1523\/JNEUROSCI.16-19-06125.1996","article-title":"Mitochondrial dysfunction is a primary event in glutamate neurotoxicity","volume":"16","author":"Schinder","year":"1996","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.114.217372_bib48","doi-asserted-by":"crossref","first-page":"14850","DOI":"10.1523\/JNEUROSCI.3922-11.2011","article-title":"Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus","volume":"31","author":"Serrano","year":"2011","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.114.217372_bib49","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/S0021-9258(18)46043-7","article-title":"Localized Ca2+ entry preferentially effects protein dephosphorylation, phosphorylation, and glutamate release","volume":"267","author":"Sihra","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.114.217372_bib50","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/JGP.0b013e31818cd3a4","article-title":"Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study","volume":"16","author":"Small","year":"2008","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1124\/jpet.114.217372_bib51","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1074\/jbc.R600038200","article-title":"Prostaglandin E receptors","volume":"282","author":"Sugimoto","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.114.217372_bib52","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuropharm.2014.01.040","article-title":"Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms","volume":"81","author":"Suto","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1124\/jpet.114.217372_bib53","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3233\/JAD-2010-090667","article-title":"Neuroinflammation in Alzheimer\u2019s disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy?","volume":"21","author":"Trepanier","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1124\/jpet.114.217372_bib54","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0005-2760(98)00163-5","article-title":"Prostaglandin D2 and sleep regulation","volume":"1436","author":"Urade","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.114.217372_bib55","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1111\/j.1460-9568.1997.tb01369.x","article-title":"Presynaptic modulation of glutamate release targets different calcium channels in rat cerebrocortical nerve terminals","volume":"9","author":"V\u00e1zquez","year":"1997","journal-title":"Eur J Neurosci"},{"key":"10.1124\/jpet.114.217372_bib56","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1124\/jpet.103.064881","article-title":"Noncompetitive metabotropic glutamate5 receptor antagonist (E)-2-methyl-6-styryl-pyridine (SIB1893) depresses glutamate release through inhibition of voltage-dependent Ca2+ entry in rat cerebrocortical nerve terminals (synaptosomes)","volume":"309","author":"Wang","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.114.217372_bib57","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroscience.2004.01.019","article-title":"Mechanisms underlying the riluzole inhibition of glutamate release from rat cerebral cortex nerve terminals (synaptosomes)","volume":"125","author":"Wang","year":"2004","journal-title":"Neuroscience"},{"key":"10.1124\/jpet.114.217372_bib58","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0166-2236(96)01015-6","article-title":"Presynaptic inhibition of elicited neurotransmitter release","volume":"20","author":"Wu","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1124\/jpet.114.217372_bib59","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s12031-013-9996-5","article-title":"Neuroprotective effects of NMDA and group I metabotropic glutamate receptor antagonists against neurodegeneration induced by homocysteine in rat hippocampus: in vivo study","volume":"50","author":"Yeganeh","year":"2013","journal-title":"J Mol Neurosci"},{"key":"10.1124\/jpet.114.217372_bib60","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/jnr.20597","article-title":"Heterogeneous expression and regulation of hippocampal prostaglandin E2 receptors","volume":"81","author":"Zhu","year":"2005","journal-title":"J Neurosci Res"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524188234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524188234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.114.217372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T17:54:13Z","timestamp":1739987653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524188234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0022356524188234"],"URL":"https:\/\/doi.org\/10.1124\/jpet.114.217372","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclooxygenase 2 Inhibitor Celecoxib Inhibits Glutamate Release by Attenuating the PGE2\/EP2 Pathway in Rat Cerebral Cortex Endings","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.114.217372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2014 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}