{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:54:19Z","timestamp":1790250859446,"version":"4.1.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1124\/jpet.115.226373","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T01:59:37Z","timestamp":1439517577000},"page":"99-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["P-Glycoprotein Transport of Neurotoxic Pesticides"],"prefix":"10.1016","volume":"355","author":[{"given":"Sarah E.","family":"Lacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasse","family":"Skagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Veit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica L.","family":"Woodahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.115.226373_bib1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/toxsci\/kfs160","article-title":"Synchronized activity of organic cation transporter 3 (Oct3\/Slc22a3) and multidrug and toxin extrusion 1 (Mate1\/Slc47a1) transporter in transplacental passage of MPP+ in rat","volume":"128","author":"Ahmadimoghaddam","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1124\/jpet.115.226373_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0041-008X(96)80035-4","article-title":"Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein","volume":"141","author":"Bain","year":"1996","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.115.226373_bib3","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2174\/138161211797440122","article-title":"Blood-brain barrier P-glycoprotein function in neurodegenerative disease","volume":"17","author":"Bartels","year":"2011","journal-title":"Curr Pharm Des"},{"key":"10.1124\/jpet.115.226373_bib4","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.neurobiolaging.2008.02.002","article-title":"Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration","volume":"30","author":"Bartels","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1124\/jpet.115.226373_bib5","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00702-008-0030-y","article-title":"Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson\u2019s disease, PSP and MSA","volume":"115","author":"Bartels","year":"2008","journal-title":"J Neural Transm"},{"key":"10.1124\/jpet.115.226373_bib6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1124\/jpet.113.203257","article-title":"Substrate-dependent ligand inhibition of the human organic cation transporter OCT2","volume":"346","author":"Belzer","year":"2013","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.226373_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jbt.21458","article-title":"Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides","volume":"27","author":"Bircsak","year":"2013","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1124\/jpet.115.226373_bib8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/sj.bjp.0703078","article-title":"Characterization of MPP+ secretion across human intestinal Caco-2 cell monolayers: role of P-glycoprotein and a novel Na(+)-dependent organic cation transport mechanism","volume":"129","author":"Bleasby","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1124\/jpet.115.226373_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0753-3322(99)80076-6","article-title":"Pathophysiology of Parkinson\u2019s disease","volume":"53","author":"Bonnet","year":"1999","journal-title":"Biomed Pharmacother"},{"key":"10.1124\/jpet.115.226373_bib10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/319056a0","article-title":"1-methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway","volume":"319","author":"Bradbury","year":"1986","journal-title":"Nature"},{"key":"10.1124\/jpet.115.226373_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/clpt.2013.81","article-title":"In vitro methods to support transporter evaluation in drug discovery and development","volume":"94","author":"Brouwer","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.115.226373_bib12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fncel.2015.00124","article-title":"Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases","volume":"9","author":"Chin-Chan","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1124\/jpet.115.226373_bib13","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/aje\/kwp006","article-title":"Parkinson\u2019s disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California","volume":"169","author":"Costello","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1124\/jpet.115.226373_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/10599240801986215","article-title":"Pesticide\/environmental exposures and Parkinson\u2019s disease in East Texas","volume":"13","author":"Dhillon","year":"2008","journal-title":"J Agromed"},{"key":"10.1124\/jpet.115.226373_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00008571-200305000-00004","article-title":"Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson\u2019s disease","volume":"13","author":"Dro\u017adzik","year":"2003","journal-title":"Pharmacogenetics"},{"key":"10.1124\/jpet.115.226373_bib16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/archneurol.2010.101","article-title":"Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease","volume":"67","author":"Dutheil","year":"2010","journal-title":"Arch Neurol"},{"issue":"Suppl 1","key":"10.1124\/jpet.115.226373_bib17","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/1475-2883-2-S1-S8","article-title":"Ivermectin: does P-glycoprotein play a role in neurotoxicity?","volume":"2","author":"Edwards","year":"2003","journal-title":"Filaria J"},{"key":"10.1124\/jpet.115.226373_bib18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1124\/dmd.107.017434","article-title":"In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system","volume":"36","author":"Feng","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1124\/jpet.115.226373_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1001\/archneur.62.1.91","article-title":"Pesticides and risk of Parkinson disease: a population-based case-control study","volume":"62","author":"Firestone","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1124\/jpet.115.226373_bib20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/ana.410360119","article-title":"Parkinson\u2019s