{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:59:30Z","timestamp":1790621970934,"version":"4.1.0"},"reference-count":192,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1124\/jpet.115.225656","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T01:59:50Z","timestamp":1436234390000},"page":"358-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["The Pharmacological and Physiological Role of Multidrug-Resistant Protein 4"],"prefix":"10.1016","volume":"354","author":[{"given":"Jiagen","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.115.225656_bib1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1124\/jpet.108.136523","article-title":"The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene","volume":"325","author":"Abla","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.225656_bib2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1186\/2193-1801-3-732","article-title":"Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine","volume":"3","author":"Adema","year":"2014","journal-title":"Springerplus"},{"key":"10.1124\/jpet.115.225656_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/01.qai.0000225013.53568.69","article-title":"Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study","volume":"42","author":"Anderson","year":"2006","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1124\/jpet.115.225656_bib4","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1182\/blood-2008-11-191098","article-title":"Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia","volume":"114","author":"Ansari","year":"2009","journal-title":"Blood"},{"key":"10.1124\/jpet.115.225656_bib5","doi-asserted-by":"crossref","first-page":"22250","DOI":"10.1074\/jbc.M314111200","article-title":"Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice","volume":"279","author":"Assem","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib6","doi-asserted-by":"crossref","first-page":"143202","DOI":"10.1155\/2013\/143202","article-title":"Clinicopathological impact of ABCC1\/MRP1 and ABCC4\/MRP4 in epithelial ovarian carcinoma","volume":"2013","author":"Bagnoli","year":"2013","journal-title":"BioMed Res Int"},{"key":"10.1124\/jpet.115.225656_bib7","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s00535-010-0248-y","article-title":"The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease","volume":"45","author":"Ban","year":"2010","journal-title":"J Gastroenterol"},{"key":"10.1124\/jpet.115.225656_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1124\/mol.113.091314","article-title":"A novel pathway for arsenic elimination: human multidrug resistance protein 4 (MRP4\/ABCC4) mediates cellular export of dimethylarsinic acid (DMAV) and the diglutathione conjugate of monomethylarsonous acid (MMAIII)","volume":"86","author":"Banerjee","year":"2014","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/humrep\/del328","volume":"22","author":"Battersby","year":"2007","journal-title":"Hum Reprod"},{"key":"10.1124\/jpet.115.225656_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/cpt.8","article-title":"Advances, nuances, and potential pitfalls when exploiting the therapeutic potential of RNA interference","volume":"97","author":"Battistella","year":"2015","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.115.225656_bib11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1158\/0008-5472.CAN-06-2680","article-title":"Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage","volume":"67","author":"Belinsky","year":"2007","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib12","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.bcp.2009.12.002","article-title":"Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin","volume":"79","author":"Beretta","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/hiv.12072","article-title":"Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration","volume":"14","author":"Bickel","year":"2013","journal-title":"HIV Med"},{"key":"10.1124\/jpet.115.225656_bib14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/hep.24682","article-title":"Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs","volume":"55","author":"Borel","year":"2012","journal-title":"Hepatology"},{"key":"10.1124\/jpet.115.225656_bib15","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1160\/TH12-04-0232","article-title":"Reduction of cAMP and cGMP inhibitory effects in human platelets by MRP4-mediated transport","volume":"108","author":"Borgognone","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1124\/jpet.115.225656_bib16","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/jnci\/92.16.1295","article-title":"A family of drug transporters: the multidrug resistance-associated proteins","volume":"92","author":"Borst","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1124\/jpet.115.225656_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1124\/pr.107.00106","article-title":"Mitogen-activated protein (MAP) kinase\/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer","volume":"60","author":"Boutros","year":"2008","journal-title":"Pharmacol Rev"},{"key":"10.1124\/jpet.115.225656_bib18","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/FPC.0000000000000084","article-title":"cAMP regulates expression of the cyclic nucleotide transporter MRP4 (ABCC4) through the EPAC pathway","volume":"24","author":"Br\u00f6derdorf","year":"2014","journal-title":"Pharmacogenet Genomics"},{"key":"10.1124\/jpet.115.225656_bib19","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1182\/blood-2009-09-243741","article-title":"Multidrug resistance-associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia","volume":"114","author":"Br\u00fcggemann","year":"2009","journal-title":"Blood"},{"key":"10.1124\/jpet.115.225656_bib20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.pcan.4500912","article-title":"Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells","volume":"10","author":"Cai","year":"2007","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1124\/jpet.115.225656_bib21","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/ALN.0000000000000526","article-title":"Overexpression of cyclic adenosine monophosphate effluent protein MRP4 induces an altered response to \u03b2-adrenergic stimulation in the senescent rat heart","volume":"122","author":"Carillion","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1124\/jpet.115.225656_bib22","doi-asserted-by":"crossref","first-page":"e0120651","DOI":"10.1371\/journal.pone.0120651","article-title":"Dual role of cAMP in the transcriptional regulation of multidrug resistance-associated protein 4 (MRP4) in pancreatic adenocarcinoma cell lines","volume":"10","author":"Carozzo","year":"2015","journal-title":"PLoS One"},{"key":"10.1124\/jpet.115.225656_bib23","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/MPA.0b013e318264d0f8","article-title":"PGE2 regulates pancreatic stellate cell activity via the EP4 