{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:55:58Z","timestamp":1783464958632,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpet.aspetjournals.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1124\/jpet.115.227934","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T04:30:30Z","timestamp":1445315430000},"page":"137-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Andrographolide Ameliorates Abdominal Aortic Aneurysm Progression by Inhibiting Inflammatory Cell Infiltration through Downregulation of Cytokine and Integrin Expression"],"prefix":"10.1016","volume":"356","author":[{"given":"Jun","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Sheibani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Craig","family":"Kent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1124\/jpet.115.227934_bib1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/STROKEAHA.108.532556","article-title":"Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation","volume":"40","author":"Aoki","year":"2009","journal-title":"Stroke"},{"key":"10.1124\/jpet.115.227934_bib2","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1161\/CIRCULATIONAHA.107.728303","article-title":"NF-kappaB is a key mediator of cerebral aneurysm formation","volume":"116","author":"Aoki","year":"2007","journal-title":"Circulation"},{"key":"10.1124\/jpet.115.227934_bib3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jama.2013.950","article-title":"Surveillance intervals for small abdominal aortic aneurysms: a meta-analysis","volume":"309","author":"Bown","year":"2013","journal-title":"JAMA"},{"key":"10.1124\/jpet.115.227934_bib4","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s10067-009-1180-5","article-title":"Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial","volume":"28","author":"Burgos","year":"2009","journal-title":"Clin Rheumatol"},{"key":"10.1124\/jpet.115.227934_bib5","first-page":"360","article-title":"Kinetics of cellular proliferation after arterial injury. V. Role of acute distension in the induction of smooth muscle proliferation","volume":"60","author":"Clowes","year":"1989","journal-title":"Lab Invest"},{"key":"10.1124\/jpet.115.227934_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/s-2004-818938","article-title":"Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy","volume":"70","author":"Coon","year":"2004","journal-title":"Planta Med"},{"key":"10.1124\/jpet.115.227934_bib7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1172\/JCI22309","article-title":"Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context?","volume":"114","author":"Curci","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.115.227934_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/01.ATV.0000118013.72016.ea","article-title":"Mouse models of abdominal aortic aneurysms","volume":"24","author":"Daugherty","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/jpet.115.227934_bib9","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.jvs.2014.01.007","article-title":"Epidemiology of aortic aneurysm repair in the United States from 2000 to 2010","volume":"59","author":"Dua","year":"2014","journal-title":"J Vasc Surg"},{"key":"10.1124\/jpet.115.227934_bib10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/CIRCULATIONAHA.104.517391","article-title":"Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation","volume":"112","author":"Eliason","year":"2005","journal-title":"Circulation"},{"key":"10.1124\/jpet.115.227934_bib11","first-page":"CD001835","article-title":"Surgery for small asymptomatic abdominal aortic aneurysms","volume":"3","author":"Filardo","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1124\/jpet.115.227934_bib12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"385","year":"2015","journal-title":"Lancet"},{"key":"10.1124\/jpet.115.227934_bib13","first-page":"276","article-title":"Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride","volume":"92","author":"Handa","year":"1990","journal-title":"Indian J Med Res"},{"key":"10.1124\/jpet.115.227934_bib14","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1074\/jbc.M110.123968","article-title":"Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells","volume":"286","author":"Hsieh","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.227934_bib15","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1091\/mbc.e07-02-0166","article-title":"Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment","volume":"18","author":"Ip","year":"2007","journal-title":"Mol Biol Cell"},{"key":"10.1124\/jpet.115.227934_bib16","doi-asserted-by":"crossref","unstructured":"Jayakumar T, Hsieh CY, Lee JJ and Sheu JR (2013) Experimental and clinical pharmacology of andrographis paniculata and its major bioactive phytoconstituent andrographolide. Evid Based Complement Alternat Med 2013:846740.","DOI":"10.1155\/2013\/846740"},{"key":"10.1124\/jpet.115.227934_bib17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2147\/VHRM.S2700","article-title":"TNF-alpha-mediated inflammation in cerebral aneurysms: a potential link to growth and