disease and brain levels of organochlorine pesticides","volume":"36","author":"Fleming","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1124\/jpet.115.226373_bib21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00008571-200210000-00004","article-title":"Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson\u2019s disease","volume":"12","author":"Furuno","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1124\/jpet.115.226373_bib22","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1523\/JNEUROSCI.22-03-00782.2002","article-title":"Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons","volume":"22","author":"Gao","year":"2002","journal-title":"J Neurosci"},{"key":"10.1124\/jpet.115.226373_bib23","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1289\/ehp.0900852","article-title":"Well-water consumption and Parkinson\u2019s disease in rural California","volume":"117","author":"Gatto","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1124\/jpet.115.226373_bib24","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1023\/A:1025733918160","article-title":"Membrane transporters in drug disposition","volume":"25","author":"Giacomini","year":"1997","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1124\/jpet.115.226373_bib25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","article-title":"Membrane transporters in drug development","volume":"9","author":"Giacomini","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1124\/jpet.115.226373_bib26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-pharmtox-011613-135937","article-title":"Environmental toxins and Parkinson\u2019s disease","volume":"54","author":"Goldman","year":"2014","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1124\/jpet.115.226373_bib27","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.tips.2008.03.007","article-title":"Parkinson\u2019s disease and pesticides: a toxicological perspective","volume":"29","author":"Hatcher","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"10.1124\/jpet.115.226373_bib28","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.expneurol.2006.12.020","article-title":"Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system","volume":"204","author":"Hatcher","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1124\/jpet.115.226373_bib29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/clpt.2013.74","article-title":"Emerging transporters of clinical importance: an update from the International Transporter Consortium","volume":"94","author":"Hillgren","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.115.226373_bib30","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.bbamem.2015.04.001","article-title":"Functional characterization of the organic cation transporters (OCTs) in human airway pulmonary epithelial cells","volume":"1848","author":"Ingoglia","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.115.226373_bib31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.neuro.2007.04.003","article-title":"Developmental exposure to pesticides zineb and\/or endosulfan renders the nigrostriatal dopamine system more susceptible to these environmental chemicals later in life","volume":"28","author":"Jia","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.115.226373_bib32","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/jat.1218","article-title":"Exposure to mixtures of endosulfan and zineb induces apoptotic and necrotic cell death in SH-SY5Y neuroblastoma cells, in vitro","volume":"27","author":"Jia","year":"2007","journal-title":"J Appl Toxicol"},{"key":"10.1124\/jpet.115.226373_bib33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/clpt.2013.34","article-title":"Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position","volume":"94","author":"Kalvass","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1124\/jpet.115.226373_bib34","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1126\/science.1243619","article-title":"Epidemiology. Paths from pesticides to Parkinson\u2019s","volume":"341","author":"Kamel","year":"2013","journal-title":"Science"},{"key":"10.1124\/jpet.115.226373_bib35","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1756-6606-1-12","article-title":"Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): implications for neurodegeneration in Parkinson\u2019s disease","volume":"1","author":"Kanthasamy","year":"2008","journal-title":"Mol Brain"},{"key":"10.1124\/jpet.115.226373_bib36","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/ana.20369","article-title":"Blood-brain barrier dysfunction in parkinsonian midbrain in vivo","volume":"57","author":"Kortekaas","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1124\/jpet.115.226373_bib37","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1124\/jpet.113.209791","article-title":"Absence of P-glycoprotein transport in the pharmacokinetics and toxicity of the herbicide paraquat","volume":"348","author":"Lacher","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.226373_bib38","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"10.1124\/jpet.115.226373_bib39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3940(84)90293-3","article-title":"1-Methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra","volume":"48","author":"Langston","year":"1984","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.115.226373_bib40","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000052148","article-title":"P-glycoprotein, multidrug-resistance-associated protein and Parkinson\u2019s disease","volume":"45","author":"Le Couteur","year":"2001","journal-title":"Eur Neurol"},{"key":"10.1124\/jpet.115.226373_bib41","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.toxlet.2005.09.003","article-title":"Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein","volume":"161","author":"Lecoeur","year":"2006","journal-title":"Toxicol Lett"},{"key":"10.1124\/jpet.115.226373_bib42","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1136\/jmg.2003.013003","article-title":"MDR1, the blood-brain barrier transporter, is associated with Parkinson\u2019s disease in ethnic Chinese","volume":"41","author":"Lee","year":"2004","journal-title":"J Med