receptor","volume":"42","author":"Charo","year":"2013","journal-title":"Pancreas"},{"key":"10.1124\/jpet.115.225656_bib24","doi-asserted-by":"crossref","first-page":"G235","DOI":"10.1152\/ajpgi.00334.2004","article-title":"Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell","volume":"288","author":"Chaudhuri","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.115.225656_bib25","first-page":"1","article-title":"RNAi-mediated silencing of ATP-binding cassette C4 protein inhibits cell growth in MGC80-3 gastric cancer cell lines","volume":"60","author":"Chen","year":"2014","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"10.1124\/jpet.115.225656_bib26","doi-asserted-by":"crossref","first-page":"33747","DOI":"10.1074\/jbc.M104833200","article-title":"Transport of cyclic nucleotides and estradiol 17-\u03b2-d-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine","volume":"276","author":"Chen","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib27","first-page":"3144","article-title":"Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system","volume":"62","author":"Chen","year":"2002","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bcp.2014.05.023","article-title":"High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)","volume":"91","author":"Cheung","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bcp.2014.11.006","article-title":"Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen","volume":"93","author":"Cheung","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ncomms1181","article-title":"Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance","volume":"2","author":"Chinen","year":"2011","journal-title":"Nat Commun"},{"key":"10.1124\/jpet.115.225656_bib31","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1124\/mol.106.031823","article-title":"Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney","volume":"71","author":"Ci","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib32","doi-asserted-by":"crossref","first-page":"9308","DOI":"10.18632\/oncotarget.2425","article-title":"Multidrug resistance protein 4\/ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia","volume":"5","author":"Copsel","year":"2014","journal-title":"Oncotarget"},{"key":"10.1124\/jpet.115.225656_bib33","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1074\/jbc.M110.166868","article-title":"Multidrug resistance protein 4 (MRP4\/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation","volume":"286","author":"Copsel","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib34","first-page":"6912","article-title":"Modulation of c-jun and jun-B messenger RNA and inhibition of DNA synthesis by prostaglandin E2 in Syrian hamster embryo cells","volume":"52","author":"Cowlen","year":"1992","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib35","doi-asserted-by":"crossref","unstructured":"Crean D, Bellwon P, Aschauer L, Limonciel A, Moenks K, Hewitt P, Schmidt T, Herrgen K, Dekant W, Lukas A, et al. (2014) Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing. Toxicol In Vitro DOI:10.1016\/j.tiv.2014.11.015 [published ahead of print].","DOI":"10.1016\/j.tiv.2014.11.015"},{"key":"10.1124\/jpet.115.225656_bib36","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1101\/gr.184901","article-title":"The human ATP-binding cassette (ABC) transporter superfamily","volume":"11","author":"Dean","year":"2001","journal-title":"Genome Res"},{"key":"10.1124\/jpet.115.225656_bib37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1124\/dmd.111.041731","article-title":"Oral availability of cefadroxil depends on ABCC3 and ABCC4","volume":"40","author":"de Waart","year":"2012","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.115.225656_bib38","first-page":"108","article-title":"PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system","volume":"27","author":"Ding","year":"2005","journal-title":"Exp Oncol"},{"key":"10.1124\/jpet.115.225656_bib39","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0005-2760(86)90145-1","article-title":"Leukotriene synthesis by human gastrointestinal tissues","volume":"878","author":"Dreyling","year":"1986","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.115.225656_bib40","doi-asserted-by":"crossref","first-page":"29819","DOI":"10.1074\/jbc.C300182200","article-title":"Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras","volume":"278","author":"Dumaz","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.trsl.2014.01.006","article-title":"Renal glucuronidation and multidrug resistance protein 2-\/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus","volume":"164","author":"El-Sheikh","year":"2014","journal-title":"Transl Res"},{"key":"10.1124\/jpet.115.225656_bib42","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/jpet.106.110379","article-title":"Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2\/ABCC2- and MRP4\/ABCC4-mediated methotrexate transport","volume":"320","author":"El-Sheikh","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.225656_bib43","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/bjp.2008.343","article-title":"Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4","volume":"155","author":"El-Sheikh","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib44","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1124\/mol.107.043661","article-title":"Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4\/ABCC4)","volume":"74","author":"El-Sheikh","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib45","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4049\/jimmunol.0902028","article-title":"Prostaglandin E2 inhibits IFN-\u03b1 secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement","volume":"184","author":"Fabricius","year":"2010","journal-title":"J Immunol"},{"key":"10.1124\/jpet.115.225656_bib46","first-page":"354908","article-title":"Tenofovir nephrotoxicity: 2011 update","volume":"2011","author":"Fernandez-Fernandez","year":"2011","journal-title":"Aids Res Treat"},{"key":"10.1124\/jpet.115.225656_bib47","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1124\/dmd.114.057554","article-title":"Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat","volume":"42","author":"Ferslew","year":"2014","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.115.225656_bib48","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1152\/physrev.1976.56.4.652","article-title":"Role of cyclic nucleotides in cell growth and differentiation","volume":"56","author":"Friedman","year":"1976","journal-title":"Physiol Rev"},{"key":"10.1124\/jpet.115.225656_bib49","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1124\/mol.113.086967","article-title":"Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4\/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity","volume":"84","author":"Fukuda","year":"2013","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.prostaglandins.2013.08.002","article-title":"Contribution