rupture","volume":"4","author":"Jayaraman","year":"2008","journal-title":"Vasc Health Risk Manag"},{"issue":"4B","key":"10.1124\/jpet.115.227934_bib18","first-page":"2439","article-title":"Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression","volume":"27","author":"Jiang","year":"2007","journal-title":"Anticancer Res"},{"key":"10.1124\/jpet.115.227934_bib19","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1056\/NEJMcp1401430","article-title":"Clinical practice. Abdominal aortic aneurysms","volume":"371","author":"Kent","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1124\/jpet.115.227934_bib20","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1091\/mbc.e11-06-0531","article-title":"Protein kinase C \u03b4 regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42","volume":"23","author":"Lengfeld","year":"2012","journal-title":"Mol Biol Cell"},{"key":"10.1124\/jpet.115.227934_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0014-5793(97)00093-8","article-title":"Reactive oxygen species induce apoptosis of vascular smooth muscle cell","volume":"404","author":"Li","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1124\/jpet.115.227934_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1161\/CIRCRESAHA.117.305262","article-title":"Thrombospondin-1 (TSP1) contributes to the development of vascular inflammation by regulating monocytic cell motility in mouse models of abdominal aortic aneurysm","volume":"117","author":"Liu","year":"2015","journal-title":"Circ Res"},{"key":"10.1124\/jpet.115.227934_bib23","unstructured":"Liu Z, Wang Q, Ren J, Assa CR, Morgan S, Giles J, Han Q, Liu B (2014) Murine abdominal aortic aneurysm model by orthotopic allograft transplantation of elastase-treated abdominal aorta. J Vasc Surg DOI: S0741-5214(14)01000-3 [published ahead of print]."},{"key":"10.1124\/jpet.115.227934_bib24","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI0215334","article-title":"Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms","volume":"110","author":"Longo","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.115.227934_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bcp.2014.06.024","article-title":"Andrographolide inhibits TNF\u03b1-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K\/Akt\/Nrf2 and PI3K\/Akt\/AP-1 pathways in human endothelial cells","volume":"91","author":"Lu","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.227934_bib26","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.bcp.2012.06.030","article-title":"Suppression of NF-\u03baB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade","volume":"84","author":"Lu","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1124\/jpet.115.227934_bib27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.surg.2007.04.017","article-title":"Deletion of CCR2 but not CCR5 or CXCR3 inhibits aortic aneurysm formation","volume":"142","author":"MacTaggart","year":"2007","journal-title":"Surgery"},{"key":"10.1124\/jpet.115.227934_bib28","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1161\/CIRCRESAHA.107.148668","article-title":"Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model","volume":"101","author":"Miyake","year":"2007","journal-title":"Circ Res"},{"key":"10.1124\/jpet.115.227934_bib29","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/sj.gt.3302704","article-title":"Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit model","volume":"13","author":"Miyake","year":"2006","journal-title":"Gene Ther"},{"key":"10.1124\/jpet.115.227934_bib30","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.jtcvs.2011.07.053","article-title":"Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation","volume":"142","author":"Moehle","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1124\/jpet.115.227934_bib31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/01.CIR.0000105725.61763.A2","article-title":"Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors","volume":"109","author":"Nakashima","year":"2004","journal-title":"Circulation"},{"key":"10.1124\/jpet.115.227934_bib50","unstructured":"National Research Council (2011) Guide for the Care and Use of Laboratory Animals. 8th edition. Washington (DC): National Academies Press, US."},{"key":"10.1124\/jpet.115.227934_bib32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrcardio.2010.180","article-title":"Pathophysiology and epidemiology of abdominal aortic aneurysms","volume":"8","author":"Nordon","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"10.1124\/jpet.115.227934_bib33","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1124\/jpet.115.227934_bib34","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI8931","article-title":"Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms","volume":"105","author":"Pyo","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.115.227934_bib35","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.1074\/jbc.M113.515957","article-title":"Protein kinase C-\u03b4 (PKC\u03b4) regulates proinflammatory chemokine expression through cytosolic interaction with the NF-\u03baB subunit p65 in vascular smooth muscle