Genet"},{"key":"10.1124\/jpet.115.226373_bib43","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1023\/B:PHAM.0000036905.82914.8e","article-title":"Functional expression and localization of P-glycoprotein in the central nervous system: relevance to the pathogenesis and treatment of neurological disorders","volume":"21","author":"Lee","year":"2004","journal-title":"Pharm Res"},{"key":"10.1124\/jpet.115.226373_bib44","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/01.jom.0000174294.58575.3e","article-title":"Evaluation of epidemiologic and animal data associating pesticides with Parkinson\u2019s disease","volume":"47","author":"Li","year":"2005","journal-title":"J Occup Environ Med"},{"key":"10.1124\/jpet.115.226373_bib45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neulet.2014.02.025","article-title":"Novel and functional ABCB1 gene variant in sporadic Parkinson\u2019s disease","volume":"566","author":"Li","year":"2014","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.115.226373_bib46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1081\/DMR-120026871","article-title":"Clinical relevance of P-glycoprotein in drug therapy","volume":"35","author":"Lin","year":"2003","journal-title":"Drug Metab Rev"},{"key":"10.1124\/jpet.115.226373_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2165\/00003088-200342010-00003","article-title":"Role of P-glycoprotein in pharmacokinetics: clinical implications","volume":"42","author":"Lin","year":"2003","journal-title":"Clin Pharmacokinet"},{"key":"10.1124\/jpet.115.226373_bib48","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1212\/WNL.48.6.1583","article-title":"Environmental risk factors and Parkinson\u2019s disease: a case-control study in Taiwan","volume":"48","author":"Liou","year":"1997","journal-title":"Neurology"},{"key":"10.1124\/jpet.115.226373_bib49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-2999(01)01055-X","article-title":"Effect of P-glycoprotein modulators on the human extraneuronal monoamine transporter","volume":"422","author":"Martel","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.115.226373_bib50","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00008571-200111000-00012","article-title":"Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene","volume":"11","author":"Mealey","year":"2001","journal-title":"Pharmacogenetics"},{"key":"10.1124\/jpet.115.226373_bib51","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.2460\/javma.2003.223.1453","article-title":"Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity","volume":"223","author":"Mealey","year":"2003","journal-title":"J Am Vet Med Assoc"},{"key":"10.1124\/jpet.115.226373_bib52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.taap.2013.01.025","article-title":"Pesticides and human chronic diseases: evidences, mechanisms, and perspectives","volume":"268","author":"Mostafalou","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.115.226373_bib53","first-page":"354","article-title":"Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in Collies","volume":"17","author":"Nelson","year":"2003","journal-title":"J Vet Intern Med"},{"key":"10.1124\/jpet.115.226373_bib54","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1212\/WNL.0b013e318294b3c8","article-title":"Exposure to pesticides or solvents and risk of Parkinson disease","volume":"80","author":"Pezzoli","year":"2013","journal-title":"Neurology"},{"key":"10.1124\/jpet.115.226373_bib55","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.etap.2006.04.002","article-title":"Pesticides and their binary combinations as P-glycoprotein inhibitors in NIH 3T3\/MDR1 cells","volume":"22","author":"Piv\u010devi\u0107","year":"2006","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1124\/jpet.115.226373_bib56","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0022-3565(24)29270-3","article-title":"Rational use of in vitro P-glycoprotein assays in drug discovery","volume":"299","author":"Polli","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.226373_bib57","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.taap.2014.07.015","article-title":"Interaction of environmental contaminants with zebrafish organic anion transporting polypeptide, Oatp1d1 (Slco1d1)","volume":"280","author":"Popovic","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1124\/jpet.115.226373_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/156802609787521544","article-title":"P-gp transporter and its role in neurodegenerative diseases","volume":"9","author":"Rapposelli","year":"2009","journal-title":"Curr Top Med Chem"},{"key":"10.1124\/jpet.115.226373_bib59","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1096\/fj.06-5864fje","article-title":"Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson\u2019s disease","volume":"20","author":"Richardson","year":"2006","journal-title":"FASEB J"},{"key":"10.1124\/jpet.115.226373_bib60","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-2999(02)02955-2","article-title":"MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin","volume":"460","author":"Roulet","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1124\/jpet.115.226373_bib61","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0092-8674(94)90212-7","article-title":"Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs","volume":"77","author":"Schinkel","year":"1994","journal-title":"Cell"},{"key":"10.1124\/jpet.115.226373_bib62","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1212\/WNL.42.7.1328","article-title":"Parkinson\u2019s disease and exposure to agricultural work and pesticide chemicals","volume":"42","author":"Semchuk","year":"1992","journal-title":"Neurology"},{"key":"10.1124\/jpet.115.226373_bib63","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuro.2009.12.007","article-title":"Organochlorine pesticides dieldrin and lindane induce cooperative toxicity in dopaminergic neurons: role of oxidative stress","volume":"31","author":"Sharma","year":"2010","journal-title":"Neurotoxicology"},{"key":"10.1124\/jpet.115.226373_bib64","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1042\/bse0500161","article-title":"The P-glycoprotein multidrug transporter","volume":"50","author":"Sharom","year":"2011","journal-title":"Essays