of multidrug resistance-associated proteins (MRPs) to the release of prostanoids from A549 cells","volume":"106","author":"Furugen","year":"2013","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1124\/jpet.115.225656_bib51","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1093\/intimm\/12.6.851","article-title":"Regulation of TCR-induced IFN-\u03b3 release from islet-reactive non-obese diabetic CD8+ T cells by prostaglandin E2 receptor signaling","volume":"12","author":"Ganapathy","year":"2000","journal-title":"Int Immunol"},{"key":"10.1124\/jpet.115.225656_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00228-014-1769-8","article-title":"Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients","volume":"71","author":"Gao","year":"2015","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib53","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.fertnstert.2013.01.146","article-title":"Augmented epithelial multidrug resistance\u2013associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A4","volume":"99","author":"Gori","year":"2013","journal-title":"Fertil Steril"},{"key":"10.1124\/jpet.115.225656_bib54","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.tpj.6500451","article-title":"Variability in human hepatic MRP4 expression: influence of cholestasis and genotype","volume":"8","author":"Gradhand","year":"2008","journal-title":"Pharmacogenomics J"},{"key":"10.1124\/jpet.115.225656_bib55","doi-asserted-by":"crossref","first-page":"7192","DOI":"10.1038\/onc.2008.356","article-title":"Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver","volume":"27","author":"Gray","year":"2008","journal-title":"Oncogene"},{"key":"10.1124\/jpet.115.225656_bib56","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1158\/1078-0432.CCR-08-0442","article-title":"Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival","volume":"15","author":"Guo","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib57","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1158\/1078-0432.CCR-06-0021","article-title":"Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy","volume":"12","author":"Halder","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib58","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1681\/ASN.2005090966","article-title":"Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide","volume":"18","author":"Hasegawa","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/jpet.115.225656_bib59","doi-asserted-by":"crossref","first-page":"15054","DOI":"10.1074\/jbc.M111.337931","article-title":"Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4","volume":"287","author":"Hayashi","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/0973-1482.143334","article-title":"The overexpression of MRP4 is related to multidrug resistance in osteosarcoma cells","volume":"11","author":"He","year":"2015","journal-title":"J Cancer Res Ther"},{"key":"10.1124\/jpet.115.225656_bib61","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/jnci\/djr256","article-title":"ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux","volume":"103","author":"Henderson","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"10.1124\/jpet.115.225656_bib62","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/pros.20809","article-title":"Androgen regulation of multidrug resistance-associated protein 4 (MRP4\/ABCC4) in prostate cancer","volume":"68","author":"Ho","year":"2008","journal-title":"Prostate"},{"key":"10.1124\/jpet.115.225656_bib63","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1158\/0008-5472.CAN-07-6778","article-title":"Down-regulation of Na+\/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4","volume":"68","author":"Hoque","year":"2008","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib64","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2008.12.014","article-title":"Involvement of NHERF1 in apical membrane localization of MRP4 in polarized kidney cells","volume":"379","author":"Hoque","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.115.225656_bib65","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fonc.2012.00178","article-title":"ABCC4\/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma","volume":"2","author":"Huynh","year":"2012","journal-title":"Front Oncol"},{"key":"10.1124\/jpet.115.225656_bib66","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1254\/jphs.FP0060651","article-title":"Blockade of leukotriene B4 signaling pathway induces apoptosis and suppresses cell proliferation in colon cancer","volume":"103","author":"Ihara","year":"2007","journal-title":"J Pharmacol Sci"},{"key":"10.1124\/jpet.115.225656_bib67","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1124\/mol.106.028233","article-title":"Functional involvement of multidrug resistance-associated protein 4 (MRP4\/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir","volume":"71","author":"Imaoka","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib68","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm0797-775","article-title":"Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury","volume":"3","author":"Indolfi","year":"1997","journal-title":"Nat Med"},{"key":"10.1124\/jpet.115.225656_bib69","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/QAD.0b013e32832407f7","article-title":"Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient","volume":"23","author":"Izzedine","year":"2009","journal-title":"AIDS"},{"key":"10.1124\/jpet.115.225656_bib70","doi-asserted-by":"crossref","first-page":"7750","DOI":"10.1158\/0008-5472.CAN-07-6689","article-title":"Prostaglandin E2 regulates tumor angiogenesis in prostate cancer","volume":"68","author":"Jain","year":"2008","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib71","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1592\/phco.24.4.415.33182","article-title":"Tenofovir-related nephrotoxicity: case report and review of the literature","volume":"24","author":"James","year":"2004","journal-title":"Pharmacotherapy"},{"key":"10.1124\/jpet.115.225656_bib72","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.2353\/ajpath.2010.090425","article-title":"Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: evidence from patients with delta-storage pool deficiencies","volume":"176","author":"Jedlitschky","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1124\/jpet.115.225656_bib73","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1182\/blood-2003-12-4330","article-title":"The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage","volume":"104","author":"Jedlitschky","year":"2004","journal-title":"Blood"},{"key":"10.1124\/jpet.115.225656_bib74","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3109\/03602530903491741","article-title":"ABCC2\/Abcc2: a multispecific transporter with dominant excretory functions","volume":"42","author":"Jemnitz","year":"2010","journal-title":"Drug