cells","volume":"289","author":"Ren","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1124\/jpet.115.227934_bib36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/cvr\/cvs298","article-title":"Importance of endothelial NF-\u03baB signalling in vascular remodelling and aortic aneurysm formation","volume":"97","author":"Saito","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1124\/jpet.115.227934_bib37","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.ATV.0000214999.12921.4f","article-title":"Inflammation and cellular immune responses in abdominal aortic aneurysms","volume":"26","author":"Shimizu","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/jpet.115.227934_bib38","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1161\/ATVBAHA.111.244921","article-title":"Protein kinase C-delta mediates adventitial cell migration through regulation of monocyte chemoattractant protein-1 expression in a rat angioplasty model","volume":"32","author":"Si","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1124\/jpet.115.227934_bib39","first-page":"171","article-title":"Isolation and characterization of murine retinal endothelial cells","volume":"9","author":"Su","year":"2003","journal-title":"Mol Vis"},{"key":"10.1124\/jpet.115.227934_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1196\/annals.1383.029","article-title":"Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds","volume":"1085","author":"Thompson","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1124\/jpet.115.227934_bib41","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1172\/JCI118037","article-title":"Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages","volume":"96","author":"Thompson","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1124\/jpet.115.227934_bib42","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.atherosclerosis.2015.06.014","article-title":"TRIF adaptor signaling is important in abdominal aortic aneurysm formation","volume":"241","author":"Vorkapic","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1124\/jpet.115.227934_bib43","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1161\/CIRCRESAHA.116.304899","article-title":"Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation","volume":"116","author":"Wang","year":"2015","journal-title":"Circ Res"},{"key":"10.1124\/jpet.115.227934_bib44","doi-asserted-by":"crossref","first-page":"e92053","DOI":"10.1371\/journal.pone.0092053","article-title":"Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1124\/jpet.115.227934_bib45","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/cr.2007.89","article-title":"Andrographolide inhibits NF-kappaBeta activation and attenuates neointimal hyperplasia in arterial restenosis","volume":"17","author":"Wang","year":"2007","journal-title":"Cell Res"},{"key":"10.1124\/jpet.115.227934_bib46","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1124\/jpet.107.133918","article-title":"Andrographolide up-regulates cellular-reduced glutathione level and protects cardiomyocytes against hypoxia\/reoxygenation injury","volume":"325","author":"Woo","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1124\/jpet.115.227934_bib47","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.4049\/jimmunol.173.6.4207","article-title":"Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50","volume":"173","author":"Xia","year":"2004","journal-title":"J Immunol"},{"key":"10.1124\/jpet.115.227934_bib48","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1055\/s-2003-45185","article-title":"Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats","volume":"69","author":"Yu","year":"2003","journal-title":"Planta Med"},{"key":"10.1124\/jpet.115.227934_bib49","doi-asserted-by":"crossref","first-page":"e56407","DOI":"10.1371\/journal.pone.0056407","article-title":"Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-\u03baB","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"}],"container-title":["The Journal of Pharmacology and Experimental Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524191999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022356524191999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1124\/jpet.115.227934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T19:40:37Z","timestamp":1739994037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022356524191999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0022356524191999"],"URL":"https:\/\/doi.org\/10.1124\/jpet.115.227934","relation":{},"ISSN":["0022-3565"],"issn-type":[{"value":"0022-3565","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Andrographolide Ameliorates Abdominal Aortic Aneurysm Progression by Inhibiting Inflammatory Cell Infiltration through Downregulation of Cytokine and Integrin Expression","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pharmacology and Experimental Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1124\/jpet.115.227934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by The American Society for Pharmacology and Experimental Therapeutics","name":"copyright","label":"Copyright"}]}}