Biochem"},{"key":"10.1124\/jpet.115.226373_bib65","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.brainresbull.2011.09.017","article-title":"Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson\u2019s disease in vitro and in vivo","volume":"86","author":"Slotkin","year":"2011","journal-title":"Brain Res Bull"},{"issue":"Suppl 2","key":"10.1124\/jpet.115.226373_bib66","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.parkreldis.2008.04.008","article-title":"Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson\u2019s disease","volume":"14","author":"Sonsalla","year":"2008","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1124\/jpet.115.226373_bib67","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.bbamem.2007.04.001","article-title":"Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function","volume":"1768","author":"Sreeramulu","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1124\/jpet.115.226373_bib68","doi-asserted-by":"crossref","first-page":"13972","DOI":"10.1073\/pnas.242594999","article-title":"Etiology of Parkinson\u2019s disease: genetics and environment revisited","volume":"99","author":"Steece-Collier","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1124\/jpet.115.226373_bib69","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/archneur.62.3.460","article-title":"Effect of MDR1 haplotype on risk of Parkinson disease","volume":"62","author":"Tan","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1124\/jpet.115.226373_bib70","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neulet.2004.09.046","article-title":"Analysis of MDR1 haplotypes in Parkinson\u2019s disease in a white population","volume":"372","author":"Tan","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1124\/jpet.115.226373_bib71","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1289\/ehp.1002839","article-title":"Rotenone, paraquat, and Parkinson\u2019s disease","volume":"119","author":"Tanner","year":"2011","journal-title":"Environ Health Perspect"},{"key":"10.1124\/jpet.115.226373_bib72","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-8993(00)02960-7","article-title":"Increased striatal dopamine turnover following acute administration of rotenone to mice","volume":"885","author":"Thiffault","year":"2000","journal-title":"Brain Res"},{"key":"10.1124\/jpet.115.226373_bib73","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00441-004-0937-z","article-title":"Neurotoxicant-induced animal models of Parkinson\u2019s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration","volume":"318","author":"Uversky","year":"2004","journal-title":"Cell Tissue Res"},{"key":"10.1124\/jpet.115.226373_bib74","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0014-5793(01)02597-2","article-title":"Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson\u2019s disease","volume":"500","author":"Uversky","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.115.226373_bib75","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1517\/17425250903193079","article-title":"ABCB1: the role in Parkinson\u2019s disease and pharmacokinetics of antiparkinsonian drugs","volume":"5","author":"Vautier","year":"2009","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1124\/jpet.115.226373_bib76","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.nbd.2006.02.012","article-title":"Inhibitory effects of pesticides on proteasome activity: implication in Parkinson\u2019s disease","volume":"23","author":"Wang","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1124\/jpet.115.226373_bib77","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1212\/WNL.0b013e3181d76a93","article-title":"Persistent organochlorine pesticides in serum and risk of Parkinson disease","volume":"74","author":"Weisskopf","year":"2010","journal-title":"Neurology"},{"key":"10.1124\/jpet.115.226373_bib78","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.parkreldis.2008.11.010","article-title":"Association of a polymorphism in the ABCB1 gene with Parkinson\u2019s disease","volume":"15","author":"Westerlund","year":"2009","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1124\/jpet.115.226373_bib79","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00441-008-0686-5","article-title":"Expression of multi-drug resistance 1 mRNA in human and rodent tissues: reduced levels in Parkinson patients","volume":"334","author":"Westerlund","year":"2008","journal-title":"Cell Tissue Res"},{"issue":"Suppl 1","key":"10.1124\/jpet.115.226373_bib80","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1007\/s10654-011-9581-6","article-title":"Epidemiology and etiology of Parkinson\u2019s disease: a review of the evidence","volume":"26","author":"Wirdefeldt","year":"2011","journal-title":"Eur J Epidemiol"},{"key":"10.1124\/jpet.115.226373_bib81","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1124\/jpet.104.065383","article-title":"Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P-glycoprotein","volume":"310","author":"Woodahl","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.226373_bib82","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/jcbfm.2014.162","article-title":"Decreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice","volume":"35","author":"Wu","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1124\/jpet.115.226373_bib83","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/clpt.2013.45","article-title":"ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans","volume":"94","author":"Zamek-Gliszczynski","year":"2013","journal-title":"Clin Pharmacol Ther"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524191355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524191355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.115.226373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:36:25Z","timestamp":1739993785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524191355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0022356524191355"],"URL":"https:\/\/doi.org\/10.1124\/jpet.115.226373","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P-Glycoprotein Transport of Neurotoxic Pesticides","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.115.226373","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}