Metab Rev"},{"key":"10.1124\/jpet.115.225656_bib75","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1021\/mp800116f","article-title":"c-Myc amplification altered the gene expression of ABC- and SLC-transporters in human breast epithelial cells","volume":"6","author":"Kang","year":"2009","journal-title":"Mol Pharm"},{"key":"10.1124\/jpet.115.225656_bib76","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0092-8674(94)90257-7","article-title":"Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation","volume":"79","author":"Kato","year":"1994","journal-title":"Cell"},{"key":"10.1124\/jpet.115.225656_bib77","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/QAI.0b013e31815e7478","article-title":"Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients","volume":"47","author":"Kiser","year":"2008","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1124\/jpet.115.225656_bib78","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.clpt.6100269","article-title":"The effect of lopinavir\/ritonavir on the renal clearance of tenofovir in HIV-infected patients","volume":"83","author":"Kiser","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.115.225656_bib79","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1124\/dmd.113.054304","article-title":"Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4","volume":"42","author":"K\u00f6ck","year":"2014","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.115.225656_bib80","doi-asserted-by":"crossref","first-page":"e41320","DOI":"10.1371\/journal.pone.0041320","article-title":"Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells","volume":"7","author":"Kolodecik","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/jpet.115.225656_bib81","first-page":"3537","article-title":"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines","volume":"57","author":"Kool","year":"1997","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib82","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1158\/0008-5472.CAN-07-6790","article-title":"Transporter-mediated protection against thiopurine-induced hematopoietic toxicity","volume":"68","author":"Krishnamurthy","year":"2008","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib83","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1158\/0008-5472.CAN-05-0216","article-title":"Prostaglandin E2 activates mitogen-activated protein kinase\/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner","volume":"65","author":"Krysan","year":"2005","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib84","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/sj.onc.1208450","article-title":"Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP","volume":"24","author":"Kuiperij","year":"2005","journal-title":"Oncogene"},{"key":"10.1124\/jpet.115.225656_bib85","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/sj.onc.1201038","article-title":"Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts","volume":"14","author":"L\u2019Allemain","year":"1997","journal-title":"Oncogene"},{"key":"10.1124\/jpet.115.225656_bib86","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1158\/0008-5472.CAN-05-0530","article-title":"Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery","volume":"65","author":"Landen","year":"2005","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib87","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.prostaglandins.2008.05.001","article-title":"PGE2 and LTB4 tissue levels in benign and cancerous prostates","volume":"87","author":"Larr\u00e9","year":"2008","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1124\/jpet.115.225656_bib88","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1093\/jnci\/92.23.1934","article-title":"Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells","volume":"92","author":"Lee","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1124\/jpet.115.225656_bib89","doi-asserted-by":"crossref","first-page":"7612","DOI":"10.1128\/MCB.24.17.7612-7621.2004","article-title":"Mrp4 confers resistance to topotecan and protects the brain from chemotherapy","volume":"24","author":"Leggas","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1124\/jpet.115.225656_bib90","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0006-2952(00)00295-1","article-title":"Rapid desensitization and slow recovery of the cyclic AMP response mediated by histamine H2 receptors in the U937 cell line","volume":"60","author":"Lemos Legnazzi","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib91","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.cell.2007.09.037","article-title":"Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia","volume":"131","author":"Li","year":"2007","journal-title":"Cell"},{"key":"10.1124\/jpet.115.225656_bib92","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0895-3988(10)60063-3","article-title":"CagA+ H. pylori induces Akt1 phosphorylation and inhibits transcription of p21WAF1\/CIP1 and p27KIP1 via PI3K\/Akt1 pathway","volume":"23","author":"Li","year":"2010","journal-title":"Biomed Environ Sci"},{"key":"10.1124\/jpet.115.225656_bib93","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jns.2013.06.025","article-title":"The efficacy and safety of aspirin plus dipyridamole versus aspirin in secondary prevention following TIA or stroke: a meta-analysis of randomized controlled trials","volume":"332","author":"Li","year":"2013","journal-title":"J Neurol Sci"},{"key":"10.1124\/jpet.115.225656_bib94","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejphar.2014.05.001","article-title":"Multidrug resistance protein 4 (MRP4\/ABCC4) regulates thrombus formation in vitro and in vivo","volume":"737","author":"Lien","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib95","doi-asserted-by":"crossref","first-page":"e1251","DOI":"10.1038\/cddis.2014.229","article-title":"Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk\/MAP kinase pathway mediated by cAMP\/PKA signaling","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1124\/jpet.115.225656_bib96","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0013-9351(02)00081-6","article-title":"Variability in human metabolism of arsenic","volume":"92","author":"Loffredo","year":"2003","journal-title":"Environ Res"},{"key":"10.1124\/jpet.115.225656_bib97","doi-asserted-by":"crossref","first-page":"e111664","DOI":"10.1371\/journal.pone.0111664","article-title":"Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides","volume":"9","author":"Lu","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/jpet.115.225656_bib98","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.gene.2007.02.030","article-title":"Selection and validation of optimal siRNA target sites for RNAi-mediated gene silencing","volume":"395","author":"Luo","year":"2007","journal-title":"Gene"},{"key":"10.1124\/jpet.115.225656_bib99","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejps.2014.05.023","article-title":"Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway","volume":"62","author":"Maeng","year":"2014","journal-title":"Eur J Pharm Sci"},{"key":"10.1124\/jpet.115.225656_bib100","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.bcp.2006.02.005","article-title":"Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice","volume":"71","author":"Maher","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib101","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1124\/dmd.105.003780","article-title":"Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice","volume":"33","author":"Maher","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.115.225656_bib102","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.bcp.2013.10.017","article-title":"ABCC4 is regulated by microRNA-124a and microRNA-506","volume":"87","author":"Markova","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib103","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/mt.2013.216","article-title":"In vitro and in vivo efficacy of SYL040012, a novel siRNA compound for treatment of glaucoma","volume":"22","author":"Mart\u00ednez","year":"2014","journal-title":"Mol Ther"},{"key":"10.1124\/jpet.115.225656_bib104","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/bcp.12432","article-title":"Aspirin influences megakaryocytic gene expression leading to up-regulation of multidrug resistance protein-4 in human platelets","volume":"78","author":"Massimi","year":"2014","journal-title":"Br J Clin Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib105","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.1167\/iovs.12-10781","article-title":"Forskolin modifies retinal vascular development in Mrp4-knockout mice","volume":"53","author":"Matsumiya","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.115.225656_bib106","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jacc.2011.03.049","article-title":"Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting","volume":"58","author":"Mattiello","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1124\/jpet.115.225656_bib107","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1124\/dmd.107.016352","article-title":"Evaluation of the role of breast cancer resistance protein (BCRP\/ABCG2) and multidrug resistance-associated protein 4 (MRP4\/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one)","volume":"35","author":"Mizuno","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.115.225656_bib108","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1124\/jpet.105.093765","article-title":"Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor \u03b1","volume":"317","author":"Moffit","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.225656_bib109","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.bcp.2005.12.037","article-title":"Histamine H2 receptor overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate cAMP signalling","volume":"71","author":"Monczor","year":"2006","journal-title":"Biochem Pharmacol"},{"issue":"Suppl 3","key":"10.1124\/jpet.115.225656_bib110","doi-asserted-by":"crossref","first-page":"19565","DOI":"10.7448\/IAS.17.4.19565","article-title":"The impact of tenofovir disoproxil fumarate on kidney function: four-year data from the HIV-infected outpatient cohort","volume":"17","author":"Monteiro","year":"2014","journal-title":"J Int AIDS Soc"},{"key":"10.1124\/jpet.115.225656_bib111","doi-asserted-by":"crossref","first-page":"11246","DOI":"10.1074\/jbc.M114.605410","article-title":"Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea","volume":"290","author":"Moon","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib112","doi-asserted-by":"crossref","first-page":"567","DOI":"10.5414\/CNP71567","article-title":"Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction","volume":"71","author":"Morelle","year":"2009","journal-title":"Clin Nephrol"},{"key":"10.1124\/jpet.115.225656_bib113","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1189\/jlb.0405226","article-title":"Prostaglandin E2 promotes degranulation-independent release of MCP-1 from mast cells","volume":"79","author":"Nakayama","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1124\/jpet.115.225656_bib114","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.4161\/cbt.8.12.8562","article-title":"Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells","volume":"8","author":"Naviglio","year":"2009","journal-title":"Cancer Biol Ther"},{"key":"10.1124\/jpet.115.225656_bib115","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tiv.2014.09.010","article-title":"ABCB1 and ABCC4 efflux transporters are involved in methyl parathion detoxification in ZFL cells","volume":"29","author":"Nornberg","year":"2015","journal-title":"Toxicol In Vitro"},{"key":"10.1124\/jpet.115.225656_bib116","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/S0959-8049(97)00284-0","article-title":"Evidence that the MYCN oncogene regulates MRP gene expression in neuroblastoma","volume":"33","author":"Norris","year":"1997","journal-title":"Eur J Cancer"},{"key":"10.1124\/jpet.115.225656_bib117","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1056\/NEJM199601253340405","article-title":"Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma","volume":"334","author":"Norris","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.115.225656_bib118","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1158\/1535-7163.MCT-04-0161","article-title":"Expression of multidrug transporter MRP4\/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro","volume":"4","author":"Norris","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1124\/jpet.115.225656_bib119","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1002\/ijc.24207","article-title":"Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs","volume":"124","author":"Oevermann","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1124\/jpet.115.225656_bib120","doi-asserted-by":"crossref","unstructured":"Ozcan G, Ozpolat B, Coleman RL, Sood AK, Lopez-Berestein G (2015) Preclinical and clinical development of siRNA-based therapeutics. Adv Drug Deliv Rev DOI:10.1016\/j.addr.2015.01.007 [published ahead of print].","DOI":"10.1016\/j.addr.2015.01.007"},{"key":"10.1124\/jpet.115.225656_bib121","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1681\/ASN.2013040438","article-title":"Na\u207a\/H\u207a exchanger regulatory factor 3 is critical for multidrug resistance protein 4-mediated drug efflux in the kidney","volume":"25","author":"Park","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/jpet.115.225656_bib122","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1124\/jpet.110.173278","article-title":"The effects of the stromal cell-derived cyclooxygenase-2 metabolite prostaglandin E2 on the proliferation of colon cancer cells","volume":"336","author":"Park","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.225656_bib123","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.bi.44.070175.002423","article-title":"Role of cyclic nucleotides in growth control","volume":"44","author":"Pastan","year":"1975","journal-title":"Annu Rev Biochem"},{"key":"10.1124\/jpet.115.225656_bib124","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1167\/iovs.12-11107","article-title":"MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure","volume":"54","author":"Pattabiraman","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1124\/jpet.115.225656_bib125","doi-asserted-by":"crossref","first-page":"19532","DOI":"10.1074\/jbc.M109.078584","article-title":"Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells","volume":"285","author":"Porro","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib126","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1158\/1541-7786.MCR-10-0510","article-title":"c-MYC oncoprotein dictates transcriptional profiles of ATP-binding cassette transporter genes in chronic myelogenous leukemia CD34+ hematopoietic progenitor cells","volume":"9","author":"Porro","year":"2011","journal-title":"Mol Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib127","doi-asserted-by":"crossref","first-page":"16959","DOI":"10.1074\/jbc.M701214200","article-title":"Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo","volume":"282","author":"Rao","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib128","doi-asserted-by":"crossref","first-page":"e29331","DOI":"10.1371\/journal.pone.0029331","article-title":"Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma","volume":"7","author":"Rasmuson","year":"2012","journal-title":"PLoS One"},{"key":"10.1124\/jpet.115.225656_bib129","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1016\/j.bmcl.2008.05.047","article-title":"Molecular model of the outward facing state of the human multidrug resistance protein 4 (MRP4\/ABCC4)","volume":"18","author":"Ravna","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1124\/jpet.115.225656_bib130","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1128\/AAC.00251-06","article-title":"Mechanism of active renal tubular efflux of tenofovir","volume":"50","author":"Ray","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/jpet.115.225656_bib131","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1124\/mol.63.5.1094","article-title":"Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5","volume":"63","author":"Reid","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib132","doi-asserted-by":"crossref","first-page":"9244","DOI":"10.1073\/pnas.1033060100","article-title":"The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs","volume":"100","author":"Reid","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.225656_bib133","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbagrm.2011.01.008","article-title":"Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter","volume":"1809","author":"Renga","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.115.225656_bib134","doi-asserted-by":"crossref","first-page":"G640","DOI":"10.1152\/ajpgi.00354.2005","article-title":"Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione","volume":"290","author":"Rius","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.115.225656_bib135","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/jpet.107.131342","article-title":"ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4)","volume":"324","author":"Rius","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.225656_bib136","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1053\/jhep.2003.50331","article-title":"Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane","volume":"38","author":"Rius","year":"2003","journal-title":"Hepatology"},{"key":"10.1124\/jpet.115.225656_bib137","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1097\/01.ju.0000180411.03808.cb","article-title":"Prostanoid transport by multidrug resistance protein 4 (MRP4\/ABCC4) localized in tissues of the human urogenital tract","volume":"174","author":"Rius","year":"2005","journal-title":"J Urol"},{"key":"10.1124\/jpet.115.225656_bib138","first-page":"869","article-title":"Dipyridamole: a critical evaluation","volume":"18","author":"Rivey","year":"1984","journal-title":"Drug Intell Clin Pharm"},{"key":"10.1124\/jpet.115.225656_bib139","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1128\/AAC.04930-14","article-title":"Influence of ABCC2 and ABCC4 polymorphisms on tenofovir plasma concentrations in Thai HIV-infected patients","volume":"59","author":"Rungtivasuwan","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/jpet.115.225656_bib140","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tips.2008.01.006","article-title":"Multidrug resistance protein 4 (MRP4\/ABCC4): a versatile efflux transporter for drugs and signalling molecules","volume":"29","author":"Russel","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.115.225656_bib141","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1128\/AAC.00194-11","article-title":"Population pharmacokinetic\/pharmacogenetic model for optimization of efavirenz therapy in Caucasian HIV-infected patients","volume":"55","author":"S\u00e1nchez","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1124\/jpet.115.225656_bib142","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1096\/fj.11-194027","article-title":"Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes","volume":"26","author":"Sassi","year":"2012","journal-title":"FASEB J"},{"key":"10.1124\/jpet.115.225656_bib143","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1172\/JCI35067","article-title":"Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation","volume":"118","author":"Sassi","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.115.225656_bib144","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s11095-007-9401-6","article-title":"Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers","volume":"25","author":"Sato","year":"2008","journal-title":"Pharm Res"},{"key":"10.1124\/jpet.115.225656_bib145","doi-asserted-by":"crossref","first-page":"48855","DOI":"10.1074\/jbc.M408849200","article-title":"Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state","volume":"279","author":"Sauna","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib146","doi-asserted-by":"crossref","first-page":"39411","DOI":"10.1074\/jbc.M106340200","article-title":"Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450","volume":"276","author":"Schuetz","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib147","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejphar.2012.02.018","article-title":"MRP4 and CFTR in the regulation of cAMP and \u03b2-adrenergic contraction in cardiac myocytes","volume":"681","author":"Sellers","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib148","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1124\/mol.51.6.983","article-title":"Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937","volume":"51","author":"Shayo","year":"1997","journal-title":"Mol Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib149","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.bbrc.2003.12.166","article-title":"The time-course of cyclic AMP signaling is critical for leukemia U-937 cell differentiation","volume":"314","author":"Shayo","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.115.225656_bib150","first-page":"362","article-title":"Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells","volume":"58","author":"Sheng","year":"1998","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib151","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/cimm.1999.1575","article-title":"Prostaglandin E2 and stem cell factor can deliver opposing signals to B lymphocyte precursors","volume":"198","author":"Shimozato","year":"1999","journal-title":"Cell Immunol"},{"key":"10.1124\/jpet.115.225656_bib152","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.cellsig.2015.03.022","article-title":"PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration","volume":"27","author":"Sinha","year":"2015","journal-title":"Cell Signal"},{"key":"10.1124\/jpet.115.225656_bib153","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1074\/jbc.M112.435925","article-title":"Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides","volume":"288","author":"Sinha","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.225656_bib154","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1158\/0008-5472.CAN-06-4174","article-title":"Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells","volume":"67","author":"Sinha","year":"2007","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib155","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1097\/01.ASN.0000143473.64430.AC","article-title":"Contribution of multidrug resistance protein 2 (MRP2\/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter","volume":"15","author":"Smeets","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/jpet.115.225656_bib156","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5732\/cjc.011.10329","article-title":"Multidrug resistance associated proteins in multidrug resistance","volume":"31","author":"Sodani","year":"2012","journal-title":"Chinese J Cancer"},{"key":"10.1124\/jpet.115.225656_bib157","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0021-9150(90)90150-H","article-title":"Serum-induced proliferation of rabbit aortic smooth muscle cells from the contractile state is inhibited by 8-Br-cAMP but not 8-Br-cGMP","volume":"82","author":"Southgate","year":"1990","journal-title":"Atherosclerosis"},{"key":"10.1124\/jpet.115.225656_bib158","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1093\/carcin\/bgu043","article-title":"ABCC4 copy number variation is associated with susceptibility to esophageal squamous cell carcinoma","volume":"35","author":"Sun","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1124\/jpet.115.225656_bib159","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrd1984","article-title":"Targeting multidrug resistance in cancer","volume":"5","author":"Szak\u00e1cs","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/jpet.115.225656_bib160","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.bbrc.2010.08.109","article-title":"MRP4 knockdown enhances migration, suppresses apoptosis, and produces aggregated morphology in human retinal vascular endothelial cells","volume":"400","author":"Tagami","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.115.225656_bib161","doi-asserted-by":"crossref","unstructured":"Tanaka Y, Manabe A, Fukushima H, Suzuki R, Nakadate H, Kondoh K, Nakamura K, Koh K, Fukushima T, Tsuchida M, et al. (2014) Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia. Pharmacogenomics J DOI:10.1038\/tpj.2014.74 [published ahead of print].","DOI":"10.1038\/tpj.2014.74"},{"key":"10.1124\/jpet.115.225656_bib162","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/138920006774832550","article-title":"Topotecan is a substrate for multidrug resistance associated protein 4","volume":"7","author":"Tian","year":"2006","journal-title":"Curr Drug Metab"},{"key":"10.1124\/jpet.115.225656_bib163","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1007\/s11095-005-7595-z","article-title":"Human multidrug resistance associated protein 4 confers resistance to camptothecins","volume":"22","author":"Tian","year":"2005","journal-title":"Pharm Res"},{"key":"10.1124\/jpet.115.225656_bib164","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.bbrc.2005.07.166","article-title":"LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways","volume":"335","author":"Tong","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.115.225656_bib165","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1007\/s11095-007-9453-7","article-title":"Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter","volume":"24","author":"Uchida","year":"2007","journal-title":"Pharm Res"},{"key":"10.1124\/jpet.115.225656_bib166","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1681\/ASN.V133595","article-title":"The MRP4\/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP","volume":"13","author":"van Aubel","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1124\/jpet.115.225656_bib167","doi-asserted-by":"crossref","first-page":"F327","DOI":"10.1152\/ajprenal.00133.2004","article-title":"Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites","volume":"288","author":"Van Aubel","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1124\/jpet.115.225656_bib168","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1182\/blood-2008-03-147850","article-title":"A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration","volume":"112","author":"van de Ven","year":"2008","journal-title":"Blood"},{"key":"10.1124\/jpet.115.225656_bib169","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1210\/endo.142.3.8035","article-title":"Respective roles of carbamylcholine and cyclic adenosine monophosphate in their synergistic regulation of cell cycle in thyroid primary cultures","volume":"142","author":"Van Keymeulen","year":"2001","journal-title":"Endocrinology"},{"key":"10.1124\/jpet.115.225656_bib170","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2119\/molmed.2014.00166","article-title":"Blockade of multidrug resistance-associated proteins aggravates acute pancreatitis and blunts atrial natriuretic factor\u2019s beneficial effect in rats: role of MRP4 (ABCC4)","volume":"21","author":"Ventimiglia","year":"2015","journal-title":"Mol Med"},{"key":"10.1124\/jpet.115.225656_bib171","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1158\/0008-5472.CAN-09-0390","article-title":"Prostaglandin F2\u03b1\u2013F-prostanoid receptor signalling promotes neutrophil chemotaxis via chemokine (CXC motif) ligand-1 in endometrial adenocarcinoma","volume":"69","author":"Wallace","year":"2009","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib172","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1158\/0008-5472.CAN-04-3671","article-title":"Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen\u2013activated protein kinase cascade","volume":"65","author":"Wang","year":"2005","journal-title":"Cancer Res"},{"key":"10.1124\/jpet.115.225656_bib173","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrc2809","article-title":"Eicosanoids and cancer","volume":"10","author":"Wang","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1124\/jpet.115.225656_bib174","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/PPO.0000000000000003","article-title":"An inflammatory mediator, prostaglandin E2, in colorectal cancer","volume":"19","author":"Wang","year":"2013","journal-title":"Cancer J"},{"key":"10.1124\/jpet.115.225656_bib175","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1084\/jem.20052124","article-title":"CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer","volume":"203","author":"Wang","year":"2006","journal-title":"J Exp Med"},{"key":"10.1124\/jpet.115.225656_bib176","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ccr.2004.08.011","article-title":"Prostaglandin E2 promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor \u03b4","volume":"6","author":"Wang","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1124\/jpet.115.225656_bib177","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/j.1349-7006.2009.01246.x","article-title":"DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation","volume":"100","author":"Wang","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1124\/jpet.115.225656_bib178","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.taap.2014.11.002","article-title":"Suppression of c-Myc is involved in multi-walled carbon nanotubes\u2019 down-regulation of ATP-binding cassette transporters in human colon adenocarcinoma cells","volume":"282","author":"Wang","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.115.225656_bib179","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/bbrc.1996.0976","article-title":"Cyclic AMP inhibits expression of D-type cyclins and cdk4 and induces p27Kip1 in G-CSF-treated NFS-60 cells","volume":"224","author":"Ward","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1124\/jpet.115.225656_bib180","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1124\/dmd.114.062539","article-title":"Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors","volume":"43","author":"Welch","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.115.225656_bib181","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1124\/dmd.111.044438","article-title":"Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4","volume":"40","author":"Wittgen","year":"2012","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.115.225656_bib182","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1111\/j.1742-4658.2005.04888.x","article-title":"Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5)","volume":"272","author":"Wu","year":"2005","journal-title":"FEBS J"},{"key":"10.1124\/jpet.115.225656_bib183","doi-asserted-by":"crossref","first-page":"G126","DOI":"10.1152\/ajpgi.00522.2010","article-title":"Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression","volume":"299","author":"Xu","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1124\/jpet.115.225656_bib184","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1124\/dmd.107.017459","article-title":"Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor","volume":"35","author":"Yamada","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.115.225656_bib185","doi-asserted-by":"crossref","first-page":"e85446","DOI":"10.1371\/journal.pone.0085446","article-title":"Prognostic significance and molecular mechanism of ATP-binding cassette subfamily C member 4 in resistance to neoadjuvant radiotherapy of locally advanced rectal carcinoma","volume":"9","author":"Yu","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/jpet.115.225656_bib186","doi-asserted-by":"crossref","first-page":"8561","DOI":"10.1073\/pnas.0503363102","article-title":"Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A","volume":"102","author":"Zambon","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.225656_bib187","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1164\/rccm.201003-0422OC","article-title":"RNA interference therapy in lung transplant patients infected with respiratory syncytial virus","volume":"183","author":"Zamora","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1124\/jpet.115.225656_bib188","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/bj20021886","article-title":"Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4)","volume":"371","author":"Zelcer","year":"2003","journal-title":"Biochem J"},{"key":"10.1124\/jpet.115.225656_bib189","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.canlet.2009.10.003","article-title":"Silencing MRP4 by small interfering RNA reverses acquired DDP resistance of gastric cancer cell","volume":"291","author":"Zhang","year":"2010","journal-title":"Cancer Lett"},{"key":"10.1124\/jpet.115.225656_bib190","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.gene.2011.09.029","article-title":"The ABCC4 gene is a promising target for pancreatic cancer therapy","volume":"491","author":"Zhang","year":"2012","journal-title":"Gene"},{"key":"10.1124\/jpet.115.225656_bib191","doi-asserted-by":"crossref","first-page":"20723","DOI":"10.1073\/pnas.1314307110","article-title":"Mutant KRAS is a druggable target for pancreatic cancer","volume":"110","author":"Zorde Khvalevsky","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.225656_bib192","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1200\/JCO.2012.46.8280","article-title":"Dasatinib in children and adolescents with relapsed or refractory leukemia: results of the CA180-018 phase I dose-escalation study of the Innovative Therapies for Children with Cancer Consortium","volume":"31","author":"Zwaan","year":"2013","journal-title":"J Clin Oncol"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524190921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524190921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.115.225656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T18:02:15Z","timestamp":1739988135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524190921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":192,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0022356524190921"],"URL":"https:\/\/doi.org\/10.1124\/jpet.115.225656","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Pharmacological and Physiological Role of Multidrug-Resistant Protein 4","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.115.225656","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}